LOCUS       NM_001394919            5021 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            1 (LTBP1), transcript variant 20, mRNA.
ACCESSION   NM_001394919
VERSION     NM_001394919.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5021)
  AUTHORS   Jiang,X., Yin,S., Yin,X., Wang,Y., Fang,T., Yang,S., Bian,X.,
            Li,G., Xue,Y. and Zhang,L.
  TITLE     A prognostic marker LTBP1 is associated with epithelial mesenchymal
            transition and can promote the progression of gastric cancer
  JOURNAL   Funct Integr Genomics 24 (1), 30 (2024)
   PUBMED   38358412
  REMARK    GeneRIF: A prognostic marker LTBP1 is associated with epithelial
            mesenchymal transition and can promote the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5021)
  AUTHORS   Wenk,D., Khan,S., Ignatchenko,V., May,T., Bernardini,M.Q. and
            Kislinger,T.
  TITLE     Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals
            LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous
            Ovarian Carcinoma
  JOURNAL   J Proteome Res 23 (2), 749-759 (2024)
   PUBMED   38266179
  REMARK    GeneRIF: Targeted Mass Spectrometry of Longitudinal Patient Sera
            Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade
            Serous Ovarian Carcinoma.
REFERENCE   3  (bases 1 to 5021)
  AUTHORS   Gu,H., Wang,W., Sun,C., Ding,L., Li,L., Shu,P. and Xu,J.
  TITLE     Immune suppressive signaling regulated by latent transforming
            growth factor beta binding protein 1 promotes metastasis in
            cervical cancer
  JOURNAL   Braz J Med Biol Res 55, e12206 (2023)
   PUBMED   36629522
  REMARK    GeneRIF: Immune suppressive signaling regulated by latent
            transforming growth factor beta binding protein 1 promotes
            metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5021)
  AUTHORS   Przyklenk,M., Georgieva,V.S., Metzen,F., Mostert,S., Kobbe,B.,
            Callewaert,B., Sengle,G., Brachvogel,B., Mecham,R.P., Paulsson,M.,
            Wagener,R., Koch,M. and Schiavinato,A.
  TITLE     LTBP1 promotes fibrillin incorporation into the extracellular
            matrix
  JOURNAL   Matrix Biol 110, 60-75 (2022)
   PUBMED   35452817
  REMARK    GeneRIF: LTBP1 promotes fibrillin incorporation into the
            extracellular matrix.
REFERENCE   5  (bases 1 to 5021)
  AUTHORS   Taipale,J., Saharinen,J., Hedman,K. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta 1 and its binding protein
            are components of extracellular matrix microfibrils
  JOURNAL   J Histochem Cytochem 44 (8), 875-889 (1996)
   PUBMED   8756760
REFERENCE   6  (bases 1 to 5021)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   7  (bases 1 to 5021)
  AUTHORS   Olofsson,A., Ichijo,H., Moren,A., ten Dijke,P., Miyazono,K. and
            Heldin,C.H.
  TITLE     Efficient association of an amino-terminally extended form of human
            latent transforming growth factor-beta binding protein with the
            extracellular matrix
  JOURNAL   J Biol Chem 270 (52), 31294-31297 (1995)
   PUBMED   8537398
REFERENCE   8  (bases 1 to 5021)
  AUTHORS   Stenman,G., Sahlin,P., Olofsson,A., Geurts van Kessel,A. and
            Miyazono,K.
  TITLE     Assignment of the gene encoding the latent TGF-beta 1-binding
            protein (LTBP1) to human chromosome 2, region p12-->q22
  JOURNAL   Cytogenet Cell Genet 66 (2), 117-119 (1994)
   PUBMED   8287682
REFERENCE   9  (bases 1 to 5021)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 5021)
  AUTHORS   Kanzaki,T., Olofsson,A., Moren,A., Wernstedt,C., Hellman,U.,
            Miyazono,K., Claesson-Welsh,L. and Heldin,C.H.
  TITLE     TGF-beta 1 binding protein: a component of the large latent complex
            of TGF-beta 1 with multiple repeat sequences
  JOURNAL   Cell 61 (6), 1051-1061 (1990)
   PUBMED   2350783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019195.10, AC019127.10 and
            AC020594.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent TGF-beta binding proteins (LTBPs). The secretion and
            activation of TGF-betas is regulated by their association with
            latency-associated proteins and with latent TGF-beta binding
            proteins. The product of this gene targets latent complexes of
            transforming growth factor beta to the extracellular matrix, where
            the latent cytokine is subsequently activated by several different
            mechanisms. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC019195.10        138996-139360       c
            366-590             AC019195.10        86876-87100         c
            591-865             AC019195.10        85105-85379         c
            866-968             AC019195.10        56302-56404         c
            969-1040            AC019195.10        51805-51876         c
            1041-1163           AC019195.10        30172-30294         c
            1164-1331           AC019195.10        21112-21279         c
            1332-1559           AC019195.10        16445-16672         c
            1560-1582           AC019195.10        14346-14368         c
            1583-1682           AC019195.10        11135-11234         c
            1683-1778           AC019195.10        10564-10659         c
            1779-1904           AC019127.10        1701-1826
            1905-2030           AC019127.10        3010-3135
            2031-2153           AC019127.10        3846-3968
            2154-2273           AC019127.10        8084-8203
            2274-2396           AC019127.10        21205-21327
            2397-2519           AC019127.10        28496-28618
            2520-2642           AC019127.10        29567-29689
            2643-2765           AC019127.10        37479-37601
            2766-2891           AC019127.10        43189-43314
            2892-3074           AC019127.10        88642-88824
            3075-3161           AC019127.10        89474-89560
            3162-3290           AC019127.10        91435-91563
            3291-3431           AC019127.10        92261-92401
            3432-3602           AC019127.10        93378-93548
            3603-3725           AC020594.6         14111-14233
            3726-3875           AC020594.6         22060-22209
            3876-5021           AC020594.6         23291-24436
FEATURES             Location/Qualifiers
     source          1..5021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..5021
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
     exon            1..365
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..4057
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="isoform 20 precursor is encoded by transcript
                     variant 20; TGF-beta1-BP-1; transforming growth factor
                     beta-1-binding protein 1; LTBP-1"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform 20 precursor"
                     /protein_id="NP_001381848.1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
                     /translation="MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSC
                     QNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGK
                     LCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH
                     VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVI
                     PHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPS
                     YHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
                     TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCP
                     LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPA
                     KEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHL
                     HPQFPVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLP
                     VRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEE
                     GTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCP
                     DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKG
                     YTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ
                     HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGS
                     YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRT
                     CEDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPC
                     PVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPG
                     YECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKR
                     CIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCA
                     LCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQ
                     AEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA
                     KCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE"
     exon            366..590
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1331
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1559
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1582
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1682
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1778
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1904
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2030
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2153
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2273
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2396
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2519
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2642
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2765
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2891
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3074
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3161
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3290
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3431
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3602
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3725
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3875
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..5021
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="major polyA site"
     regulatory      4990..4995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: ATTAAA"
     polyA_site      5021
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
ORIGIN      
        1 agagacacca ctgaatacag agcagcgagc actgaaggct tccctctttc cttaaacctg
       61 tcgggttgtg ggctctctct tttcccctct tgctcctttc ttttcttttt ttctgttttt
      121 ttaaaccttc caaggcaagt tcatggatac taagctgatg tgtttgttgt tctttttctc
      181 cctgcctccg ctcctagtga gtaaccacac tggccgcatc aaggtggtct ttactccgag
      241 catctgtaaa gtgacctgca ccaagggcag ctgtcagaac agctgtgaga aggggaacac
      301 caccactctc attagtgaga atggtcatgc tgccgacacc ctgacggcca cgaacttccg
      361 agtggtaatt tgccatcttc catgtatgaa tggtggccag tgcagttcaa gggacaaatg
      421 tcagtgccct ccaaatttca caggaaaact ttgtcagatc ccagtccatg gtgccagcgt
      481 gcctaaactt tatcagcatt cccagcagcc aggcaaggcg ttggggacgc atgtcatcca
      541 ttcaacacat accttgcctc tgaccgtgac tagccagcaa ggagtcaaag tgaaatttcc
      601 tcctaacata gtcaatatcc atgtgaaaca tcctcctgaa gcttccgtcc agatacatca
      661 ggtttcaaga attgatggcc caacaggcca gaagacaaaa gaagctcaac caggccaatc
      721 ccaagtctcg taccaagggc ttcctgtcca gaagacccag accatacatt ccacatactc
      781 ccaccagcag gtcattcctc acgtctaccc cgtggctgct aagacacagc ttggccggtg
      841 cttccaggaa accattgggt cacagtgtgg caaagcgctc cctggccttt caaagcaaga
      901 ggactgctgt ggaactgtgg gtacctcctg gggctttaac aaatgccaga aatgccccaa
      961 gaaaccatct tatcatggat acaaccaaat gatggaatgc ctaccgggtt ataagcgggt
     1021 taacaacacc ttttgccaag atattaatga atgtcagcta caaggtgtat gccctaatgg
     1081 tgagtgtttg aataccatgg gcagctatcg atgtacctgc aaaataggat ttgggccgga
     1141 tcctaccttt tcaagttgtg ttcctgatcc ccctgtgatc tcggaagaga aagggccctg
     1201 ttaccgactt gtcagttctg gaagacagtg tatgcaccct ctgtctgttc acctcaccaa
     1261 gcagctctgc tgttgtagtg tgggcaaggc ctggggccca cactgtgaga aatgtcccct
     1321 tccaggcaca gctgctttta aggaaatctg tcctggtgga atgggttata cggtttctgg
     1381 cgttcataga cgcaggccaa tccatcacca tgtaggtaaa ggacctgtat ttgtcaagcc
     1441 aaagaacact caacctgttg ctaaaagtac tcatcctcca cctctcccag ccaaggaaga
     1501 gccagtggag gccctgacct tctcccggga acacgggcca ggagtggcgg agccagaagt
     1561 ggcaactgca ccccctgaaa aggaaatacc ttcattggat caagagaaaa ccaaacttga
     1621 gcctggtcaa ccccagctgt ctccaggcat ttccactatt catctgcatc cacagtttcc
     1681 agtgattgaa aaaacatcac ctcctgtgcc tgttgaagta gctcctgaag cttctacgtc
     1741 tagtgccagc caagtgattg ctcctactca agtgacagaa atcaatgaat gtactgtgaa
     1801 ccctgatatc tgtggagcag gacactgcat taacctacca gtgagatata cctgtatatg
     1861 ctacgagggc tacaggttca gtgaacaaca gaggaaatgt gtggatattg atgagtgtac
     1921 tcaggtccaa cacctctgct cccagggccg ctgtgaaaac accgagggaa gtttcttgtg
     1981 catttgccca gcaggattta tggccagtga ggagggtact aactgcatag atgttgacga
     2041 atgcctgagg ccggacgtct gtggggaggg gcactgtgtc aatactgtgg gggccttccg
     2101 gtgtgaatac tgtgacagcg ggtaccgcat gactcagaga ggccgttgtg aggatattga
     2161 tgaatgtttg aatccaagca cttgtccaga tgagcagtgt gtgaattctc ctggatctta
     2221 ccagtgcgtt ccctgcacag aaggattccg aggctggaat ggacagtgcc ttgatgtgga
     2281 cgagtgcctg gaaccaaacg tctgcgcaaa tggtgattgt tccaaccttg aaggctccta
     2341 catgtgttca tgccacaaag gctatacccg gactccggac cacaagcact gtagagatat
     2401 tgatgaatgt cagcaaggga atctatgtgt aaacgggcag tgcaaaaata ccgagggctc
     2461 cttcaggtgc acctgtggac aggggtacca gctgtcggca gctaaagacc agtgtgaaga
     2521 cattgatgaa tgccagcacc gtcatctctg tgctcatggg cagtgcagga acactgaggg
     2581 ctcttttcaa tgtgtgtgtg accagggtta cagagcatct gggcttggag accactgtga
     2641 agatatcaat gaatgcttgg aggacaagag tgtttgccag agaggagact gcattaatac
     2701 tgcagggtcc tatgattgta cttgtccgga tggatttcag ctagatgaca ataaaacatg
     2761 tcaagatatt aatgaatgtg aacatccagg gctctgtggt ccgcaagggg agtgcctaaa
     2821 cacagagggt tctttccatt gtgtctgcca gcagggtttc tcaatctctg cagatggccg
     2881 tacgtgtgaa gatttagatg tagatgtaga tcaacccaaa gaagaaaaga aagaatgcta
     2941 ctataatctc aatgacgcca gtctctgtga taatgtgttg gcccccaatg tcacgaaaca
     3001 agaatgctgc tgtacatcag gcgtgggatg gggagataac tgcgaaatct tcccctgccc
     3061 ggtcttggga actgctgagt tcactgaaat gtgtcccaaa gggaaaggtt ttgtgcctgc
     3121 tggagaatca tcttctgaag ctggtggtga gaactataaa gatgcagatg aatgcctact
     3181 ttttggacaa gaaatctgca aaaatggttt ctgtttgaac actcggcctg ggtatgaatg
     3241 ctactgtaag caagggacgt actatgatcc tgtgaaactg cagtgctttg atatggatga
     3301 atgtcaagac cccagtagtt gtattgatgg ccagtgtgtt aatacagagg gctcttacaa
     3361 ctgcttctgt actcacccca tggtcctgga tgcgtcagaa aaaagatgta tacgaccggc
     3421 tgagtcaaac gaacaaatag aagaaactga tgtctaccaa gatttgtgct gggaacatct
     3481 gagtgatgaa tacgtgtgta gccggcctct tgtgggcaag cagacaacgt acactgagtg
     3541 ctgctgtctg tatggagagg cctggggcat gcagtgtgcc ctctgccccc tgaaggattc
     3601 agatgactat gctcagctgt gtaacatccc cgtgacggga cgccggcagc catatggacg
     3661 ggacgccttg gttgacttca gtgaacagta tactccagaa gccgatccct acttcatcca
     3721 agaccgtttt ctaaatagct ttgaggagtt acaggctgag gaatgcggca tcctcaatgg
     3781 atgtgaaaat ggtcgctgtg tgagggtcca ggaaggttac acctgcgatt gctttgatgg
     3841 gtatcacttg gatacggcca agatgacctg tgtcgatgta aatgaatgcg atgagttgaa
     3901 caaccggatg tctctctgca agaatgccaa gtgcattaac accgatggtt cctacaagtg
     3961 tttgtgtctg ccaggctacg tgccttctga caagccaaac tactgcactc cgttgaatac
     4021 cgccttgaat ttagagaaag acagtgacct ggagtgaaac agaatctaca taacctaagc
     4081 ccatatactc tgcactgtgt aaaggaaaag ggagaaatgt attatacttg agacattgca
     4141 cctaccccgg aaggctggaa atacagaaac agcatggaat tgcaagtcct ctgaagacaa
     4201 tgagaggatt taggatgagc ccgataggtg tggcagacca aatggacatt tctctaaaaa
     4261 accagtatat atagtctgtt catatgtaaa attcaatgga agagaggtgg aacagtgctg
     4321 ttattttaaa cagaaggttg tattattatg ttgttttgtt tttttactat tgcttgatta
     4381 aatttggcat ttaaatagtg gtggaaatat tttatataat tttcattttt tggttgtgca
     4441 gttccttggc tactgttttt cttttacttc agttttttaa aaatctcaaa tgaaaaagtc
     4501 ttcgatacaa tattgttaag ctgtattata agtattgtta cacagggtta tgcaattccc
     4561 ggcctggagc atttttgaaa ttcaaattgt ctgtcctgtg gagcaggcag tgattttgtt
     4621 ccaaaacttt gtatacacat ttggagaaaa gtactttata ttttcagtgt tttgtctgat
     4681 tttaatgtcc gttcttagcc aagctgctag caggtgttaa ttggatccct ttccttcact
     4741 gaaatggaag agtttataag cttacgttag tattgtaata tgtaaagtaa gcccaacaaa
     4801 aatttttaaa aatttgatga tccccaatat atctaccatt gtatgttaaa taaatcacca
     4861 tttttgtaga aaaaattcta cctgagagta attgtcaatg agtacatgtg tataagttgt
     4921 atcccactct ccccactttt atcttttcca gtggtcttct gttaatgtag tgtcttttac
     4981 aagttaatca ttaaatttgt tagatcttgt tatgggctaa a
//
