LOCUS       NM_021070               4580 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            3 (LTBP3), transcript variant 2, mRNA.
ACCESSION   NM_021070 XM_938706
VERSION     NM_021070.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Hadid,Y., Daher,Z., Mahroum,M., Shalata,A., Nakhleh Francis,Y.,
            Shalata,H., Broneshter Vinter,R., Ziv,M., Furman,C., Ali,V.,
            Levitaz,J. and Shalata,A.
  TITLE     [IDENTIFICATION OF A NOVEL LTBP3 GENE PATHOGENIC VARIANT IN DRUZE
            ARAB PATIENTS PRESENTED WITH SYNDROMIC SHORT STATURE WITH
            BRACHYOLMIA AND AMELOGENESIS IMPERFECTA]
  JOURNAL   Harefuah 162 (6), 352-358 (2023)
   PUBMED   37394436
  REMARK    GeneRIF: [IDENTIFICATION OF A NOVEL LTBP3 GENE PATHOGENIC VARIANT
            IN DRUZE ARAB PATIENTS PRESENTED WITH SYNDROMIC SHORT STATURE WITH
            BRACHYOLMIA AND AMELOGENESIS IMPERFECTA].
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Kantaputra,P., Guven,Y., Kalayci,T., Ozer,P.K., Panyarak,W.,
            Intachai,W., Olsen,B., Carlson,B.M., Praditsap,O., Tongsima,S.,
            Ngamphiw,C., Jatooratthawichot,P., Tucker,A.S. and Ketudat
            Cairns,J.R.
  TITLE     Expanding genotypic and phenotypic spectrums of LTBP3 variants in
            dental anomalies and short stature syndrome
  JOURNAL   Clin Genet 102 (1), 66-71 (2022)
   PUBMED   35352826
  REMARK    GeneRIF: Expanding genotypic and phenotypic spectrums of LTBP3
            variants in dental anomalies and short stature syndrome.
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Zhu,G., Luo,M., Chen,Q., Zhang,Y., Zhao,K., Zhang,Y., Shu,C.,
            Yang,H. and Zhou,Z.
  TITLE     Novel LTBP3 mutations associated with thoracic aortic aneurysms and
            dissections
  JOURNAL   Orphanet J Rare Dis 16 (1), 513 (2021)
   PUBMED   34906192
  REMARK    GeneRIF: Novel LTBP3 mutations associated with thoracic aortic
            aneurysms and dissections.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Halbgebauer,D., Roos,J., Funcke,J.B., Neubauer,H., Hamilton,B.S.,
            Simon,E., Amri,E.Z., Debatin,K.M., Wabitsch,M.,
            Fischer-Posovszky,P. and Tews,D.
  TITLE     Latent TGFbeta-binding proteins regulate UCP1 expression and
            function via TGFbeta2
  JOURNAL   Mol Metab 53, 101336 (2021)
   PUBMED   34481123
  REMARK    GeneRIF: Latent TGFbeta-binding proteins regulate UCP1 expression
            and function via TGFbeta2.
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Zhao,T., Zhao,J., Ma,C., Wei,J., Wei,B. and Liu,J.
  TITLE     Common variants in LTBP3 gene contributed to the risk of hip
            osteoarthritis in Han Chinese population
  JOURNAL   Biosci Rep 40 (6) (2020)
   PUBMED   32452514
  REMARK    GeneRIF: Common variants in LTBP3 gene contributed to the risk of
            hip osteoarthritis in Han Chinese population.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Saharinen,J., Hyytiainen,M., Taipale,J. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta binding proteins
            (LTBPs)--structural extracellular matrix proteins for targeting
            TGF-beta action
  JOURNAL   Cytokine Growth Factor Rev 10 (2), 99-117 (1999)
   PUBMED   10743502
  REMARK    Review article
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Michel,K., Roth,S., Trautwein,C., Gong,W., Flemming,P. and
            Gressner,A.M.
  TITLE     Analysis of the expression pattern of the latent transforming
            growth factor beta binding protein isoforms in normal and diseased
            human liver reveals a new splice variant missing the
            proteinase-sensitive hinge region
  JOURNAL   Hepatology 27 (6), 1592-1599 (1998)
   PUBMED   9620332
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Moren,A., Olofsson,A., Stenman,G., Sahlin,P., Kanzaki,T.,
            Claesson-Welsh,L., ten Dijke,P., Miyazono,K. and Heldin,C.H.
  TITLE     Identification and characterization of LTBP-2, a novel latent
            transforming growth factor-beta-binding protein
  JOURNAL   J Biol Chem 269 (51), 32469-32478 (1994)
   PUBMED   7798248
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Marzin,P. and Cormier-Daire,V.
  TITLE     Geleophysic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024477.1, AF135960.3 and
            AF318354.1.
            
            On Aug 19, 2009 this sequence version replaced NM_021070.3.
            
            Summary: The protein encoded by this gene forms a complex with
            transforming growth factor beta (TGF-beta) proteins and may be
            involved in their subcellular localization. Activation of this
            complex requires removal of the encoded binding protein. This
            protein also may play a structural role in the extracellular
            matrix. Three transcript variants encoding different isoforms have
            been found for this gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, as compared to variant 1. The
            resulting isoform (2) lacks an internal segment but has identical
            N- and C-termini, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135960.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AK024477.1         1-269
            270-4317            AF135960.3         1-4048
            4318-4580           AF318354.1         3488-3750
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4580
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="latent transforming growth factor beta binding
                     protein 3"
                     /db_xref="GeneID:4054"
                     /db_xref="HGNC:HGNC:6716"
                     /db_xref="MIM:602090"
     exon            1..600
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..4040
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; latent TGF beta binding protein 3"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 3 isoform 2 precursor"
                     /protein_id="NP_066548.2"
                     /db_xref="CCDS:CCDS8103.1"
                     /db_xref="GeneID:4054"
                     /db_xref="HGNC:HGNC:6716"
                     /db_xref="MIM:602090"
                     /translation="MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGG
                     PAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDT
                     LTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR
                     TGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQIS
                     AEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPL
                     GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR
                     GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT
                     QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA
                     FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEE
                     ERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVE
                     IAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP
                     CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGH
                     YKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG
                     ACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG
                     ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGH
                     RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPH
                     HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP
                     DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN
                     LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERR
                     DVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSES
                     NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR
                     CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR"
     exon            601..930
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1133
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1239
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1332
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1455
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1614
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1800
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1817
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1890
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1989
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2115
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2247
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2376
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2499
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2622
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2745
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2865
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2994
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3162
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3246
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3375
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3513
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3675
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3756
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3888
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4561
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="hexamer: GATAAA"
     polyA_site      4302
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="major polyA site"
     polyA_site      4561
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
ORIGIN      
        1 cttgctccgg cctcctcgct cctgcctgag ttcggggcct ggtctgggct tcgtcctggg
       61 gctgggaagt ttctgcgctc cccgctgtcc agtctgcatc tccgcgcctc ccgccgggcc
      121 cccgcggtcc cctcccgccc gcttcccccg ctgccctccc tcgctgcccc ctaccctctc
      181 ccggggctcc cggccctcta ctcccttcgg gcgcgggccc ctcgccccgc ccgggcgcgc
      241 cccccctccc ccgggtcctg cggccccgga tgcccgggcc ccgaggggct gctggcggcc
      301 tggcccctga gatgcgcggg gcgggggcgg cggggctgct ggcgctgctg ctgctgctgc
      361 tgctgctgct gctgggcctg ggcggcaggg tcgagggggg gccggccggc gagcggggcg
      421 caggcggggg cggggcgctg gcccgcgagc gcttcaaggt ggtctttgcg ccggtgatct
      481 gcaagcggac ctgtctcaag ggccagtgtc gggacagttg tcagcagggc tccaacatga
      541 cgctcatcgg agagaacggc cacagcacag acacgctcac gggctccggc ttccgcgtgg
      601 tggtgtgccc tctcccctgc atgaatggcg gccagtgctc ctcgcgaaac cagtgcctgt
      661 gtcccccgga cttcactggg cgcttctgcc aggtgcccgc aggaggagcc ggtgggggta
      721 ccggcggctc aggccccggc ctgagcagga caggggccct gtccacaggg gcgctgccgc
      781 ccctggctcc ggagggcgac tctgtggcca gcaagcacgc catctacgcc gtccaggtga
      841 tcgctgaccc tcctgggccc ggggaggggc ctcctgccca gcacgcagcc ttcctggtgc
      901 ccctaggccc gggacagatc tcagcagaag tgcaggcccc gccccccgtg gtgaatgtgc
      961 gcgtccatca cccgcccgag gcctcagtcc aggtgcaccg cattgagagc tcgaacgccg
     1021 agagcgcagc cccctcccag cacctgctgc cgcaccccaa gccctcgcac ccccggccgc
     1081 ccacccagaa gcccctgggc cgctgctttc aggacactct gcccaagcag ccgtgtggca
     1141 gcaaccccct ccccggcctc accaagcagg aagactgctg cggtagcatc ggcactgcct
     1201 ggggccagag caagtgccac aagtgtcccc agctgcagta cacaggagtg cagaagccag
     1261 ggcctgtacg tggggaagtg ggcgctgact gtccccaggg ctacaagagg cttaacagca
     1321 cccactgcca ggacatcaac gagtgcgcaa tgccgggcgt gtgtcgccat ggtgactgcc
     1381 tcaacaaccc tggctcctat cgctgtgtct gcccacctgg ccatagttta ggcccctccc
     1441 gtacacagtg cattgcagac aaaccggagg agaagagcct gtgtttccgc ctggtgagcc
     1501 ctgagcacca gtgccagcac ccactgacca cccgcctgac ccgccagctc tgctgctgca
     1561 gtgtcggcaa ggcctggggc gcgcggtgtc agcgctgccc aacagatggc accgctgcgt
     1621 tcaaggagat ctgcccagct gggaagggat accacattct cacctcccac cagacgctca
     1681 ccattcaggg cgagagtgac ttttcccttt tcctgcaccc tgacgggcca cccaagcccc
     1741 agcagcttcc ggagagccct agccaggctc caccacctga ggacacagag gaagagagag
     1801 gggtgaccac ggactcaccg gtgagtgagg agaggtcagt gcagcagagc cacccaactg
     1861 ccaccacgac tcctgcccgg ccctaccccg agctgatctc ccgtccctcg cccccgacca
     1921 tgcgctggtt cctgccggac ttgcctcctt cccgcagcgc cgtagagatc gctcccactc
     1981 aggtcacaga gactgatgag tgccgactga accagaacat ctgtggccac ggagagtgcg
     2041 tgccgggccc ccctgactac tcctgccact gcaaccccgg ctaccggtca catccccagc
     2101 accgctactg cgtggatgtg aacgagtgcg aggcagagcc ctgtggcccg gggaggggca
     2161 tctgcatgaa caccggcggc tcctacaatt gccactgcaa ccgcggctac cgcctgcacg
     2221 tgggcgccgg ggggcgctcg tgcgtggacc tgaacgaatg cgccaagccc cacctgtgcg
     2281 gcgacggcgg cttctgcatc aactttcccg gtcactacaa gtgcaactgc taccccggct
     2341 accggctcaa agcctcccgg cctcctgtgt gcgaagacat cgacgagtgc cgggacccaa
     2401 gctcttgccc ggatggcaaa tgcgagaaca agcccgggag cttcaagtgc atcgcctgtc
     2461 agcctggcta ccgcagccag gggggcgggg cctgtcgcga cgtgaacgag tgcgccgagg
     2521 gcagcccctg ctcgcctggc tggtgcgaga acctcccggg ctccttccgc tgcacctgtg
     2581 cccagggcta cgcgcccgcg cccgacggcc gcagttgctt ggatgtggac gagtgtgagg
     2641 ctggggacgt gtgtgacaat ggcatctgca gcaacacgcc aggatctttc cagtgtcagt
     2701 gcctctctgg ctaccatctg tccagggacc ggagccactg cgaggacatt gatgagtgtg
     2761 acttccctgc agcctgcatt gggggtgact gcatcaatac caatggctcc tacagatgtc
     2821 tttgccccca ggggcatcgg ctggtgggtg gcaggaaatg ccaagacata gatgagtgca
     2881 gccaggaccc gagcctgtgc cttccccatg gggcctgcaa gaaccttcag ggctcctatg
     2941 tgtgtgtctg cgatgagggc ttcactccca cccaggacca gcacggttgt gaggaggtgg
     3001 agcagcccca ccacaagaag gagtgctacc tgaacttcga tgacacagtg ttctgcgaca
     3061 gcgtattggc caccaacgtg acccagcagg agtgctgctg ctctctgggg gccggctggg
     3121 gcgaccactg cgaaatctac ccctgcccag tctacagctc agccgagttc cacagcctct
     3181 gcccagacgg aaagggctac acccaggaca acaacatcgt caactacggc atcccagccc
     3241 accgtgacat cgacgagtgc atgttgttcg ggtcggagat ttgcaaggag ggcaagtgcg
     3301 tgaacacgca gcctggctac gagtgctact gcaagcaggg cttctactac gacgggaacc
     3361 tgctggaatg cgtggacgtg gacgagtgcc tggacgagtc caactgccgg aacggagtgt
     3421 gtgagaacac gcgcggcggc taccgctgtg cctgcacgcc ccctgccgag tacagtcccg
     3481 cgcagcgcca gtgcctgagc ccggaagaga tggagcgtgc cccggagcgg cgcgacgtgt
     3541 gctggagcca gcgcggagag gacggcatgt gcgctggccc cctggccggg cctgccctca
     3601 ccttcgacga ctgctgctgc cgccagggcc gcggctgggg cgcccaatgc cgaccgtgcc
     3661 cgccgcgcgg cgcggggtcc cattgcccga catcgcagag cgagagcaat tccttctggg
     3721 acacaagccc cctgctgttg gggaagcccc caagagatga ggacagttca gaggaggatt
     3781 cagacgagtg tcgctgcgtg agtggccgct gcgtgccgcg gccgggcggc gccgtgtgcg
     3841 agtgtcccgg cggcttccag ctcgacgcct cccgcgcccg ctgcgtggat atcgacgagt
     3901 gccgagagct gaaccagcgc gggctgctgt gcaagagcga gcgctgcgtg aacaccagcg
     3961 gctccttccg ctgcgtctgc aaagccggct tcgcgcgcag ccgcccgcac ggggcctgcg
     4021 ttccccagcg ccgccgctga cgccgccgac gccgccctcg gcccagacct cggtgatcac
     4081 tgagggattt ccgcgagctc ggcctcactt ctgccccgac ttgtggctcg gacccaggga
     4141 ccttcagggc ccgcagaccc tcccggcgcc ttgagacccg aggcgcccct accggccccc
     4201 ctccccggtt agcgggcggt tgtaaggtct ccggcgggcg ctgcctgcct tcctcccaga
     4261 gggtgtttcc tagaaactga taaatcagat cgtgcctctt tacccttggc tttcgaagca
     4321 aattgatgtt cacgtctgac gtgggcgcgg gctgcgcagg gcggcgccag accccagccg
     4381 cctcccaggg gctagactga gcccggcaca aggggtgtga aatagaattt attgtggctc
     4441 tgattatgta cacgtgagat ggcctggctg ggccggccgg gctcacatgg tttgtacaat
     4501 aaatacatct gtggggcggg ctctccgcag ccgggaaggg ccaccgccac ggttcagtcc
     4561 aaaaaaaaaa aaaaaaaaaa
//
