LOCUS       NM_001394925            4865 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            1 (LTBP1), transcript variant 25, mRNA.
ACCESSION   NM_001394925
VERSION     NM_001394925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4865)
  AUTHORS   Jiang,X., Yin,S., Yin,X., Wang,Y., Fang,T., Yang,S., Bian,X.,
            Li,G., Xue,Y. and Zhang,L.
  TITLE     A prognostic marker LTBP1 is associated with epithelial mesenchymal
            transition and can promote the progression of gastric cancer
  JOURNAL   Funct Integr Genomics 24 (1), 30 (2024)
   PUBMED   38358412
  REMARK    GeneRIF: A prognostic marker LTBP1 is associated with epithelial
            mesenchymal transition and can promote the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4865)
  AUTHORS   Wenk,D., Khan,S., Ignatchenko,V., May,T., Bernardini,M.Q. and
            Kislinger,T.
  TITLE     Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals
            LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous
            Ovarian Carcinoma
  JOURNAL   J Proteome Res 23 (2), 749-759 (2024)
   PUBMED   38266179
  REMARK    GeneRIF: Targeted Mass Spectrometry of Longitudinal Patient Sera
            Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade
            Serous Ovarian Carcinoma.
REFERENCE   3  (bases 1 to 4865)
  AUTHORS   Gu,H., Wang,W., Sun,C., Ding,L., Li,L., Shu,P. and Xu,J.
  TITLE     Immune suppressive signaling regulated by latent transforming
            growth factor beta binding protein 1 promotes metastasis in
            cervical cancer
  JOURNAL   Braz J Med Biol Res 55, e12206 (2023)
   PUBMED   36629522
  REMARK    GeneRIF: Immune suppressive signaling regulated by latent
            transforming growth factor beta binding protein 1 promotes
            metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4865)
  AUTHORS   Przyklenk,M., Georgieva,V.S., Metzen,F., Mostert,S., Kobbe,B.,
            Callewaert,B., Sengle,G., Brachvogel,B., Mecham,R.P., Paulsson,M.,
            Wagener,R., Koch,M. and Schiavinato,A.
  TITLE     LTBP1 promotes fibrillin incorporation into the extracellular
            matrix
  JOURNAL   Matrix Biol 110, 60-75 (2022)
   PUBMED   35452817
  REMARK    GeneRIF: LTBP1 promotes fibrillin incorporation into the
            extracellular matrix.
REFERENCE   5  (bases 1 to 4865)
  AUTHORS   Taipale,J., Saharinen,J., Hedman,K. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta 1 and its binding protein
            are components of extracellular matrix microfibrils
  JOURNAL   J Histochem Cytochem 44 (8), 875-889 (1996)
   PUBMED   8756760
REFERENCE   6  (bases 1 to 4865)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   7  (bases 1 to 4865)
  AUTHORS   Olofsson,A., Ichijo,H., Moren,A., ten Dijke,P., Miyazono,K. and
            Heldin,C.H.
  TITLE     Efficient association of an amino-terminally extended form of human
            latent transforming growth factor-beta binding protein with the
            extracellular matrix
  JOURNAL   J Biol Chem 270 (52), 31294-31297 (1995)
   PUBMED   8537398
REFERENCE   8  (bases 1 to 4865)
  AUTHORS   Stenman,G., Sahlin,P., Olofsson,A., Geurts van Kessel,A. and
            Miyazono,K.
  TITLE     Assignment of the gene encoding the latent TGF-beta 1-binding
            protein (LTBP1) to human chromosome 2, region p12-->q22
  JOURNAL   Cytogenet Cell Genet 66 (2), 117-119 (1994)
   PUBMED   8287682
REFERENCE   9  (bases 1 to 4865)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 4865)
  AUTHORS   Kanzaki,T., Olofsson,A., Moren,A., Wernstedt,C., Hellman,U.,
            Miyazono,K., Claesson-Welsh,L. and Heldin,C.H.
  TITLE     TGF-beta 1 binding protein: a component of the large latent complex
            of TGF-beta 1 with multiple repeat sequences
  JOURNAL   Cell 61 (6), 1051-1061 (1990)
   PUBMED   2350783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019195.10, AC019127.10 and
            AC020594.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent TGF-beta binding proteins (LTBPs). The secretion and
            activation of TGF-betas is regulated by their association with
            latency-associated proteins and with latent TGF-beta binding
            proteins. The product of this gene targets latent complexes of
            transforming growth factor beta to the extracellular matrix, where
            the latent cytokine is subsequently activated by several different
            mechanisms. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3694433.1,
                                           SRR14038191.46571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC019195.10        138996-139360       c
            366-590             AC019195.10        86876-87100         c
            591-865             AC019195.10        85105-85379         c
            866-968             AC019195.10        56302-56404         c
            969-1040            AC019195.10        51805-51876         c
            1041-1163           AC019195.10        30172-30294         c
            1164-1331           AC019195.10        21112-21279         c
            1332-1400           AC019195.10        16445-16513         c
            1401-1423           AC019195.10        14346-14368         c
            1424-1523           AC019195.10        11135-11234         c
            1524-1622           AC019195.10        10564-10662         c
            1623-1748           AC019127.10        1701-1826
            1749-1874           AC019127.10        3010-3135
            1875-1997           AC019127.10        3846-3968
            1998-2117           AC019127.10        8084-8203
            2118-2240           AC019127.10        21205-21327
            2241-2363           AC019127.10        28496-28618
            2364-2486           AC019127.10        29567-29689
            2487-2609           AC019127.10        37479-37601
            2610-2735           AC019127.10        43189-43314
            2736-2918           AC019127.10        88642-88824
            2919-3005           AC019127.10        89474-89560
            3006-3134           AC019127.10        91435-91563
            3135-3275           AC019127.10        92261-92401
            3276-3446           AC019127.10        93378-93548
            3447-3569           AC020594.6         14111-14233
            3570-3719           AC020594.6         22060-22209
            3720-4865           AC020594.6         23291-24436
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..4865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
     exon            1..365
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3901
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="isoform 25 precursor is encoded by transcript
                     variant 25; TGF-beta1-BP-1; transforming growth factor
                     beta-1-binding protein 1; LTBP-1"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform 25 precursor"
                     /protein_id="NP_001381854.1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
                     /translation="MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSC
                     QNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGK
                     LCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH
                     VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVI
                     PHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPS
                     YHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
                     TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCP
                     LPGTAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGI
                     STIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAG
                     HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAG
                     FMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECL
                     NPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYM
                     CSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE
                     DIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC
                     INTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSI
                     SADGRTCEDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDN
                     CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFC
                     LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL
                     DASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEA
                     WGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLN
                     SFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRM
                     SLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE"
     exon            366..590
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1331
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1400
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1423
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1523
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1622
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1748
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1874
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1997
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2117
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2240
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2363
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2486
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2609
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2735
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2918
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3005
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3134
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3275
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3446
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3569
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3719
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..4865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4693..4698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: AATAAA"
     polyA_site      4719
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="major polyA site"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: ATTAAA"
     polyA_site      4865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
ORIGIN      
        1 agagacacca ctgaatacag agcagcgagc actgaaggct tccctctttc cttaaacctg
       61 tcgggttgtg ggctctctct tttcccctct tgctcctttc ttttcttttt ttctgttttt
      121 ttaaaccttc caaggcaagt tcatggatac taagctgatg tgtttgttgt tctttttctc
      181 cctgcctccg ctcctagtga gtaaccacac tggccgcatc aaggtggtct ttactccgag
      241 catctgtaaa gtgacctgca ccaagggcag ctgtcagaac agctgtgaga aggggaacac
      301 caccactctc attagtgaga atggtcatgc tgccgacacc ctgacggcca cgaacttccg
      361 agtggtaatt tgccatcttc catgtatgaa tggtggccag tgcagttcaa gggacaaatg
      421 tcagtgccct ccaaatttca caggaaaact ttgtcagatc ccagtccatg gtgccagcgt
      481 gcctaaactt tatcagcatt cccagcagcc aggcaaggcg ttggggacgc atgtcatcca
      541 ttcaacacat accttgcctc tgaccgtgac tagccagcaa ggagtcaaag tgaaatttcc
      601 tcctaacata gtcaatatcc atgtgaaaca tcctcctgaa gcttccgtcc agatacatca
      661 ggtttcaaga attgatggcc caacaggcca gaagacaaaa gaagctcaac caggccaatc
      721 ccaagtctcg taccaagggc ttcctgtcca gaagacccag accatacatt ccacatactc
      781 ccaccagcag gtcattcctc acgtctaccc cgtggctgct aagacacagc ttggccggtg
      841 cttccaggaa accattgggt cacagtgtgg caaagcgctc cctggccttt caaagcaaga
      901 ggactgctgt ggaactgtgg gtacctcctg gggctttaac aaatgccaga aatgccccaa
      961 gaaaccatct tatcatggat acaaccaaat gatggaatgc ctaccgggtt ataagcgggt
     1021 taacaacacc ttttgccaag atattaatga atgtcagcta caaggtgtat gccctaatgg
     1081 tgagtgtttg aataccatgg gcagctatcg atgtacctgc aaaataggat ttgggccgga
     1141 tcctaccttt tcaagttgtg ttcctgatcc ccctgtgatc tcggaagaga aagggccctg
     1201 ttaccgactt gtcagttctg gaagacagtg tatgcaccct ctgtctgttc acctcaccaa
     1261 gcagctctgc tgttgtagtg tgggcaaggc ctggggccca cactgtgaga aatgtcccct
     1321 tccaggcaca gccaaggaag agccagtgga ggccctgacc ttctcccggg aacacgggcc
     1381 aggagtggcg gagccagaag tggcaactgc accccctgaa aaggaaatac cttcattgga
     1441 tcaagagaaa accaaacttg agcctggtca accccagctg tctccaggca tttccactat
     1501 tcatctgcat ccacagtttc cagtagtgat tgaaaaaaca tcacctcctg tgcctgttga
     1561 agtagctcct gaagcttcta cgtctagtgc cagccaagtg attgctccta ctcaagtgac
     1621 agaaatcaat gaatgtactg tgaaccctga tatctgtgga gcaggacact gcattaacct
     1681 accagtgaga tatacctgta tatgctacga gggctacagg ttcagtgaac aacagaggaa
     1741 atgtgtggat attgatgagt gtactcaggt ccaacacctc tgctcccagg gccgctgtga
     1801 aaacaccgag ggaagtttct tgtgcatttg cccagcagga tttatggcca gtgaggaggg
     1861 tactaactgc atagatgttg acgaatgcct gaggccggac gtctgtgggg aggggcactg
     1921 tgtcaatact gtgggggcct tccggtgtga atactgtgac agcgggtacc gcatgactca
     1981 gagaggccgt tgtgaggata ttgatgaatg tttgaatcca agcacttgtc cagatgagca
     2041 gtgtgtgaat tctcctggat cttaccagtg cgttccctgc acagaaggat tccgaggctg
     2101 gaatggacag tgccttgatg tggacgagtg cctggaacca aacgtctgcg caaatggtga
     2161 ttgttccaac cttgaaggct cctacatgtg ttcatgccac aaaggctata cccggactcc
     2221 ggaccacaag cactgtagag atattgatga atgtcagcaa gggaatctat gtgtaaacgg
     2281 gcagtgcaaa aataccgagg gctccttcag gtgcacctgt ggacaggggt accagctgtc
     2341 ggcagctaaa gaccagtgtg aagacattga tgaatgccag caccgtcatc tctgtgctca
     2401 tgggcagtgc aggaacactg agggctcttt tcaatgtgtg tgtgaccagg gttacagagc
     2461 atctgggctt ggagaccact gtgaagatat caatgaatgc ttggaggaca agagtgtttg
     2521 ccagagagga gactgcatta atactgcagg gtcctatgat tgtacttgtc cggatggatt
     2581 tcagctagat gacaataaaa catgtcaaga tattaatgaa tgtgaacatc cagggctctg
     2641 tggtccgcaa ggggagtgcc taaacacaga gggttctttc cattgtgtct gccagcaggg
     2701 tttctcaatc tctgcagatg gccgtacgtg tgaagattta gatgtagatg tagatcaacc
     2761 caaagaagaa aagaaagaat gctactataa tctcaatgac gccagtctct gtgataatgt
     2821 gttggccccc aatgtcacga aacaagaatg ctgctgtaca tcaggcgtgg gatggggaga
     2881 taactgcgaa atcttcccct gcccggtctt gggaactgct gagttcactg aaatgtgtcc
     2941 caaagggaaa ggttttgtgc ctgctggaga atcatcttct gaagctggtg gtgagaacta
     3001 taaagatgca gatgaatgcc tactttttgg acaagaaatc tgcaaaaatg gtttctgttt
     3061 gaacactcgg cctgggtatg aatgctactg taagcaaggg acgtactatg atcctgtgaa
     3121 actgcagtgc tttgatatgg atgaatgtca agaccccagt agttgtattg atggccagtg
     3181 tgttaataca gagggctctt acaactgctt ctgtactcac cccatggtcc tggatgcgtc
     3241 agaaaaaaga tgtatacgac cggctgagtc aaacgaacaa atagaagaaa ctgatgtcta
     3301 ccaagatttg tgctgggaac atctgagtga tgaatacgtg tgtagccggc ctcttgtggg
     3361 caagcagaca acgtacactg agtgctgctg tctgtatgga gaggcctggg gcatgcagtg
     3421 tgccctctgc cccctgaagg attcagatga ctatgctcag ctgtgtaaca tccccgtgac
     3481 gggacgccgg cagccatatg gacgggacgc cttggttgac ttcagtgaac agtatactcc
     3541 agaagccgat ccctacttca tccaagaccg ttttctaaat agctttgagg agttacaggc
     3601 tgaggaatgc ggcatcctca atggatgtga aaatggtcgc tgtgtgaggg tccaggaagg
     3661 ttacacctgc gattgctttg atgggtatca cttggatacg gccaagatga cctgtgtcga
     3721 tgtaaatgaa tgcgatgagt tgaacaaccg gatgtctctc tgcaagaatg ccaagtgcat
     3781 taacaccgat ggttcctaca agtgtttgtg tctgccaggc tacgtgcctt ctgacaagcc
     3841 aaactactgc actccgttga ataccgcctt gaatttagag aaagacagtg acctggagtg
     3901 aaacagaatc tacataacct aagcccatat actctgcact gtgtaaagga aaagggagaa
     3961 atgtattata cttgagacat tgcacctacc ccggaaggct ggaaatacag aaacagcatg
     4021 gaattgcaag tcctctgaag acaatgagag gatttaggat gagcccgata ggtgtggcag
     4081 accaaatgga catttctcta aaaaaccagt atatatagtc tgttcatatg taaaattcaa
     4141 tggaagagag gtggaacagt gctgttattt taaacagaag gttgtattat tatgttgttt
     4201 tgttttttta ctattgcttg attaaatttg gcatttaaat agtggtggaa atattttata
     4261 taattttcat tttttggttg tgcagttcct tggctactgt ttttctttta cttcagtttt
     4321 ttaaaaatct caaatgaaaa agtcttcgat acaatattgt taagctgtat tataagtatt
     4381 gttacacagg gttatgcaat tcccggcctg gagcattttt gaaattcaaa ttgtctgtcc
     4441 tgtggagcag gcagtgattt tgttccaaaa ctttgtatac acatttggag aaaagtactt
     4501 tatattttca gtgttttgtc tgattttaat gtccgttctt agccaagctg ctagcaggtg
     4561 ttaattggat ccctttcctt cactgaaatg gaagagttta taagcttacg ttagtattgt
     4621 aatatgtaaa gtaagcccaa caaaaatttt taaaaatttg atgatcccca atatatctac
     4681 cattgtatgt taaataaatc accatttttg tagaaaaaat tctacctgag agtaattgtc
     4741 aatgagtaca tgtgtataag ttgtatccca ctctccccac ttttatcttt tccagtggtc
     4801 ttctgttaat gtagtgtctt ttacaagtta atcattaaat ttgttagatc ttgttatggg
     4861 ctaaa
//
