LOCUS       NM_001042545            4961 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            4 (LTBP4), transcript variant 3, mRNA.
ACCESSION   NM_001042545
VERSION     NM_001042545.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4961)
  AUTHORS   Ishii,M., Yamaguchi,Y., Takada,K., Hamaya,H., Ogawa,S. and
            Akishita,M.
  TITLE     Effect of decreased expression of latent TGF-beta binding proteins
            4 on the pathogenesis of emphysema as an age-related disease
  JOURNAL   Arch Gerontol Geriatr 127, 105597 (2024)
   PUBMED   39121531
  REMARK    GeneRIF: Effect of decreased expression of latent TGF-beta binding
            proteins 4 on the pathogenesis of emphysema as an age-related
            disease.
            Review article
REFERENCE   2  (bases 1 to 4961)
  AUTHORS   Chang,Y., Wang,X., Tian,X., Cao,Z., Zhen,X., Zhao,W., Luo,B. and
            Gao,Y.
  TITLE     Novel indel variation of LTBP4 gene associates with risk of sudden
            cardiac death in Chinese populations with coronary artery disease
  JOURNAL   Leg Med (Tokyo) 69, 102437 (2024)
   PUBMED   38547642
  REMARK    GeneRIF: Novel indel variation of LTBP4 gene associates with risk
            of sudden cardiac death in Chinese populations with coronary artery
            disease.
REFERENCE   3  (bases 1 to 4961)
  AUTHORS   Su,C.T., See,D.H.W., Huang,Y.J., Jao,T.M., Liu,S.Y., Chou,C.Y.,
            Lai,C.F., Lin,W.C., Wang,C.Y., Huang,J.W. and Hung,K.Y.
  TITLE     LTBP4 Protects Against Renal Fibrosis via Mitochondrial and
            Vascular Impacts
  JOURNAL   Circ Res 133 (1), 71-85 (2023)
   PUBMED   37232163
  REMARK    GeneRIF: LTBP4 Protects Against Renal Fibrosis via Mitochondrial
            and Vascular Impacts.
REFERENCE   4  (bases 1 to 4961)
  AUTHORS   Ibarra-Tapia,I.Y., Juarez-Sandoval,A., Perez,I.T.,
            Cano-Martinez,L.J., Sanchez-Garcia,S., Ruiz-Batalla,J.M.,
            Aroche-Reyes,I.A., Garcia,S., Canto,P., Mejia,D.R. and
            Coral-Vazquez,R.M.
  TITLE     Association of polymorphisms rs2303729, rs10880, and rs1131620 of
            LTBP4 with sarcopenia in elderly patients with type 2 diabetes
            mellitus
  JOURNAL   Ann Hum Biol 49 (7-8), 311-316 (2022)
   PUBMED   36524797
  REMARK    GeneRIF: Association of polymorphisms rs2303729, rs10880, and
            rs1131620 of LTBP4 with sarcopenia in elderly patients with type 2
            diabetes mellitus.
REFERENCE   5  (bases 1 to 4961)
  AUTHORS   Oklu,R. and Hesketh,R.
  TITLE     The latent transforming growth factor beta binding protein (LTBP)
            family
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 601-610 (2000)
   PUBMED   11104663
  REMARK    Review article
REFERENCE   6  (bases 1 to 4961)
  AUTHORS   Saharinen,J. and Keski-Oja,J.
  TITLE     Specific sequence motif of 8-Cys repeats of TGF-beta binding
            proteins, LTBPs, creates a hydrophobic interaction surface for
            binding of small latent TGF-beta
  JOURNAL   Mol Biol Cell 11 (8), 2691-2704 (2000)
   PUBMED   10930463
REFERENCE   7  (bases 1 to 4961)
  AUTHORS   Saharinen,J., Taipale,J., Monni,O. and Keski-Oja,J.
  TITLE     Identification and characterization of a new latent transforming
            growth factor-beta-binding protein, LTBP-4
  JOURNAL   J Biol Chem 273 (29), 18459-18469 (1998)
   PUBMED   9660815
REFERENCE   8  (bases 1 to 4961)
  AUTHORS   Giltay,R., Kostka,G. and Timpl,R.
  TITLE     Sequence and expression of a novel member (LTBP-4) of the family of
            latent transforming growth factor-beta binding proteins
  JOURNAL   FEBS Lett 411 (2-3), 164-168 (1997)
   PUBMED   9271198
REFERENCE   9  (bases 1 to 4961)
  AUTHORS   Callewaert,B.L. and Urban,Z.
  TITLE     LTBP4-Related Cutis Laxa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26866239
REFERENCE   10 (bases 1 to 4961)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010412.9, AF051344.2,
            Y13622.1, AK128191.1 and BQ001109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001042545.1.
            
            Summary: The protein encoded by this gene binds transforming growth
            factor beta (TGFB) as it is secreted and targeted to the
            extracellular matrix. TGFB is biologically latent after secretion
            and insertion into the extracellular matrix, and sheds TGFB and
            other proteins upon activation. Defects in this gene may be a cause
            of cutis laxa and severe pulmonary, gastrointestinal, and urinary
            abnormalities. Three transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (c)
            has a shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3453003.1, AF051344.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396819.8/ ENSP00000380031.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC010412.9         22058-22059
            3-397               AF051344.2         1-395
            398-1874            Y13622.1           469-1945
            1875-2176           AF051344.2         1873-2174
            2177-2196           Y13622.1           2248-2267
            2197-2275           AF051344.2         2195-2273
            2276-2676           Y13622.1           2347-2747
            2677-3055           AF051344.2         2675-3053
            3056-3233           Y13622.1           3127-3304
            3234-3239           AF051344.2         3232-3237
            3240-4960           AK128191.1         1420-3140
            4961-4961           BQ001109.1         21-21               c
FEATURES             Location/Qualifiers
     source          1..4961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..4961
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="latent transforming growth factor beta binding
                     protein 4"
                     /db_xref="GeneID:8425"
                     /db_xref="HGNC:HGNC:6717"
                     /db_xref="MIM:604710"
     exon            1..269
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..4693
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; latent transforming growth factor-beta binding
                     protein 4L"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 4 isoform c precursor"
                     /protein_id="NP_001036010.1"
                     /db_xref="CCDS:CCDS74370.1"
                     /db_xref="GeneID:8425"
                     /db_xref="HGNC:HGNC:6717"
                     /db_xref="MIM:604710"
                     /translation="MAGGVRLLWVSLLVLLAQLGPQPGLGRLGERLRVRFTPVVCGLR
                     CVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRC
                     LCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHP
                     QEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASG
                     FGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGP
                     CPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV
                     ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC
                     PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR
                     PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSG
                     FRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC
                     HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLP
                     GSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP
                     CQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQ
                     ECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG
                     YRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE
                     CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENS
                     PGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY
                     QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECET
                     LQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVL
                     PARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEG
                     WGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCV
                     NTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL
                     DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDC
                     ALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPP
                     ALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSR
                     DTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFD
                     GYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAP
                     ARPRA"
     exon            270..461
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            462..709
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            710..812
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            813..887
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1010
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1175
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1325
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1445
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1577
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1703
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1829
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2072
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2198
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2318
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2450
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2576
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2699
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2831
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2963
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3089
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3236
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3503
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3575
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3704
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3851
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..4004
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4385
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4538
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..4961
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4940..4945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="hexamer: ATTAAA"
     polyA_site      4961
                     /gene="LTBP4"
                     /gene_synonym="ARCL1C; LTBP-4; LTBP4L; LTBP4S"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcggc gctgcagcca tggcgggcgg cgtgcggctg ctctgggtgt cgctattggt
       61 gctgctggcg cagctagggc cgcagcctgg actgggccgg ctcggagagc gtctccgcgt
      121 gcgcttcacc ccggtcgtgt gcggcctgcg ctgcgtccat gggccgaccg gctcccgctg
      181 taccccgacc tgcgcgcccc gcaacgccac cagcgtggac agcggcgctc ccggcggggc
      241 ggccccgggg ggacccggct tccgcgcctt cctgtgtccc ttgatctgtc acaatggcgg
      301 tgtgtgcgtg aagcctgacc gctgcctctg tcccccggac ttcgctggca agttctgcca
      361 gttgcactcc tcgggcgccc ggcccccggc cccggctgta ccaggcctca cccgctccgt
      421 gtacactatg ccactggcca accaccgcga cgacgagcac ggcgtggcat ctatggtgag
      481 cgtccacgtg gagcacccgc aggaggcgtc ggtggtggtg caccaggtgg agcgtgtgtc
      541 tggcccttgg gaggaggcgg acgctgaggc ggtggcgcgg gcggaagcgg cggcgcgggc
      601 ggaggcggca gcgccctaca cggtgttggc acagagcgcg ccgcgggagg acggctactc
      661 agatgcctcg ggcttcggtt actgctttcg ggagctgcgc ggaggcgaat gcgcgtcccc
      721 gctgcccggg ctccggacgc aggaggtctg ctgccgaggg gccggcttgg cctggggcgt
      781 tcacgactgt cagctgtgct ccgagcgcct ggggaactcc gaaagagtga gcgccccaga
      841 tggaccttgt ccaaccggct ttgaaagagt taatgggtcc tgcgaagatg tggatgagtg
      901 cgcgactggc gggcgctgcc agcacggcga gtgtgcaaac acgcgcggcg ggtacacgtg
      961 tgtgtgcccc gacggctttc tgctcgactc gtcccgcagc agctgcatct cccaacacgt
     1021 gatctcagag gccaaagggc cctgcttccg cgtgctccgc gacggcggct gttcgctgcc
     1081 cattctgcgg aacatcacta aacagatctg ctgctgcagc cgcgtaggca aggcctgggg
     1141 ccggggctgc cagctctgcc cacccttcgg ctcagagggt ttccgggaga tctgcccggc
     1201 tggtcctggt taccactact cggcctccga cctccgctac aacaccagac ccctgggcca
     1261 ggagccaccc cgagtgtcac tcagccagcc tcgtaccctg ccagccacct ctcggccatc
     1321 tgcaggcttt ctgcccaccc atcgcctgga gccccggcct gaaccccggc ccgatccccg
     1381 gcccggccct gagcttccct tgcccagcat ccctgcctgg actggtcctg agattcctga
     1441 atcaggtccc tcctccggca tgtgtcagcg caacccccag gtctgcggcc caggacgctg
     1501 catttcccgg cccagcggct acacctgcgc ttgcgactct ggcttccggc tcagccccca
     1561 gggcacccga tgcattgatg tggacgaatg tcgccgcgtg cccccgccct gtgctcccgg
     1621 gcgctgcgag aactcaccag gcagcttccg ctgcgtgtgc ggcccgggct tccgagccgg
     1681 cccacgggct gcggaatgcc tggatgtgga cgagtgccac cgcgtgccgc cgccgtgtga
     1741 cctcgggcgc tgcgagaaca cgccaggcag cttcctgtgc gtgtgccccg ccgggtacca
     1801 ggctgcaccg cacggagcca gctgccagga tgtggatgaa tgcacccaga gcccaggcct
     1861 gtgtggccga ggggcctgca agaacctgcc tggctctttc cgctgtgttt gcccggctgg
     1921 cttccggggc tcggcgtgtg aagaggatgt ggatgagtgt gcccaggagc cgccgccctg
     1981 tgggcccggc cgctgtgaca acacggcagg ctcctttcac tgtgcctgcc ctgctggctt
     2041 ccgctcccga gggcccgggg ccccctgcca agatgtggat gagtgtgccc gaagcccccc
     2101 accctgcacc tacggccggt gtgagaacac agaaggcagc ttccagtgtg tctgccccat
     2161 gggcttccaa cccaacactg ctggctccga gtgcgaggat gtggatgagt gtgagaacca
     2221 cctcgcatgc cctgggcagg agtgtgtgaa ctcgcccggc tccttccagt gcaggacctg
     2281 tccttctggc caccacctgc accgtggcag atgcactgat gtggacgaat gcagttcggg
     2341 tgcccctccc tgtggtcccc acggccactg cactaacacc gaaggctcct tccgctgcag
     2401 ctgcgcgcca ggctaccggg cgccgtcggg tcggcccggg ccctgcgcag acgtgaacga
     2461 gtgcctggag ggcgatttct gcttccctca cggcgagtgc ctcaacactg acggctcctt
     2521 tgcctgtact tgtgcccctg gctaccgacc cggaccccgc ggagcctctt gcctcgacgt
     2581 tgacgagtgc agcgaggagg acctttgcca gagcggcatc tgtaccaaca ccgacggctc
     2641 cttcgagtgc atctgtcctc cgggacaccg cgctggcccg gacctcgcct cctgcctcga
     2701 cgtggacgaa tgtcgcgagc gaggcccagc cctgtgcggg tcgcagcgct gtgagaactc
     2761 tcccggctcc taccgctgtg tccgggactg cgatcctggg taccacgcgg gccccgaggg
     2821 cacctgtgac gatgtggatg agtgccaaga atatggtccc gagatttgtg gagcccagcg
     2881 ttgtgagaac acccctggct cctaccgctg cacaccagcc tgtgaccctg gctatcagcc
     2941 cacgccaggg ggcggatgcc aggatgtgga cgaatgccgg aaccggtcct tctgcggtgc
     3001 ccacgccgtg tgccagaacc tgcccggctc cttccagtgc ctctgtgacc agggttacga
     3061 gggggcacgg gatgggcgtc actgcgtgga tgtgaacgag tgtgaaacac tacagggtgt
     3121 atgtggagct gccctgtgtg aaaatgtcga aggctccttc ctctgtgtct gccccaacag
     3181 cccggaagag tttgacccca tgactggacg ctgtgttccc ccacgaactt ctgctggcac
     3241 gttcccaggc tcgcagcccc aggcacctgc tagccccgtt ctgcccgcca ggccacctcc
     3301 gccacccctg ccccgccgac ccagcacacc taggcagggc cctgtgggga gtgggcgccg
     3361 ggagtgctac tttgacacag cggccccgga tgcatgtgac aacatcctgg ctcggaatgt
     3421 gacatggcag gagtgctgct gtactgtggg tgagggctgg ggcagcggct gccgcatcca
     3481 gcagtgcccg ggcaccgaga cagctgagta ccagtcattg tgccctcacg gccggggcta
     3541 cctggcgccc agtggagacc tgagcctccg gagagacgtg gacgaatgtc agctcttccg
     3601 agaccaggtg tgcaagagtg gcgtgtgtgt gaacacggcc ccgggctact catgctattg
     3661 cagcaacggc tactactacc acacacagcg gctggagtgc atcgacaatg acgagtgcgc
     3721 cgatgaggaa ccggcctgtg agggcggccg ctgtgtcaac actgtgggct cttatcactg
     3781 tacctgcgag cccccactgg tgctggatgg ctcgcagcgc cgctgcgtct ccaacgagag
     3841 ccagagcctc gatgacaatc tgggagtgtg ctggcaggaa gtgggggctg acctcgtgtg
     3901 cagccaccct cggctggacc gtcaggccac ctacacagag tgctgctgcc tgtatggaga
     3961 ggcctggggc atggactgcg ccctctgccc tgcgcaggac tcagatgact tcgaggccct
     4021 gtgcaatgtg ctacgccccc ccgcatatag ccccccgcga ccaggtggct ttggactccc
     4081 ctacgagtac ggcccagact taggtccacc ttaccagggc ctcccatatg ggcctgagtt
     4141 gtacccacca cctgcgctac cctacgaccc ctacccaccg ccacctgggc ccttcgcccg
     4201 ccgggaggct ccttatgggg caccccgctt cgacatgcca gactttgagg acgatggtgg
     4261 cccctatggc gaatctgagg ctcctgcgcc acctggcccg ggcacccgct ggccctatcg
     4321 gtcccgggac acccgccgct ccttcccaga gcccgaggag cctcctgaag gtggaagcta
     4381 tgctggttcc ctggctgagc cctacgagga gctggaggcg gaggagtgcg ggatcctgga
     4441 cggctgcacc aacggccgct gcgtgcgcgt ccccgaaggc ttcacctgcc gttgcttcga
     4501 cggctaccgc ctggacatga cccgcatggc ctgcgttgac atcaacgagt gtgatgaggc
     4561 cgaggctgcc tccccgctgt gcgtcaacgc gcgttgcctc aacacggatg gctccttccg
     4621 ctgcatctgc cgcccgggat tcgcacccac gcaccagccg caccactgtg cgcccgcacg
     4681 gccccgggcc tgagccctgg cacccgctgg ccgcccaccc gcgcccgcca ctcggggccc
     4741 ctgccgcgca tcctgcagcc cgcttatgcg tatgtgcacg gggccgcccg cctggacctg
     4801 gagaagggac ctacggacgc ctggaagctg cgacgccctg cactgctccc gcctccacca
     4861 gcgcctccca ctgatgtcgt ggtcccgggc ctggcccagg ggccccttta catgccctct
     4921 cccttttata aaattttcca ttaaaaacca cctattttct a
//
