LOCUS       NP_057103                392 aa            linear   PRI 28-APR-2025
DEFINITION  putative RNA-binding protein Luc7-like 2 isoform 1 [Homo sapiens].
ACCESSION   NP_057103 NP_057091
VERSION     NP_057103.2
DBSOURCE    REFSEQ: accession NM_016019.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Yue,Q., Wang,Z., Shen,Y., Lan,Y., Zhong,X., Luo,X., Yang,T.,
            Zhang,M., Zuo,B., Zeng,T., Lu,J., Wang,Y., Liu,B. and Guo,H.
  TITLE     Histone H3K9 Lactylation Confers Temozolomide Resistance in
            Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention
  JOURNAL   Adv Sci (Weinh) 11 (19), e2309290 (2024)
   PUBMED   38477507
  REMARK    GeneRIF: Histone H3K9 Lactylation Confers Temozolomide Resistance
            in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention.
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Jourdain,A.A., Begg,B.E., Mick,E., Shah,H., Calvo,S.E.,
            Skinner,O.S., Sharma,R., Blue,S.M., Yeo,G.W., Burge,C.B. and
            Mootha,V.K.
  TITLE     Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from
            glycolysis to OXPHOS
  JOURNAL   Mol Cell 81 (9), 1905-1919 (2021)
   PUBMED   33852893
  REMARK    GeneRIF: Loss of LUC7L2 and U1 snRNP subunits shifts energy
            metabolism from glycolysis to OXPHOS.
REFERENCE   4  (residues 1 to 392)
  AUTHORS   Daniels,N.J., Hershberger,C.E., Gu,X., Schueger,C.,
            DiPasquale,W.M., Brick,J., Saunthararajah,Y., Maciejewski,J.P. and
            Padgett,R.A.
  TITLE     Functional analyses of human LUC7-like proteins involved in
            splicing regulation and myeloid neoplasms
  JOURNAL   Cell Rep 35 (2), 108989 (2021)
   PUBMED   33852859
  REMARK    GeneRIF: Functional analyses of human LUC7-like proteins involved
            in splicing regulation and myeloid neoplasms.
REFERENCE   5  (residues 1 to 392)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   6  (residues 1 to 392)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (residues 1 to 392)
  AUTHORS   Kwon,M.J., Oh,E., Lee,S., Roh,M.R., Kim,S.E., Lee,Y., Choi,Y.L.,
            In,Y.H., Park,T., Koh,S.S. and Shin,Y.K.
  TITLE     Identification of novel reference genes using multiplatform
            expression data and their validation for quantitative gene
            expression analysis
  JOURNAL   PLoS One 4 (7), e6162 (2009)
   PUBMED   19584937
  REMARK    Erratum:[PLoS One. 2009;4(8). doi:
            10.1371/annotation/695436c7-3329-4bdc-9832-f427ecc33698]
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 392)
  AUTHORS   Webby,C.J., Wolf,A., Gromak,N., Dreger,M., Kramer,H., Kessler,B.,
            Nielsen,M.L., Schmitz,C., Butler,D.S., Yates,J.R. 3rd,
            Delahunty,C.M., Hahn,P., Lengeling,A., Mann,M., Proudfoot,N.J.,
            Schofield,C.J. and Bottger,A.
  TITLE     Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated
            with RNA splicing
  JOURNAL   Science 325 (5936), 90-93 (2009)
   PUBMED   19574390
REFERENCE   9  (residues 1 to 392)
  AUTHORS   Howell,V.M., Jones,J.M., Bergren,S.K., Li,L., Billi,A.C.,
            Avenarius,M.R. and Meisler,M.H.
  TITLE     Evidence for a direct role of the disease modifier SCNM1 in
            splicing
  JOURNAL   Hum Mol Genet 16 (20), 2506-2516 (2007)
   PUBMED   17656373
REFERENCE   10 (residues 1 to 392)
  AUTHORS   Puig,O., Bragado-Nilsson,E., Koski,T. and Seraphin,B.
  TITLE     The U1 snRNP-associated factor Luc7p affects 5' splice site
            selection in yeast and human
  JOURNAL   Nucleic Acids Res 35 (17), 5874-5885 (2007)
   PUBMED   17726058
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY018775.1 and BC017163.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Sep 21, 2011 this sequence version replaced
            NP_057091.1, NP_057103.1.
            
            Summary: This gene encodes a protein that contains a C2H2-type zinc
            finger, coiled-coil region and arginine, serine-rich (RS) domain. A
            similar protein in mouse interacts with sodium channel modifier 1,
            and the encoded protein may be involved in the recognition of
            non-consensus splice donor sites in association with the U1 snRNP
            spliceosomal subunit. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017163.2, SRR3476690.574563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354926.9/ ENSP00000347005.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..392
                     /product="putative RNA-binding protein Luc7-like 2 isoform
                     1"
                     /note="putative RNA-binding protein Luc7-like 2; LUC7-like
                     2"
                     /calculated_mol_wt=46383
     Region          5..241
                     /region_name="LUC7"
                     /note="LUC7 N_terminus; pfam03194"
                     /db_xref="CDD:460842"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y383.2)"
     Region          235..392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y383.2)"
     Site            266
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, by JMJD6.
                     /evidence=ECO:0000269|PubMed:19574390; propagated from
                     UniProtKB/Swiss-Prot (Q9Y383.2)"
     Site            269
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, by JMJD6.
                     /evidence=ECO:0000269|PubMed:19574390; propagated from
                     UniProtKB/Swiss-Prot (Q9Y383.2)"
     CDS             1..392
                     /gene="LUC7L2"
                     /gene_synonym="CGI-59; CGI-74; LUC7B2"
                     /coded_by="NM_016019.5:369..1547"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS43656.1"
                     /db_xref="GeneID:51631"
                     /db_xref="HGNC:HGNC:21608"
                     /db_xref="MIM:613056"
ORIGIN      
        1 msaqaqmram ldqlmgtsrd gdttrqrikf sddrvckshl lnccphdvls gtrmdlgecl
       61 kvhdlalrad yeiaskeqdf ffeldamdhl qsfiadcdrr tevakkrlae tqeeisaeva
      121 akaervheln eeigkllakv eqlgaegnve esqkvmdeve karakkreae evyrnsmpas
      181 sfqqqklrvc evcsaylglh dndrrladhf ggklhlgfie irekleelkr vvaekqekrn
      241 qerlkrreer ereereklrr srshsknpkr srsrehrrhr srsmsrerkr rtrsksrekr
      301 hrhrsrsssr srsrshqrsr hssrdrsrer skrrsskerf rdqdlascdr drssrdrspr
      361 drdrkdkkrs yesangrsed rrsseereag ei
//
