LOCUS       NM_002344               3072 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens leukocyte receptor tyrosine kinase (LTK), transcript
            variant 1, mRNA.
ACCESSION   NM_002344
VERSION     NM_002344.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Yeung,M.C.F., Dermawan,J.K., Liu,A.P.Y., Lam,A.Y.L., Antonescu,C.R.
            and Shek,T.W.H.
  TITLE     Spindle cell neoplasms with novel LTK fusion - Expanding the
            spectrum of kinase fusion-positive soft tissue tumors
  JOURNAL   Genes Chromosomes Cancer 63 (3), e23227 (2024)
   PUBMED   38517106
  REMARK    GeneRIF: Spindle cell neoplasms with novel LTK fusion - Expanding
            the spectrum of kinase fusion-positive soft tissue tumors.
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Izumi,H., Matsumoto,S., Liu,J., Tanaka,K., Mori,S., Hayashi,K.,
            Kumagai,S., Shibata,Y., Hayashida,T., Watanabe,K., Fukuhara,T.,
            Ikeda,T., Yoh,K., Kato,T., Nishino,K., Nakamura,A., Nakachi,I.,
            Kuyama,S., Furuya,N., Sakakibara-Konishi,J., Okamoto,I., Taima,K.,
            Ebi,N., Daga,H., Yamasaki,A., Kodani,M., Udagawa,H., Kirita,K.,
            Zenke,Y., Nosaki,K., Sugiyama,E., Sakai,T., Nakai,T., Ishii,G.,
            Niho,S., Ohtsu,A., Kobayashi,S.S. and Goto,K.
  TITLE     The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung
            cancer
  JOURNAL   Nature 600 (7888), 319-323 (2021)
   PUBMED   34819663
  REMARK    GeneRIF: The CLIP1-LTK fusion is an oncogenic driver in
            non-small-cell lung cancer.
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   De Munck,S., Provost,M., Kurikawa,M., Omori,I., Mukohyama,J.,
            Felix,J., Bloch,Y., Abdel-Wahab,O., Bazan,J.F., Yoshimi,A. and
            Savvides,S.N.
  TITLE     Structural basis of cytokine-mediated activation of ALK family
            receptors
  JOURNAL   Nature 600 (7887), 143-147 (2021)
   PUBMED   34646012
  REMARK    GeneRIF: Structural basis of cytokine-mediated activation of ALK
            family receptors.
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Centonze,F.G., Reiterer,V., Nalbach,K., Saito,K., Pawlowski,K.,
            Behrends,C. and Farhan,H.
  TITLE     LTK is an ER-resident receptor tyrosine kinase that regulates
            secretion
  JOURNAL   J Cell Biol 218 (8), 2470-2480 (2019)
   PUBMED   31227593
  REMARK    GeneRIF: LTK-to-Sec12 signaling represents the first example of an
            endoplasmic reticulum-resident signaling module with the potential
            to regulate proteostasis.
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Ueno,H., Hirano,N., Kozutsumi,H., Sasaki,K., Tanaka,T., Yazaki,Y.
            and Hirai,H.
  TITLE     An epidermal growth factor receptor-leukocyte tyrosine kinase
            chimeric receptor generates ligand-dependent growth signals through
            the Ras signaling pathway
  JOURNAL   J Biol Chem 270 (34), 20135-20142 (1995)
   PUBMED   7650032
REFERENCE   7  (bases 1 to 3072)
  AUTHORS   Krolewski,J.J. and Dalla-Favera,R.
  TITLE     The ltk gene encodes a novel receptor-type protein tyrosine kinase
  JOURNAL   EMBO J 10 (10), 2911-2919 (1991)
   PUBMED   1655406
REFERENCE   8  (bases 1 to 3072)
  AUTHORS   Krolewski,J.J., Lee,R., Eddy,R., Shows,T.B. and Dalla-Favera,R.
  TITLE     Identification and chromosomal mapping of new human tyrosine kinase
            genes
  JOURNAL   Oncogene 5 (3), 277-282 (1990)
   PUBMED   2156206
REFERENCE   9  (bases 1 to 3072)
  AUTHORS   Maru,Y., Hirai,H. and Takaku,F.
  TITLE     Human ltk: gene structure and preferential expression in human
            leukemic cells
  JOURNAL   Oncogene Res 5 (3), 199-204 (1990)
   PUBMED   2320375
REFERENCE   10 (bases 1 to 3072)
  AUTHORS   Ben-Neriah,Y. and Bauskin,A.R.
  TITLE     Leukocytes express a novel gene encoding a putative transmembrane
            protein-kinase devoid of an extracellular domain
  JOURNAL   Nature 333 (6174), 672-676 (1988)
   PUBMED   2836739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296892.1, D16105.1,
            CA394397.1 and AC087721.4.
            
            On Nov 22, 2018 this sequence version replaced NM_002344.5.
            
            Summary: The protein encoded by this gene is a member of the
            ros/insulin receptor family of tyrosine kinases. Tyrosine-specific
            phosphorylation of proteins is a key to the control of diverse
            pathways leading to cell growth and differentiation. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16105.1, AK314006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263800.11/ ENSP00000263800.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AK296892.1         61-303
            244-3006            D16105.1           223-2985
            3007-3067           CA394397.1         508-568
            3068-3072           AC087721.4         190708-190712       c
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3072
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /note="leukocyte receptor tyrosine kinase"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
     exon            1..161
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2713
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte tyrosine kinase receptor; protein
                     tyrosine kinase 1"
                     /codon_start=1
                     /product="leukocyte tyrosine kinase receptor isoform 1
                     precursor"
                     /protein_id="NP_002335.2"
                     /db_xref="CCDS:CCDS10077.1"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
                     /translation="MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDP
                     KVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAA
                     GQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILV
                     GQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVF
                     RVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGG
                     WTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGG
                     DASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQ
                     AELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVK
                     QKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPA
                     NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIIS
                     KFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLA
                     QDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDR
                     ALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGG
                     RMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPT
                     PEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQN
                     LWNPTYRS"
     exon            162..305
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..477
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..628
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..775
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..932
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1115
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1214
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1367
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1463
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1659
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1750
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1815
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1945
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2043
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2136
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2238
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2373
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2464
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..3072
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3048..3053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /note="hexamer: AATAAA"
     polyA_site      3072
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /note="major polyA site"
ORIGIN      
        1 agcacacccc tgtaagtggt ggccagggct gccgtggcaa aatgagctgt caactttagg
       61 ttgacagggg tgtggccgcg accgcaaggg cttttgttgc cgggtggacc caacagggat
      121 gggctgctgg ggacagctgc tggtgtggtt cggagccgcg ggcgccattc tctgctctag
      181 cccggggtcc caggagactt ttctgcggtc ctcgcccctg ccgctggcaa gtcccagccc
      241 ccgggacccg aaagtcagcg ccccgcctag tatcttggag ccagcctccc cgctgaattc
      301 tccgggcacc gaggggtctt ggctgttttc tacctgcggg gccagcggcc ggcatgggcc
      361 cacacagaca caatgtgacg gggcgtacgc ggggaccagc gtggtggtga ccgtgggggc
      421 cgccgggcag ctgagaggcg tgcagctgtg gcgcgtgccg ggccctggcc agtatctgat
      481 ctcagcctac ggagccgcgg gcggcaaagg cgccaagaac cacctgtcgc gggcgcatgg
      541 cgtcttcgtc tcagcaatct tctccctcgg tctcggggag tcgctgtaca tcctggtggg
      601 gcagcaggga gaggacgcct gtcccggagg tagcccggag agccagctcg tctgcctcgg
      661 ggagtctcga gccgttgaag agcacgcggc gatggatggg agcgaagggg tcccggggtc
      721 gcggcgctgg gcgggaggtg gcgggggtgg cgggggcgcc acctacgttt tccgggtgcg
      781 cgctggcgag ctggaaccgt tgctggtggc ggccggaggc ggcggtcggg cctacctgag
      841 gccgcgggac cgaggccgga ctcaggcctc ccccgagaaa ctggagaacc gctcggaggc
      901 gcccgggagc ggcgggagag gcggggcggc aggtggtggg ggcggctgga cgtcgcgggc
      961 tccctctccg caggccggcc gctcactgca ggagggggcg gagggcggcc agggctgctc
     1021 cgaggcttgg gcgacccttg gctgggccgc ggccggcggc ttcgggggcg gcggcggggc
     1081 ctgcactgcg ggcggaggcg gcggcggcta cagggggggc gacgcttcag agactgacaa
     1141 cctctgggct gatggggaag atggagtatc cttcatacac cccagcagcg agctcttcct
     1201 gcagcctctg gcagtcaccg agaaccacgg agaggtagag atccgaaggc acctcaactg
     1261 cagtcactgc cctttgagag actgccaatg gcaggcagag ctccagctgg ctgaatgcct
     1321 gtgcccagaa ggcatggagc tagctgtgga taacgtcacc tgcatggacc tgcacaagcc
     1381 cccaggccct ctggttctga tggtggctgt ggtggcaacc tcaacactga gcctccttat
     1441 ggtgtgtggg gtcctgattc tggtgaagca gaagaagtgg cagggcctgc aggagatgag
     1501 gctgccgagc cctgagcttg agctgagcaa gcttcgaacc tctgccatca ggacagcccc
     1561 caatccctat tattgccagg tggggcttgg cccggcccag tcctggcctc tgccaccagg
     1621 tgtcaccgag gtttccccag ccaatgttac tctgctcaga gccctgggcc atggtgcctt
     1681 tggggaggtg tatgagggac tggtaattgg ccttcctggg gactccagtc ccctgcaggt
     1741 agctatcaag accctgccag aactctgctc gcctcaggat gagctggatt tcctcatgga
     1801 ggccctcatc atcagcaagt ttcgccatca gaacattgtg cggtgtgtgg ggctcagcct
     1861 cagggccacc cctcgcctca ttctgctgga actgatgtct ggaggggaca tgaagagttt
     1921 cctgaggcac agtcggccac acctgggcca gccatcacct ctggtcatgc gggacctgct
     1981 gcaactggcc caggacatag cccagggctg ccactacctg gaggaaaatc acttcatcca
     2041 cagggatatt gccgcccgga actgcctgct gagctgcgct ggacccagcc gagtggccaa
     2101 gattggggac tttgggatgg cacgagatat ctaccgggcc agttattacc gcagggggga
     2161 ccgggccttg ctcccagtca agtggatgcc cccagaggcc ttcctggagg gcatcttcac
     2221 atccaagaca gattcctggt cttttggggt gctgctctgg gagatcttct cactgggcta
     2281 catgccctat cctgggcgca ccaaccagga ggtgctggac ttcgtcgttg gaggaggccg
     2341 gatggaccct cctaggggct gcccagggcc tgtgtaccgc atcatgaccc agtgttggca
     2401 gcacgagcct gagctccgcc ctagctttgc cagcatcttg gagcgtctgc agtactgcac
     2461 tcaggacccg gatgtgctga attcactcct gccaatggag ctggggccca ccccagagga
     2521 ggaagggact tctgggctgg ggaacagatc tttggagtgc ctaagacccc cacagcccca
     2581 ggaactgagt ccagagaagt tgaaaagctg gggaggtagc cctcttggcc cctggctgtc
     2641 ctctggcctc aagcccctca aatccagggg cctccaacct cagaaccttt ggaatcccac
     2701 ttatcgctcc tgagccccaa ggggccctga gggtaaggac tgaggcactg agggtccctc
     2761 cctatactcc tcaggctcct gggtggcctg ttatgccagc ggcctctgtt ccctgcagtc
     2821 tgtgctgtgt gtctgggcct gtctcggggc tggcctggca gcgctgcact tgccatgctg
     2881 gaaaccagcc caggcctccc agggaagggc ccagccactt ccagcttttg atcttggggc
     2941 cagaggccgc cttacacaca ccccaggtgt ccatggggag cactggattg ctctcccatt
     3001 atgagcatcc ttcatctggg cagacccccc accctgcaga tgcttctaat aaaaagctct
     3061 tctcatcctc ca
//
