LOCUS       NM_002345               2671 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lumican (LUM), mRNA.
ACCESSION   NM_002345
VERSION     NM_002345.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Park,S.J., Ji,E., Yoo,H.J., Kim,K., Ji,S., Baek,J.Y., Lee,J.Y.,
            Jung,H.W., Jang,I.Y., Lee,E., Hong,N. and Kim,B.J.
  TITLE     Circulating lumican as a potential biomarker for osteosarcopenia in
            older adults
  JOURNAL   Bone 179, 116959 (2024)
   PUBMED   37956822
  REMARK    GeneRIF: Circulating lumican as a potential biomarker for
            osteosarcopenia in older adults.
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Xu,W., Chen,S., Jiang,Q., He,J., Zhang,F., Wang,Z., Ruan,C. and
            Shi,B.
  TITLE     LUM as a novel prognostic marker and its correlation with immune
            infiltration in gastric cancer: a study based on
            immunohistochemical analysis and bioinformatics
  JOURNAL   BMC Gastroenterol 23 (1), 455 (2023)
   PUBMED   38129820
  REMARK    GeneRIF: LUM as a novel prognostic marker and its correlation with
            immune infiltration in gastric cancer: a study based on
            immunohistochemical analysis and bioinformatics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Tsui,M.C., Liu,H.Y., Chu,H.S., Chen,W.L., Hu,F.R., Kao,W.W. and
            Wang,I.J.
  TITLE     The versatile roles of lumican in eye diseases: A review
  JOURNAL   Ocul Surf 29, 388-397 (2023)
   PUBMED   37327869
  REMARK    GeneRIF: The versatile roles of lumican in eye diseases: A review.
            Review article
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Wang,K., Wang,Y., Cao,Y., Wang,H., Zhou,Y., Gao,L., Zeng,Z.,
            Cheng,M., Jin,X., Chen,J., Wen,F. and Wang,T.
  TITLE     Lumican is elevated in the lung in human and experimental acute
            respiratory distress syndrome and promotes early fibrotic responses
            to lung injury
  JOURNAL   J Transl Med 20 (1), 392 (2022)
   PUBMED   36059026
  REMARK    GeneRIF: Lumican is elevated in the lung in human and experimental
            acute respiratory distress syndrome and promotes early fibrotic
            responses to lung injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Li,Z., Sun,C., Chen,M. and Wang,B.
  TITLE     Lumican silencing alleviates tumor necrosis factor-alpha-induced
            nucleus pulposus cell inflammation and senescence by inhibiting
            apoptosis signal regulating kinase 1/p38 signaling pathway via
            inactivating Fas ligand expression
  JOURNAL   Bioengineered 12 (1), 6891-6901 (2021)
   PUBMED   34516336
  REMARK    GeneRIF: Lumican silencing alleviates tumor necrosis
            factor-alpha-induced nucleus pulposus cell inflammation and
            senescence by inhibiting apoptosis signal regulating kinase 1/p38
            signaling pathway via inactivating Fas ligand expression.
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Svensson,L., Narlid,I. and Oldberg,A.
  TITLE     Fibromodulin and lumican bind to the same region on collagen type I
            fibrils
  JOURNAL   FEBS Lett 470 (2), 178-182 (2000)
   PUBMED   10734230
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Matsushima,N., Ohyanagi,T., Tanaka,T. and Kretsinger,R.H.
  TITLE     Super-motifs and evolution of tandem leucine-rich repeats within
            the small proteoglycans--biglycan, decorin, lumican, fibromodulin,
            PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
  JOURNAL   Proteins 38 (2), 210-225 (2000)
   PUBMED   10656267
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Grover,J., Chen,X.N., Korenberg,J.R. and Roughley,P.J.
  TITLE     The human lumican gene. Organization, chromosomal location, and
            expression in articular cartilage
  JOURNAL   J Biol Chem 270 (37), 21942-21949 (1995)
   PUBMED   7665616
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Chakravarti,S., Stallings,R.L., SundarRaj,N., Cornuet,P.K. and
            Hassell,J.R.
  TITLE     Primary structure of human lumican (keratan sulfate proteoglycan)
            and localization of the gene (LUM) to chromosome 12q21.3-q22
  JOURNAL   Genomics 27 (3), 481-488 (1995)
   PUBMED   7558030
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   Rada,J.A., Cornuet,P.K. and Hassell,J.R.
  TITLE     Regulation of corneal collagen fibrillogenesis in vitro by corneal
            proteoglycan (lumican and decorin) core proteins
  JOURNAL   Exp Eye Res 56 (6), 635-648 (1993)
   PUBMED   8595806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007038.1, AA036658.1 and
            AC078873.22.
            
            On Nov 22, 2018 this sequence version replaced NM_002345.3.
            
            Summary: This gene encodes a member of the small leucine-rich
            proteoglycan (SLRP) family that includes decorin, biglycan,
            fibromodulin, keratocan, epiphycan, and osteoglycin. In these
            bifunctional molecules, the protein moiety binds collagen fibrils
            and the highly charged hydrophilic glycosaminoglycans regulate
            interfibrillar spacings. Lumican is the major keratan sulfate
            proteoglycan of the cornea but is also distributed in interstitial
            collagenous matrices throughout the body. Lumican may regulate
            collagen fibril organization and circumferential growth, corneal
            transparency, and epithelial cell migration and tissue repair.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.239784.1,
                                           SRR5189655.100352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266718.5/ ENSP00000266718.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1749              BC007038.1         24-1772
            1750-1839           AA036658.1         371-460
            1840-1845           AA036658.1         462-467
            1846-2671           AC078873.22        159387-160212       c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..2671
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="lumican"
                     /db_xref="GeneID:4060"
                     /db_xref="HGNC:HGNC:6724"
                     /db_xref="MIM:600616"
     exon            1..97
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            98..980
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2671
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="hexamer: AATAAA"
     polyA_site      1752
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="major polyA site"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="hexamer: AATAGA"
     polyA_site      1828
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
                     /note="hexamer: GATAAA"
     polyA_site      2671
                     /gene="LUM"
                     /gene_synonym="LDC; SLRR2D"
ORIGIN      
        1 agttccgtcc tgacagagtt cacagcatat attggtggat tcttgtccat agtgcatctg
       61 ctttaagaat taacgaaagc agtgtcaaga cagtaaggat tcaaaccatt tgccaaaaat
      121 gagtctaagt gcatttactc tcttcctggc attgattggt ggtaccagtg gccagtacta
      181 tgattatgat tttcccctat caatttatgg gcaatcatca ccaaactgtg caccagaatg
      241 taactgccct gaaagctacc caagtgccat gtactgtgat gagctgaaat tgaaaagtgt
      301 accaatggtg cctcctggaa tcaagtatct ttaccttagg aataaccaga ttgaccatat
      361 tgatgaaaag gcctttgaga atgtaactga tctgcagtgg ctcattctag atcacaacct
      421 tctagaaaac tccaagataa aagggagagt tttctctaaa ttgaaacaac tgaagaagct
      481 gcatataaac cacaacaacc tgacagagtc tgtgggccca cttcccaaat ctctggagga
      541 tctgcagctt actcataaca agatcacaaa gctgggctct tttgaaggat tggtaaacct
      601 gaccttcatc catctccagc acaatcggct gaaagaggat gctgtttcag ctgcttttaa
      661 aggtcttaaa tcactcgaat accttgactt gagcttcaat cagatagcca gactgccttc
      721 tggtctccct gtctctcttc taactctcta cttagacaac aataagatca gcaacatccc
      781 tgatgagtat ttcaagcgtt ttaatgcatt gcagtatctg cgtttatctc acaacgaact
      841 ggctgatagt ggaatacctg gaaattcttt caatgtgtca tccctggttg agctggatct
      901 gtcctataac aagcttaaaa acataccaac tgtcaatgaa aaccttgaaa actattacct
      961 ggaggtcaat caacttgaga agtttgacat aaagagcttc tgcaagatcc tggggccatt
     1021 atcctactcc aagatcaagc atttgcgttt ggatggcaat cgcatctcag aaaccagtct
     1081 tccaccggat atgtatgaat gtctacgtgt tgctaacgaa gtcactctta attaatatct
     1141 gtatcctgga acaatatttt atggttatgt ttttctgtgt gtcagttttc atagtatcca
     1201 tattttatta ctgtttatta cttccatgaa ttttaaaatc tgagggaaat gttttgtaaa
     1261 catttatttt ttttaaagaa aagatgaaag gcaggcctat ttcatcacaa gaacacacac
     1321 atatacacga atagacatca aactcaatgc tttatttgta aatttagtgt ttttttattt
     1381 ctactgtcaa atgatgtgca aaacctttta ctggttgcat ggaaatcagc caagttttat
     1441 aatccttaaa tcttaatgtt cctcaaagct tggattaaat acatatggat gttactctct
     1501 tgcaccaaat tatcttgata cattcaaatt tgtctggtta aaaaataggt ggtagatatt
     1561 gaggccaaga atattgcaaa atacatgaag cttcatgcac ttaaagaagt atttttagaa
     1621 taagaatttg catacttacc tagtgaaact tttctagaat tatttttcac tctaagtcat
     1681 gtatgtttct ctttgattat ttgcatgtta tgtttaataa gctactagca aaataaaaca
     1741 tagcaaatgg catcactgtg tttgacttct tgtgaaattt ctgtactttg tatataaaat
     1801 acataaaaca atagattaga aatcaaaaga tatctctggc ctgcaatatt ttactgatgt
     1861 gaacatagga ttttccacta aataatttgt ctacttctag cattcactta caaagagttc
     1921 ttaaaaacac ctataatagg tacttagatt tcacaactta cttagatatt tgtcattatt
     1981 cccattcctg gtgtttttac tggttcatat acaatggtat tctattagat aagaagctgc
     2041 tatgtgatct cagcactcac tccttggttg tcaagaaatg gtggataact cacaggatta
     2101 aaaatgaatg aatataaaat tttctgaaat agatatttaa aaaatcattt tagcttgaag
     2161 ccaatatgtc tggatcatag gttttgagtt cataatccag taataacagc tttcagcttt
     2221 ctatgagtat atacaattct atacaatgat aaatactctg catataattt ataaaaataa
     2281 cttctgtttt acctagttaa caataaaacc tatgtgtgga gccaaatgtt atgcagacaa
     2341 aggtctgctc atcccatacc agtgtatata tagtcaaata tgtgtctagt acaaataaaa
     2401 tgtatctcta aggcataaaa tgttttaaca caccactttt agtgaactct atcttatggt
     2461 acagcggcct ttcatcagag gatcatcatt gagactgagt tgactggcag atatgtgcga
     2521 tggatattac attaggtaca atgtgtattt ttgattttca tgagttttct acattaaggt
     2581 aaattcctta gagtgtgata gcagcctcag tttatttgtt ggtttaaact tgaaatctac
     2641 tttttctcga taaaactata atgtagatga a
//
