LOCUS       NM_003573               5052 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            4 (LTBP4), transcript variant 2, mRNA.
ACCESSION   NM_003573
VERSION     NM_003573.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5052)
  AUTHORS   Ishii,M., Yamaguchi,Y., Takada,K., Hamaya,H., Ogawa,S. and
            Akishita,M.
  TITLE     Effect of decreased expression of latent TGF-beta binding proteins
            4 on the pathogenesis of emphysema as an age-related disease
  JOURNAL   Arch Gerontol Geriatr 127, 105597 (2024)
   PUBMED   39121531
  REMARK    GeneRIF: Effect of decreased expression of latent TGF-beta binding
            proteins 4 on the pathogenesis of emphysema as an age-related
            disease.
            Review article
REFERENCE   2  (bases 1 to 5052)
  AUTHORS   Chang,Y., Wang,X., Tian,X., Cao,Z., Zhen,X., Zhao,W., Luo,B. and
            Gao,Y.
  TITLE     Novel indel variation of LTBP4 gene associates with risk of sudden
            cardiac death in Chinese populations with coronary artery disease
  JOURNAL   Leg Med (Tokyo) 69, 102437 (2024)
   PUBMED   38547642
  REMARK    GeneRIF: Novel indel variation of LTBP4 gene associates with risk
            of sudden cardiac death in Chinese populations with coronary artery
            disease.
REFERENCE   3  (bases 1 to 5052)
  AUTHORS   Su,C.T., See,D.H.W., Huang,Y.J., Jao,T.M., Liu,S.Y., Chou,C.Y.,
            Lai,C.F., Lin,W.C., Wang,C.Y., Huang,J.W. and Hung,K.Y.
  TITLE     LTBP4 Protects Against Renal Fibrosis via Mitochondrial and
            Vascular Impacts
  JOURNAL   Circ Res 133 (1), 71-85 (2023)
   PUBMED   37232163
  REMARK    GeneRIF: LTBP4 Protects Against Renal Fibrosis via Mitochondrial
            and Vascular Impacts.
REFERENCE   4  (bases 1 to 5052)
  AUTHORS   Ibarra-Tapia,I.Y., Juarez-Sandoval,A., Perez,I.T.,
            Cano-Martinez,L.J., Sanchez-Garcia,S., Ruiz-Batalla,J.M.,
            Aroche-Reyes,I.A., Garcia,S., Canto,P., Mejia,D.R. and
            Coral-Vazquez,R.M.
  TITLE     Association of polymorphisms rs2303729, rs10880, and rs1131620 of
            LTBP4 with sarcopenia in elderly patients with type 2 diabetes
            mellitus
  JOURNAL   Ann Hum Biol 49 (7-8), 311-316 (2022)
   PUBMED   36524797
  REMARK    GeneRIF: Association of polymorphisms rs2303729, rs10880, and
            rs1131620 of LTBP4 with sarcopenia in elderly patients with type 2
            diabetes mellitus.
REFERENCE   5  (bases 1 to 5052)
  AUTHORS   Oklu,R. and Hesketh,R.
  TITLE     The latent transforming growth factor beta binding protein (LTBP)
            family
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 601-610 (2000)
   PUBMED   11104663
  REMARK    Review article
REFERENCE   6  (bases 1 to 5052)
  AUTHORS   Saharinen,J. and Keski-Oja,J.
  TITLE     Specific sequence motif of 8-Cys repeats of TGF-beta binding
            proteins, LTBPs, creates a hydrophobic interaction surface for
            binding of small latent TGF-beta
  JOURNAL   Mol Biol Cell 11 (8), 2691-2704 (2000)
   PUBMED   10930463
REFERENCE   7  (bases 1 to 5052)
  AUTHORS   Saharinen,J., Taipale,J., Monni,O. and Keski-Oja,J.
  TITLE     Identification and characterization of a new latent transforming
            growth factor-beta-binding protein, LTBP-4
  JOURNAL   J Biol Chem 273 (29), 18459-18469 (1998)
   PUBMED   9660815
REFERENCE   8  (bases 1 to 5052)
  AUTHORS   Giltay,R., Kostka,G. and Timpl,R.
  TITLE     Sequence and expression of a novel member (LTBP-4) of the family of
            latent transforming growth factor-beta binding proteins
  JOURNAL   FEBS Lett 411 (2-3), 164-168 (1997)
   PUBMED   9271198
REFERENCE   9  (bases 1 to 5052)
  AUTHORS   Callewaert,B.L. and Urban,Z.
  TITLE     LTBP4-Related Cutis Laxa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26866239
REFERENCE   10 (bases 1 to 5052)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y13622.1, AF051345.2,
            AK128191.1 and BQ001109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 14, 2006 this sequence version replaced NM_003573.1.
            
            Summary: The protein encoded by this gene binds transforming growth
            factor beta (TGFB) as it is secreted and targeted to the
            extracellular matrix. TGFB is biologically latent after secretion
            and insertion into the extracellular matrix, and sheds TGFB and
            other proteins upon activation. Defects in this gene may be a cause
            of cutis laxa and severe pulmonary, gastrointestinal, and urinary
            abnormalities. Three transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13622.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                Y13622.1           1-31
            32-75               AF051345.2         162-205
            76-396              Y13622.1           76-396
            397-468             AF051345.2         508-579
            469-1945            Y13622.1           469-1945
            1946-2247           AF051345.2         2057-2358
            2248-2267           Y13622.1           2248-2267
            2268-2346           AF051345.2         2379-2457
            2347-2747           Y13622.1           2347-2747
            2748-3310           AF051345.2         2859-3421
            3311-5031           AK128191.1         1420-3140
            5032-5052           BQ001109.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..5052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..5052
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="latent transforming growth factor beta binding
                     protein 4"
                     /db_xref="GeneID:8425"
                     /db_xref="HGNC:HGNC:6717"
                     /db_xref="MIM:604710"
     CDS             1..4764
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="isoform b is encoded by transcript variant 2;
                     latent transforming growth factor-beta binding protein 4L"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 4 isoform b"
                     /protein_id="NP_003564.2"
                     /db_xref="CCDS:CCDS74368.1"
                     /db_xref="GeneID:8425"
                     /db_xref="HGNC:HGNC:6717"
                     /db_xref="MIM:604710"
                     /translation="MGDVKALLFVAAARARRLGGAAASESLAVSEAFCRVRSCQPKKC
                     AGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRR
                     PPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGL
                     TRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARA
                     EAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCR
                     GAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGE
                     CANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQ
                     ICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVS
                     LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPS
                     SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRC
                     ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ
                     AAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPP
                     PCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQC
                     VCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDV
                     DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE
                     CLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHR
                     AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDEC
                     QEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQN
                     LPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEF
                     DPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC
                     YFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY
                     LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE
                     CADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGA
                     DLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRP
                     GGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDM
                     PDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE
                     LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV
                     NARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA"
     exon            1..16
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            17..75
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            76..230
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            231..340
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            341..532
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            533..780
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            781..883
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            884..958
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1081
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1246
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1396
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1516
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1648
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1774
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1900
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2143
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2269
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2389
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2521
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2647
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2770
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2902
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3034
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3160
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3307
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3574
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3646
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3775
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3922
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4075
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4456
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4609
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4610..5034
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5011..5016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="hexamer: ATTAAA"
     polyA_site      5032
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="major polyA site"
ORIGIN      
        1 atgggagacg taaaagcgtt gctgtttgtc gctgctgccc gggccagacg tctaggagga
       61 gccgctgcat ccgagtccct ggctgtctcc gaagccttct gcagggtccg aagctgccag
      121 cccaaaaagt gtgcaggccc ccagcggtgc ctgaacccag tgcctgcagt gcccagtccc
      181 agccccagcg tgaggaagag acaggtgtcc ctcaactggc agccactgac gctccaggag
      241 gccagagctc tactgaagcg gcggcggccc cgggggccag ggggccgggg actactgaga
      301 aggaggcccc cacagcgtgc ccccgctggc aaggccccgg tcctgtgtcc cttgatctgt
      361 cacaatggcg gtgtgtgcgt gaagcctgac cgctgcctct gtcccccgga cttcgctggc
      421 aagttctgcc agttgcactc ctcgggcgcc cggcccccgg ccccggctgt accaggcctc
      481 acccgctccg tgtacactat gccactggcc aaccaccgcg acgacgagca cggcgtggca
      541 tctatggtga gcgtccacgt ggagcacccg caggaggcgt cggtggtggt gcaccaggtg
      601 gagcgtgtgt ctggcccttg ggaggaggcg gacgctgagg cggtggcgcg ggcggaagcg
      661 gcggcgcggg cggaggcggc agcgccctac acggtgttgg cacagagcgc gccgcgggag
      721 gacggctact cagatgcctc gggcttcggt tactgctttc gggagctgcg cggaggcgaa
      781 tgcgcgtccc cgctgcccgg gctccggacg caggaggtct gctgccgagg ggccggcttg
      841 gcctggggcg ttcacgactg tcagctgtgc tccgagcgcc tggggaactc cgaaagagtg
      901 agcgccccag atggaccttg tccaaccggc tttgaaagag ttaatgggtc ctgcgaagat
      961 gtggatgagt gcgcgactgg cgggcgctgc cagcacggcg agtgtgcaaa cacgcgcggc
     1021 gggtacacgt gtgtgtgccc cgacggcttt ctgctcgact cgtcccgcag cagctgcatc
     1081 tcccaacacg tgatctcaga ggccaaaggg ccctgcttcc gcgtgctccg cgacggcggc
     1141 tgttcgctgc ccattctgcg gaacatcact aaacagatct gctgctgcag ccgcgtaggc
     1201 aaggcctggg gccggggctg ccagctctgc ccacccttcg gctcagaggg tttccgggag
     1261 atctgcccgg ctggtcctgg ttaccactac tcggcctccg acctccgcta caacaccaga
     1321 cccctgggcc aggagccacc ccgagtgtca ctcagccagc ctcgtaccct gccagccacc
     1381 tctcggccat ctgcaggctt tctgcccacc catcgcctgg agccccggcc tgaaccccgg
     1441 cccgatcccc ggcccggccc tgagcttccc ttgcccagca tccctgcctg gactggtcct
     1501 gagattcctg aatcaggtcc ctcctccggc atgtgtcagc gcaaccccca ggtctgcggc
     1561 ccaggacgct gcatttcccg gcccagcggc tacacctgcg cttgcgactc tggcttccgg
     1621 ctcagccccc agggcacccg atgcattgat gtggacgaat gtcgccgcgt gcccccgccc
     1681 tgtgctcccg ggcgctgcga gaactcacca ggcagcttcc gctgcgtgtg cggcccgggc
     1741 ttccgagccg gcccacgggc tgcggaatgc ctggatgtgg acgagtgcca ccgcgtgccg
     1801 ccgccgtgtg acctcgggcg ctgcgagaac acgccaggca gcttcctgtg cgtgtgcccc
     1861 gccgggtacc aggctgcacc gcacggagcc agctgccagg atgtggatga atgcacccag
     1921 agcccaggcc tgtgtggccg aggggcctgc aagaacctgc ctggctcttt ccgctgtgtt
     1981 tgcccggctg gcttccgggg ctcggcgtgt gaagaggatg tggatgagtg tgcccaggag
     2041 ccgccgccct gtgggcccgg ccgctgtgac aacacggcag gctcctttca ctgtgcctgc
     2101 cctgctggct tccgctcccg agggcccggg gccccctgcc aagatgtgga tgagtgtgcc
     2161 cgaagccccc caccctgcac ctacggccgg tgtgagaaca cagaaggcag cttccagtgt
     2221 gtctgcccca tgggcttcca acccaacact gctggctccg agtgcgagga tgtggatgag
     2281 tgtgagaacc acctcgcatg ccctgggcag gagtgtgtga actcgcccgg ctccttccag
     2341 tgcaggacct gtccttctgg ccaccacctg caccgtggca gatgcactga tgtggacgaa
     2401 tgcagttcgg gtgcccctcc ctgtggtccc cacggccact gcactaacac cgaaggctcc
     2461 ttccgctgca gctgcgcgcc aggctaccgg gcgccgtcgg gtcggcccgg gccctgcgca
     2521 gacgtgaacg agtgcctgga gggcgatttc tgcttccctc acggcgagtg cctcaacact
     2581 gacggctcct ttgcctgtac ttgtgcccct ggctaccgac ccggaccccg cggagcctct
     2641 tgcctcgacg ttgacgagtg cagcgaggag gacctttgcc agagcggcat ctgtaccaac
     2701 accgacggct ccttcgagtg catctgtcct ccgggacacc gcgctggccc ggacctcgcc
     2761 tcctgcctcg acgtggacga atgtcgcgag cgaggcccag ccctgtgcgg gtcgcagcgc
     2821 tgtgagaact ctcccggctc ctaccgctgt gtccgggact gcgatcctgg gtaccacgcg
     2881 ggccccgagg gcacctgtga cgatgtggat gagtgccaag aatatggtcc cgagatttgt
     2941 ggagcccagc gttgtgagaa cacccctggc tcctaccgct gcacaccagc ctgtgaccct
     3001 ggctatcagc ccacgccagg gggcggatgc caggatgtgg acgaatgccg gaaccggtcc
     3061 ttctgcggtg cccacgccgt gtgccagaac ctgcccggct ccttccagtg cctctgtgac
     3121 cagggttacg agggggcacg ggatgggcgt cactgcgtgg atgtgaacga gtgtgaaaca
     3181 ctacagggtg tatgtggagc tgccctgtgt gaaaatgtcg aaggctcctt cctctgtgtc
     3241 tgccccaaca gcccggaaga gtttgacccc atgactggac gctgtgttcc cccacgaact
     3301 tctgctggca cgttcccagg ctcgcagccc caggcacctg ctagccccgt tctgcccgcc
     3361 aggccacctc cgccacccct gccccgccga cccagcacac ctaggcaggg ccctgtgggg
     3421 agtgggcgcc gggagtgcta ctttgacaca gcggccccgg atgcatgtga caacatcctg
     3481 gctcggaatg tgacatggca ggagtgctgc tgtactgtgg gtgagggctg gggcagcggc
     3541 tgccgcatcc agcagtgccc gggcaccgag acagctgagt accagtcatt gtgccctcac
     3601 ggccggggct acctggcgcc cagtggagac ctgagcctcc ggagagacgt ggacgaatgt
     3661 cagctcttcc gagaccaggt gtgcaagagt ggcgtgtgtg tgaacacggc cccgggctac
     3721 tcatgctatt gcagcaacgg ctactactac cacacacagc ggctggagtg catcgacaat
     3781 gacgagtgcg ccgatgagga accggcctgt gagggcggcc gctgtgtcaa cactgtgggc
     3841 tcttatcact gtacctgcga gcccccactg gtgctggatg gctcgcagcg ccgctgcgtc
     3901 tccaacgaga gccagagcct cgatgacaat ctgggagtgt gctggcagga agtgggggct
     3961 gacctcgtgt gcagccaccc tcggctggac cgtcaggcca cctacacaga gtgctgctgc
     4021 ctgtatggag aggcctgggg catggactgc gccctctgcc ctgcgcagga ctcagatgac
     4081 ttcgaggccc tgtgcaatgt gctacgcccc cccgcatata gccccccgcg accaggtggc
     4141 tttggactcc cctacgagta cggcccagac ttaggtccac cttaccaggg cctcccatat
     4201 gggcctgagt tgtacccacc acctgcgcta ccctacgacc cctacccacc gccacctggg
     4261 cccttcgccc gccgggaggc tccttatggg gcaccccgct tcgacatgcc agactttgag
     4321 gacgatggtg gcccctatgg cgaatctgag gctcctgcgc cacctggccc gggcacccgc
     4381 tggccctatc ggtcccggga cacccgccgc tccttcccag agcccgagga gcctcctgaa
     4441 ggtggaagct atgctggttc cctggctgag ccctacgagg agctggaggc ggaggagtgc
     4501 gggatcctgg acggctgcac caacggccgc tgcgtgcgcg tccccgaagg cttcacctgc
     4561 cgttgcttcg acggctaccg cctggacatg acccgcatgg cctgcgttga catcaacgag
     4621 tgtgatgagg ccgaggctgc ctccccgctg tgcgtcaacg cgcgttgcct caacacggat
     4681 ggctccttcc gctgcatctg ccgcccggga ttcgcaccca cgcaccagcc gcaccactgt
     4741 gcgcccgcac ggccccgggc ctgagccctg gcacccgctg gccgcccacc cgcgcccgcc
     4801 actcggggcc cctgccgcgc atcctgcagc ccgcttatgc gtatgtgcac ggggccgccc
     4861 gcctggacct ggagaaggga cctacggacg cctggaagct gcgacgccct gcactgctcc
     4921 cgcctccacc agcgcctccc actgatgtcg tggtcccggg cctggcccag gggccccttt
     4981 acatgccctc tcccttttat aaaattttcc attaaaaacc acctattttc tatcaaaaaa
     5041 aaaaaaaaaa aa
//
