LOCUS       NM_203403               2683 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens leucine rich adaptor protein 1 like (LURAP1L), mRNA.
ACCESSION   NM_203403 XM_210019
VERSION     NM_203403.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX508229.1, BC036923.1, BM739457.1, AK095824.1, BE464662.1 and
            CD678148.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203403.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.731637.1,
                                           SRR3476690.637694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319264.4/ ENSP00000321026.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BX508229.1         14-40
            28-843              BC036923.1         1-816
            844-1183            BM739457.1         67-406
            1184-1752           AK095824.1         1190-1758
            1753-2074           BE464662.1         1-322               c
            2075-2683           CD678148.1         30-638              c
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23"
     gene            1..2683
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /note="leucine rich adaptor protein 1 like"
                     /db_xref="GeneID:286343"
                     /db_xref="HGNC:HGNC:31452"
                     /db_xref="MIM:616130"
     exon            1..1008
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..1383
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /note="leucine repeat adaptor protein 35b"
                     /codon_start=1
                     /product="leucine rich adaptor protein 1-like"
                     /protein_id="NP_981948.1"
                     /db_xref="CCDS:CCDS6473.1"
                     /db_xref="GeneID:286343"
                     /db_xref="HGNC:HGNC:31452"
                     /db_xref="MIM:616130"
                     /translation="MEDSPLPDLRDIELKLGRKVPESLVRSLRGEEPVPRERDRDPCG
                     GSGGGGGGGGGCSSSSSYCSFPPSLSSSSSSSPTSGSPRGSHSSALERLETKLHLLRQ
                     EMVNLRATDVRLMRQLLVINESIESIKWMIEEKATITSRGSSLSGSLCSLLESQSTSL
                     RGSYNSLHDGSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDSQALHKRP
                     KLDSEYYCFG"
     exon            1009..2683
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /note="major polyA site"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
                     /note="hexamer: ATTAAA"
     polyA_site      2683
                     /gene="LURAP1L"
                     /gene_synonym="bA3L8.2; C9orf150; HYST0841; LRAP35b"
ORIGIN      
        1 aatgacttgg atcaaacagc ctaaatggga agaaggacat ttttgctgca tcaaggaagc
       61 cgttaaactc ctgctaagct aactagctct tttttatggg tccatgcaca cgaccgaact
      121 cctctttcac tgaccagaga ttatttctga caacccagga tatcccgaaa gcttggaggc
      181 atatggctgg aaaatgaaac gacccaggac atcgtttctg gctgcatcat tattttgtgt
      241 cgcgtagtac cagatgggca gtcagtgagc ggcgcaggga tgtgaacgga cggttttata
      301 atgtgaaaat tttcccttgg taaagctaaa acagatttaa tttccctctc ttttctttca
      361 ctacttcccc ctctttattc cccctctgtc tgcaatatca gtgaactcaa ctttgcagtg
      421 aggtggccaa aaagagagag aatgaggaga tcttgatcat cttagtgtcg gaggagtcgc
      481 agcggactgg gaactgcagc tgcgaccccc cgcgtcctgt gcggatttca gggctgatac
      541 cgcataggcg gttatggaaa ggacggtaca ccggagcggc ggaggataga gaccctggcc
      601 cccggagagg tctgctgatt tcgcagcagc cttcgaagcc gtggctgcct ttcatctgct
      661 gcgttttatt actattatcg ccgttccgga aaagtcatgg aagacagccc gctgccagac
      721 ctcagagaca tcgagctgaa gctggggcgc aaagtacccg agagtctagt gcgctctctc
      781 cgtggggagg agccggttcc cagggaaagg gacagggacc cctgcggggg gagcggtggt
      841 ggtggcggcg gcggcggcgg ctgcagtagc agcagcagct actgcagctt ccctccctcc
      901 ttgtcgtcct cctcttcgtc ctccccaacc tctggctccc cacgaggtag ccactctagc
      961 gccctggaga ggctagaaac caagcttcac ctcctcaggc aagagatggt taacctcaga
     1021 gccacagacg tcaggctcat gcgccagttg cttgtaatca atgagagcat cgagtccatc
     1081 aagtggatga tcgaagaaaa agccaccatt accagcagag gcagcagcct cagtggcagc
     1141 ctgtgcagtt tgttggagag tcagagcacc tccttacgtg gcagctacaa cagcctacac
     1201 gatggcagtg atgggctgga tggcatttcc gtgggaagtt atctggacac gttggcggat
     1261 gatgtcccag gccatcagac cccttcagac ttggaccaat tcagtgacag ctccctcata
     1321 gaggactcac aggcactaca caagcgtcct aaattggatt ctgaatacta ctgctttggc
     1381 tagtgacagt tttttgcatg ggactggtgt gcaatgaact tgtatttatc cttcttctcc
     1441 gctgctatat ttttggtgtg atttttattt taataagatg acctttttaa aagaagctga
     1501 ttttgaaact gcttaatggt attgctgttg ctcctaatac ttctcatctg agctgattta
     1561 tttttctctg ttacatctct attttttatt tattacaatg attttctccc ttcttttaca
     1621 gtagcacaaa caaagtaggg ggaaaagaat aagcaataat tatgtttttg cttttgtttt
     1681 cagagcaatg ggtcagggat tacaagaaaa actttgctaa attttacaat aaaccaaagt
     1741 ctgataacag ttaatgttgc tgcttgcgtc cttaaatgac ttaaggtttc atcttccaga
     1801 agatattgag atatattact gtttgcatat caggttgaac aaaatgcttg gaacaaaatt
     1861 aagcattatt tctagaccac aacattctag tgtataatca accatactgt tagtcacaca
     1921 cgcccacatg acaatcatct gaaagtcccc aactatacac attctgttca accaactcac
     1981 ccttgtgttg gtactttaga ttaacatttt gtcatcagtg attctaactc aaatcatatg
     2041 tttatttgtg taataaaatg tattattctc ccaaatttca aggaataatt gagattaagt
     2101 atggaggcca ttcaaggcaa aaatgtccta aatttaattg cattttgaga ttttgttggc
     2161 atttacttgt atgtattttg tgattctgat aggatgtata aatacttaga tgcatacaag
     2221 ccgatggata gaaagacaga taaatatccc gatagcctac tatcagcatc ctactactgc
     2281 ttccctaaag cagaattgtt attcatttaa gaagtctaat atgatataca ttcatcctag
     2341 tataaataaa taatctctaa gttttctgaa atggaatatt taacgcacat agacagtgga
     2401 tatttacttt aaatataatg ttattaatcc tctgcatttc ttttatcttg ataactccta
     2461 gtgagggaat ctaattaaga tttcatgctg ttctttgtaa tgataaatgt ttccggacta
     2521 aacactctat aatacaaatc aaaaaatctt ccttcttata actgagaaat gtttcaccca
     2581 aatttccttt gttattatat atttactaca catgttgaat ttattattgt ttatttccaa
     2641 ggcatgtatt attcaatttc taattaaaat atatcagggc tta
//
