LOCUS       NM_001013615            1849 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens leucine rich adaptor protein 1 (LURAP1), mRNA.
ACCESSION   NM_001013615
VERSION     NM_001013615.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Chia,S., Leung,T. and Tan,I.
  TITLE     Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta and
            CK1delta regulates EB1-dependent MT dynamics in cell migration
  JOURNAL   Cell Rep 36 (11), 109687 (2021)
   PUBMED   34525355
  REMARK    GeneRIF: Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta
            and CK1delta regulates EB1-dependent MT dynamics in cell migration.
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Jing,Z., Yuan,X., Zhang,J., Huang,X., Zhang,Z., Liu,J., Zhang,M.,
            Oyang,J., Zhang,Y., Zhang,Z. and Yang,R.
  TITLE     Chromosome 1 open reading frame 190 promotes activation of
            NF-kappaB canonical pathway and resistance of dendritic cells to
            tumor-associated inhibition in vitro
  JOURNAL   J Immunol 185 (11), 6719-6727 (2010)
   PUBMED   21048106
  REMARK    GeneRIF: C1orf190 can activate NF-kappaB, drive production of
            cytokines, and promote the antigen-presenting function and priming
            ability of dendritic cells.
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Tan,I., Yong,J., Dong,J.M., Lim,L. and Leung,T.
  TITLE     A tripartite complex containing MRCK modulates lamellar actomyosin
            retrograde flow
  JOURNAL   Cell 135 (1), 123-136 (2008)
   PUBMED   18854160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057892.1, BX370151.2 and AI077554.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001013615.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057892.1, SRR3476690.510082.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371980.4/ ENSP00000361048.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-881               AK057892.1         1-881
            882-1156            BX370151.2         202-476
            1157-1716           AK057892.1         1157-1716
            1717-1849           AI077554.1         33-165              c
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1849
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /note="leucine rich adaptor protein 1"
                     /db_xref="GeneID:541468"
                     /db_xref="HGNC:HGNC:32327"
                     /db_xref="MIM:616129"
     exon            1..291
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..813
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /note="NF-kappa-B activator C1orf190; leucine repeat
                     adapter protein 35A; leucine repeat adaptor protein 35a"
                     /codon_start=1
                     /product="leucine rich adaptor protein 1"
                     /protein_id="NP_001013633.1"
                     /db_xref="CCDS:CCDS30703.1"
                     /db_xref="GeneID:541468"
                     /db_xref="HGNC:HGNC:32327"
                     /db_xref="MIM:616129"
                     /translation="MEGTVESQTPDLRDVEGKVGRKTPEGLLRGLRGECELGTSGALL
                     LPGASSTGHDLGDKIMALKMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTS
                     HCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSTTDRLDSVSIGSFLDTVAPSELDEQG
                     PPGAPRSEMDWAKVIAGGERARTEVDVAATRLGSLRAVWKPPGERLQGGPPESPEDES
                     AKLGFEAHWFWEQCQDDVTFL"
     exon            292..1849
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      835
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /note="major polyA site"
     polyA_site      877
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
     polyA_site      924
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
     polyA_site      937
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /note="hexamer: AATAGA"
     polyA_site      1849
                     /gene="LURAP1"
                     /gene_synonym="C1orf190; LRAP35a; LRP35A"
                     /note="major polyA site"
ORIGIN      
        1 ggttttgctc cgctttagca gcggcgaagg gaggaccccc gggagccggt ccccggcgtc
       61 cggtcgccca gcccttttca ggcttgggcc cgcatggagg ggaccgtgga gtcccagacg
      121 cctgacctgc gggatgtgga gggtaaggtg ggcaggaaga cccctgaagg gctgctccgc
      181 gggctgcgag gcgagtgtga gctgggaacc tctggcgccc tgctgctccc aggggcgtct
      241 agcaccggcc acgacttggg ggacaagatc atggcgctga agatggagct ggcttacctg
      301 cgagccatcg atgtgaagat cctgcagcag ctggtgacct tgaatgaggg catcgaggca
      361 gtgcgctggc tgttggagga gcgggggacg ttgaccagtc attgcagcag cctcaccagc
      421 agtcaatata gcctgacagg cgggagccca ggccgctcaa ggcgaggcag ctgggacagc
      481 ctgccagaca ccagcaccac cgaccggctg gacagtgtct ctattggcag cttcctggac
      541 acagtggccc ccagcgagct ggatgaacag ggcccacctg gggctccacg ttccgagatg
      601 gactgggcaa aagttatagc tggtggagag agggccagga ctgaggtgga tgtggcagcc
      661 accaggctag ggagcttgag agctgtgtgg aagcccccag gggagaggct tcaaggtgga
      721 ccacctgagt caccagagga tgagagtgcc aagctgggct tcgaggccca ctggttctgg
      781 gagcagtgcc aggatgatgt gaccttcttg taacaactat tccacccttt tgtaatcctg
      841 tggctctttt atccattaga tgtggtctcc cccaaaattg attctccctc agtctgagac
      901 taggaagagg ctgcactgaa atcagttacc atggaaacct ggctcatcat ttctctagtc
      961 cctagggagt ctctgccttt atccctcaat tattgggtcc ctagagctag cttgctcttt
     1021 ctttctttct ttcttttttt gagacagggt cttatgctgt tacccaagat agagagcagt
     1081 ggcatgatca cagctcactg cagccttgac ctcctgggct caagcgatcc tcctatttca
     1141 gcctccccca tagttaggac cacaggcatg caccaccatg cccagctaat tgtttattta
     1201 tttatttttt ttttgtagag atagggtttc cctgtgttgc ccaggctggt ctcaaactcc
     1261 tgggctcaag ggatcctccc gcctcagcct cccaaagtgc tgggattatg cccagcccct
     1321 agagatactt ctatagagat attgactcta aaggattgac ctatggcttt tggtatttag
     1381 tatctctcac tactcccccc agctaagtaa ggatttaagg aatttaggac tccctggagt
     1441 taacagatga agagatgggg gcataattac ttcacccaaa gtctagaagc cttggcctct
     1501 ctcttggcca agatggagga ttgaggaggg acatggacct tcaggactaa ccctctatgg
     1561 attggccctc ccagaagcgt ttgggctggt agacccaccc cttcctacct gctgagtgat
     1621 gtcatttcct gccaggatgg gtagcccttt gtacgggtcc ttggatggta gtaggtcata
     1681 taggggcatc tgagcccctg ctgctaagtg agatcacatt atttatcgtc cataccatta
     1741 cttcttgtga acagtaacat gtcactcctc ctggcaggaa agtttctcat tgtcagatgt
     1801 ttgtgcttct tttcaggtct tactttttaa atagagtgtt ctcatttta
//
