LOCUS       NM_032860               1853 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens LTV1 ribosome biogenesis factor (LTV1), transcript
            variant 1, mRNA.
ACCESSION   NM_032860
VERSION     NM_032860.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Han,J.H., Ryan,G., Guy,A., Liu,L., Quinodoz,M., Helbling,I.,
            Lai-Cheong,J.E., Barwell,J., Folcher,M., McGrath,J.A., Moss,C. and
            Rivolta,C.
  CONSRTM   Genomics England Research Consortium
  TITLE     Mutations in the ribosome biogenesis factor gene LTV1 are linked to
            LIPHAK syndrome, a novel poikiloderma-like disorder
  JOURNAL   Hum Mol Genet 31 (12), 1970-1978 (2022)
   PUBMED   34999892
  REMARK    GeneRIF: Mutations in the ribosome biogenesis factor gene LTV1 are
            linked to LIPHAK syndrome, a novel poikiloderma-like disorder.
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Collins,J.C., Ghalei,H., Doherty,J.R., Huang,H., Culver,R.N. and
            Karbstein,K.
  TITLE     Ribosome biogenesis factor Ltv1 chaperones the assembly of the
            small subunit head
  JOURNAL   J Cell Biol 217 (12), 4141-4154 (2018)
   PUBMED   30348748
  REMARK    GeneRIF: Ribosome biogenesis factor Ltv1 chaperones the assembly of
            the small subunit head.
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Ghalei,H., Schaub,F.X., Doherty,J.R., Noguchi,Y., Roush,W.R.,
            Cleveland,J.L., Stroupe,M.E. and Karbstein,K.
  TITLE     Hrr25/CK1delta-directed release of Ltv1 from pre-40S ribosomes is
            necessary for ribosome assembly and cell growth
  JOURNAL   J Cell Biol 208 (6), 745-759 (2015)
   PUBMED   25778921
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Zhang,M., Han,G., Wang,C., Cheng,K., Li,R., Liu,H., Wei,X., Ye,M.
            and Zou,H.
  TITLE     A bead-based approach for large-scale identification of in vitro
            kinase substrates
  JOURNAL   Proteomics 11 (24), 4632-4637 (2011)
   PUBMED   22113938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA885378.1, BC009855.2 and AA453435.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032860.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1144452.1,
                                           SRR1803614.9919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367576.6/ ENSP00000356548.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA885378.1         66-98
            34-1847             BC009855.2         1-1814
            1848-1853           AA453435.1         6-11                c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..1853
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /note="LTV1 ribosome biogenesis factor"
                     /db_xref="GeneID:84946"
                     /db_xref="HGNC:HGNC:21173"
                     /db_xref="MIM:620074"
     exon            1..143
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1568
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LTV1 homolog"
                     /codon_start=1
                     /product="protein LTV1 homolog isoform 1"
                     /protein_id="NP_116249.2"
                     /db_xref="CCDS:CCDS5201.1"
                     /db_xref="GeneID:84946"
                     /db_xref="HGNC:HGNC:21173"
                     /db_xref="MIM:620074"
                     /translation="MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLLPTQ
                     KIDNEERRAEQRKYGVFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVI
                     PSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLE
                     DDFILQANKATGEEEGMDIQKSENEDDSEWEDVDDEKGDSNDDYDSAGLLSDEDCMSV
                     PGKTHRAIADHLFWSEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDDEIG
                     ALDNAELEGSIQVDSNRLQEVLNDYYKEKAENCVKLNTLEPLEDQDLPMNELDESEEE
                     EMITVVLEEAKEKWDCESICSTYSNLYNHPQLIKYQPKPKQIRISSKTGIPLNVLPKK
                     GLTAKQTERIQMINGSDLPKVSTQPRSKNESKEDKRARKQAIKEERKERRVEKKANKL
                     AFKLEKRRQEKELLNLKKNVEGLKL"
     exon            144..275
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            276..449
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            450..537
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            538..679
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            680..935
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1063
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1203
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1256
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1457
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1853
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /note="hexamer: ATTAAA"
     polyA_site      1853
                     /gene="LTV1"
                     /gene_synonym="C6orf93; dJ468K18.4; IPHAK"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgttat cgccgggtcc tggggctgca cgtgtggtga ggcctacaga agcggccttc
       61 agctggacct tggtctcccc gccggacttc gagggtgtca tcgccgcccc tgttgggggt
      121 gagcgccgcg cggctgcagc atgcctcaca ggaagaaaaa gccctttata gagaagaaga
      181 aagctgtgtc ttttcacttg gtccaccgga gccaacgaga tcctttagca gcagatgaga
      241 gtgcacccca gagggttcta ttgcccacac aaaaaataga caatgaagaa aggcgagcag
      301 aacagaggaa gtatggagtg ttctttgatg acgactatga ctacctgcag cacctgaagg
      361 aaccatctgg gccttcagag cttattccct caagtacctt cagtgcacac aacaggagag
      421 aggagaaaga agaaacgcta gtaattccaa gcactggaat taagttgcct tcatcagtgt
      481 ttgcttcaga gtttgaggaa gatgttggat tgttaaataa agcagctcca gtttcaggac
      541 ctcgactgga ttttgatcct gacattgttg cagctcttga tgatgatttt gactttgatg
      601 atccagataa tctgcttgag gatgacttta ttcttcaggc caataaggca acaggagagg
      661 aagagggaat ggatatacag aaatctgaga atgaagatga cagcgagtgg gaagatgtgg
      721 atgatgagaa gggagatagc aatgatgact atgactctgc aggcctattg tcagatgaag
      781 actgtatgtc tgtgcccgga aaaactcaca gagctatagc agatcacttg ttctggagtg
      841 aggaaacaaa gagtcgcttc acggagtatt cgatgacttc ctcagtcatg aggagaaatg
      901 aacagctgac cctacatgat gagaggtttg agaagtttta tgagcaatat gatgatgatg
      961 aaattggagc tctggataat gcagaattgg aaggttctat tcaagtggac agcaatcgct
     1021 tacaggaagt tttgaatgac tactataaag agaaggcaga gaattgtgta aaattgaata
     1081 cccttgaacc cttggaggat caagacctgc caatgaatga gcttgatgag tctgaggagg
     1141 aagaaatgat tactgtagtc cttgaagaag ccaaagagaa gtgggattgt gaatctattt
     1201 gtagtacata ctcaaattta tataaccatc cacagcttat caagtatcaa ccaaagccca
     1261 aacaaattcg aatatcttct aaaacaggaa tacctctcaa tgtcttacca aagaaaggac
     1321 tcacagcaaa gcaaactgaa agaatacaga tgattaatgg cagtgatctt cctaaagtat
     1381 caactcagcc acgttctaaa aatgaaagca aagaagataa aagagcaaga aagcaagcta
     1441 taaaagaaga gcgcaaggaa cgaagagtgg agaagaaagc taacaaatta gcatttaaac
     1501 tggagaaaag aaggcaagaa aaagagctgc tgaacttgaa gaagaatgtt gagggtctaa
     1561 agctatagac agtggagcat acagggcaag gcactttatt aggggctcct catctttggt
     1621 tattgactag aaacttcaga aagacaaaac tgtttgccat ttttactggc agataagagg
     1681 aaaatacaat atttgtatta tttttatact agtaagtgtc ccctgccaac catcttgtaa
     1741 atattgtaat actttaattt ttaatattat aagcttacat ttgctctgaa gtaaatgact
     1801 tcatgaatgt gaaatgtttg ataaattaaa ggaaaatatc ttcataacgt gaa
//
