LOCUS       NM_001130144            4833 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            3 (LTBP3), transcript variant 1, mRNA.
ACCESSION   NM_001130144 XM_001721451 XM_001721484 XM_001722323
VERSION     NM_001130144.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4833)
  AUTHORS   Hadid,Y., Daher,Z., Mahroum,M., Shalata,A., Nakhleh Francis,Y.,
            Shalata,H., Broneshter Vinter,R., Ziv,M., Furman,C., Ali,V.,
            Levitaz,J. and Shalata,A.
  TITLE     [IDENTIFICATION OF A NOVEL LTBP3 GENE PATHOGENIC VARIANT IN DRUZE
            ARAB PATIENTS PRESENTED WITH SYNDROMIC SHORT STATURE WITH
            BRACHYOLMIA AND AMELOGENESIS IMPERFECTA]
  JOURNAL   Harefuah 162 (6), 352-358 (2023)
   PUBMED   37394436
  REMARK    GeneRIF: [IDENTIFICATION OF A NOVEL LTBP3 GENE PATHOGENIC VARIANT
            IN DRUZE ARAB PATIENTS PRESENTED WITH SYNDROMIC SHORT STATURE WITH
            BRACHYOLMIA AND AMELOGENESIS IMPERFECTA].
REFERENCE   2  (bases 1 to 4833)
  AUTHORS   Kantaputra,P., Guven,Y., Kalayci,T., Ozer,P.K., Panyarak,W.,
            Intachai,W., Olsen,B., Carlson,B.M., Praditsap,O., Tongsima,S.,
            Ngamphiw,C., Jatooratthawichot,P., Tucker,A.S. and Ketudat
            Cairns,J.R.
  TITLE     Expanding genotypic and phenotypic spectrums of LTBP3 variants in
            dental anomalies and short stature syndrome
  JOURNAL   Clin Genet 102 (1), 66-71 (2022)
   PUBMED   35352826
  REMARK    GeneRIF: Expanding genotypic and phenotypic spectrums of LTBP3
            variants in dental anomalies and short stature syndrome.
REFERENCE   3  (bases 1 to 4833)
  AUTHORS   Zhu,G., Luo,M., Chen,Q., Zhang,Y., Zhao,K., Zhang,Y., Shu,C.,
            Yang,H. and Zhou,Z.
  TITLE     Novel LTBP3 mutations associated with thoracic aortic aneurysms and
            dissections
  JOURNAL   Orphanet J Rare Dis 16 (1), 513 (2021)
   PUBMED   34906192
  REMARK    GeneRIF: Novel LTBP3 mutations associated with thoracic aortic
            aneurysms and dissections.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4833)
  AUTHORS   Halbgebauer,D., Roos,J., Funcke,J.B., Neubauer,H., Hamilton,B.S.,
            Simon,E., Amri,E.Z., Debatin,K.M., Wabitsch,M.,
            Fischer-Posovszky,P. and Tews,D.
  TITLE     Latent TGFbeta-binding proteins regulate UCP1 expression and
            function via TGFbeta2
  JOURNAL   Mol Metab 53, 101336 (2021)
   PUBMED   34481123
  REMARK    GeneRIF: Latent TGFbeta-binding proteins regulate UCP1 expression
            and function via TGFbeta2.
REFERENCE   5  (bases 1 to 4833)
  AUTHORS   Zhao,T., Zhao,J., Ma,C., Wei,J., Wei,B. and Liu,J.
  TITLE     Common variants in LTBP3 gene contributed to the risk of hip
            osteoarthritis in Han Chinese population
  JOURNAL   Biosci Rep 40 (6) (2020)
   PUBMED   32452514
  REMARK    GeneRIF: Common variants in LTBP3 gene contributed to the risk of
            hip osteoarthritis in Han Chinese population.
REFERENCE   6  (bases 1 to 4833)
  AUTHORS   Saharinen,J., Hyytiainen,M., Taipale,J. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta binding proteins
            (LTBPs)--structural extracellular matrix proteins for targeting
            TGF-beta action
  JOURNAL   Cytokine Growth Factor Rev 10 (2), 99-117 (1999)
   PUBMED   10743502
  REMARK    Review article
REFERENCE   7  (bases 1 to 4833)
  AUTHORS   Michel,K., Roth,S., Trautwein,C., Gong,W., Flemming,P. and
            Gressner,A.M.
  TITLE     Analysis of the expression pattern of the latent transforming
            growth factor beta binding protein isoforms in normal and diseased
            human liver reveals a new splice variant missing the
            proteinase-sensitive hinge region
  JOURNAL   Hepatology 27 (6), 1592-1599 (1998)
   PUBMED   9620332
REFERENCE   8  (bases 1 to 4833)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   9  (bases 1 to 4833)
  AUTHORS   Moren,A., Olofsson,A., Stenman,G., Sahlin,P., Kanzaki,T.,
            Claesson-Welsh,L., ten Dijke,P., Miyazono,K. and Heldin,C.H.
  TITLE     Identification and characterization of LTBP-2, a novel latent
            transforming growth factor-beta-binding protein
  JOURNAL   J Biol Chem 269 (51), 32469-32478 (1994)
   PUBMED   7798248
REFERENCE   10 (bases 1 to 4833)
  AUTHORS   Marzin,P. and Cormier-Daire,V.
  TITLE     Geleophysic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001362.5, AK024477.1,
            AF135960.3 and AF318354.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 20, 2020 this sequence version replaced NM_001130144.2.
            
            Summary: The protein encoded by this gene forms a complex with
            transforming growth factor beta (TGF-beta) proteins and may be
            involved in their subcellular localization. Activation of this
            complex requires removal of the encoded binding protein. This
            protein also may play a structural role in the extracellular
            matrix. Three transcript variants encoding different isoforms have
            been found for this gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301873.11/ ENSP00000301873.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AP001362.5         38840-38970         c
            132-502             AK024477.1         1-371
            503-505             AF135960.3         103-105
            506-4573            AK024477.1         372-4439
            4574-4833           AF318354.1         3472-3731
FEATURES             Location/Qualifiers
     source          1..4833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4833
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="latent transforming growth factor beta binding
                     protein 3"
                     /db_xref="GeneID:4054"
                     /db_xref="HGNC:HGNC:6716"
                     /db_xref="MIM:602090"
     exon            1..731
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..4312
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; latent TGF beta binding protein 3"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 3 isoform 1 precursor"
                     /protein_id="NP_001123616.1"
                     /db_xref="CCDS:CCDS44647.1"
                     /db_xref="GeneID:4054"
                     /db_xref="HGNC:HGNC:6716"
                     /db_xref="MIM:602090"
                     /translation="MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGG
                     PAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDT
                     LTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR
                     TGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQIS
                     AEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPL
                     GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVR
                     GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT
                     QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA
                     FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEE
                     ERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVE
                     IAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP
                     CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGH
                     YKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG
                     ACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG
                     ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGH
                     RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPH
                     HKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP
                     DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN
                     LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD
                     PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDG
                     MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL
                     GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELN
                     QRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR"
     exon            732..1061
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1264
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1370
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1463
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1586
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1745
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1931
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..1948
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2021
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2120
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2246
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2378
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2507
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2630
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2753
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2876
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2996
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3125
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3293
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3377
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3506
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3644
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3785
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3947
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4028
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4160
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4833
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="hexamer: GATAAA"
     polyA_site      4574
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
                     /note="major polyA site"
     polyA_site      4833
                     /gene="LTBP3"
                     /gene_synonym="DASS; GPHYSD3; LTBP-3; LTBP2; pp6425;
                     STHAG6"
ORIGIN      
        1 acttctccct gagccctccc cgcgcgctcc ctgcctcccc gcggccgcgg gagaggagcc
       61 cggccagggg gaggcgcgga gcgggccggc cgcccggcct tcctctccct cgctcctcct
      121 ctccgcctca acttgctccg gcctcctcgc tcctgcctga gttcggggcc tggtctgggc
      181 ttcgtcctgg ggctgggaag tttctgcgct ccccgctgtc cagtctgcat ctccgcgcct
      241 cccgccgggc ccccgcggtc ccctcccgcc cgcttccccc gctgccctcc ctcgctgccc
      301 cctaccctct cccggggctc ccggccctct actcccttcg ggcgcgggcc cctcgccccg
      361 cccgggcgcg ccccccctcc cccgggtcct gcggccccgg atgcccgggc cccgaggggc
      421 tgctggcggc ctggcccctg agatgcgcgg ggcgggggcg gcggggctgc tggcgctgct
      481 gctgctgctg ctgctgctgc tgctgggcct gggcggcagg gtcgaggggg ggccggccgg
      541 cgagcggggc gcaggcgggg gcggggcgct ggcccgcgag cgcttcaagg tggtctttgc
      601 gccggtgatc tgcaagcgga cctgtctcaa gggccagtgt cgggacagtt gtcagcaggg
      661 ctccaacatg acgctcatcg gagagaacgg ccacagcaca gacacgctca cgggctccgg
      721 cttccgcgtg gtggtgtgcc ctctcccctg catgaatggc ggccagtgct cctcgcgaaa
      781 ccagtgcctg tgtcccccgg acttcactgg gcgcttctgc caggtgcccg caggaggagc
      841 cggtgggggt accggcggct caggccccgg cctgagcagg acaggggccc tgtccacagg
      901 ggcgctgccg cccctggctc cggagggcga ctctgtggcc agcaagcacg ccatctacgc
      961 cgtccaggtg atcgctgacc ctcctgggcc cggggagggg cctcctgccc agcacgcagc
     1021 cttcctggtg cccctaggcc cgggacagat ctcagcagaa gtgcaggccc cgccccccgt
     1081 ggtgaatgtg cgcgtccatc acccgcccga ggcctcagtc caggtgcacc gcattgagag
     1141 ctcgaacgcc gagagcgcag ccccctccca gcacctgctg ccgcacccca agccctcgca
     1201 cccccggccg cccacccaga agcccctggg ccgctgcttt caggacactc tgcccaagca
     1261 gccgtgtggc agcaaccccc tccccggcct caccaagcag gaagactgct gcggtagcat
     1321 cggcactgcc tggggccaga gcaagtgcca caagtgtccc cagctgcagt acacaggagt
     1381 gcagaagcca gggcctgtac gtggggaagt gggcgctgac tgtccccagg gctacaagag
     1441 gcttaacagc acccactgcc aggacatcaa cgagtgcgca atgccgggcg tgtgtcgcca
     1501 tggtgactgc ctcaacaacc ctggctccta tcgctgtgtc tgcccacctg gccatagttt
     1561 aggcccctcc cgtacacagt gcattgcaga caaaccggag gagaagagcc tgtgtttccg
     1621 cctggtgagc cctgagcacc agtgccagca cccactgacc acccgcctga cccgccagct
     1681 ctgctgctgc agtgtcggca aggcctgggg cgcgcggtgt cagcgctgcc caacagatgg
     1741 caccgctgcg ttcaaggaga tctgcccagc tgggaaggga taccacattc tcacctccca
     1801 ccagacgctc accattcagg gcgagagtga cttttccctt ttcctgcacc ctgacgggcc
     1861 acccaagccc cagcagcttc cggagagccc tagccaggct ccaccacctg aggacacaga
     1921 ggaagagaga ggggtgacca cggactcacc ggtgagtgag gagaggtcag tgcagcagag
     1981 ccacccaact gccaccacga ctcctgcccg gccctacccc gagctgatct cccgtccctc
     2041 gcccccgacc atgcgctggt tcctgccgga cttgcctcct tcccgcagcg ccgtagagat
     2101 cgctcccact caggtcacag agactgatga gtgccgactg aaccagaaca tctgtggcca
     2161 cggagagtgc gtgccgggcc cccctgacta ctcctgccac tgcaaccccg gctaccggtc
     2221 acatccccag caccgctact gcgtggatgt gaacgagtgc gaggcagagc cctgtggccc
     2281 ggggaggggc atctgcatga acaccggcgg ctcctacaat tgccactgca accgcggcta
     2341 ccgcctgcac gtgggcgccg gggggcgctc gtgcgtggac ctgaacgaat gcgccaagcc
     2401 ccacctgtgc ggcgacggcg gcttctgcat caactttccc ggtcactaca agtgcaactg
     2461 ctaccccggc taccggctca aagcctcccg gcctcctgtg tgcgaagaca tcgacgagtg
     2521 ccgggaccca agctcttgcc cggatggcaa atgcgagaac aagcccggga gcttcaagtg
     2581 catcgcctgt cagcctggct accgcagcca ggggggcggg gcctgtcgcg acgtgaacga
     2641 gtgcgccgag ggcagcccct gctcgcctgg ctggtgcgag aacctcccgg gctccttccg
     2701 ctgcacctgt gcccagggct acgcgcccgc gcccgacggc cgcagttgct tggatgtgga
     2761 cgagtgtgag gctggggacg tgtgtgacaa tggcatctgc agcaacacgc caggatcttt
     2821 ccagtgtcag tgcctctctg gctaccatct gtccagggac cggagccact gcgaggacat
     2881 tgatgagtgt gacttccctg cagcctgcat tgggggtgac tgcatcaata ccaatggctc
     2941 ctacagatgt ctttgccccc aggggcatcg gctggtgggt ggcaggaaat gccaagacat
     3001 agatgagtgc agccaggacc cgagcctgtg ccttccccat ggggcctgca agaaccttca
     3061 gggctcctat gtgtgtgtct gcgatgaggg cttcactccc acccaggacc agcacggttg
     3121 tgaggaggtg gagcagcccc accacaagaa ggagtgctac ctgaacttcg atgacacagt
     3181 gttctgcgac agcgtattgg ccaccaacgt gacccagcag gagtgctgct gctctctggg
     3241 ggccggctgg ggcgaccact gcgaaatcta cccctgccca gtctacagct cagccgagtt
     3301 ccacagcctc tgcccagacg gaaagggcta cacccaggac aacaacatcg tcaactacgg
     3361 catcccagcc caccgtgaca tcgacgagtg catgttgttc gggtcggaga tttgcaagga
     3421 gggcaagtgc gtgaacacgc agcctggcta cgagtgctac tgcaagcagg gcttctacta
     3481 cgacgggaac ctgctggaat gcgtggacgt ggacgagtgc ctggacgagt ccaactgccg
     3541 gaacggagtg tgtgagaaca cgcgcggcgg ctaccgctgt gcctgcacgc cccctgccga
     3601 gtacagtccc gcgcagcgcc agtgcctgag cccggaagag atggacgtgg acgagtgcca
     3661 ggacccggca gcctgccgcc ctggccgctg cgtcaacctg ccgggctcct accgctgcga
     3721 gtgtcgcccg ccctgggtgc ccgggccctc cggccgcgat tgccagctcc ccgagagccc
     3781 ggccgagcgt gccccggagc ggcgcgacgt gtgctggagc cagcgcggag aggacggcat
     3841 gtgcgctggc cccctggccg ggcctgccct caccttcgac gactgctgct gccgccaggg
     3901 ccgcggctgg ggcgcccaat gccgaccgtg cccgccgcgc ggcgcggggt cccattgccc
     3961 gacatcgcag agcgagagca attccttctg ggacacaagc cccctgctgt tggggaagcc
     4021 cccaagagat gaggacagtt cagaggagga ttcagacgag tgtcgctgcg tgagtggccg
     4081 ctgcgtgccg cggccgggcg gcgccgtgtg cgagtgtccc ggcggcttcc agctcgacgc
     4141 ctcccgcgcc cgctgcgtgg atatcgacga gtgccgagag ctgaaccagc gcgggctgct
     4201 gtgcaagagc gagcgctgcg tgaacaccag cggctccttc cgctgcgtct gcaaagccgg
     4261 cttcgcgcgc agccgcccgc acggggcctg cgttccccag cgccgccgct gacgccgccg
     4321 acgccgccct cggcccagac ctcggtgatc actgagggat ttccgcgagc tcggcctcac
     4381 ttctgccccg acttgtggct cggacccagg gaccttcagg gcccgcagac cctcccggcg
     4441 ccttgagacc cgaggcgccc ctaccggccc ccctccccgg ttagcgggcg gttgtaaggt
     4501 ctccggcggg cgctgcctgc cttcctccca gagggtgttt cctagaaact gataaatcag
     4561 atcgtgcctc tttacccttg gctttcgaag caaattgatg ttcacgtctg acgtgggcgc
     4621 gggctgcgca gggcggcgcc agaccccagc cgcctcccag gggctagact gagcccggca
     4681 caaggggtgt gaaatagaat ttattgtggc tctgattatg tacacgtgag atggcctggc
     4741 tgggccggcc gggctcacat ggtttgtaca ataaatacat ctgtggggcg ggctctccgc
     4801 agccgggaag ggccaccgcc acggttcagt cca
//
