LOCUS       NM_001394912            5150 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            1 (LTBP1), transcript variant 13, mRNA.
ACCESSION   NM_001394912
VERSION     NM_001394912.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5150)
  AUTHORS   Jiang,X., Yin,S., Yin,X., Wang,Y., Fang,T., Yang,S., Bian,X.,
            Li,G., Xue,Y. and Zhang,L.
  TITLE     A prognostic marker LTBP1 is associated with epithelial mesenchymal
            transition and can promote the progression of gastric cancer
  JOURNAL   Funct Integr Genomics 24 (1), 30 (2024)
   PUBMED   38358412
  REMARK    GeneRIF: A prognostic marker LTBP1 is associated with epithelial
            mesenchymal transition and can promote the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5150)
  AUTHORS   Wenk,D., Khan,S., Ignatchenko,V., May,T., Bernardini,M.Q. and
            Kislinger,T.
  TITLE     Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals
            LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous
            Ovarian Carcinoma
  JOURNAL   J Proteome Res 23 (2), 749-759 (2024)
   PUBMED   38266179
  REMARK    GeneRIF: Targeted Mass Spectrometry of Longitudinal Patient Sera
            Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade
            Serous Ovarian Carcinoma.
REFERENCE   3  (bases 1 to 5150)
  AUTHORS   Gu,H., Wang,W., Sun,C., Ding,L., Li,L., Shu,P. and Xu,J.
  TITLE     Immune suppressive signaling regulated by latent transforming
            growth factor beta binding protein 1 promotes metastasis in
            cervical cancer
  JOURNAL   Braz J Med Biol Res 55, e12206 (2023)
   PUBMED   36629522
  REMARK    GeneRIF: Immune suppressive signaling regulated by latent
            transforming growth factor beta binding protein 1 promotes
            metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5150)
  AUTHORS   Przyklenk,M., Georgieva,V.S., Metzen,F., Mostert,S., Kobbe,B.,
            Callewaert,B., Sengle,G., Brachvogel,B., Mecham,R.P., Paulsson,M.,
            Wagener,R., Koch,M. and Schiavinato,A.
  TITLE     LTBP1 promotes fibrillin incorporation into the extracellular
            matrix
  JOURNAL   Matrix Biol 110, 60-75 (2022)
   PUBMED   35452817
  REMARK    GeneRIF: LTBP1 promotes fibrillin incorporation into the
            extracellular matrix.
REFERENCE   5  (bases 1 to 5150)
  AUTHORS   Taipale,J., Saharinen,J., Hedman,K. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta 1 and its binding protein
            are components of extracellular matrix microfibrils
  JOURNAL   J Histochem Cytochem 44 (8), 875-889 (1996)
   PUBMED   8756760
REFERENCE   6  (bases 1 to 5150)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   7  (bases 1 to 5150)
  AUTHORS   Olofsson,A., Ichijo,H., Moren,A., ten Dijke,P., Miyazono,K. and
            Heldin,C.H.
  TITLE     Efficient association of an amino-terminally extended form of human
            latent transforming growth factor-beta binding protein with the
            extracellular matrix
  JOURNAL   J Biol Chem 270 (52), 31294-31297 (1995)
   PUBMED   8537398
REFERENCE   8  (bases 1 to 5150)
  AUTHORS   Stenman,G., Sahlin,P., Olofsson,A., Geurts van Kessel,A. and
            Miyazono,K.
  TITLE     Assignment of the gene encoding the latent TGF-beta 1-binding
            protein (LTBP1) to human chromosome 2, region p12-->q22
  JOURNAL   Cytogenet Cell Genet 66 (2), 117-119 (1994)
   PUBMED   8287682
REFERENCE   9  (bases 1 to 5150)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 5150)
  AUTHORS   Kanzaki,T., Olofsson,A., Moren,A., Wernstedt,C., Hellman,U.,
            Miyazono,K., Claesson-Welsh,L. and Heldin,C.H.
  TITLE     TGF-beta 1 binding protein: a component of the large latent complex
            of TGF-beta 1 with multiple repeat sequences
  JOURNAL   Cell 61 (6), 1051-1061 (1990)
   PUBMED   2350783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019195.10, AC019127.10 and
            AC020594.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent TGF-beta binding proteins (LTBPs). The secretion and
            activation of TGF-betas is regulated by their association with
            latency-associated proteins and with latent TGF-beta binding
            proteins. The product of this gene targets latent complexes of
            transforming growth factor beta to the extracellular matrix, where
            the latent cytokine is subsequently activated by several different
            mechanisms. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3094322.1,
                                           SRR14038192.1337474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC019195.10        138996-139360       c
            366-590             AC019195.10        86876-87100         c
            591-865             AC019195.10        85105-85379         c
            866-968             AC019195.10        56302-56404         c
            969-1040            AC019195.10        51805-51876         c
            1041-1163           AC019195.10        30172-30294         c
            1164-1331           AC019195.10        21112-21279         c
            1332-1559           AC019195.10        16445-16672         c
            1560-1582           AC019195.10        14346-14368         c
            1583-1682           AC019195.10        11135-11234         c
            1683-1781           AC019195.10        10564-10662         c
            1782-1907           AC019127.10        1701-1826
            1908-2033           AC019127.10        3010-3135
            2034-2156           AC019127.10        3846-3968
            2157-2276           AC019127.10        8084-8203
            2277-2399           AC019127.10        21205-21327
            2400-2522           AC019127.10        28496-28618
            2523-2645           AC019127.10        29567-29689
            2646-2768           AC019127.10        37479-37601
            2769-2894           AC019127.10        43189-43314
            2895-3020           AC019127.10        70883-71008
            3021-3203           AC019127.10        88642-88824
            3204-3290           AC019127.10        89474-89560
            3291-3419           AC019127.10        91435-91563
            3420-3560           AC019127.10        92261-92401
            3561-3731           AC019127.10        93378-93548
            3732-3854           AC020594.6         14111-14233
            3855-4004           AC020594.6         22060-22209
            4005-5150           AC020594.6         23291-24436
FEATURES             Location/Qualifiers
     source          1..5150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..5150
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
     exon            1..365
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..4186
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="isoform 13 precursor is encoded by transcript
                     variant 13; TGF-beta1-BP-1; transforming growth factor
                     beta-1-binding protein 1; LTBP-1"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform 13 precursor"
                     /protein_id="NP_001381841.1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
                     /translation="MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSC
                     QNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGK
                     LCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH
                     VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVI
                     PHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPS
                     YHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
                     TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCP
                     LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPA
                     KEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHL
                     HPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINL
                     PVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASE
                     EGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTC
                     PDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHK
                     GYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDEC
                     QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAG
                     SYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGR
                     TCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDLDVDVDQPKEEK
                     KECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKG
                     KGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVK
                     LQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETD
                     VYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCN
                     IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRC
                     VRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLP
                     GYVPSDKPNYCTPLNTALNLEKDSDLE"
     exon            366..590
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1331
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1559
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1582
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1682
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1781
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1907
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2033
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2156
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2276
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2399
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2522
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2645
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2768
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2894
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3020
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3203
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3290
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3419
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3560
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3731
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3854
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..4004
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..5150
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4978..4983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: AATAAA"
     polyA_site      5004
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="major polyA site"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: ATTAAA"
     polyA_site      5150
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
ORIGIN      
        1 agagacacca ctgaatacag agcagcgagc actgaaggct tccctctttc cttaaacctg
       61 tcgggttgtg ggctctctct tttcccctct tgctcctttc ttttcttttt ttctgttttt
      121 ttaaaccttc caaggcaagt tcatggatac taagctgatg tgtttgttgt tctttttctc
      181 cctgcctccg ctcctagtga gtaaccacac tggccgcatc aaggtggtct ttactccgag
      241 catctgtaaa gtgacctgca ccaagggcag ctgtcagaac agctgtgaga aggggaacac
      301 caccactctc attagtgaga atggtcatgc tgccgacacc ctgacggcca cgaacttccg
      361 agtggtaatt tgccatcttc catgtatgaa tggtggccag tgcagttcaa gggacaaatg
      421 tcagtgccct ccaaatttca caggaaaact ttgtcagatc ccagtccatg gtgccagcgt
      481 gcctaaactt tatcagcatt cccagcagcc aggcaaggcg ttggggacgc atgtcatcca
      541 ttcaacacat accttgcctc tgaccgtgac tagccagcaa ggagtcaaag tgaaatttcc
      601 tcctaacata gtcaatatcc atgtgaaaca tcctcctgaa gcttccgtcc agatacatca
      661 ggtttcaaga attgatggcc caacaggcca gaagacaaaa gaagctcaac caggccaatc
      721 ccaagtctcg taccaagggc ttcctgtcca gaagacccag accatacatt ccacatactc
      781 ccaccagcag gtcattcctc acgtctaccc cgtggctgct aagacacagc ttggccggtg
      841 cttccaggaa accattgggt cacagtgtgg caaagcgctc cctggccttt caaagcaaga
      901 ggactgctgt ggaactgtgg gtacctcctg gggctttaac aaatgccaga aatgccccaa
      961 gaaaccatct tatcatggat acaaccaaat gatggaatgc ctaccgggtt ataagcgggt
     1021 taacaacacc ttttgccaag atattaatga atgtcagcta caaggtgtat gccctaatgg
     1081 tgagtgtttg aataccatgg gcagctatcg atgtacctgc aaaataggat ttgggccgga
     1141 tcctaccttt tcaagttgtg ttcctgatcc ccctgtgatc tcggaagaga aagggccctg
     1201 ttaccgactt gtcagttctg gaagacagtg tatgcaccct ctgtctgttc acctcaccaa
     1261 gcagctctgc tgttgtagtg tgggcaaggc ctggggccca cactgtgaga aatgtcccct
     1321 tccaggcaca gctgctttta aggaaatctg tcctggtgga atgggttata cggtttctgg
     1381 cgttcataga cgcaggccaa tccatcacca tgtaggtaaa ggacctgtat ttgtcaagcc
     1441 aaagaacact caacctgttg ctaaaagtac tcatcctcca cctctcccag ccaaggaaga
     1501 gccagtggag gccctgacct tctcccggga acacgggcca ggagtggcgg agccagaagt
     1561 ggcaactgca ccccctgaaa aggaaatacc ttcattggat caagagaaaa ccaaacttga
     1621 gcctggtcaa ccccagctgt ctccaggcat ttccactatt catctgcatc cacagtttcc
     1681 agtagtgatt gaaaaaacat cacctcctgt gcctgttgaa gtagctcctg aagcttctac
     1741 gtctagtgcc agccaagtga ttgctcctac tcaagtgaca gaaatcaatg aatgtactgt
     1801 gaaccctgat atctgtggag caggacactg cattaaccta ccagtgagat atacctgtat
     1861 atgctacgag ggctacaggt tcagtgaaca acagaggaaa tgtgtggata ttgatgagtg
     1921 tactcaggtc caacacctct gctcccaggg ccgctgtgaa aacaccgagg gaagtttctt
     1981 gtgcatttgc ccagcaggat ttatggccag tgaggagggt actaactgca tagatgttga
     2041 cgaatgcctg aggccggacg tctgtgggga ggggcactgt gtcaatactg tgggggcctt
     2101 ccggtgtgaa tactgtgaca gcgggtaccg catgactcag agaggccgtt gtgaggatat
     2161 tgatgaatgt ttgaatccaa gcacttgtcc agatgagcag tgtgtgaatt ctcctggatc
     2221 ttaccagtgc gttccctgca cagaaggatt ccgaggctgg aatggacagt gccttgatgt
     2281 ggacgagtgc ctggaaccaa acgtctgcgc aaatggtgat tgttccaacc ttgaaggctc
     2341 ctacatgtgt tcatgccaca aaggctatac ccggactccg gaccacaagc actgtagaga
     2401 tattgatgaa tgtcagcaag ggaatctatg tgtaaacggg cagtgcaaaa ataccgaggg
     2461 ctccttcagg tgcacctgtg gacaggggta ccagctgtcg gcagctaaag accagtgtga
     2521 agacattgat gaatgccagc accgtcatct ctgtgctcat gggcagtgca ggaacactga
     2581 gggctctttt caatgtgtgt gtgaccaggg ttacagagca tctgggcttg gagaccactg
     2641 tgaagatatc aatgaatgct tggaggacaa gagtgtttgc cagagaggag actgcattaa
     2701 tactgcaggg tcctatgatt gtacttgtcc ggatggattt cagctagatg acaataaaac
     2761 atgtcaagat attaatgaat gtgaacatcc agggctctgt ggtccgcaag gggagtgcct
     2821 aaacacagag ggttctttcc attgtgtctg ccagcagggt ttctcaatct ctgcagatgg
     2881 ccgtacgtgt gaagatattg atgaatgtgt aaacaacact gtttgtgaca gtcacgggtt
     2941 ttgtgacaat acagctggct ccttccgctg cctctgttat cagggctttc aagccccaca
     3001 ggatgggcaa gggtgtgtgg atttagatgt agatgtagat caacccaaag aagaaaagaa
     3061 agaatgctac tataatctca atgacgccag tctctgtgat aatgtgttgg cccccaatgt
     3121 cacgaaacaa gaatgctgct gtacatcagg cgtgggatgg ggagataact gcgaaatctt
     3181 cccctgcccg gtcttgggaa ctgctgagtt cactgaaatg tgtcccaaag ggaaaggttt
     3241 tgtgcctgct ggagaatcat cttctgaagc tggtggtgag aactataaag atgcagatga
     3301 atgcctactt tttggacaag aaatctgcaa aaatggtttc tgtttgaaca ctcggcctgg
     3361 gtatgaatgc tactgtaagc aagggacgta ctatgatcct gtgaaactgc agtgctttga
     3421 tatggatgaa tgtcaagacc ccagtagttg tattgatggc cagtgtgtta atacagaggg
     3481 ctcttacaac tgcttctgta ctcaccccat ggtcctggat gcgtcagaaa aaagatgtat
     3541 acgaccggct gagtcaaacg aacaaataga agaaactgat gtctaccaag atttgtgctg
     3601 ggaacatctg agtgatgaat acgtgtgtag ccggcctctt gtgggcaagc agacaacgta
     3661 cactgagtgc tgctgtctgt atggagaggc ctggggcatg cagtgtgccc tctgccccct
     3721 gaaggattca gatgactatg ctcagctgtg taacatcccc gtgacgggac gccggcagcc
     3781 atatggacgg gacgccttgg ttgacttcag tgaacagtat actccagaag ccgatcccta
     3841 cttcatccaa gaccgttttc taaatagctt tgaggagtta caggctgagg aatgcggcat
     3901 cctcaatgga tgtgaaaatg gtcgctgtgt gagggtccag gaaggttaca cctgcgattg
     3961 ctttgatggg tatcacttgg atacggccaa gatgacctgt gtcgatgtaa atgaatgcga
     4021 tgagttgaac aaccggatgt ctctctgcaa gaatgccaag tgcattaaca ccgatggttc
     4081 ctacaagtgt ttgtgtctgc caggctacgt gccttctgac aagccaaact actgcactcc
     4141 gttgaatacc gccttgaatt tagagaaaga cagtgacctg gagtgaaaca gaatctacat
     4201 aacctaagcc catatactct gcactgtgta aaggaaaagg gagaaatgta ttatacttga
     4261 gacattgcac ctaccccgga aggctggaaa tacagaaaca gcatggaatt gcaagtcctc
     4321 tgaagacaat gagaggattt aggatgagcc cgataggtgt ggcagaccaa atggacattt
     4381 ctctaaaaaa ccagtatata tagtctgttc atatgtaaaa ttcaatggaa gagaggtgga
     4441 acagtgctgt tattttaaac agaaggttgt attattatgt tgttttgttt ttttactatt
     4501 gcttgattaa atttggcatt taaatagtgg tggaaatatt ttatataatt ttcatttttt
     4561 ggttgtgcag ttccttggct actgtttttc ttttacttca gttttttaaa aatctcaaat
     4621 gaaaaagtct tcgatacaat attgttaagc tgtattataa gtattgttac acagggttat
     4681 gcaattcccg gcctggagca tttttgaaat tcaaattgtc tgtcctgtgg agcaggcagt
     4741 gattttgttc caaaactttg tatacacatt tggagaaaag tactttatat tttcagtgtt
     4801 ttgtctgatt ttaatgtccg ttcttagcca agctgctagc aggtgttaat tggatccctt
     4861 tccttcactg aaatggaaga gtttataagc ttacgttagt attgtaatat gtaaagtaag
     4921 cccaacaaaa atttttaaaa atttgatgat ccccaatata tctaccattg tatgttaaat
     4981 aaatcaccat ttttgtagaa aaaattctac ctgagagtaa ttgtcaatga gtacatgtgt
     5041 ataagttgta tcccactctc cccactttta tcttttccag tggtcttctg ttaatgtagt
     5101 gtcttttaca agttaatcat taaatttgtt agatcttgtt atgggctaaa
//
