LOCUS       NM_016424               6987 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens LUC7 like 3 pre-mRNA splicing factor (LUC7L3),
            transcript variant 1, mRNA.
ACCESSION   NM_016424
VERSION     NM_016424.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6987)
  AUTHORS   Daniels,N.J., Hershberger,C.E., Gu,X., Schueger,C.,
            DiPasquale,W.M., Brick,J., Saunthararajah,Y., Maciejewski,J.P. and
            Padgett,R.A.
  TITLE     Functional analyses of human LUC7-like proteins involved in
            splicing regulation and myeloid neoplasms
  JOURNAL   Cell Rep 35 (2), 108989 (2021)
   PUBMED   33852859
  REMARK    GeneRIF: Functional analyses of human LUC7-like proteins involved
            in splicing regulation and myeloid neoplasms.
REFERENCE   2  (bases 1 to 6987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6987)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   4  (bases 1 to 6987)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   5  (bases 1 to 6987)
  AUTHORS   Li,Y., Ito,M., Sun,S., Chida,T., Nakashima,K. and Suzuki,T.
  TITLE     LUC7L3/CROP inhibits replication of hepatitis B virus via
            suppressing enhancer II/basal core promoter activity
  JOURNAL   Sci Rep 6, 36741 (2016)
   PUBMED   27857158
  REMARK    GeneRIF: LUC7 like 3 pre-mRNA splicing factor (LUC7L3, also known
            as hLuc7A or CROP) is a novel interacting partner of HBV enhancer
            II and basal core promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6987)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 6987)
  AUTHORS   Umehara,H., Nishii,Y., Morishima,M., Kakehi,Y., Kioka,N.,
            Amachi,T., Koizumi,J., Hagiwara,M. and Ueda,K.
  TITLE     Effect of cisplatin treatment on speckled distribution of a
            serine/arginine-rich nuclear protein CROP/Luc7A
  JOURNAL   Biochem Biophys Res Commun 301 (2), 324-329 (2003)
   PUBMED   12565863
  REMARK    GeneRIF: These results suggest that cisplatin affects RNA splicing
            by changing the subnuclear distribution of proteins including
            cisplatin resistance-associated overexpressed protein (CROP).
REFERENCE   8  (bases 1 to 6987)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 6987)
  AUTHORS   Chin,L.S., Singh,S.K., Wang,Q. and Murray,S.F.
  TITLE     Identification of okadaic-acid-induced genes by mRNA differential
            display in glioma cells
  JOURNAL   J Biomed Sci 7 (2), 152-159 (2000)
   PUBMED   10754390
REFERENCE   10 (bases 1 to 6987)
  AUTHORS   Nishii,Y., Morishima,M., Kakehi,Y., Umehara,K., Kioka,N.,
            Terano,Y., Amachi,T. and Ueda,K.
  TITLE     CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated
            from cisplatin-resistant cell line
  JOURNAL   FEBS Lett 465 (2-3), 153-156 (2000)
   PUBMED   10631324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA231851.1, BC047043.1,
            AK290540.1, AC005921.3 and CN271700.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016424.4.
            
            Summary: This gene encodes a protein with an N-terminal half that
            contains cysteine/histidine motifs and leucine zipper-like repeats,
            and the C-terminal half is rich in arginine and glutamate residues
            (RE domain) and arginine and serine residues (RS domain). This
            protein localizes with a speckled pattern in the nucleus, and could
            be involved in the formation of splicesome via the RE and RS
            domains. Two alternatively spliced transcript variants encoding the
            same protein have been found for this gene. [provided by RefSeq,
            Aug 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.95361.1,
                                           SRR1660803.103232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505658.6/ ENSP00000425092.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA231851.1         39-51
            14-876              BC047043.1         1-863
            877-1900            AK290540.1         882-1905
            1901-3377           AC005921.3         84549-86025
            3378-3479           CN271700.1         31-132
            3480-6987           AC005921.3         86128-89635
FEATURES             Location/Qualifiers
     source          1..6987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..6987
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="LUC7 like 3 pre-mRNA splicing factor"
                     /db_xref="GeneID:51747"
                     /db_xref="HGNC:HGNC:24309"
                     /db_xref="MIM:609434"
     exon            1..229
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1429
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LUC7-like 3; luc7-like protein 3; CRE-associated protein
                     1; cAMP regulatory element-associated protein 1; okadaic
                     acid-inducible phosphoprotein OA48-18; cisplatin
                     resistance-associated-overexpressed protein"
                     /codon_start=1
                     /product="luc7-like protein 3 isoform 1"
                     /protein_id="NP_057508.2"
                     /db_xref="CCDS:CCDS11573.1"
                     /db_xref="GeneID:51747"
                     /db_xref="HGNC:HGNC:24309"
                     /db_xref="MIM:609434"
                     /translation="MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCP
                     AELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRR
                     GHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMK
                     LVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHM
                     GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREE
                     EEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSR
                     SHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVK
                     SGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN"
     exon            230..296
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            297..336
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            337..481
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            482..556
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            557..661
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            662..823
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1107
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1268
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..6987
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="major polyA site"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
     regulatory      6957..6962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
                     /note="hexamer: AATAAA"
     polyA_site      6987
                     /gene="LUC7L3"
                     /gene_synonym="CRA; CREAP-1; CROP; hLuc7A; LUC7A; OA48-18"
ORIGIN      
        1 gtcttgtcgg ctcctgtgtg taggagggat ttcggcctga gagcgggccg aggagattgg
       61 cgacggtgtc gcccgtgttt tcgttggcgg gtgcctgggc tggtgggaac agccgcccga
      121 aggaagcacc atgatttcgg ccgcgcagtt gttggatgag ttaatgggcc gggaccgaaa
      181 cctagccccg gacgagaagc gcagcaacgt gcggtgggac cacgagagcg tttgtaaata
      241 ttatctctgt ggtttttgtc ctgcggaatt gttcacaaat acacgttctg atcttggtcc
      301 gtgtgaaaaa attcatgatg aaaatctacg aaaacagtat gagaagagct ctcgtttcat
      361 gaaagttggc tatgagagag attttttgcg atacttacag agcttacttg cagaagtaga
      421 acgtaggatc agacgaggcc atgctcgttt ggcattatct caaaaccagc agtcttctgg
      481 ggccgctggc ccaacaggca aaaatgaaga aaaaattcag gttctaacag acaaaattga
      541 tgtacttctg caacagattg aagaattagg gtctgaagga aaagtagaag aagcccaggg
      601 gatgatgaaa ttagttgagc aattaaaaga agagagagaa ctgctaaggt ccacaacgtc
      661 gacaattgaa agctttgctg cacaagaaaa acaaatggaa gtttgtgaag tatgtggagc
      721 ctttttaata gtaggagatg cccagtcccg ggtagatgac catttgatgg gaaaacaaca
      781 catgggctat gccaaaatta aagctactgt agaagaatta aaagaaaagt taaggaaaag
      841 aaccgaagaa cctgatcgtg atgagcgtct aaaaaaggag aagcaagaaa gagaagaaag
      901 agaaaaagaa cgggagagag aaagggaaga aagagaaagg aaaagacgaa gggaagagga
      961 agaaagagaa aaagaaaggg ctcgtgacag agaaagaaga aagagaagtc gttcacgaag
     1021 tagacactca agccgaacat cagacagaag atgcagcagg tctcgggacc acaaaaggtc
     1081 acgaagtaga gaaagaaggc ggagcagaag tagagatcga cgaagaagca gaagccatga
     1141 tcgatcagaa agaaaacaca gatctcgaag tcgggatcga agaagatcaa aaagccggga
     1201 tcgaaagtca tataagcaca ggagcaaaag tcgggacaga gaacaagata gaaaatccaa
     1261 ggagaaagaa aagaggggat ctgatgataa aaaaagtagt gtgaagtccg gtagtcgaga
     1321 aaagcagagt gaagacacaa acactgaatc gaaggaaagt gatactaaga atgaggtcaa
     1381 tgggaccagt gaagacatta aatctgaagg tgacactcag tccaattaaa actgatctga
     1441 taagacctca gatcagacag aggtaagtgt attgtttctc actttgatta gggctttttg
     1501 ttactgtttg acagtgcagc gtaagtatgc acagatgaag atggaactaa gccgagtaag
     1561 aagacataca aaagcctctt ctgaaggaaa agacagtgta gtcctgcaaa acattttgag
     1621 gtacattgtt ttgtctcagc tattttgtag cagactcgtg cccccattag tgtgcctctt
     1681 tggaaattat cgcccacatt tgtaatatag tcgccattga aaagttaatt atcctttttt
     1741 tagggatttt gatgtcattt cttttttttt tttaataaaa aggttgaact gttttttttt
     1801 ttctttttgg tattaagtcc atcttgtgtt ggtacattgg cagagacata tgctttaaaa
     1861 acttaaatat ttcggaggca catgttggac tactttgttt taattaaact gctagtattt
     1921 ctttgtcaag gatgtttcta gttttttgct ttattgcctt gcattctaat gcagtttgtt
     1981 ctgtaactcg agagccagta gcattggatt gatggaagtg tagggtttat gaattattgc
     2041 agctgactac catacctcac acagcgttgg tgttgtgagc ggcccatgaa aagccaaatt
     2101 aaaaatcaag gattcagtca aactaagcag gtactcatgc caggtactcc tttctctacc
     2161 cacatccatg tttgaatgct attgcctgtg atctttacgc ttaactgttg tgtatctttt
     2221 ttgttcttta caagaagtgc agaggggttt tttgtgtatt gcgtgaaaac ttataaaaca
     2281 aatgttaaca gaatggaatt ttttttcaac tgtatgtagg gctgcagtgg tggccagaat
     2341 tagatatctt taaagaattt taaatacaat aaacacttca tattattcgc cttgttacac
     2401 tcaatgcaat tctcaagtct ataagaggta tgtgcttaat atttcctact gtgtaggaga
     2461 atttgcagtc agccataggt atgtaggaat agtcactcac tggctgatac atttaaagca
     2521 gcagtgtgaa tagcaaggac agacaccttc aatttgtgaa atcaaagaac tgatgcacta
     2581 tatagaacga atttgggttt ttaaagaaat attaaaagtt aggtactgta agtgttctta
     2641 aaacctgtaa acttcattct gtgggctagt ggtgtgggac aaaatattcc taatgaaagg
     2701 aagtaccaat tagttgattt gttggtggca ttcccctttt gggaaagcaa tgtaaggtta
     2761 tgtctgtgta tgtcattcac acttaggcaa gcatacacag gcacatggct ttaagaacca
     2821 cactgatgcc ttgataatta aaaagaatac aagcattcca tgtacacatg ttaattagca
     2881 gttagtgact gggccaacac tttctcataa aaattggcct tttacatgtt gtctaattat
     2941 catttttccc caaattttgc gttgtaggac tactgttcga agatttttgg aagaatactg
     3001 agaacggcat aaagtgaaga tcgacattta aaaaatgagg tgaaagaaag ctatagtggc
     3061 atagaaaaag tataaagctc agttagtttt tttattatta ttattattaa aagttaattc
     3121 aggactgatg tgacctacca gatttcagaa catgtgttaa tagtatatat gccactgaaa
     3181 acttaggtcc tgtatcatac ttttttcttt aagacttttt aagaaatatt acttaaacat
     3241 gtggcttgct cagtgtttaa ttgcaagttt tcaatcttgg actttgaaaa caggattaaa
     3301 cgttagtatt cgtgtgaatc agactaagtg ggatttcatt tttacaactc tgctctactt
     3361 agcctttgga tttagaagta aaaataaagt atctctgact ttctgttaca aagttgattg
     3421 tctctgtcat tgaaaagttt tagtattaat ctttttctaa taaagttatt gactctgaac
     3481 tagtcccctg ttttaaatac aagagttaca ctattactag aggtgttggt gtacagtttt
     3541 atctgatttg ttctgtttaa gactaatttt tatagacttt ctaatgtttt aaataatggt
     3601 gcttcaattt taggtggtta tgaataaatt tgaattttgc ttttaatagc aaagatgtgc
     3661 agtgaactag aatatatttt tacatccctg agagattcat ttagtagaaa attccaagta
     3721 tcctgacaag cactctttag ctggctagct atgggatgat gtagaaaagc attcaagagc
     3781 tagtttttgt taagtcctgt atcaagatta acccagctgt gtcagtttat aaatgtattt
     3841 gtgtataggg tgtgtagtat atatggcaag ggttttttcc ccccacttaa gtgattattt
     3901 ttgtgtcaca tctaggaaaa ccggcagcat gtttctatct atagccagct tcttcgactg
     3961 tataaaagta ttctctccag ctacgtatat acacacatac atatatatca tagcaattcc
     4021 ttgtggttta taacttgcaa atactgctat cagtttatag gtaaagaaac agtgtgttaa
     4081 atgacttatc cagggagggt cctgtggctt catgtttatg gagttgctag gtctctgcct
     4141 catggtccag tgcctgttaa gccactgtgt tcattctaat aggcataatg aattgttaaa
     4201 gaatttacta aaatctcttc caccaaactt tgaaaaataa tgaagccgcc cccactttag
     4261 aggctctgta tgaaaaaatg ctgtggagac agagccctcc tggctcccta gctgatcctg
     4321 gagatgcagc aatagatgaa tgggttatct ctgaatttgt aagagataat tcacatgagg
     4381 attaagataa aatgggaagt aaaatctaac aaacacaaag atagctccca ggcactgctt
     4441 tgtgtagttt gacagcattg tggttgtagc agcaaaggac ttaaagtgat agtttttaaa
     4501 ccatattctg tccctaagta ataaaaaatc taggaagtta ctaaaatacc agatttgttc
     4561 tgctctgcct catctagaat caacgtctaa ctaacttaaa tgaagtataa taaatgagtt
     4621 catatgaaaa ggcttcctct atggacactt agatatattg taactattga agttacctgg
     4681 gatgtggggg tggtgggagg aggacctgcc tccccaggac atctatgact aaggcctggc
     4741 tttagttatg gagagagacg tagaagttga attttacacc caaaattgat gtgactgaag
     4801 aggaactgat tgttgctaac cagctcacaa gaatccagta ttgagaccag ttcactagaa
     4861 gaaacaaaca tttctgccat gcagaccaaa aagttattag ttggtgaata tgtattttct
     4921 ctttggaagg tctttaaggg gagcaaacca gttttaatca atcagattgc ttggtaagtt
     4981 tggaatctgc aatcagttgg tcttaaaaaa aaaaaaactt tattttggaa atttaaagac
     5041 atacacaaaa gaggaacaat ataattaacc tctgttaact catcaccaac aagactcatg
     5101 accactttta tacttcatga gtgattgtat ttgtatccac tgttttctat tattttcgag
     5161 caagtctcag acacaccatt taatctgtaa ataattcagc atgtatctct aaaagacaaa
     5221 gacctcttaa ataacagttc attagtataa aacaaattgg gtaaactttt gttggtcatc
     5281 aaactatatt agcactggtc caatagttta attttcattg agcctttcaa gaggaccgac
     5341 cagtctgctg ctcaagacat cctctcctct ggaatgtaga gataatacat atcatgctcc
     5401 tttttgttaa aacgtttttt tttccccttc aaacacagtc cattcatttt tcagtttggg
     5461 ttgaaacatc cttttcttga tcttgagctt ataataacct agtcatattg ctcagctcag
     5521 atatttttac tccctctcct taggcattct ggttccttaa atatagttag tgtcacagag
     5581 gataaataac caaccttatt tctaaggtct gagaacactt ggaccacata ttggttgagc
     5641 tcagccacct tctgattaaa gttttcagac ttgtaagaac tgaaaatttt tatggtggaa
     5701 gttctctgag ccctcatcca ttctgttttt aaaaatgcat tgcagatggg ctatgtgaat
     5761 atgtttttaa acatctgata tgtgcatgaa acaaaaaaca cttgaagtta ttatgtatac
     5821 aattctgtgg gatgggactt catgcaggat tggttttcaa gtttgatttc ctgagggatt
     5881 ttttagttgt ttgtgaaaga accccaggtc tacttttgaa attttgtatt ataattgtaa
     5941 tgttgcccat ggttaaaaaa aaaaagtgtt cagtgatcta tgtctcctac tactcctatt
     6001 tctctgtttt tcctctgcag gagcttgctg ctgttaacag ttattcttcc aagttgtttt
     6061 ctttgtgggg agatgggagg tgggaggaaa tataaacata tatgtataga tctttcaaaa
     6121 tatatgacgg tatacccgta tgttctgagt cttgctgttt ttacctggta atatttagaa
     6181 acatttattt tgagataaag gagagcactt ttaagttgaa cctgtagttt taaaaagtac
     6241 atttcaagta agccaaagca gagaagtaaa tgtatttttc attgttgtat cagaattttg
     6301 aatttactat tttaaaaatt caagagtttt gtagctgatc tatttcttcc cctcagccat
     6361 cccaaatagg tcatttgtca acagatttaa gaatgtttag aaacaacaac tttgggaaac
     6421 gggaaacaat ttggtataag tgggtgtgcc ataacctctc tcgtagccat tcattcccgg
     6481 atacataccc tagagaaact cttacacatg cgtaccaggg gatggattta agcatttgtg
     6541 tgtaatagga agaaaagaag aaaaaacccg ggaagatccc aagtgtccac caacagtgtg
     6601 ttggataaat actgtggtat attccaacag tggaattcca cagaagtgaa actgaactgc
     6661 agctgtgtat gtgaacatgg acaaaactca acaatagaag gatcaaaaaa agcaagtcac
     6721 agaagaatac atcactatgg ttccatttca atgaaagtca aaaacaggct gtcaaataca
     6781 tgataaaagg aaacgattaa gacaaaattt aatgttagcc gttttgatgg agggagaggt
     6841 gatcatgagg gcacaggggt cttcagaaga actggtgagg gtctgtttct gaagcctgtg
     6901 ggcatttcct tttttaatct gtatgtttat gtgcttttgt atgtatgata tttcttaata
     6961 aaatttaaaa agaagaatgg gaaaaaa
//
