LOCUS       NM_001394921            5006 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            1 (LTBP1), transcript variant 22, mRNA.
ACCESSION   NM_001394921
VERSION     NM_001394921.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5006)
  AUTHORS   Jiang,X., Yin,S., Yin,X., Wang,Y., Fang,T., Yang,S., Bian,X.,
            Li,G., Xue,Y. and Zhang,L.
  TITLE     A prognostic marker LTBP1 is associated with epithelial mesenchymal
            transition and can promote the progression of gastric cancer
  JOURNAL   Funct Integr Genomics 24 (1), 30 (2024)
   PUBMED   38358412
  REMARK    GeneRIF: A prognostic marker LTBP1 is associated with epithelial
            mesenchymal transition and can promote the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5006)
  AUTHORS   Wenk,D., Khan,S., Ignatchenko,V., May,T., Bernardini,M.Q. and
            Kislinger,T.
  TITLE     Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals
            LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous
            Ovarian Carcinoma
  JOURNAL   J Proteome Res 23 (2), 749-759 (2024)
   PUBMED   38266179
  REMARK    GeneRIF: Targeted Mass Spectrometry of Longitudinal Patient Sera
            Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade
            Serous Ovarian Carcinoma.
REFERENCE   3  (bases 1 to 5006)
  AUTHORS   Gu,H., Wang,W., Sun,C., Ding,L., Li,L., Shu,P. and Xu,J.
  TITLE     Immune suppressive signaling regulated by latent transforming
            growth factor beta binding protein 1 promotes metastasis in
            cervical cancer
  JOURNAL   Braz J Med Biol Res 55, e12206 (2023)
   PUBMED   36629522
  REMARK    GeneRIF: Immune suppressive signaling regulated by latent
            transforming growth factor beta binding protein 1 promotes
            metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5006)
  AUTHORS   Przyklenk,M., Georgieva,V.S., Metzen,F., Mostert,S., Kobbe,B.,
            Callewaert,B., Sengle,G., Brachvogel,B., Mecham,R.P., Paulsson,M.,
            Wagener,R., Koch,M. and Schiavinato,A.
  TITLE     LTBP1 promotes fibrillin incorporation into the extracellular
            matrix
  JOURNAL   Matrix Biol 110, 60-75 (2022)
   PUBMED   35452817
  REMARK    GeneRIF: LTBP1 promotes fibrillin incorporation into the
            extracellular matrix.
REFERENCE   5  (bases 1 to 5006)
  AUTHORS   Taipale,J., Saharinen,J., Hedman,K. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta 1 and its binding protein
            are components of extracellular matrix microfibrils
  JOURNAL   J Histochem Cytochem 44 (8), 875-889 (1996)
   PUBMED   8756760
REFERENCE   6  (bases 1 to 5006)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   7  (bases 1 to 5006)
  AUTHORS   Olofsson,A., Ichijo,H., Moren,A., ten Dijke,P., Miyazono,K. and
            Heldin,C.H.
  TITLE     Efficient association of an amino-terminally extended form of human
            latent transforming growth factor-beta binding protein with the
            extracellular matrix
  JOURNAL   J Biol Chem 270 (52), 31294-31297 (1995)
   PUBMED   8537398
REFERENCE   8  (bases 1 to 5006)
  AUTHORS   Stenman,G., Sahlin,P., Olofsson,A., Geurts van Kessel,A. and
            Miyazono,K.
  TITLE     Assignment of the gene encoding the latent TGF-beta 1-binding
            protein (LTBP1) to human chromosome 2, region p12-->q22
  JOURNAL   Cytogenet Cell Genet 66 (2), 117-119 (1994)
   PUBMED   8287682
REFERENCE   9  (bases 1 to 5006)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 5006)
  AUTHORS   Kanzaki,T., Olofsson,A., Moren,A., Wernstedt,C., Hellman,U.,
            Miyazono,K., Claesson-Welsh,L. and Heldin,C.H.
  TITLE     TGF-beta 1 binding protein: a component of the large latent complex
            of TGF-beta 1 with multiple repeat sequences
  JOURNAL   Cell 61 (6), 1051-1061 (1990)
   PUBMED   2350783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019195.10, AC019127.10 and
            AC020594.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent TGF-beta binding proteins (LTBPs). The secretion and
            activation of TGF-betas is regulated by their association with
            latency-associated proteins and with latent TGF-beta binding
            proteins. The product of this gene targets latent complexes of
            transforming growth factor beta to the extracellular matrix, where
            the latent cytokine is subsequently activated by several different
            mechanisms. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2583622.1,
                                           SRR14038192.2608683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC019195.10        138996-139360       c
            366-590             AC019195.10        86876-87100         c
            591-865             AC019195.10        85105-85379         c
            866-968             AC019195.10        56302-56404         c
            969-1040            AC019195.10        51805-51876         c
            1041-1163           AC019195.10        30172-30294         c
            1164-1331           AC019195.10        21112-21279         c
            1332-1400           AC019195.10        16445-16513         c
            1401-1423           AC019195.10        14346-14368         c
            1424-1523           AC019195.10        11135-11234         c
            1524-1619           AC019195.10        10564-10659         c
            1620-1745           AC019127.10        1701-1826
            1746-1871           AC019127.10        3010-3135
            1872-1994           AC019127.10        3846-3968
            1995-2114           AC019127.10        8084-8203
            2115-2237           AC019127.10        21205-21327
            2238-2360           AC019127.10        28496-28618
            2361-2483           AC019127.10        29567-29689
            2484-2606           AC019127.10        37479-37601
            2607-2732           AC019127.10        43189-43314
            2733-2876           AC019127.10        75412-75555
            2877-3059           AC019127.10        88642-88824
            3060-3146           AC019127.10        89474-89560
            3147-3275           AC019127.10        91435-91563
            3276-3416           AC019127.10        92261-92401
            3417-3587           AC019127.10        93378-93548
            3588-3710           AC020594.6         14111-14233
            3711-3860           AC020594.6         22060-22209
            3861-5006           AC020594.6         23291-24436
FEATURES             Location/Qualifiers
     source          1..5006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..5006
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
     exon            1..365
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..4042
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="isoform 22 precursor is encoded by transcript
                     variant 22; TGF-beta1-BP-1; transforming growth factor
                     beta-1-binding protein 1; LTBP-1"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform 22 precursor"
                     /protein_id="NP_001381850.1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
                     /translation="MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSC
                     QNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGK
                     LCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH
                     VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVI
                     PHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPS
                     YHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
                     TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCP
                     LPGTAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGI
                     STIHLHPQFPVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGH
                     CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGF
                     MASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN
                     PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMC
                     SCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCED
                     IDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCI
                     NTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSIS
                     ADGRTCEDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD
                     VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGT
                     AEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYC
                     KQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPA
                     ESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLK
                     DSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECG
                     ILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINT
                     DGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE"
     exon            366..590
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1331
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1400
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1423
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1523
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1619
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1745
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1871
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1994
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2114
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2237
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2360
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2483
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2606
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2732
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2876
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3059
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3146
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3275
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3416
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3587
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3710
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3860
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..5006
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: AATAAA"
     polyA_site      4860
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="major polyA site"
     regulatory      4975..4980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: ATTAAA"
     polyA_site      5006
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
ORIGIN      
        1 agagacacca ctgaatacag agcagcgagc actgaaggct tccctctttc cttaaacctg
       61 tcgggttgtg ggctctctct tttcccctct tgctcctttc ttttcttttt ttctgttttt
      121 ttaaaccttc caaggcaagt tcatggatac taagctgatg tgtttgttgt tctttttctc
      181 cctgcctccg ctcctagtga gtaaccacac tggccgcatc aaggtggtct ttactccgag
      241 catctgtaaa gtgacctgca ccaagggcag ctgtcagaac agctgtgaga aggggaacac
      301 caccactctc attagtgaga atggtcatgc tgccgacacc ctgacggcca cgaacttccg
      361 agtggtaatt tgccatcttc catgtatgaa tggtggccag tgcagttcaa gggacaaatg
      421 tcagtgccct ccaaatttca caggaaaact ttgtcagatc ccagtccatg gtgccagcgt
      481 gcctaaactt tatcagcatt cccagcagcc aggcaaggcg ttggggacgc atgtcatcca
      541 ttcaacacat accttgcctc tgaccgtgac tagccagcaa ggagtcaaag tgaaatttcc
      601 tcctaacata gtcaatatcc atgtgaaaca tcctcctgaa gcttccgtcc agatacatca
      661 ggtttcaaga attgatggcc caacaggcca gaagacaaaa gaagctcaac caggccaatc
      721 ccaagtctcg taccaagggc ttcctgtcca gaagacccag accatacatt ccacatactc
      781 ccaccagcag gtcattcctc acgtctaccc cgtggctgct aagacacagc ttggccggtg
      841 cttccaggaa accattgggt cacagtgtgg caaagcgctc cctggccttt caaagcaaga
      901 ggactgctgt ggaactgtgg gtacctcctg gggctttaac aaatgccaga aatgccccaa
      961 gaaaccatct tatcatggat acaaccaaat gatggaatgc ctaccgggtt ataagcgggt
     1021 taacaacacc ttttgccaag atattaatga atgtcagcta caaggtgtat gccctaatgg
     1081 tgagtgtttg aataccatgg gcagctatcg atgtacctgc aaaataggat ttgggccgga
     1141 tcctaccttt tcaagttgtg ttcctgatcc ccctgtgatc tcggaagaga aagggccctg
     1201 ttaccgactt gtcagttctg gaagacagtg tatgcaccct ctgtctgttc acctcaccaa
     1261 gcagctctgc tgttgtagtg tgggcaaggc ctggggccca cactgtgaga aatgtcccct
     1321 tccaggcaca gccaaggaag agccagtgga ggccctgacc ttctcccggg aacacgggcc
     1381 aggagtggcg gagccagaag tggcaactgc accccctgaa aaggaaatac cttcattgga
     1441 tcaagagaaa accaaacttg agcctggtca accccagctg tctccaggca tttccactat
     1501 tcatctgcat ccacagtttc cagtgattga aaaaacatca cctcctgtgc ctgttgaagt
     1561 agctcctgaa gcttctacgt ctagtgccag ccaagtgatt gctcctactc aagtgacaga
     1621 aatcaatgaa tgtactgtga accctgatat ctgtggagca ggacactgca ttaacctacc
     1681 agtgagatat acctgtatat gctacgaggg ctacaggttc agtgaacaac agaggaaatg
     1741 tgtggatatt gatgagtgta ctcaggtcca acacctctgc tcccagggcc gctgtgaaaa
     1801 caccgaggga agtttcttgt gcatttgccc agcaggattt atggccagtg aggagggtac
     1861 taactgcata gatgttgacg aatgcctgag gccggacgtc tgtggggagg ggcactgtgt
     1921 caatactgtg ggggccttcc ggtgtgaata ctgtgacagc gggtaccgca tgactcagag
     1981 aggccgttgt gaggatattg atgaatgttt gaatccaagc acttgtccag atgagcagtg
     2041 tgtgaattct cctggatctt accagtgcgt tccctgcaca gaaggattcc gaggctggaa
     2101 tggacagtgc cttgatgtgg acgagtgcct ggaaccaaac gtctgcgcaa atggtgattg
     2161 ttccaacctt gaaggctcct acatgtgttc atgccacaaa ggctataccc ggactccgga
     2221 ccacaagcac tgtagagata ttgatgaatg tcagcaaggg aatctatgtg taaacgggca
     2281 gtgcaaaaat accgagggct ccttcaggtg cacctgtgga caggggtacc agctgtcggc
     2341 agctaaagac cagtgtgaag acattgatga atgccagcac cgtcatctct gtgctcatgg
     2401 gcagtgcagg aacactgagg gctcttttca atgtgtgtgt gaccagggtt acagagcatc
     2461 tgggcttgga gaccactgtg aagatatcaa tgaatgcttg gaggacaaga gtgtttgcca
     2521 gagaggagac tgcattaata ctgcagggtc ctatgattgt acttgtccgg atggatttca
     2581 gctagatgac aataaaacat gtcaagatat taatgaatgt gaacatccag ggctctgtgg
     2641 tccgcaaggg gagtgcctaa acacagaggg ttctttccat tgtgtctgcc agcagggttt
     2701 ctcaatctct gcagatggcc gtacgtgtga agatgtgaat gaatgtgaac tgctcagtgg
     2761 ggtgtgtggt gaagccttct gtgaaaacgt ggaagggtcc ttcctgtgcg tgtgtgctga
     2821 tgaaaaccaa gagtacagcc ccatgactgg gcagtgccgc tcccggacct ccacagattt
     2881 agatgtagat gtagatcaac ccaaagaaga aaagaaagaa tgctactata atctcaatga
     2941 cgccagtctc tgtgataatg tgttggcccc caatgtcacg aaacaagaat gctgctgtac
     3001 atcaggcgtg ggatggggag ataactgcga aatcttcccc tgcccggtct tgggaactgc
     3061 tgagttcact gaaatgtgtc ccaaagggaa aggttttgtg cctgctggag aatcatcttc
     3121 tgaagctggt ggtgagaact ataaagatgc agatgaatgc ctactttttg gacaagaaat
     3181 ctgcaaaaat ggtttctgtt tgaacactcg gcctgggtat gaatgctact gtaagcaagg
     3241 gacgtactat gatcctgtga aactgcagtg ctttgatatg gatgaatgtc aagaccccag
     3301 tagttgtatt gatggccagt gtgttaatac agagggctct tacaactgct tctgtactca
     3361 ccccatggtc ctggatgcgt cagaaaaaag atgtatacga ccggctgagt caaacgaaca
     3421 aatagaagaa actgatgtct accaagattt gtgctgggaa catctgagtg atgaatacgt
     3481 gtgtagccgg cctcttgtgg gcaagcagac aacgtacact gagtgctgct gtctgtatgg
     3541 agaggcctgg ggcatgcagt gtgccctctg ccccctgaag gattcagatg actatgctca
     3601 gctgtgtaac atccccgtga cgggacgccg gcagccatat ggacgggacg ccttggttga
     3661 cttcagtgaa cagtatactc cagaagccga tccctacttc atccaagacc gttttctaaa
     3721 tagctttgag gagttacagg ctgaggaatg cggcatcctc aatggatgtg aaaatggtcg
     3781 ctgtgtgagg gtccaggaag gttacacctg cgattgcttt gatgggtatc acttggatac
     3841 ggccaagatg acctgtgtcg atgtaaatga atgcgatgag ttgaacaacc ggatgtctct
     3901 ctgcaagaat gccaagtgca ttaacaccga tggttcctac aagtgtttgt gtctgccagg
     3961 ctacgtgcct tctgacaagc caaactactg cactccgttg aataccgcct tgaatttaga
     4021 gaaagacagt gacctggagt gaaacagaat ctacataacc taagcccata tactctgcac
     4081 tgtgtaaagg aaaagggaga aatgtattat acttgagaca ttgcacctac cccggaaggc
     4141 tggaaataca gaaacagcat ggaattgcaa gtcctctgaa gacaatgaga ggatttagga
     4201 tgagcccgat aggtgtggca gaccaaatgg acatttctct aaaaaaccag tatatatagt
     4261 ctgttcatat gtaaaattca atggaagaga ggtggaacag tgctgttatt ttaaacagaa
     4321 ggttgtatta ttatgttgtt ttgttttttt actattgctt gattaaattt ggcatttaaa
     4381 tagtggtgga aatattttat ataattttca ttttttggtt gtgcagttcc ttggctactg
     4441 tttttctttt acttcagttt tttaaaaatc tcaaatgaaa aagtcttcga tacaatattg
     4501 ttaagctgta ttataagtat tgttacacag ggttatgcaa ttcccggcct ggagcatttt
     4561 tgaaattcaa attgtctgtc ctgtggagca ggcagtgatt ttgttccaaa actttgtata
     4621 cacatttgga gaaaagtact ttatattttc agtgttttgt ctgattttaa tgtccgttct
     4681 tagccaagct gctagcaggt gttaattgga tccctttcct tcactgaaat ggaagagttt
     4741 ataagcttac gttagtattg taatatgtaa agtaagccca acaaaaattt ttaaaaattt
     4801 gatgatcccc aatatatcta ccattgtatg ttaaataaat caccattttt gtagaaaaaa
     4861 ttctacctga gagtaattgt caatgagtac atgtgtataa gttgtatccc actctcccca
     4921 cttttatctt ttccagtggt cttctgttaa tgtagtgtct tttacaagtt aatcattaaa
     4981 tttgttagat cttgttatgg gctaaa
//
