LOCUS       NM_153451               2484 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LTO1 maturation factor of ABCE1 (LTO1), mRNA.
ACCESSION   NM_153451
VERSION     NM_153451.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Mahieu,C.I., Mancini,A.G., Vikram,E.P., Planells-Palop,V.,
            Joseph,N.M. and Tward,A.D.
  TITLE     ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13
            Amplicon in Squamous Cell Carcinoma
  JOURNAL   Mol Cancer Res 22 (2), 152-168 (2024)
   PUBMED   37930255
  REMARK    GeneRIF: ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the
            11q13 Amplicon in Squamous Cell Carcinoma.
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Luo,X., Jiang,Y., Chen,F., Wei,Z., Qiu,Y., Xu,H., Tian,G., Gong,W.,
            Yuan,Y., Feng,H., Zhong,L., Ji,N., Xu,X., Sun,C., Li,T., Li,J.,
            Feng,X., Deng,P., Zeng,X., Zhou,M., Zhou,Y., Dan,H., Jiang,L. and
            Chen,Q.
  TITLE     ORAOV1-B Promotes OSCC Metastasis via the NF-kappaB-TNFalpha Loop
  JOURNAL   J Dent Res 100 (8), 858-867 (2021)
   PUBMED   33655785
  REMARK    GeneRIF: ORAOV1-B Promotes OSCC Metastasis via the
            NF-kappaB-TNFalpha Loop.
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Ha,S.Y., Yeo,S.Y., Lee,K.W. and Kim,S.H.
  TITLE     Validation of ORAOV1 as a new treatment target in hepatocellular
            carcinoma
  JOURNAL   J Cancer Res Clin Oncol 147 (2), 423-433 (2021)
   PUBMED   33161447
  REMARK    GeneRIF: Validation of ORAOV1 as a new treatment target in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Paul,V.D., Muhlenhoff,U., Stumpfig,M., Seebacher,J., Kugler,K.G.,
            Renicke,C., Taxis,C., Gavin,A.C., Pierik,A.J. and Lill,R.
  TITLE     The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the
            ABC protein Rli1 for iron-sulfur cluster insertion
  JOURNAL   Elife 4, e08231 (2015)
   PUBMED   26182403
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Jiang,L., Zeng,X., Wang,Z., Ji,N., Zhou,Y., Liu,X. and Chen,Q.
  TITLE     Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and
            apoptosis in cervical cancer HeLa cells
  JOURNAL   Mol Cancer 9, 20 (2010)
   PUBMED   20105337
  REMARK    GeneRIF: ORAOV1 has an important role in regulating cell growth of
            cervical cancer HeLa cells through regulating the cell cycle and
            apoptosis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Jiang,L., Yang,H.S., Wang,Z., Zhou,Y., Zhou,M., Zeng,X. and
            Chen,Q.M.
  TITLE     ORAOV1-A correlates with poor differentiation in oral cancer
  JOURNAL   J Dent Res 88 (5), 433-438 (2009)
   PUBMED   19493886
  REMARK    GeneRIF: In OSCC tissue samples, the expression frequency of
            ORAOV1-A (51.1%) was much higher than that in normal samples
            (10.5%).  ORAOV1-A may play a functional role in the tumorigenesis
            of OSCC.
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Jiang,L., Zeng,X., Yang,H., Wang,Z., Shen,J., Bai,J., Zhang,Y.,
            Gao,F., Zhou,M. and Chen,Q.
  TITLE     Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell
            growth and tumor angiogenesis in oral squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (8), 1779-1786 (2008)
   PUBMED   18688849
  REMARK    GeneRIF: ORAOV1 plays pivotal roles in the growth and angiogenesis
            of oral squamous cell carcinoma.
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Xia,J., Chen,Q., Li,B. and Zeng,X.
  TITLE     Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis:
            association with clinicopathological features
  JOURNAL   Oral Oncol 43 (5), 508-514 (2007)
   PUBMED   17005439
  REMARK    GeneRIF: data suggested potential roles in oral carcinogenesis and
            that TAOS1 might be involved earlier than EMS1. Both genes might be
            candidate biomarkers for diagnosis and prognosis in OSCC
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Huang,X., Gollin,S.M., Raja,S. and Godfrey,T.E.
  TITLE     High-resolution mapping of the 11q13 amplicon and identification of
            a gene, TAOS1, that is amplified and overexpressed in oral cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (17), 11369-11374 (2002)
   PUBMED   12172009
  REMARK    GeneRIF: High-resolution mapping of the 11q13 amplicon and
            identification of a gene that is amplified and overexpressed in
            oral cancer cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026600.1 and AF503940.1.
            
            On Jun 2, 2019 this sequence version replaced NM_153451.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503940.1, BC065542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279147.9/ ENSP00000279147.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AK026600.1         64-333
            271-2484            AF503940.1         265-2478
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..2484
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /note="LTO1 maturation factor of ABCE1"
                     /db_xref="GeneID:220064"
                     /db_xref="HGNC:HGNC:17589"
                     /db_xref="MIM:607224"
     exon            1..164
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..528
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /note="oral cancer overexpressed protein 1-A;
                     tumor-amplified and overexpressed sequence 1; LTO1, ABCE1
                     maturation factor; oral cancer-overexpressed protein 1;
                     oral cancer overexpressed 1"
                     /codon_start=1
                     /product="protein LTO1 homolog"
                     /protein_id="NP_703152.1"
                     /db_xref="CCDS:CCDS8192.1"
                     /db_xref="GeneID:220064"
                     /db_xref="HGNC:HGNC:17589"
                     /db_xref="MIM:607224"
                     /translation="MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTL
                     HGAKIGSEIGCYQGFAFAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKL
                     HEDLDKIRGKFKQFCSLLNVQPDFKISAEGSGLSF"
     exon            165..270
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..341
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..459
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..2484
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /note="hexamer: AGTAAA"
     polyA_site      2484
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgggt ctcgtctcct cccaagcgga gcatttgtgc ctgaagctgc cgggtctgct
       61 acggcaccgc ggggctgcag aaacccgggg gccaagggcg ggctgcttgc cgctatggct
      121 ggcagtcagg acatattcga tgccatcgtg atggcggatg agaggtttca tggggaaggg
      181 tatcgggaag gctatgaaga aggcagtagt ttgggtgtga tggagggaag gcagcatggc
      241 acgctgcatg gagccaaaat cgggtctgag atcgggtgct accaaggttt tgcttttgca
      301 tggaaatgtc tactgcacag ttgcaccact gagaaggaca gcagaaagat gaaggtctta
      361 gaatcattga ttggaatgat ccagaaattc ccttatgatg accctactta cgataaactc
      421 catgaagact tagacaagat cagaggaaaa tttaaacagt tttgttcgtt actcaatgtt
      481 cagccagact ttaaaattag tgcagaaggt tccggacttt cattttgagg aggatggatg
      541 aacagagacc gaacgtcgag gaacagatgt gtgtgtgacg tgtttagaaa tgcggtgaag
      601 ggccagacgg tgctgggaag gcagttgttc attgggaggg tgagggttcc ggttcggccg
      661 tgggagggct tccttccctg gggttttctg cctgtgtcac cttggtgccc gtcttggggc
      721 ctcgccacac atgccctttg ttgggctgaa gccgtccctg gcagagccct cgtgcattga
      781 cttgacagcc tctccggcag cacaggccta gctggttctg ggttggagtt ggctctggat
      841 agggtcagtc accaggcctg gactgaaggc agttattttt attattatta ttatttgcaa
      901 tgagagagat ggttggcccc gaatgaggct catgggaggt ttggacgggt gctgtgccgc
      961 atgtcgaggc cgattgtgtg ccaggcggtg cgggacgtgc ctcccgtgtg ttatttaatc
     1021 ccttcaggag cccacaagat gggtgttatt ctcattttac agaggaggga ggggagacgc
     1081 gaagggattg cctggtctaa gggcacccag cagcagagct aggacttccg ccctaaggct
     1141 gtgcctcact gccaccaggc acagccgcct ccggaatgca caggcgagtc cctgccctcc
     1201 ctcccaggcc gcacaggtcc tgccaagcct cacggagcac gggggagtct gtggtggcca
     1261 gtttacctgg gcatctggct gagaggaaga aaggccaacc tgatcctgag gggacccaga
     1321 catatccttt gcactgtccc tagaggggcg atgagctttg cagcattaaa aaatggtgaa
     1381 ggggggaaat attttgaacc aaagaccaaa tgttaggccg ccgttatatt tgcagaagct
     1441 ttgagaacca tgcgtatagc ctcctgcatt ctcccctctc ctaggagctc ttttgtctct
     1501 gtccttacga ggcgtcatac agaggcagtg gggtgggcac agatgagcag agtggatggt
     1561 tcggtgggtc cccacgaggc gagtggtggt catatgtgat ggcacgtgtt cacacaccct
     1621 cctgtgtacc cccccagggt caccgaagtc cccacacgct ggctctccac acccctcctg
     1681 ttccagaaag catgtccgaa agcagtccag gagattatta aggggtcgcc atgaatccac
     1741 tttggtttta aaaccattcc cgaatgtcct agtggattgt gttgtgctgc ctaagctgcc
     1801 ggctgcagga gccagagaag tgacccccgc gggagcagcg gcaggtggat ctccacggtg
     1861 gctcgctttg tttttgtttt gttttttctt ttaagacgga gtctcactct gtcgccgagt
     1921 ttggagtgta ttggcgcgat ctcggctcac tgtaacctcc gcctcctgaa ttcaagtgat
     1981 tctcctgcct cagcctccct agtagctggg attataggcg ccccccacca cgcccaagta
     2041 acttttgtat ttttagtaga gatggggttt tgccttgttg gccaggctgg tcttgaactc
     2101 ccagcctgaa atgatccacc cacgtccacc taccaaagtg ctggaattgc aggcatgagc
     2161 caccactccc ggcctgcttt ttgtttttga agacaggact taggtctcct cctcccgaac
     2221 tctaaacctg cgtgtgtggc tgtgcaccgc tcgtttgtag cgtcacctca ggtctgggga
     2281 agtctgtgct ggcatctcct cattgtgcct tcatcagagc tggtgccttc gggccagaaa
     2341 gactctcgtt ctttctagat ggtgggatca ggggcctttg ctgtgtttcc cttggtggat
     2401 ttttgtgttt tgtaagttgt ctattttgat aatgtattat ttttataact gtaaaaaaag
     2461 taaatagcat attttaaagt gaaa
//
