LOCUS       NP_703152                137 aa            linear   PRI 29-APR-2025
DEFINITION  protein LTO1 homolog [Homo sapiens].
ACCESSION   NP_703152
VERSION     NP_703152.1
DBSOURCE    REFSEQ: accession NM_153451.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 137)
  AUTHORS   Mahieu,C.I., Mancini,A.G., Vikram,E.P., Planells-Palop,V.,
            Joseph,N.M. and Tward,A.D.
  TITLE     ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13
            Amplicon in Squamous Cell Carcinoma
  JOURNAL   Mol Cancer Res 22 (2), 152-168 (2024)
   PUBMED   37930255
  REMARK    GeneRIF: ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the
            11q13 Amplicon in Squamous Cell Carcinoma.
REFERENCE   2  (residues 1 to 137)
  AUTHORS   Luo,X., Jiang,Y., Chen,F., Wei,Z., Qiu,Y., Xu,H., Tian,G., Gong,W.,
            Yuan,Y., Feng,H., Zhong,L., Ji,N., Xu,X., Sun,C., Li,T., Li,J.,
            Feng,X., Deng,P., Zeng,X., Zhou,M., Zhou,Y., Dan,H., Jiang,L. and
            Chen,Q.
  TITLE     ORAOV1-B Promotes OSCC Metastasis via the NF-kappaB-TNFalpha Loop
  JOURNAL   J Dent Res 100 (8), 858-867 (2021)
   PUBMED   33655785
  REMARK    GeneRIF: ORAOV1-B Promotes OSCC Metastasis via the
            NF-kappaB-TNFalpha Loop.
REFERENCE   3  (residues 1 to 137)
  AUTHORS   Ha,S.Y., Yeo,S.Y., Lee,K.W. and Kim,S.H.
  TITLE     Validation of ORAOV1 as a new treatment target in hepatocellular
            carcinoma
  JOURNAL   J Cancer Res Clin Oncol 147 (2), 423-433 (2021)
   PUBMED   33161447
  REMARK    GeneRIF: Validation of ORAOV1 as a new treatment target in
            hepatocellular carcinoma.
REFERENCE   4  (residues 1 to 137)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 137)
  AUTHORS   Paul,V.D., Muhlenhoff,U., Stumpfig,M., Seebacher,J., Kugler,K.G.,
            Renicke,C., Taxis,C., Gavin,A.C., Pierik,A.J. and Lill,R.
  TITLE     The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the
            ABC protein Rli1 for iron-sulfur cluster insertion
  JOURNAL   Elife 4, e08231 (2015)
   PUBMED   26182403
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 137)
  AUTHORS   Jiang,L., Zeng,X., Wang,Z., Ji,N., Zhou,Y., Liu,X. and Chen,Q.
  TITLE     Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and
            apoptosis in cervical cancer HeLa cells
  JOURNAL   Mol Cancer 9, 20 (2010)
   PUBMED   20105337
  REMARK    GeneRIF: ORAOV1 has an important role in regulating cell growth of
            cervical cancer HeLa cells through regulating the cell cycle and
            apoptosis.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 137)
  AUTHORS   Jiang,L., Yang,H.S., Wang,Z., Zhou,Y., Zhou,M., Zeng,X. and
            Chen,Q.M.
  TITLE     ORAOV1-A correlates with poor differentiation in oral cancer
  JOURNAL   J Dent Res 88 (5), 433-438 (2009)
   PUBMED   19493886
  REMARK    GeneRIF: In OSCC tissue samples, the expression frequency of
            ORAOV1-A (51.1%) was much higher than that in normal samples
            (10.5%).  ORAOV1-A may play a functional role in the tumorigenesis
            of OSCC.
REFERENCE   8  (residues 1 to 137)
  AUTHORS   Jiang,L., Zeng,X., Yang,H., Wang,Z., Shen,J., Bai,J., Zhang,Y.,
            Gao,F., Zhou,M. and Chen,Q.
  TITLE     Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell
            growth and tumor angiogenesis in oral squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (8), 1779-1786 (2008)
   PUBMED   18688849
  REMARK    GeneRIF: ORAOV1 plays pivotal roles in the growth and angiogenesis
            of oral squamous cell carcinoma.
REFERENCE   9  (residues 1 to 137)
  AUTHORS   Xia,J., Chen,Q., Li,B. and Zeng,X.
  TITLE     Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis:
            association with clinicopathological features
  JOURNAL   Oral Oncol 43 (5), 508-514 (2007)
   PUBMED   17005439
  REMARK    GeneRIF: data suggested potential roles in oral carcinogenesis and
            that TAOS1 might be involved earlier than EMS1. Both genes might be
            candidate biomarkers for diagnosis and prognosis in OSCC
REFERENCE   10 (residues 1 to 137)
  AUTHORS   Huang,X., Gollin,S.M., Raja,S. and Godfrey,T.E.
  TITLE     High-resolution mapping of the 11q13 amplicon and identification of
            a gene, TAOS1, that is amplified and overexpressed in oral cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (17), 11369-11374 (2002)
   PUBMED   12172009
  REMARK    GeneRIF: High-resolution mapping of the 11q13 amplicon and
            identification of a gene that is amplified and overexpressed in
            oral cancer cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026600.1 and AF503940.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503940.1, BC065542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279147.9/ ENSP00000279147.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     Protein         1..137
                     /product="protein LTO1 homolog"
                     /note="oral cancer overexpressed protein 1-A;
                     tumor-amplified and overexpressed sequence 1; LTO1, ABCE1
                     maturation factor; oral cancer-overexpressed protein 1;
                     oral cancer overexpressed 1"
                     /calculated_mol_wt=15223
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q8WV07.2)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8WV07.2)"
     Region          22..60
                     /region_name="Yae1_N"
                     /note="Essential protein Yae1, N terminal; pfam09811"
                     /db_xref="CDD:430844"
     Region          22..58
                     /region_name="deca-GX3 motif, required for interaction
                     with YAE1 and the CIA complex.
                     /evidence=ECO:0000250|UniProtKB:P53846"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WV07.2)"
     CDS             1..137
                     /gene="LTO1"
                     /gene_synonym="CIAB1; ORAOV1; TAOS1"
                     /coded_by="NM_153451.3:115..528"
                     /db_xref="CCDS:CCDS8192.1"
                     /db_xref="GeneID:220064"
                     /db_xref="HGNC:HGNC:17589"
                     /db_xref="MIM:607224"
ORIGIN      
        1 magsqdifda ivmaderfhg egyregyeeg sslgvmegrq hgtlhgakig seigcyqgfa
       61 fawkcllhsc ttekdsrkmk vlesligmiq kfpyddptyd klhedldkir gkfkqfcsll
      121 nvqpdfkisa egsglsf
//
