LOCUS       NM_000428               8460 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            2 (LTBP2), mRNA.
ACCESSION   NM_000428 NM_032035
VERSION     NM_000428.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8460)
  AUTHORS   Gao,L., Zhang,R., Zhang,W., Lan,Y., Li,X., Cai,Q. and Liu,J.
  TITLE     Integrated bioinformatics analysis and experimental validation on
            malignant progression and immune cell infiltration of LTBP2 in
            gliomas
  JOURNAL   BMC Cancer 24 (1), 1252 (2024)
   PUBMED   39390437
  REMARK    GeneRIF: Integrated bioinformatics analysis and experimental
            validation on malignant progression and immune cell infiltration of
            LTBP2 in gliomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8460)
  AUTHORS   Bozkurt,B., Bagci,O., Uzum,S. and Cora,T.
  TITLE     A novel LTBP2 gene variant in a Turkish family with juvenile-onset
            open-angle glaucoma
  JOURNAL   Ophthalmic Genet 45 (4), 384-389 (2024)
   PUBMED   38557215
  REMARK    GeneRIF: A novel LTBP2 gene variant in a Turkish family with
            juvenile-onset open-angle glaucoma.
REFERENCE   3  (bases 1 to 8460)
  AUTHORS   Chen,J., Wan,J., Jin,J., Jin,G., Zheng,Y., Zheng,D. and Zhong,L.
  TITLE     Autosomal Dominant Weill-Marchesani-Like Syndrome in a Chinese
            Family due to Novel Haplotypic Mutations in LTBP2
  JOURNAL   Ophthalmic Res 67 (1), 340-347 (2024)
   PUBMED   38772353
  REMARK    GeneRIF: Autosomal Dominant Weill-Marchesani-Like Syndrome in a
            Chinese Family due to Novel Haplotypic Mutations in LTBP2.
REFERENCE   4  (bases 1 to 8460)
  AUTHORS   Liu,L., Guo,D., Yang,F., Qi,H., Zhou,Y., Zheng,D. and Jin,G.
  TITLE     Identification and phenotypic analysis of novel LTBP2 mutations in
            a Chinese cohort with congenital ectopia lentis
  JOURNAL   Mol Vis 29, 169-179 (2023)
   PUBMED   38222456
  REMARK    GeneRIF: Identification and phenotypic analysis of novel LTBP2
            mutations in a Chinese cohort with congenital ectopia lentis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8460)
  AUTHORS   Bashir,M.M., Han,M.D., Abrams,W.R., Tucker,T., Ma,R.I., Gibson,M.,
            Ritty,T., Mecham,R. and Rosenbloom,J.
  TITLE     Analysis of the human gene encoding latent transforming growth
            factor-beta-binding protein-2
  JOURNAL   Int J Biochem Cell Biol 28 (5), 531-542 (1996)
   PUBMED   8697098
REFERENCE   6  (bases 1 to 8460)
  AUTHORS   Chambaz,E.M., Souchelnitskiy,S., Pellerin,S., Defaye,G., Cochet,C.
            and Feige,J.J.
  TITLE     Transforming growth factors-beta s: a multifunctional cytokine
            family. Implication in the regulation of adrenocortical cell
            endocrine functions
  JOURNAL   Horm Res 45 (3-5), 222-226 (1996)
   PUBMED   8964588
  REMARK    Review article
REFERENCE   7  (bases 1 to 8460)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   8  (bases 1 to 8460)
  AUTHORS   Moren,A., Olofsson,A., Stenman,G., Sahlin,P., Kanzaki,T.,
            Claesson-Welsh,L., ten Dijke,P., Miyazono,K. and Heldin,C.H.
  TITLE     Identification and characterization of LTBP-2, a novel latent
            transforming growth factor-beta-binding protein
  JOURNAL   J Biol Chem 269 (51), 32469-32478 (1994)
   PUBMED   7798248
REFERENCE   9  (bases 1 to 8460)
  AUTHORS   Abu-Amero,K.K. and Edward,D.P.
  TITLE     Primary Congenital Glaucoma
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301314
REFERENCE   10 (bases 1 to 8460)
  AUTHORS   Marzin,P., Cormier-Daire,V. and Tsilou,E.
  TITLE     Weill-Marchesani Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013451.8 and AC005479.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000428.2.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent transforming growth factor (TGF)-beta binding proteins
            (LTBP), which are extracellular matrix proteins with multi-domain
            structure. This protein is the largest member of the LTBP family
            possessing unique regions and with most similarity to the
            fibrillins. It has thus been suggested that it may have multiple
            functions: as a member of the TGF-beta latent complex, as a
            structural component of microfibrils, and a role in cell adhesion.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078659.1, AB209865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261978.9/ ENSP00000261978.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AC013451.8         99539-100325        c
            788-858             AC013451.8         91723-91793         c
            859-1123            AC013451.8         73942-74206         c
            1124-1314           AC013451.8         43591-43781         c
            1315-1485           AC013451.8         40980-41150         c
            1486-1692           AC013451.8         40275-40481         c
            1693-1979           AC013451.8         39152-39438         c
            1980-2082           AC013451.8         37951-38053         c
            2083-2157           AC013451.8         24014-24088         c
            2158-2280           AC005479.2         2379-2501
            2281-2445           AC005479.2         5805-5969
            2446-2661           AC005479.2         6229-6444
            2662-2681           AC005479.2         7561-7580
            2682-2721           AC005479.2         8813-8852
            2722-2823           AC005479.2         9702-9803
            2824-2952           AC005479.2         12009-12137
            2953-3081           AC005479.2         12888-13016
            3082-3201           AC005479.2         17986-18105
            3202-3321           AC005479.2         23563-23682
            3322-3444           AC005479.2         24714-24836
            3445-3570           AC005479.2         25068-25193
            3571-3696           AC005479.2         25564-25689
            3697-3819           AC005479.2         25975-26097
            3820-3945           AC005479.2         26198-26323
            3946-4068           AC005479.2         26832-26954
            4069-4200           AC005479.2         27617-27748
            4201-4326           AC005479.2         28104-28229
            4327-4470           AC005479.2         28736-28879
            4471-4662           AC005479.2         29753-29944
            4663-4746           AC005479.2         30066-30149
            4747-4875           AC005479.2         30873-31001
            4876-5013           AC005479.2         31321-31458
            5014-5181           AC005479.2         31541-31708
            5182-5463           AC005479.2         31993-32274
            5464-5613           AC005479.2         33337-33486
            5614-8460           AC005479.2         33898-36744
FEATURES             Location/Qualifiers
     source          1..8460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..8460
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /note="latent transforming growth factor beta binding
                     protein 2"
                     /db_xref="GeneID:4053"
                     /db_xref="HGNC:HGNC:6715"
                     /db_xref="MIM:602091"
     exon            1..787
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..5759
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /note="LTBP-2"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 2 precursor"
                     /protein_id="NP_000419.1"
                     /db_xref="CCDS:CCDS9831.1"
                     /db_xref="GeneID:4053"
                     /db_xref="HGNC:HGNC:6715"
                     /db_xref="MIM:602091"
                     /translation="MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYE
                     PAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAE
                     ARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPR
                     GRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARC
                     EEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPA
                     GTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLE
                     HPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK
                     SGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLE
                     APLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVE
                     TRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANP
                     LLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDIN
                     ECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGT
                     CTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLS
                     MRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVT
                     TSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVC
                     GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCY
                     PGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDIN
                     ECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEG
                     SFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDG
                     TACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC
                     LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA
                     PGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE
                     CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD
                     NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEE
                     YDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC
                     CCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGP
                     GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCF
                     CSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECC
                     CQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSI
                     YGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPP
                     AGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGP
                     AVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE"
     exon            788..858
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1123
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1314
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1485
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1692
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1979
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2082
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2157
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2280
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2445
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2661
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2681
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2721
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2823
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2952
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3081
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3201
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3321
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3444
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3570
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3696
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3819
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3945
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4068
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4200
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4326
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..4470
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4662
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4746
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..4875
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            4876..5013
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5181
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5182..5463
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5464..5613
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            5614..8460
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6866..6871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /note="hexamer: AATAAA"
     polyA_site      6886
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /note="major polyA site"
     regulatory      8440..8445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
                     /note="hexamer: AATAAA"
     polyA_site      8460
                     /gene="LTBP2"
                     /gene_synonym="C14orf141; GLC3D; LTBP3; MSPKA; MSTP031;
                     WMS3"
ORIGIN      
        1 ccaaaaataa aaccgtccgg gtccccttca gacggctgca ggcacaggga ggaggcgcga
       61 aggtgcagca gccgtgcgag cccagctgga gtaggagcgc ggactcgagg ctcggggcgc
      121 gcagccctcg ttccgccgag agccgggccc ccagtcggcc gcttcagggc cccctagact
      181 cagagaagct ggccgccggg cggggccggg agaacagccc gcgggcgtcc agcgtgccga
      241 ccacaaagct cttcgcggtg cccgcgcgca ccactctcca gccgccccgc gccatgaggc
      301 cgcggaccaa agcccgcagc ccggggcgcg ccctgcggaa cccctggaga ggcttcctgc
      361 cgctcaccct ggctctcttc gtgggcgcgg gtcatgccca aagggacccc gtagggagat
      421 acgagccggc tggtggagac gcgaatcgac tgcggcgccc tgggggcagc tacccggcag
      481 cggctgcagc caaggtgtac agtctgttcc gggagcagga cgcgcctgtc gcgggcttgc
      541 agcccgtgga gcgggcccag ccgggctggg ggagccccag gaggcccacc gaggcggagg
      601 ccaggaggcc gtcccgcgcg cagcagtcgc ggcgtgtcca gccacctgcg cagacccgga
      661 gaagcactcc cctgggccag cagcaaccag caccccggac ccgggccgcg ccggctctcc
      721 cacgcctggg gaccccacag cggtctgggg ctgcgccccc aaccccgccg cgagggcggc
      781 tcacggggag gaacgtctgc gggggacagt gctgcccagg atggacaaca gcaaacagca
      841 ccaaccactg tatcaaaccc gtttgcgagc cgccgtgcca gaaccggggc tcctgcagcc
      901 gcccgcagct ctgtgtctgc cgctctggtt tccgtggagc ccgctgcgag gaggtcattc
      961 ccgatgagga atttgacccc cagaactcca ggctggcacc tcgacgctgg gccgagcgtt
     1021 cacccaacct gcgcaggagc agtgcggctg gagagggcac cttggccaga gcacagccgc
     1081 cagcaccaca gtcgccgccc gcaccacagt cgccaccagc tgggaccctg agtggcctca
     1141 gccagaccca cccttcccag cagcacgtgg ggttgtcccg cactgtccga cttcacccga
     1201 ctgccacggc cagtagccag ctctcttcca acgccctgcc cccgggacca ggccttgagc
     1261 agagagatgg cacccaacag gcggtacctc tggagcaccc ctcatccccc tgggggctga
     1321 acctcacgga gaaaatcaag aagatcaaga tcgtcttcac tcccaccatc tgcaagcaga
     1381 cctgtgcccg tggacactgt gccaacagct gtgagagggg cgacaccacc accctgtaca
     1441 gccagggcgg ccatgggcac gatcccaagt ctggcttccg catctatttc tgccagatcc
     1501 cctgcctgaa cggaggccgc tgcatcggca gggacgaatg ctggtgcccc gccaactcca
     1561 ccgggaagtt ctgccacctg cctatcccgc agccggacag ggagcctcca gggagggggt
     1621 cccgccccag ggccttgctg gaagccccac tgaagcagtc cactttcaca ctgccgctct
     1681 ccaaccagct ggcctccgtg aacccctccc tggtgaaggt gcacattcac cacccacccg
     1741 aggcctcagt gcagatccac caggtggccc aggtgcgggg cggggtggag gaggccctag
     1801 tggagaacag cgtggagacc agacccccgc cctggctgcc tgccagccct ggccacagcc
     1861 tctgggacag caacaacatc cctgctcggt ctggagagcc ccctcggcca ctgcccccag
     1921 cagcacccag gcctcgagga ctgctgggcc ggtgttacct gaacactgtg aacggacagt
     1981 gtgccaaccc tctgctggag ctgactaccc aggaggactg ctgtggcagt gtgggagcct
     2041 tctggggggt gactttgtgt gccccatgcc cacccagacc agcctccccg gtgattgaga
     2101 atggccagct ggagtgtcct caggggtaca agagactgaa cctcactcac tgccaagata
     2161 tcaacgagtg cttgaccctg ggcctgtgca aggacgcgga gtgtgtgaat accaggggca
     2221 gctacctgtg cacatgcaga cctggcctca tgctggatcc atcgcggagc cgctgtgtgt
     2281 cggacaaggc aatctccatg ctgcagggac tgtgctaccg gtcgctgggg cccggcacct
     2341 gcaccctgcc tttggcccag cggatcacca agcagatatg ctgctgcagc cgcgtgggca
     2401 aagcatgggg cagcgagtgt gagaaatgcc ctctgcctgg cacagaggcc ttcagagaga
     2461 tctgccctgc cggccacggc tacacctacg cgagctccga catccgcctg tccatgagga
     2521 aagccgagga ggaggaactg gcaaggcccc caagggagca agggcagagg agcagcgggg
     2581 cactgcccgg gccagcagag aggcagcccc tccgggtcgt cacggacacc tggcttgagg
     2641 ccgggaccat ccctgacaag ggtgactctc aggctggcca ggtcacgacc agtgtcactc
     2701 atgcacctgc ctgggtcaca gggaatgcca caaccccacc aatgcctgaa caggggattg
     2761 cagagataca ggaagaacaa gtgaccccct ccactgatgt gctggtgacc ctgagcaccc
     2821 caggcattga cagatgcgct gctggagcca ccaacgtctg tggccctgga acctgcgtga
     2881 acctccccga tggatacaga tgtgtctgca gccctggcta ccagctgcac cccagccagg
     2941 cctactgcac agatgacaac gagtgtctga gggacccctg caagggaaaa gggcgctgca
     3001 tcaaccgcgt ggggtcctac tcctgcttct gctaccctgg ctacactctg gccacctcag
     3061 gggcgacaca ggagtgtcaa gatatcaatg agtgtgagca gccaggggtg tgcagcgggg
     3121 ggcagtgcac caacaccgag ggctcgtacc actgcgagtg tgatcagggc tacatcatgg
     3181 tcaggaaagg acactgccaa gatatcaacg aatgccgtca ccccggtacc tgccctgatg
     3241 ggagatgcgt caattcccct ggctcctaca cttgtctggc ctgtgaggag ggctaccggg
     3301 gccagagtgg gagctgtgta gatgtgaatg agtgtctgac tcccggggtc tgtgcccatg
     3361 gaaagtgcac caacctagaa ggctccttca gatgctcttg tgagcagggc tatgaggtca
     3421 cctcagatga gaagggctgc caagatgtgg atgagtgtgc cagccgggcc tcatgcccca
     3481 caggcctctg cctcaacacg gagggctcct tcgcctgctc tgcctgtgag aacgggtact
     3541 gggtgaatga agacggcact gcctgtgaag acctagatga gtgtgccttc ccgggagtct
     3601 gcccctccgg agtctgcacc aacacggctg gctccttctc ctgcaaggac tgcgatgggg
     3661 gctaccggcc cagccccctg ggtgactcct gtgaagatgt ggatgaatgt gaagaccccc
     3721 agagcagctg cctgggaggc gagtgcaaga acactgtggg ctcctaccag tgcctctgtc
     3781 cccagggctt ccagctggcc aatggcaccg tgtgtgagga tgtgaatgag tgcatggggg
     3841 aggagcactg cgcaccccac ggcgagtgcc tcaacagcca cgggtctttc ttctgtctgt
     3901 gcgcgcctgg cttcgtcagc gcagaggggg gcaccagctg ccaggatgtg gacgagtgtg
     3961 ccaccacaga cccgtgtgtg ggagggcact gtgtcaacac cgagggctcc ttcaactgtc
     4021 tatgtgagac tggcttccag ccctccccag agagtggaga gtgtgtggat attgacgagt
     4081 gtgaggacta tggagacccg gtgtgtggca cctggaagtg tgaaaacagc cctggctcct
     4141 accgctgtgt tctgggctgc cagcctggct tccacatggc cccgaacgga gactgcattg
     4201 acatagacga gtgcgccaac gacaccatgt gtggcagcca cggcttctgt gacaacactg
     4261 atggctcctt ccgctgcctc tgtgaccagg gcttcgagat ctctccctca ggctgggact
     4321 gtgtggatgt gaacgagtgt gagcttatgc tggcggtatg tggggccgcg ctctgtgaga
     4381 acgtggaggg ctccttcctg tgcctctgtg ccagtgacct ggaggagtac gatgcccagg
     4441 aggggcactg ccgcccacgg ggggctggag gtcagagtat gtctgaggcc ccaacggggg
     4501 accatgcccc ggcccccacc cgcatggact gctactccgg gcagaagggc catgcgccct
     4561 gctccagtgt cctgggccgg aacaccacac aggctgaatg ctgctgcacc cagggcgcta
     4621 gctggggaga tgcctgtgac ctctgcccgt ctgaggactc agctgaattc agcgagatct
     4681 gccctagtgg aaaaggctac attcctgtgg aaggagcctg gacgtttgga cagaccatgt
     4741 acacagatgc ggatgagtgt gtgatattcg ggcctggtct ctgcccgaac ggccggtgcc
     4801 tcaacaccgt gcctggttat gtctgcctgt gcaatcccgg cttccactac gatgcttccc
     4861 acaagaagtg tgaggatcac gatgagtgcc aggacctggc ctgtgagaat ggcgagtgcg
     4921 tcaacacgga gggctccttc cactgcttct gcagcccccc gctcaccctg gacctcagcc
     4981 agcagcgctg catgaacagc accagcagca cggaggacct ccctgaccac gacatccaca
     5041 tggacatctg ctggaaaaaa gtcaccaatg atgtgtgcag cgaacccctg cgtgggcacc
     5101 gcaccaccta cacggaatgc tgctgccagg acggcgaggc ctggagccag cagtgtgctc
     5161 tgtgtccccc gaggagctct gaggtctatg ctcagctgtg caacgtggct cgcattgagg
     5221 cagagcggga ggccggggtc cacttccggc caggctatga gtatggcccc gggcccgatg
     5281 acctgcacta cagcatctat ggcccagatg gggccccctt ctacaactac ctgggccccg
     5341 aggacaccgt ccctgagcct gccttcccca acacagccgg tcactcagcg gaccgcacac
     5401 ccatccttga gtctcctttg cagccctcag aactccagcc ccactacgtg gccagccatc
     5461 cagagccccc agccggcttc gaagggcttc aggcggagga gtgcggcatc ctgaacggct
     5521 gtgagaatgg ccgctgtgtg cgcgtgcggg agggctacac ctgtgactgt tttgagggct
     5581 tccagctgga tgcggcccac atggcctgcg tagatgtgaa tgagtgtgat gacttgaacg
     5641 ggcctgctgt gctctgtgtc catggttact gcgagaacac agagggctcc taccgctgcc
     5701 actgctcccc gggatatgtg gctgaggcag ggccccccca ctgcactgcc aaggagtagc
     5761 agtcaggggt cagtgtggca actacctgga aatggcctcc agtcacaggc aggggccttg
     5821 aggatgattt cctagctggg aagacaccgt gacatcaggc cagaggtttc caatcagcct
     5881 tgcctgcttt catctctccc agcttagcct ctggctgtaa gcttcggtca ttgcctccat
     5941 gcccttgctt ggctcaagca ccaccaatcg ctttaatgct tcagccaccg catgaggccc
     6001 tgtccaccac ctttcctggc cttgctatgg gatgcttacc aaaggatggc cctcatccac
     6061 cctcccaagc tgtgcgagca tgcaaggccc catggcctca cactgcagac acccctttcc
     6121 agccacaatc caccatcatc ctgacgatcc cacaactggg acagaggcta catctgccct
     6181 agggaggtcc ttcagaatct gtggagcaag aaaggatttg gggaagcttg gggactgact
     6241 ccagagcccc ctcctaagaa ccatcaccac cactcagcca atctgttctg ggccctgatt
     6301 ttgccacacc tccatcctgt agcccattct ctgaccccaa ggagtggcag aagatccctt
     6361 cactcagaga agcaaggctg atattagctt gttgaatgta agagacacaa atgaagaaga
     6421 acaaagagcc tgagaaagca gcaagaggac atgatgaaaa atacgtggag ttgatgagaa
     6481 aggggagcca aggctttata cgtctaaaga aaatattcag tagctgaatc cgcccagtga
     6541 tagcctgtgg gcaccagcag caagggctgc catgggatac agcacccatc tacaaagacc
     6601 tctattacat aaacactgct tcttacagga aacaaacctc ttctgggatc tccttttgtg
     6661 aaaaccagtt tgatgtgcta aaagtaaaaa gtctattttc cagtgtggtc ttgttcagaa
     6721 gcagccagat ttccaatgtt gtttttcccc tccactcaga aacccctgcc ctttcccttc
     6781 agaaaacgat ggcaggcatt cctctgagtt tacaagcaga gactcactcc aacccaaact
     6841 agctgggagt tcagaaccat ggtggaataa agaaatgtgc atctggtctc ttctgttgtt
     6901 tttatttcat atcagattaa atttctttac catgttggct aagtctaaat attagagatg
     6961 aggctgtgcc tactccctgg ccagctctgc tgatagccta tgatgggttc caatgggaaa
     7021 tgactcttta ctattaaaag acaaggaaag ctctgacttc gtacttctct gatgaatggc
     7081 aatgtaaatg aacaaggctc catgtgactg gagcatggaa gtgaatgcta ctttcttaat
     7141 ttaatctgcc ctgtcctacc tgctcctctg attgttagcc atcacataac ttattgaatg
     7201 cttgccatgt gccaggcact gtgctgagtg ccatacatac atttcattta attatccaat
     7261 aatcctactt actattgttt attctcaatt tacaggtgag gaaactgaga catagaaagc
     7321 ttaaataatt tgctctaggt ccctatacta attgagatgt tttcagcaga caaaaataag
     7381 tcactcttac gcatgtaaaa atattctttc actcataata aaagaaatgc aacttaaaac
     7441 catactgaga tcctttttaa aactgtcaga ttggcaaaga tcaaaaagct tgttaagact
     7501 cctagctggc aagcatgtgg gaaataggta ctctcataac agctgacaga agtacatatt
     7561 gaagaggaca atatggcaat gtccttcaaa attataaaag cactaactct ttgatccagt
     7621 agtttccact tctaggaact taaccttcag atatattttc accagatata aaatgacata
     7681 cgtaagaagt tattactgca tcatttgtaa tagctaaaga ttagaaacaa ttaattgcta
     7741 tggaaccctt aaaaaaggtg gctctaaatt ccttaagaaa gatatccaaa acaaattaag
     7801 gggaaaaggg agggttgcat aacagcatgt aacataacac tatttgtcta aagaatgggg
     7861 aaagagaagc ggttgtctgt tcacctcatc cttgccactc cgccttatac ctcaccatcg
     7921 gagaacttac catcccccaa atatatcctg ctggcactac accttcgtaa ctgctgttcc
     7981 cactgccccc acaacactcc aatctccacc ttcctgccaa ccttgagata ttgtatgcat
     8041 atatacatat ttcctttgtt taaaatacaa atagcatact atgcatgctg ttctgcactt
     8101 tgcttttttt ttatacttgc aattagagct gcctcatttc attttacagc tgtatactat
     8161 tccattgaat ggataaacca taatttattt aatcagtccc tcactgacag acgtttccat
     8221 tgtttcctgt cttttgctat aaataatgct gtaatgaata ttcttgtgca tatttcacat
     8281 taatttatgg gattacatct gcaggataaa ttcttagaac caatggtggt ttgtggggag
     8341 ggtgacaggg tggataggta caggattggg agacttttca ctgtatctcc ttttgtattt
     8401 ttttgaattt tgtaccatat gtatcaccta ttcaaaaaaa ataaaatatt tttaaataca
//
