LOCUS       NM_201412               1434 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LUC7 like (LUC7L), transcript variant 2, mRNA.
ACCESSION   NM_201412
VERSION     NM_201412.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Daniels,N.J., Hershberger,C.E., Gu,X., Schueger,C.,
            DiPasquale,W.M., Brick,J., Saunthararajah,Y., Maciejewski,J.P. and
            Padgett,R.A.
  TITLE     Functional analyses of human LUC7-like proteins involved in
            splicing regulation and myeloid neoplasms
  JOURNAL   Cell Rep 35 (2), 108989 (2021)
   PUBMED   33852859
  REMARK    GeneRIF: Functional analyses of human LUC7-like proteins involved
            in splicing regulation and myeloid neoplasms.
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Washietl,S., Pedersen,J.S., Korbel,J.O., Stocsits,C., Gruber,A.R.,
            Hackermuller,J., Hertel,J., Lindemeyer,M., Reiche,K., Tanzer,A.,
            Ucla,C., Wyss,C., Antonarakis,S.E., Denoeud,F., Lagarde,J.,
            Drenkow,J., Kapranov,P., Gingeras,T.R., Guigo,R., Snyder,M.,
            Gerstein,M.B., Reymond,A., Hofacker,I.L. and Stadler,P.F.
  TITLE     Structured RNAs in the ENCODE selected regions of the human genome
  JOURNAL   Genome Res 17 (6), 852-864 (2007)
   PUBMED   17568003
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Tufarelli,C., Frischauf,A.M., Hardison,R., Flint,J. and Higgs,D.R.
  TITLE     Characterization of a widely expressed gene (LUC7-LIKE; LUC7L)
            defining the centromeric boundary of the human alpha-globin domain
  JOURNAL   Genomics 71 (3), 307-314 (2001)
   PUBMED   11170747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY095072.1 and AY005111.1.
            
            On Feb 27, 2020 this sequence version replaced NM_201412.2.
            
            Summary: The LUC7L gene may represent a mammalian heterochromatic
            gene, encoding a putative RNA-binding protein similar to the yeast
            Luc7p subunit of the U1 snRNP splicing complex that is normally
            required for 5-prime splice site selection (Tufarelli et al., 2001
            [PubMed 11170747]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY005111.1, AK223084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293872.13/ ENSP00000293872.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               HY095072.1         35-205
            172-1434            AY005111.1         173-1435
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1434
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /note="LUC7 like"
                     /db_xref="GeneID:55692"
                     /db_xref="HGNC:HGNC:6723"
                     /db_xref="MIM:607782"
     exon            1..171
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1226
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /note="isoform b is encoded by transcript variant 2;
                     sarcoplasmic reticulum protein LUC7B1; putative
                     RNA-binding protein Luc7-like 1; putative SR protein
                     LUC7B1"
                     /codon_start=1
                     /product="putative RNA-binding protein Luc7-like 1 isoform
                     b"
                     /protein_id="NP_958815.1"
                     /db_xref="CCDS:CCDS32348.1"
                     /db_xref="GeneID:55692"
                     /db_xref="HGNC:HGNC:6723"
                     /db_xref="MIM:607782"
                     /translation="MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCC
                     PHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTE
                     LAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVE
                     KVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGF
                     IQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRR
                     RRRSRSTSRERRKLSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSAKYKFSRERASRE
                     ESWESGRSERGPPDWRLESSNGKMASRRSEEKEAGEI"
     exon            172..266
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            267..365
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            366..476
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            477..620
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            621..797
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            798..886
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            887..916
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1084
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1434
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="LUC7L"
                     /gene_synonym="hLuc7B1; Luc7; LUC7B1; SR+89"
                     /note="major polyA site"
ORIGIN      
        1 aaagagccga gtgggctcga ggccgacgcg accatcgttt gtcgacgccg ctgccaccgc
       61 ctgcctgaga gaagtcgtcg cggccgaccc cgtcgcctcc gccggctacc atgtccgccc
      121 aggcgcagat gcgggccctg ctggaccagc tcatgggcac ggctcgggac ggagacgaaa
      181 ccagacagag ggtcaagttt acagatgacc gtgtctgcaa gagtcacctt ctggactgct
      241 gcccccatga catcctggct gggacgcgca tggatttagg agaatgtacc aaaatccacg
      301 acttggccct ccgagcagat tatgagattg caagtaaaga aagagacctg ttttttgaat
      361 tagatgcaat ggatcacttg gagtccttta ttgctgaatg tgatcggaga actgagctcg
      421 ccaagaagcg gctggcagaa acacaggagg aaatcagtgc ggaagtttct gcaaaggcag
      481 aaaaagtaca tgagttaaat gaagaaatag gaaaactcct tgctaaagcc gaacagctag
      541 gggctgaagg taatgtggat gaatcccaga agattcttat ggaagtggaa aaagttcgtg
      601 cgaagaaaaa agaagctgag gaagaataca gaaattccat gcctgcatcc agttttcagc
      661 agcaaaagct gcgtgtctgc gaggtctgtt cagcctacct tggtctccat gacaatgacc
      721 gtcgcctggc agaccacttc ggtggcaagt tacacttggg gttcattcag atccgagaga
      781 agcttgatca gttgaggaaa actgtcgctg aaaagcagga gaagagaaat caggatcgct
      841 tgaggaggag agaggagagg gaacgggagg agcgtctgag caggaggtcg ggatcaagaa
      901 ccagagatcg caggaggtca cgctcccggg atcggcgtcg gaggcggtca agatctacct
      961 cccgagagcg acggaaattg tcccggtccc ggtcccgaga tagacatcgg cgccaccgca
     1021 gccgttcccg gagccacagc cggggacatc gtcgggcttc ccgggaccga agtgcgaaat
     1081 acaagttctc cagagagcgg gcatccagag aggagtcctg ggagagcggg cggagcgagc
     1141 gagggccccc ggactggagg cttgagagct ccaacgggaa gatggcttca cggaggtcag
     1201 aagagaagga ggccggcgag atctgaaccc gtctcccggg tgctgtaaat agtctgataa
     1261 acgttcacac agtctaaaat taccctttat atttgctgaa tacaactcat cttttgtagt
     1321 ttaaaatttc tattgttttg gagctagctg tgagtttcta gaagtgtaca gagttgctcc
     1381 tgtgttcccg ggtcatgttg agtaggaata aataaatctg atgctgcctc ctga
//
