LOCUS       NP_056380               1766 aa            linear   PRI 28-APR-2025
DEFINITION  E3 ubiquitin-protein ligase listerin isoform 1 [Homo sapiens].
ACCESSION   NP_056380
VERSION     NP_056380.3
DBSOURCE    REFSEQ: accession NM_015565.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1766)
  AUTHORS   Qin,F., Cai,B., Wang,P., Cao,R., Zhang,Y., Wen,H., Zheng,Y.,
            Zhao,W., Gao,C. and Liu,B.
  TITLE     LTN1 promotes RLR degradation to inhibit immune response to RNA
            virus through the ESCRT pathway
  JOURNAL   Autophagy 20 (6), 1270-1285 (2024)
   PUBMED   38060409
  REMARK    GeneRIF: LTN1 promotes RLR degradation to inhibit immune response
            to RNA virus through the ESCRT pathway.
REFERENCE   2  (residues 1 to 1766)
  AUTHORS   Farhang,S., Sabaie,H., Gharesouran,J., Asadi,M.R., Arsang-Jang,S.,
            Ghafouri-Fard,S., Taheri,M. and Rezazadeh,M.
  TITLE     Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein
            Ligase 1 Genes in the Periphery of Patients with Schizophrenia
  JOURNAL   J Mol Neurosci 72 (2), 246-254 (2022)
   PUBMED   34676516
  REMARK    GeneRIF: Expression Analysis of Ermin and Listerin E3 Ubiquitin
            Protein Ligase 1 Genes in the Periphery of Patients with
            Schizophrenia.
REFERENCE   3  (residues 1 to 1766)
  AUTHORS   Matsuo,Y., Ikeuchi,K., Saeki,Y., Iwasaki,S., Schmidt,C.,
            Udagawa,T., Sato,F., Tsuchiya,H., Becker,T., Tanaka,K.,
            Ingolia,N.T., Beckmann,R. and Inada,T.
  TITLE     Ubiquitination of stalled ribosome triggers ribosome-associated
            quality control
  JOURNAL   Nat Commun 8 (1), 159 (2017)
   PUBMED   28757607
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1766)
  AUTHORS   von der Malsburg,K., Shao,S. and Hegde,R.S.
  TITLE     The ribosome quality control pathway can access nascent
            polypeptides stalled at the Sec61 translocon
  JOURNAL   Mol Biol Cell 26 (12), 2168-2180 (2015)
   PUBMED   25877867
  REMARK    GeneRIF: E3 ligase listerin accesses nascent polypeptides stalled
            at the Sec61 translocon via a gap in the ribosome-translocon
            junction near the Sec61 lateral gate.
REFERENCE   5  (residues 1 to 1766)
  AUTHORS   Shao,S., Brown,A., Santhanam,B. and Hegde,R.S.
  TITLE     Structure and assembly pathway of the ribosome quality control
            complex
  JOURNAL   Mol Cell 57 (3), 433-444 (2015)
   PUBMED   25578875
  REMARK    GeneRIF: Results show that Listerin specificity for nascent
            chain-60S complexes depends on nuclear export mediator factor.
REFERENCE   6  (residues 1 to 1766)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   7  (residues 1 to 1766)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 1766)
  AUTHORS   Bengtson,M.H. and Joazeiro,C.A.
  TITLE     Role of a ribosome-associated E3 ubiquitin ligase in protein
            quality control
  JOURNAL   Nature 467 (7314), 470-473 (2010)
   PUBMED   20835226
REFERENCE   9  (residues 1 to 1766)
  AUTHORS   Chu,J., Hong,N.A., Masuda,C.A., Jenkins,B.V., Nelms,K.A.,
            Goodnow,C.C., Glynne,R.J., Wu,H., Masliah,E., Joazeiro,C.A. and
            Kay,S.A.
  TITLE     A mouse forward genetics screen identifies LISTERIN as an E3
            ubiquitin ligase involved in neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 106 (7), 2097-2103 (2009)
   PUBMED   19196968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB452437.1, BC140790.1, AB018257.2 and BF059116.1.
            
            On Sep 13, 2018 this sequence version replaced NP_056380.2.
            
            Summary: Like most RING finger proteins, LTN1 functions as an E3
            ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by
            OMIM, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.19104.1,
                                           SRR11853559.21293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361371.10/ ENSP00000354977.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     Protein         1..1766
                     /product="E3 ubiquitin-protein ligase listerin isoform 1"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 160; zinc finger protein 294;
                     E3 ubiquitin-protein ligase listerin; RING-type E3
                     ubiquitin transferase listerin"
                     /calculated_mol_wt=200422
     Region          59..>262
                     /region_name="COG5219"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]"
                     /db_xref="CDD:227544"
     Region          59..96
                     /region_name="HEAT 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          100..138
                     /region_name="HEAT 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          273..314
                     /region_name="HEAT 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          335..372
                     /region_name="HEAT 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          380..418
                     /region_name="HEAT 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          433..473
                     /region_name="HEAT 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          513..551
                     /region_name="HEAT 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          611..658
                     /region_name="HEAT 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          676..714
                     /region_name="HEAT 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          768..810
                     /region_name="HEAT 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          911..949
                     /region_name="HEAT 11. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          1068..1105
                     /region_name="HEAT 12. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          1184..1227
                     /region_name="HEAT 13. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          1314..1352
                     /region_name="HEAT 14. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          1377..1414
                     /region_name="HEAT 15. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          1475..1512
                     /region_name="HEAT 16. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O94822.6)"
     Region          <1477..1765
                     /region_name="COG5219"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]"
                     /db_xref="CDD:227544"
     CDS             1..1766
                     /gene="LTN1"
                     /gene_synonym="C21orf10; C21orf98; RNF160; ZNF294"
                     /coded_by="NM_015565.3:73..5373"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33527.3"
                     /db_xref="GeneID:26046"
                     /db_xref="HGNC:HGNC:13082"
                     /db_xref="MIM:613083"
ORIGIN      
        1 mggknkqrtk gnlrpsnsgr aaellakeqg tvpgfigfgt sqsdlgyvpa iqgaeeidsl
       61 vdsdfrmvlr klskkdvttk lkamqefgtm cterdtetvk gvlpywprif ckisldhdrr
      121 vreatqqafe klilkvkkql apylkslmgy wlmaqcdtyt paafaakdaf eaafppskqp
      181 eaiafckdei tsvlqdhlik etpdtlsdpq tvpeeereak fyrvvtcsll alkrllcllp
      241 dneldsleek fksllsqnkf wkygkhsvpq irsayfelvs alcqripqlm keeaskvsps
      301 vllsiddsdp ivcpalweav lytlttiedc wlhvnakksv fpklstvire ggrglatviy
      361 pyllpfiskl pqsitnpkld ffknfltslv aglstertkt sslessavis affeclrfim
      421 qqnlgeeeie qmlvndqlip fidavlkdpg lqhgqlfnhl aetlssweak adtekdekta
      481 hnlenvlihf werlseicva kisepeadve svlgvsnllq vlqkpksslk sskkkngkvr
      541 fadeilesnk enekcvsseg ekiegweltt epslthnssg llsplrkkpl edlvckladi
      601 sinyvnerks eqhlrflstl ldsfsssrvf kmllgdekqs ivqakpleia klvqknpavq
      661 flyqkligwl nedqrkdfgf lvdilysalr ccdndmerkk vlddltkvdl kwnsllkiie
      721 kacpssdkha lvtpwlkgdi lgeklvnlad clcnedlesr vsseshfser wtllslvlsq
      781 hvkndyligd vyveriivrl hetlfktkkl seaessdssv sficdvayny fssakgcllm
      841 pssedllltl fqlcaqskek thlpdflick lkntwlsgvn llvhqtdssy kestflhlsa
      901 lwlknqvqas sldinslqvl lsavddllnt llesedsylm gvyigsvmpn dsewekmrqs
      961 lpmqwlhrpl legrlslnye cfktdfkeqd iktlpshlct sallskmvli alrketvlen
     1021 nelekiiael lyslqwceel dnppifligf ceilqkmnit ydnlrvlgnt sgllqllfnr
     1081 srehgtlwsl iiaklilsrs issdevkphy krkesffplt egnlhtiqsl cpflskeekk
     1141 efsaqcipal lgwtkkdlcs tnggfghlai fnsclqtksi ddgellhgil kiiiswkkeh
     1201 ediflfscnl seaspevlgv nieiirflsl flkycsspla esewdfimcs mlawlettse
     1261 nqalysiplv qlfacvscdl acdlsaffds ttldtignlp vnlisewkef fsqgihslll
     1321 pilvtvtgen kdvsetsfqn amlkpmcetl tyiskeqlls hklparlvad qktnlpeylq
     1381 tllntlapll lfrarpvqia vyhmlyklmp elpqydqdnl ksygdeeeep alsppaalms
     1441 llsiqedlle nvlgcipvgq ivtikplsed fcyvlgyllt wkliltffka assqlralys
     1501 mylrktksln kllyhlfrlm penptyaeta vevpnkdpkt ffteelqlsi rettmlpyhi
     1561 phlacsvyhm tlkdlpamvr lwwnssekrv fnivdrftsk yvssvlsfqe issvqtstql
     1621 fngmtvkara ttrevmatyt iedivielii qlpsnyplgs iivesgkrvg vavqqwrnwm
     1681 lqlstylthq ngsimeglal wknnvdkrfe gvedcmicfs vihgfnyslp kkacrtckkk
     1741 fhsaclykwf tssnkstcpl cretff
//
