LOCUS       NM_001394906            5291 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens latent transforming growth factor beta binding protein
            1 (LTBP1), transcript variant 7, mRNA.
ACCESSION   NM_001394906
VERSION     NM_001394906.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5291)
  AUTHORS   Jiang,X., Yin,S., Yin,X., Wang,Y., Fang,T., Yang,S., Bian,X.,
            Li,G., Xue,Y. and Zhang,L.
  TITLE     A prognostic marker LTBP1 is associated with epithelial mesenchymal
            transition and can promote the progression of gastric cancer
  JOURNAL   Funct Integr Genomics 24 (1), 30 (2024)
   PUBMED   38358412
  REMARK    GeneRIF: A prognostic marker LTBP1 is associated with epithelial
            mesenchymal transition and can promote the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5291)
  AUTHORS   Wenk,D., Khan,S., Ignatchenko,V., May,T., Bernardini,M.Q. and
            Kislinger,T.
  TITLE     Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals
            LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous
            Ovarian Carcinoma
  JOURNAL   J Proteome Res 23 (2), 749-759 (2024)
   PUBMED   38266179
  REMARK    GeneRIF: Targeted Mass Spectrometry of Longitudinal Patient Sera
            Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade
            Serous Ovarian Carcinoma.
REFERENCE   3  (bases 1 to 5291)
  AUTHORS   Gu,H., Wang,W., Sun,C., Ding,L., Li,L., Shu,P. and Xu,J.
  TITLE     Immune suppressive signaling regulated by latent transforming
            growth factor beta binding protein 1 promotes metastasis in
            cervical cancer
  JOURNAL   Braz J Med Biol Res 55, e12206 (2023)
   PUBMED   36629522
  REMARK    GeneRIF: Immune suppressive signaling regulated by latent
            transforming growth factor beta binding protein 1 promotes
            metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5291)
  AUTHORS   Przyklenk,M., Georgieva,V.S., Metzen,F., Mostert,S., Kobbe,B.,
            Callewaert,B., Sengle,G., Brachvogel,B., Mecham,R.P., Paulsson,M.,
            Wagener,R., Koch,M. and Schiavinato,A.
  TITLE     LTBP1 promotes fibrillin incorporation into the extracellular
            matrix
  JOURNAL   Matrix Biol 110, 60-75 (2022)
   PUBMED   35452817
  REMARK    GeneRIF: LTBP1 promotes fibrillin incorporation into the
            extracellular matrix.
REFERENCE   5  (bases 1 to 5291)
  AUTHORS   Taipale,J., Saharinen,J., Hedman,K. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta 1 and its binding protein
            are components of extracellular matrix microfibrils
  JOURNAL   J Histochem Cytochem 44 (8), 875-889 (1996)
   PUBMED   8756760
REFERENCE   6  (bases 1 to 5291)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   7  (bases 1 to 5291)
  AUTHORS   Olofsson,A., Ichijo,H., Moren,A., ten Dijke,P., Miyazono,K. and
            Heldin,C.H.
  TITLE     Efficient association of an amino-terminally extended form of human
            latent transforming growth factor-beta binding protein with the
            extracellular matrix
  JOURNAL   J Biol Chem 270 (52), 31294-31297 (1995)
   PUBMED   8537398
REFERENCE   8  (bases 1 to 5291)
  AUTHORS   Stenman,G., Sahlin,P., Olofsson,A., Geurts van Kessel,A. and
            Miyazono,K.
  TITLE     Assignment of the gene encoding the latent TGF-beta 1-binding
            protein (LTBP1) to human chromosome 2, region p12-->q22
  JOURNAL   Cytogenet Cell Genet 66 (2), 117-119 (1994)
   PUBMED   8287682
REFERENCE   9  (bases 1 to 5291)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 5291)
  AUTHORS   Kanzaki,T., Olofsson,A., Moren,A., Wernstedt,C., Hellman,U.,
            Miyazono,K., Claesson-Welsh,L. and Heldin,C.H.
  TITLE     TGF-beta 1 binding protein: a component of the large latent complex
            of TGF-beta 1 with multiple repeat sequences
  JOURNAL   Cell 61 (6), 1051-1061 (1990)
   PUBMED   2350783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019195.10, AC019127.10 and
            AC020594.6.
            
            Summary: The protein encoded by this gene belongs to the family of
            latent TGF-beta binding proteins (LTBPs). The secretion and
            activation of TGF-betas is regulated by their association with
            latency-associated proteins and with latent TGF-beta binding
            proteins. The product of this gene targets latent complexes of
            transforming growth factor beta to the extracellular matrix, where
            the latent cytokine is subsequently activated by several different
            mechanisms. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1497153.1,
                                           SRR14038191.1227767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC019195.10        138996-139360       c
            366-590             AC019195.10        86876-87100         c
            591-865             AC019195.10        85105-85379         c
            866-968             AC019195.10        56302-56404         c
            969-1040            AC019195.10        51805-51876         c
            1041-1163           AC019195.10        30172-30294         c
            1164-1331           AC019195.10        21112-21279         c
            1332-1559           AC019195.10        16445-16672         c
            1560-1582           AC019195.10        14346-14368         c
            1583-1682           AC019195.10        11135-11234         c
            1683-1778           AC019195.10        10564-10659         c
            1779-1904           AC019127.10        1701-1826
            1905-2030           AC019127.10        3010-3135
            2031-2153           AC019127.10        3846-3968
            2154-2273           AC019127.10        8084-8203
            2274-2396           AC019127.10        21205-21327
            2397-2519           AC019127.10        28496-28618
            2520-2642           AC019127.10        29567-29689
            2643-2765           AC019127.10        37479-37601
            2766-2891           AC019127.10        43189-43314
            2892-3017           AC019127.10        70883-71008
            3018-3161           AC019127.10        75412-75555
            3162-3344           AC019127.10        88642-88824
            3345-3431           AC019127.10        89474-89560
            3432-3560           AC019127.10        91435-91563
            3561-3701           AC019127.10        92261-92401
            3702-3872           AC019127.10        93378-93548
            3873-3995           AC020594.6         14111-14233
            3996-4145           AC020594.6         22060-22209
            4146-5291           AC020594.6         23291-24436
FEATURES             Location/Qualifiers
     source          1..5291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..5291
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
     exon            1..365
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..4327
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="isoform 7 precursor is encoded by transcript
                     variant 7; TGF-beta1-BP-1; transforming growth factor
                     beta-1-binding protein 1; LTBP-1"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform 7 precursor"
                     /protein_id="NP_001381835.1"
                     /db_xref="GeneID:4052"
                     /db_xref="HGNC:HGNC:6714"
                     /db_xref="MIM:150390"
                     /translation="MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSC
                     QNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGK
                     LCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH
                     VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVI
                     PHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPS
                     YHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
                     TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCP
                     LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPA
                     KEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHL
                     HPQFPVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLP
                     VRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEE
                     GTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCP
                     DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKG
                     YTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ
                     HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGS
                     YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRT
                     CEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE
                     AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDAS
                     LCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSS
                     EAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD
                     PSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLS
                     DEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYG
                     RDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDC
                     FDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC
                     TPLNTALNLEKDSDLE"
     exon            366..590
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..865
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1331
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1559
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1582
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1682
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1778
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1904
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2030
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2153
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2273
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2396
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2519
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2642
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2765
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2891
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3017
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3161
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3344
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3431
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3560
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3701
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3872
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..3995
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4145
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..5291
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: AATAAA"
     polyA_site      5145
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="major polyA site"
     regulatory      5260..5265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
                     /note="hexamer: ATTAAA"
     polyA_site      5291
                     /gene="LTBP1"
                     /gene_synonym="ARCL2E"
ORIGIN      
        1 agagacacca ctgaatacag agcagcgagc actgaaggct tccctctttc cttaaacctg
       61 tcgggttgtg ggctctctct tttcccctct tgctcctttc ttttcttttt ttctgttttt
      121 ttaaaccttc caaggcaagt tcatggatac taagctgatg tgtttgttgt tctttttctc
      181 cctgcctccg ctcctagtga gtaaccacac tggccgcatc aaggtggtct ttactccgag
      241 catctgtaaa gtgacctgca ccaagggcag ctgtcagaac agctgtgaga aggggaacac
      301 caccactctc attagtgaga atggtcatgc tgccgacacc ctgacggcca cgaacttccg
      361 agtggtaatt tgccatcttc catgtatgaa tggtggccag tgcagttcaa gggacaaatg
      421 tcagtgccct ccaaatttca caggaaaact ttgtcagatc ccagtccatg gtgccagcgt
      481 gcctaaactt tatcagcatt cccagcagcc aggcaaggcg ttggggacgc atgtcatcca
      541 ttcaacacat accttgcctc tgaccgtgac tagccagcaa ggagtcaaag tgaaatttcc
      601 tcctaacata gtcaatatcc atgtgaaaca tcctcctgaa gcttccgtcc agatacatca
      661 ggtttcaaga attgatggcc caacaggcca gaagacaaaa gaagctcaac caggccaatc
      721 ccaagtctcg taccaagggc ttcctgtcca gaagacccag accatacatt ccacatactc
      781 ccaccagcag gtcattcctc acgtctaccc cgtggctgct aagacacagc ttggccggtg
      841 cttccaggaa accattgggt cacagtgtgg caaagcgctc cctggccttt caaagcaaga
      901 ggactgctgt ggaactgtgg gtacctcctg gggctttaac aaatgccaga aatgccccaa
      961 gaaaccatct tatcatggat acaaccaaat gatggaatgc ctaccgggtt ataagcgggt
     1021 taacaacacc ttttgccaag atattaatga atgtcagcta caaggtgtat gccctaatgg
     1081 tgagtgtttg aataccatgg gcagctatcg atgtacctgc aaaataggat ttgggccgga
     1141 tcctaccttt tcaagttgtg ttcctgatcc ccctgtgatc tcggaagaga aagggccctg
     1201 ttaccgactt gtcagttctg gaagacagtg tatgcaccct ctgtctgttc acctcaccaa
     1261 gcagctctgc tgttgtagtg tgggcaaggc ctggggccca cactgtgaga aatgtcccct
     1321 tccaggcaca gctgctttta aggaaatctg tcctggtgga atgggttata cggtttctgg
     1381 cgttcataga cgcaggccaa tccatcacca tgtaggtaaa ggacctgtat ttgtcaagcc
     1441 aaagaacact caacctgttg ctaaaagtac tcatcctcca cctctcccag ccaaggaaga
     1501 gccagtggag gccctgacct tctcccggga acacgggcca ggagtggcgg agccagaagt
     1561 ggcaactgca ccccctgaaa aggaaatacc ttcattggat caagagaaaa ccaaacttga
     1621 gcctggtcaa ccccagctgt ctccaggcat ttccactatt catctgcatc cacagtttcc
     1681 agtgattgaa aaaacatcac ctcctgtgcc tgttgaagta gctcctgaag cttctacgtc
     1741 tagtgccagc caagtgattg ctcctactca agtgacagaa atcaatgaat gtactgtgaa
     1801 ccctgatatc tgtggagcag gacactgcat taacctacca gtgagatata cctgtatatg
     1861 ctacgagggc tacaggttca gtgaacaaca gaggaaatgt gtggatattg atgagtgtac
     1921 tcaggtccaa cacctctgct cccagggccg ctgtgaaaac accgagggaa gtttcttgtg
     1981 catttgccca gcaggattta tggccagtga ggagggtact aactgcatag atgttgacga
     2041 atgcctgagg ccggacgtct gtggggaggg gcactgtgtc aatactgtgg gggccttccg
     2101 gtgtgaatac tgtgacagcg ggtaccgcat gactcagaga ggccgttgtg aggatattga
     2161 tgaatgtttg aatccaagca cttgtccaga tgagcagtgt gtgaattctc ctggatctta
     2221 ccagtgcgtt ccctgcacag aaggattccg aggctggaat ggacagtgcc ttgatgtgga
     2281 cgagtgcctg gaaccaaacg tctgcgcaaa tggtgattgt tccaaccttg aaggctccta
     2341 catgtgttca tgccacaaag gctatacccg gactccggac cacaagcact gtagagatat
     2401 tgatgaatgt cagcaaggga atctatgtgt aaacgggcag tgcaaaaata ccgagggctc
     2461 cttcaggtgc acctgtggac aggggtacca gctgtcggca gctaaagacc agtgtgaaga
     2521 cattgatgaa tgccagcacc gtcatctctg tgctcatggg cagtgcagga acactgaggg
     2581 ctcttttcaa tgtgtgtgtg accagggtta cagagcatct gggcttggag accactgtga
     2641 agatatcaat gaatgcttgg aggacaagag tgtttgccag agaggagact gcattaatac
     2701 tgcagggtcc tatgattgta cttgtccgga tggatttcag ctagatgaca ataaaacatg
     2761 tcaagatatt aatgaatgtg aacatccagg gctctgtggt ccgcaagggg agtgcctaaa
     2821 cacagagggt tctttccatt gtgtctgcca gcagggtttc tcaatctctg cagatggccg
     2881 tacgtgtgaa gatattgatg aatgtgtaaa caacactgtt tgtgacagtc acgggttttg
     2941 tgacaataca gctggctcct tccgctgcct ctgttatcag ggctttcaag ccccacagga
     3001 tgggcaaggg tgtgtggatg tgaatgaatg tgaactgctc agtggggtgt gtggtgaagc
     3061 cttctgtgaa aacgtggaag ggtccttcct gtgcgtgtgt gctgatgaaa accaagagta
     3121 cagccccatg actgggcagt gccgctcccg gacctccaca gatttagatg tagatgtaga
     3181 tcaacccaaa gaagaaaaga aagaatgcta ctataatctc aatgacgcca gtctctgtga
     3241 taatgtgttg gcccccaatg tcacgaaaca agaatgctgc tgtacatcag gcgtgggatg
     3301 gggagataac tgcgaaatct tcccctgccc ggtcttggga actgctgagt tcactgaaat
     3361 gtgtcccaaa gggaaaggtt ttgtgcctgc tggagaatca tcttctgaag ctggtggtga
     3421 gaactataaa gatgcagatg aatgcctact ttttggacaa gaaatctgca aaaatggttt
     3481 ctgtttgaac actcggcctg ggtatgaatg ctactgtaag caagggacgt actatgatcc
     3541 tgtgaaactg cagtgctttg atatggatga atgtcaagac cccagtagtt gtattgatgg
     3601 ccagtgtgtt aatacagagg gctcttacaa ctgcttctgt actcacccca tggtcctgga
     3661 tgcgtcagaa aaaagatgta tacgaccggc tgagtcaaac gaacaaatag aagaaactga
     3721 tgtctaccaa gatttgtgct gggaacatct gagtgatgaa tacgtgtgta gccggcctct
     3781 tgtgggcaag cagacaacgt acactgagtg ctgctgtctg tatggagagg cctggggcat
     3841 gcagtgtgcc ctctgccccc tgaaggattc agatgactat gctcagctgt gtaacatccc
     3901 cgtgacggga cgccggcagc catatggacg ggacgccttg gttgacttca gtgaacagta
     3961 tactccagaa gccgatccct acttcatcca agaccgtttt ctaaatagct ttgaggagtt
     4021 acaggctgag gaatgcggca tcctcaatgg atgtgaaaat ggtcgctgtg tgagggtcca
     4081 ggaaggttac acctgcgatt gctttgatgg gtatcacttg gatacggcca agatgacctg
     4141 tgtcgatgta aatgaatgcg atgagttgaa caaccggatg tctctctgca agaatgccaa
     4201 gtgcattaac accgatggtt cctacaagtg tttgtgtctg ccaggctacg tgccttctga
     4261 caagccaaac tactgcactc cgttgaatac cgccttgaat ttagagaaag acagtgacct
     4321 ggagtgaaac agaatctaca taacctaagc ccatatactc tgcactgtgt aaaggaaaag
     4381 ggagaaatgt attatacttg agacattgca cctaccccgg aaggctggaa atacagaaac
     4441 agcatggaat tgcaagtcct ctgaagacaa tgagaggatt taggatgagc ccgataggtg
     4501 tggcagacca aatggacatt tctctaaaaa accagtatat atagtctgtt catatgtaaa
     4561 attcaatgga agagaggtgg aacagtgctg ttattttaaa cagaaggttg tattattatg
     4621 ttgttttgtt tttttactat tgcttgatta aatttggcat ttaaatagtg gtggaaatat
     4681 tttatataat tttcattttt tggttgtgca gttccttggc tactgttttt cttttacttc
     4741 agttttttaa aaatctcaaa tgaaaaagtc ttcgatacaa tattgttaag ctgtattata
     4801 agtattgtta cacagggtta tgcaattccc ggcctggagc atttttgaaa ttcaaattgt
     4861 ctgtcctgtg gagcaggcag tgattttgtt ccaaaacttt gtatacacat ttggagaaaa
     4921 gtactttata ttttcagtgt tttgtctgat tttaatgtcc gttcttagcc aagctgctag
     4981 caggtgttaa ttggatccct ttccttcact gaaatggaag agtttataag cttacgttag
     5041 tattgtaata tgtaaagtaa gcccaacaaa aatttttaaa aatttgatga tccccaatat
     5101 atctaccatt gtatgttaaa taaatcacca tttttgtaga aaaaattcta cctgagagta
     5161 attgtcaatg agtacatgtg tataagttgt atcccactct ccccactttt atcttttcca
     5221 gtggtcttct gttaatgtag tgtcttttac aagttaatca ttaaatttgt tagatcttgt
     5281 tatgggctaa a
//
