LOCUS       NM_019839               1500 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leukotriene B4 receptor 2 (LTB4R2), transcript variant
            1, mRNA.
ACCESSION   NM_019839
VERSION     NM_019839.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Zhang,X., Wu,H., Yan,X., Ma,J. and Chen,Z.
  TITLE     LTB4R Promotes the Occurrence and Progression of Clear Cell Renal
            Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway
  JOURNAL   Cells 11 (22), 3606 (2022)
   PUBMED   36429034
  REMARK    GeneRIF: LTB4R Promotes the Occurrence and Progression of Clear
            Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Yuan,X., He,Y., Luo,C. and Wang,W.
  TITLE     Leukotriene B4 receptor 2 correlates with prognosis and immune
            infiltration in clear cell renal cell carcinoma
  JOURNAL   Invest New Drugs 40 (2), 232-244 (2022)
   PUBMED   34633577
  REMARK    GeneRIF: Leukotriene B4 receptor 2 correlates with prognosis and
            immune infiltration in clear cell renal cell carcinoma.
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Zhang,X., Zhang,X., Liu,P., Liu,K., Li,W., Chen,Q. and Ma,W.
  TITLE     [Prognostic implications and functional enrichment analysis of
            LTB4R in patients with acute myeloid leukemia]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (3), 309-320 (2022)
   PUBMED   35426793
  REMARK    GeneRIF: [Prognostic implications and functional enrichment
            analysis of LTB4R in patients with acute myeloid leukemia].
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Long,S., Ji,S., Xiao,K., Xue,P. and Zhu,S.
  TITLE     Prognostic and immunological value of LTB4R in pan-cancer
  JOURNAL   Math Biosci Eng 18 (6), 9336-9356 (2021)
   PUBMED   34814348
  REMARK    GeneRIF: Prognostic and immunological value of LTB4R in pan-cancer.
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Jang,J.H., Park,D., Park,G.S., Kwak,D.W., Park,J., Yu,D.Y.,
            You,H.J. and Kim,J.H.
  TITLE     Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor
            formation by promoting interleukin-6-mediated inflammation
  JOURNAL   Exp Mol Med 53 (10), 1559-1568 (2021)
   PUBMED   34635780
  REMARK    GeneRIF: Leukotriene B4 receptor-2 contributes to KRAS-driven lung
            tumor formation by promoting interleukin-6-mediated inflammation.
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Kamohara,M., Takasaki,J., Matsumoto,M., Saito,T., Ohishi,T.,
            Ishii,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of another leukotriene B4
            receptor
  JOURNAL   J Biol Chem 275 (35), 27000-27004 (2000)
   PUBMED   10889186
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Yokomizo,T., Kato,K., Terawaki,K., Izumi,T. and Shimizu,T.
  TITLE     A second leukotriene B(4) receptor, BLT2. A new therapeutic target
            in inflammation and immunological disorders
  JOURNAL   J Exp Med 192 (3), 421-432 (2000)
   PUBMED   10934230
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Kato,K., Yokomizo,T., Izumi,T. and Shimizu,T.
  TITLE     Cell-specific transcriptional regulation of human leukotriene B(4)
            receptor gene
  JOURNAL   J Exp Med 192 (3), 413-420 (2000)
   PUBMED   10934229
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Nilsson,N.E., Tryselius,Y. and Owman,C.
  TITLE     Genomic organization of the leukotriene B(4) receptor locus of
            human chromosome 14
  JOURNAL   Biochem Biophys Res Commun 274 (2), 383-388 (2000)
   PUBMED   10913347
REFERENCE   10 (bases 1 to 1500)
  AUTHORS   Tryselius,Y., Nilsson,N.E., Kotarsky,K., Olde,B. and Owman,C.
  TITLE     Cloning and characterization of cDNA encoding a novel human
            leukotriene B(4) receptor
  JOURNAL   Biochem Biophys Res Commun 274 (2), 377-382 (2000)
   PUBMED   10913346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL096870.5, DC408599.1, AB032558.1 and AK304169.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019839.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304169.1, AB032558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533293.2/ ENSP00000433290.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL096870.5         79805-79815         c
            12-45               DC408599.1         1-34
            46-1221             AB032558.1         1-1176
            1222-1500           AK304169.1         1203-1481
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1500
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /note="leukotriene B4 receptor 2"
                     /db_xref="GeneID:56413"
                     /db_xref="HGNC:HGNC:19260"
                     /db_xref="MIM:605773"
     exon            1..116
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            117..1500
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1203
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /note="leukotriene B4 receptor BLT2; seven transmembrane
                     receptor BLTR2; LTB4 receptor JULF2"
                     /codon_start=1
                     /product="leukotriene B4 receptor 2"
                     /protein_id="NP_062813.2"
                     /db_xref="CCDS:CCDS9625.2"
                     /db_xref="GeneID:56413"
                     /db_xref="HGNC:HGNC:19260"
                     /db_xref="MIM:605773"
                     /translation="MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWS
                     LAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCA
                     LSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYR
                     HLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRH
                     GARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTAL
                     AFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLK
                     VVGQGRGNGDPGGGMEKDGPEWDL"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /note="hexamer: AATACA"
     polyA_site      1500
                     /gene="LTB4R2"
                     /gene_synonym="BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2;
                     LTB4-R2; NOP9"
                     /note="major polyA site"
ORIGIN      
        1 attcttgtct taccctctgc aaatgtgata ggcacaggac aggagtaggc acctcgccta
       61 ctgctgctta acctttcagc ttctccaggc ccccaatcct gcttgctccc agcttggccc
      121 agaaggatgt cggtctgcta ccgtccccca gggaacgaga cactgctgag ctggaagact
      181 tcgcgggcca caggcacagc cttcctgctg ctggcggcgc tgctggggct gcctggcaac
      241 ggcttcgtgg tgtggagctt ggcgggctgg cggcctgcac gggggcgacc gctggcggcc
      301 acgcttgtgc tgcacctggc gctggccgac ggcgcggtgc tgctgctcac gccgctcttt
      361 gtggccttcc tgacccggca ggcctggccg ctgggccagg cgggctgcaa ggcggtgtac
      421 tacgtgtgcg cgctcagcat gtacgccagc gtgctgctca ccggcctgct cagcctgcag
      481 cgctgcctcg cagtcacccg ccccttcctg gcgcctcggc tgcgcagccc ggccctggcc
      541 cgccgcctgc tgctggcggt ctggctggcc gccctgttgc tcgccgtccc ggccgccgtc
      601 taccgccacc tgtggaggga ccgcgtatgc cagctgtgcc acccgtcgcc ggtccacgcc
      661 gccgcccacc tgagcctgga gactctgacc gctttcgtgc ttcctttcgg gctgatgctc
      721 ggctgctaca gcgtgacgct ggcacggctg cggggcgccc gctggggctc cgggcggcac
      781 ggggcgcggg tgggccggct ggtgagcgcc atcgtgcttg ccttcggctt gctctgggcc
      841 ccctaccacg cagtcaacct tctgcaggcg gtcgcagcgc tggctccacc ggaaggggcc
      901 ttggcgaagc tgggcggagc cggccaggcg gcgcgagcgg gaactacggc cttggccttc
      961 ttcagttcta gcgtcaaccc ggtgctctac gtcttcaccg ctggagatct gctgccccgg
     1021 gcaggtcccc gtttcctcac gcggctcttc gaaggctctg gggaggcccg agggggcggc
     1081 cgctctaggg aagggaccat ggagctccga actacccctc agctgaaagt ggtggggcag
     1141 ggccgcggca atggagaccc ggggggtggg atggagaagg acggtccgga atgggacctt
     1201 tgacagcaga ccctacaacc tgctgccctt ccctgtccct ttccaccccc cacccaccct
     1261 ccagaggtca gtgttctggg acatttgggg acccttcttt gactagagtt tggatctggc
     1321 tgggtaggat tactatacac ttggggcagg cccaggctcc tccaaactga gggattatga
     1381 gggtggtgat ggtccctgtt aaggactatt gtgtgcttgc aagttggcat gtacccatgt
     1441 gccagcattg cttacttgtt gccaatagct gttattgtga aatacactgg gaagccatta
//
