LOCUS       NM_016019               2661 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LUC7 like 2, pre-mRNA splicing factor (LUC7L2),
            transcript variant 1, mRNA.
ACCESSION   NM_016019 NM_016007
VERSION     NM_016019.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Yue,Q., Wang,Z., Shen,Y., Lan,Y., Zhong,X., Luo,X., Yang,T.,
            Zhang,M., Zuo,B., Zeng,T., Lu,J., Wang,Y., Liu,B. and Guo,H.
  TITLE     Histone H3K9 Lactylation Confers Temozolomide Resistance in
            Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention
  JOURNAL   Adv Sci (Weinh) 11 (19), e2309290 (2024)
   PUBMED   38477507
  REMARK    GeneRIF: Histone H3K9 Lactylation Confers Temozolomide Resistance
            in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention.
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Jourdain,A.A., Begg,B.E., Mick,E., Shah,H., Calvo,S.E.,
            Skinner,O.S., Sharma,R., Blue,S.M., Yeo,G.W., Burge,C.B. and
            Mootha,V.K.
  TITLE     Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from
            glycolysis to OXPHOS
  JOURNAL   Mol Cell 81 (9), 1905-1919 (2021)
   PUBMED   33852893
  REMARK    GeneRIF: Loss of LUC7L2 and U1 snRNP subunits shifts energy
            metabolism from glycolysis to OXPHOS.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Daniels,N.J., Hershberger,C.E., Gu,X., Schueger,C.,
            DiPasquale,W.M., Brick,J., Saunthararajah,Y., Maciejewski,J.P. and
            Padgett,R.A.
  TITLE     Functional analyses of human LUC7-like proteins involved in
            splicing regulation and myeloid neoplasms
  JOURNAL   Cell Rep 35 (2), 108989 (2021)
   PUBMED   33852859
  REMARK    GeneRIF: Functional analyses of human LUC7-like proteins involved
            in splicing regulation and myeloid neoplasms.
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Kwon,M.J., Oh,E., Lee,S., Roh,M.R., Kim,S.E., Lee,Y., Choi,Y.L.,
            In,Y.H., Park,T., Koh,S.S. and Shin,Y.K.
  TITLE     Identification of novel reference genes using multiplatform
            expression data and their validation for quantitative gene
            expression analysis
  JOURNAL   PLoS One 4 (7), e6162 (2009)
   PUBMED   19584937
  REMARK    Erratum:[PLoS One. 2009;4(8). doi:
            10.1371/annotation/695436c7-3329-4bdc-9832-f427ecc33698]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Webby,C.J., Wolf,A., Gromak,N., Dreger,M., Kramer,H., Kessler,B.,
            Nielsen,M.L., Schmitz,C., Butler,D.S., Yates,J.R. 3rd,
            Delahunty,C.M., Hahn,P., Lengeling,A., Mann,M., Proudfoot,N.J.,
            Schofield,C.J. and Bottger,A.
  TITLE     Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated
            with RNA splicing
  JOURNAL   Science 325 (5936), 90-93 (2009)
   PUBMED   19574390
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Howell,V.M., Jones,J.M., Bergren,S.K., Li,L., Billi,A.C.,
            Avenarius,M.R. and Meisler,M.H.
  TITLE     Evidence for a direct role of the disease modifier SCNM1 in
            splicing
  JOURNAL   Hum Mol Genet 16 (20), 2506-2516 (2007)
   PUBMED   17656373
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Puig,O., Bragado-Nilsson,E., Koski,T. and Seraphin,B.
  TITLE     The U1 snRNP-associated factor Luc7p affects 5' splice site
            selection in yeast and human
  JOURNAL   Nucleic Acids Res 35 (17), 5874-5885 (2007)
   PUBMED   17726058
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY018775.1 and BC017163.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016019.4.
            
            Summary: This gene encodes a protein that contains a C2H2-type zinc
            finger, coiled-coil region and arginine, serine-rich (RS) domain. A
            similar protein in mouse interacts with sodium channel modifier 1,
            and the encoded protein may be involved in the recognition of
            non-consensus splice donor sites in association with the U1 snRNP
            spliceosomal subunit. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017163.2, SRR3476690.574563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354926.9/ ENSP00000347005.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                HY018775.1         49-83
            36-2661             BC017163.2         1-2626
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2661
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /note="LUC7 like 2, pre-mRNA splicing factor"
                     /db_xref="GeneID:51631"
                     /db_xref="HGNC:HGNC:21608"
                     /db_xref="MIM:613056"
     exon            1..429
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1547
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative RNA-binding protein Luc7-like 2; LUC7-like 2"
                     /codon_start=1
                     /product="putative RNA-binding protein Luc7-like 2 isoform
                     1"
                     /protein_id="NP_057103.2"
                     /db_xref="CCDS:CCDS43656.1"
                     /db_xref="GeneID:51631"
                     /db_xref="HGNC:HGNC:21608"
                     /db_xref="MIM:613056"
                     /translation="MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCC
                     PHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTE
                     VAKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVE
                     KARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGF
                     IEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREH
                     RRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRR
                     SSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI
                     "
     exon            430..524
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..623
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..734
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..878
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1055
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1147
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1177
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1369
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2661
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /note="hexamer: AGTAAA"
     polyA_site      2409
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /note="hexamer: AATAAA"
     polyA_site      2661
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /note="major polyA site"
ORIGIN      
        1 gctcccgtcg tggcgacggt ggcggcgagc ggcgtcagag cttgaggggg ggttgacggc
       61 ttctggcggg tggcggtgtt gaaggcgaga gcttgcttgg cccgtgtcgc ttctgtccca
      121 agaaccggac ggagagtgag ggcacgaggg tcgctgtcgg gggctgtcgt cttccacgta
      181 cacgtcgtcg tgaggagcgc agtccggact cttcccgcaa cccctccggc tccctttccg
      241 cacgcctcga ggcggcggcg gccaccgaga cagcagcgca ccttccccca tcccttcccc
      301 ttatccccca gcccaaaagg gcccggtctg cgccccaccc ccgcccgtcc gcccgctacg
      361 ccgccgccat gtcggcgcag gcccagatgc gcgcgatgct ggaccagttg atgggcacct
      421 cccgggacgg agatacaact cgtcaacgaa tcaaattcag tgatgacaga gtatgcaaga
      481 gtcaccttct caactgttgt cctcatgatg tcctttctgg aactagaatg gatcttggag
      541 aatgtctgaa agtccatgac ctggctttaa gagcggatta tgaaattgca tccaaagaac
      601 aagatttttt ctttgaactt gatgccatgg atcatctgca gtcattcatt gcagattgtg
      661 atcgtagaac agaagtggcc aagaaaagat tagcagaaac tcaagaagag attagtgctg
      721 aagtagcagc aaaggcagaa cgtgttcatg agttaaatga agaaattggt aaattgttag
      781 ccaaggtgga acaactagga gctgaaggga atgtggagga atcccagaaa gtaatggatg
      841 aagtagagaa agcacgggca aagaaaagag aagcagagga agtttatcgg aattctatgc
      901 cagcttccag ttttcagcag cagaaacttc gagtctgtga agtctgctct gcctatttag
      961 gacttcatga taatgacaga cgactggctg atcattttgg gggtaaactg cacctgggat
     1021 ttattgaaat aagagagaag cttgaagaat taaagagagt cgtagctgag aagcaggaga
     1081 aaagaaacca ggaacggctg aaacgaagag aagagagaga gagagaagaa agggagaagc
     1141 tgaggaggtc ccgatcacac agcaagaatc caaaaagatc caggtccaga gagcatcgca
     1201 gacatcgatc tcgctccatg tcacgtgaac gcaagaggag aactcgatcc aaatctcggg
     1261 agaaacgcca tcgccacagg tcccgctcca gcagccgtag ccgcagccgt agccaccaga
     1321 gaagtcggca cagttctaga gataggagca gagaacgatc caagaggaga tcctcaaaag
     1381 aaagattcag agaccaagac ttagcatcat gtgacagaga caggagttca agagacagat
     1441 cacctcgtga cagagatcgg aaagataaga agcggtccta tgagagtgct aatggcagat
     1501 cagaagacag gaggagctct gaagagcgcg aagcagggga gatctaacta gctgtgtaca
     1561 tttcttcagt ccttaagctt cctacggagt tacgtactat tgtttagttc acagctgttc
     1621 agggtgacag tgagcagatc cagacaccag atccagctag gctagatgta cagtatctaa
     1681 cttgatctga actgaacctg ttttccttga tgatgcctaa aactacatcc atagtttctg
     1741 gtgaacctgt aatacagttc tgaaagtaca gttttatata ataagatgct gatctcttta
     1801 ttctttcaag taagagtgct agtgaacaaa ttgtgttact tgccttggga ttttttgaac
     1861 gtttgtaaaa tgctgtcttc ctagtccaaa cagctgcagc tttgggcatt tttcttttta
     1921 attattcttc ctctgacttt gtatccctta atacctacac tctccaattg taagagaaag
     1981 ggggcaggga agcaatatag cttccattct aaggctgtat tcccgttatg aattactagc
     2041 tgattacagt tcagagcatt gatcctggaa tgtgtgctgg agaaatttaa aatactgggg
     2101 ttttttgttt aatggtgcct atttagagtt ggaagttgaa cagctgttgc attacatact
     2161 tttgcttttt tattgaaatt ttgaaatcaa acgtcttgat ttttctgttc tgttgaattg
     2221 ctatgttcag gatgttctag ggggtggggg cagggactct tttcgtaata agcacttgtt
     2281 ttattttgtg tgtgtggagt ataaaggcta cacccttatt gtaaaaaaat aataataata
     2341 aaatgaaaga aacaatcacc accaccatta ttaaactgta acttgtctag taaattgtca
     2401 ctagaactat ttgctgtggg catttcctct attctgttac gtcattaaca gtgccttact
     2461 gtgcaaggca ccaaaggaca taaatacgta cttgcaaaga ttccagatga gctgttcatg
     2521 tgggcccctt gctgactata ttccagccac ttcagggttg tttgtaatga ccgttataga
     2581 gaagggctcg acctgcagaa gaaactgggg tgtttttatt ctcattcaac aaacccaaat
     2641 aaaaacagta tatgtaacca a
//
