LOCUS       NM_001414308            2119 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lymphotoxin beta receptor (LTBR), transcript variant
            8, mRNA.
ACCESSION   NM_001414308
VERSION     NM_001414308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Tang,Q., Yuan,Y., Li,L., Xu,Y., Ji,W., Xiao,S., Han,Y., Miao,W.,
            Cai,J., You,P., Chen,M., Ding,S., Li,Z., Qi,Z., Hou,W. and Luo,H.
  TITLE     Comprehensive analysis reveals that LTBR is a immune-related
            biomarker for glioma
  JOURNAL   Comput Biol Med 174, 108457 (2024)
   PUBMED   38599071
  REMARK    GeneRIF: Comprehensive analysis reveals that LTBR is a
            immune-related biomarker for glioma.
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Wu,Y., Zhao,S., Guo,W., Liu,Y., Requena Mullor,M.D.M.,
            Rodriguez,R.A. and Wei,R.
  TITLE     Systematic analysis of the prognostic value and immunological
            function of LTBR in human cancer
  JOURNAL   Aging (Albany NY) 16 (1), 129-152 (2024)
   PUBMED   38175686
  REMARK    GeneRIF: Systematic analysis of the prognostic value and
            immunological function of LTBR in human cancer.
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Abudukeyoumu,A., Lai,Z.Z., Lu,J.J., Zhang,X., Hou,D.Y., Dong,J.,
            Wu,J.N., Li,M.Q. and Xie,F.
  TITLE     A LIGHT-HVEM/LTbetaR axis contributes to the fibrosis of
            intrauterine adhesion
  JOURNAL   J Reprod Immunol 153, 103693 (2022)
   PUBMED   35987137
  REMARK    GeneRIF: A LIGHT-HVEM/LTbetaR axis contributes to the fibrosis of
            intrauterine adhesion.
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Remouchamps,C., Boutaffala,L., Ganeff,C. and Dejardin,E.
  TITLE     Biology and signal transduction pathways of the
            Lymphotoxin-alphabeta/LTbetaR system
  JOURNAL   Cytokine Growth Factor Rev 22 (5-6), 301-310 (2011)
   PUBMED   22152226
  REMARK    Review article
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
            Yagita,H. and Okumura,K.
  TITLE     TRAF5, an activator of NF-kappaB and putative signal transducer for
            the lymphotoxin-beta receptor
  JOURNAL   J Biol Chem 271 (25), 14661-14664 (1996)
   PUBMED   8663299
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Browning,J.L., Miatkowski,K., Sizing,I., Griffiths,D., Zafari,M.,
            Benjamin,C.D., Meier,W. and Mackay,F.
  TITLE     Signaling through the lymphotoxin beta receptor induces the death
            of some adenocarcinoma tumor lines
  JOURNAL   J Exp Med 183 (3), 867-878 (1996)
   PUBMED   8642291
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
            Marynen,P.
  TITLE     Isolation and regional assignment of human chromosome 12p cDNAs
  JOURNAL   Genomics 29 (1), 44-52 (1995)
   PUBMED   8530100
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Crowe,P.D., VanArsdale,T.L., Walter,B.N., Ware,C.F., Hession,C.,
            Ehrenfels,B., Browning,J.L., Din,W.S., Goodwin,R.G. and Smith,C.A.
  TITLE     A lymphotoxin-beta-specific receptor
  JOURNAL   Science 264 (5159), 707-710 (1994)
   PUBMED   8171323
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
            Marynen,P.
  TITLE     Construction and evaluation of a hncDNA library of human 12p
            transcribed sequences derived from a somatic cell hybrid
  JOURNAL   Genomics 16 (1), 214-218 (1993)
   PUBMED   8486360
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005840.2.
            
            Summary: This gene encodes a member of the tumor necrosis factor
            receptor superfamily. The major ligands of this receptor include
            lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily
            member 14. The encoded protein plays a role in signalling during
            the development of lymphoid and other organs, lipid metabolism,
            immune response, and programmed cell death. Activity of this
            receptor has also been linked to carcinogenesis. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2121337.1,
                                           SRR14038191.3349832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC005840.2         100290-100582       c
            294-390             AC005840.2         100060-100156       c
            391-501             AC005840.2         99597-99707         c
            502-654             AC005840.2         99365-99517         c
            655-751             AC005840.2         98582-98678         c
            752-849             AC005840.2         98300-98397         c
            850-957             AC005840.2         96239-96346         c
            958-983             AC005840.2         95919-95944         c
            984-1212            AC005840.2         94404-94632         c
            1213-2119           AC005840.2         93178-94084         c
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2119
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /note="lymphotoxin beta receptor"
                     /db_xref="GeneID:4055"
                     /db_xref="HGNC:HGNC:6718"
                     /db_xref="MIM:600979"
     exon            1..293
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1490
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8; tumor necrosis factor C receptor; lymphotoxin B
                     receptor; tumor necrosis factor receptor type III;
                     lymphotoxin beta receptor (TNFR superfamily, member 3);
                     tumor necrosis factor receptor 2-related protein"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 3 isoform 8 precursor"
                     /protein_id="NP_001401237.1"
                     /db_xref="GeneID:4055"
                     /db_xref="HGNC:HGNC:6718"
                     /db_xref="MIM:600979"
                     /translation="MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCR
                     DQEKEYYEPQHRICCSRCPPAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPV
                     MGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNN
                     HCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSG
                     TMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPP
                     KAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQS
                     QVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPP
                     GLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD"
     exon            294..390
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..501
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..654
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..849
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..957
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..983
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1212
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..2119
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="LTBR"
                     /gene_synonym="D12S370; LT-BETA-R; TNF-R-III; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
                     /note="major polyA site"
ORIGIN      
        1 actcccactt cctgagctcc gccatgggag ccctggaggc ccggcctggc cgctcccggc
       61 cctggggtgc acatcggccc tgagtcccgt cccaggctct gggctcgggc agccgccgcc
      121 accgctgccc aggacgtcgg gcctcctgcc ttcctcccag gcccccacgt tgctggccgc
      181 ctggccgagt ggccgccatg ctcctgcctt gggccacctc tgcccccggc ctggcctggg
      241 ggcctctggt gctgggcctc ttcgggctcc tggcagcatc gcagccccag gcggtgcctc
      301 catatgcgtc ggagaaccag acctgcaggg accaggaaaa ggaatactat gagccccagc
      361 accgcatctg ctgctcccgc tgcccgccag ctaaatgtag ccgcatccgg gacacagttt
      421 gtgccacatg tgccgagaat tcctacaacg agcactggaa ctacctgacc atctgccagc
      481 tgtgccgccc ctgtgaccca gtgatgggcc tcgaggagat tgccccctgc acaagcaaac
      541 ggaagaccca gtgccgctgc cagccgggaa tgttctgtgc tgcctgggcc ctcgagtgta
      601 cacactgcga gctactttct gactgcccgc ctggcactga agccgagctc aaagatgaag
      661 ttgggaaggg taacaaccac tgcgtcccct gcaaggccgg gcacttccag aatacctcct
      721 cccccagcgc ccgctgccag ccccacacca ggtgtgagaa ccaaggtctg gtggaggcag
      781 ctccaggcac tgcccagtcc gacacaacct gcaaaaatcc attagagcca ctgcccccag
      841 agatgtcagg aaccatgctg atgctggccg ttctgctgcc actggccttc tttctgctcc
      901 ttgccaccgt cttctcctgc atctggaaga gccacccttc tctctgcagg aaactgggat
      961 cgctgctcaa gaggcgtccg cagggagagg gacccaatcc tgtagctgga agctgggagc
     1021 ctccgaaggc ccatccatac ttccctgact tggtacagcc actgctaccc atttctggag
     1081 atgtttcccc agtatccact gggctccccg cagccccagt tttggaggca ggggtgccgc
     1141 aacagcagag tcctctggac ctgaccaggg agccgcagtt ggaacccggg gagcagagcc
     1201 aggtggccca cggtaccaat ggcattcatg tcaccggcgg gtctatgact atcactggca
     1261 acatctacat ctacaatgga ccagtactgg ggggaccacc gggtcctgga gacctcccag
     1321 ctacccccga acctccatac cccattcccg aagaggggga ccctggccct cccgggctct
     1381 ctacacccca ccaggaagat ggcaaggctt ggcacctagc ggagacagag cactgtggtg
     1441 ccacaccctc taacaggggc ccaaggaacc aatttatcac ccatgactga ctgagtctga
     1501 gaaaaggcag aagaaggggg gcacaagggc accttctccc ttgaggctgc cctgcccacg
     1561 tgggattcac aggggcctga gtagggcccg gggaagcaga gccctaaggg attaaggctc
     1621 agacacctct gagagcaggt gggcactggc tgggtacggt gccctccaca ggactctccc
     1681 tactgcctga gcaaacctga ggcctcccgg cagacccacc caccccctgg ggctgctcag
     1741 cctcaggcac ggacagggca catgatacca actgctgccc actacggcac gccgcaccgg
     1801 agcacggcac cgagggagcc gccacacggt cacctgcaag gacgtcacgg gcccctctaa
     1861 aggattcgtg gtgctcatcc ccaagcttca gagacccttt ggggttccac acttcacgtg
     1921 gactgaggta gaccctgcat gaagatgaaa ttatagggag gacgctcctt ccctcccctc
     1981 ctagaggaga ggaaagggag tcattaacaa ctagggggtt gggtaggatt cctaggtatg
     2041 gggaagagtt ttggaagggg aggaaaatgg caagtgtatt tatattgtaa ccacatgcaa
     2101 ataaaaagaa tgggaccta
//
