LOCUS       NM_001143919            2703 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens leukotriene B4 receptor (LTB4R), transcript variant 2,
            mRNA.
ACCESSION   NM_001143919
VERSION     NM_001143919.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Wang,N., He,X., Zhao,J., Jiang,H., Cheng,X., Xia,Y., Eric Xu,H. and
            He,Y.
  TITLE     Structural basis of leukotriene B4 receptor 1 activation
  JOURNAL   Nat Commun 13 (1), 1156 (2022)
   PUBMED   35241677
  REMARK    GeneRIF: Structural basis of leukotriene B4 receptor 1 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Dos Santos,H.T., Nam,K., Hunt,J.P., Buchmann,L.O., Monroe,M.M. and
            Baker,O.J.
  TITLE     SPM Receptor Expression and Localization in Irradiated Salivary
            Glands
  JOURNAL   J Histochem Cytochem 69 (8), 523-534 (2021)
   PUBMED   34339312
  REMARK    GeneRIF: SPM Receptor Expression and Localization in Irradiated
            Salivary Glands.
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Michaelian,N., Sadybekov,A., Besserer-Offroy,E., Han,G.W.,
            Krishnamurthy,H., Zamlynny,B.A., Fradera,X., Siliphaivanh,P.,
            Presland,J., Spencer,K.B., Soisson,S.M., Popov,P., Sarret,P.,
            Katritch,V. and Cherezov,V.
  TITLE     Structural insights on ligand recognition at the human leukotriene
            B4 receptor 1
  JOURNAL   Nat Commun 12 (1), 2971 (2021)
   PUBMED   34016973
  REMARK    GeneRIF: Structural insights on ligand recognition at the human
            leukotriene B4 receptor 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Fujita,K., Koide,N., Somiya,M., Kuroda,S. and Hinuma,S.
  TITLE     A regulatory role of scavenger receptor class B type 1 in
            endocytosis and lipid droplet formation induced by liposomes
            containing phosphatidylethanolamine in HEK293T cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118859 (2021)
   PUBMED   32956759
  REMARK    GeneRIF: A regulatory role of scavenger receptor class B type 1 in
            endocytosis and lipid droplet formation induced by liposomes
            containing phosphatidylethanolamine in HEK293T cells.
REFERENCE   5  (bases 1 to 2703)
  AUTHORS   He,R., Chen,Y. and Cai,Q.
  TITLE     The role of the LTB4-BLT1 axis in health and disease
  JOURNAL   Pharmacol Res 158, 104857 (2020)
   PUBMED   32439596
  REMARK    GeneRIF: The role of the LTB4-BLT1 axis in health and disease.
            Review article
            Erratum:[Pharmacol Res. 2020 Sep;159:105011. doi:
            10.1016/j.phrs.2020.105011.. PMID: 32595014]
REFERENCE   6  (bases 1 to 2703)
  AUTHORS   Maier,R., Glatz,A., Mosbacher,J. and Bilbe,G.
  TITLE     Cloning of P2Y6 cDNAs and identification of a pseudogene:
            comparison of P2Y receptor subtype expression in bone and brain
            tissues
  JOURNAL   Biochem Biophys Res Commun 237 (2), 297-302 (1997)
   PUBMED   9268704
REFERENCE   7  (bases 1 to 2703)
  AUTHORS   Yokomizo,T., Izumi,T., Chang,K., Takuwa,Y. and Shimizu,T.
  TITLE     A G-protein-coupled receptor for leukotriene B4 that mediates
            chemotaxis
  JOURNAL   Nature 387 (6633), 620-624 (1997)
   PUBMED   9177352
REFERENCE   8  (bases 1 to 2703)
  AUTHORS   Owman,C., Nilsson,C. and Lolait,S.J.
  TITLE     Cloning of cDNA encoding a putative chemoattractant receptor
  JOURNAL   Genomics 37 (2), 187-194 (1996)
   PUBMED   8921391
REFERENCE   9  (bases 1 to 2703)
  AUTHORS   Akbar,G.K., Dasari,V.R., Webb,T.E., Ayyanathan,K., Pillarisetti,K.,
            Sandhu,A.K., Athwal,R.S., Daniel,J.L., Ashby,B., Barnard,E.A. and
            Kunapuli,S.P.
  TITLE     Molecular cloning of a novel P2 purinoceptor from human
            erythroleukemia cells
  JOURNAL   J Biol Chem 271 (31), 18363-18367 (1996)
   PUBMED   8702478
REFERENCE   10 (bases 1 to 2703)
  AUTHORS   Raport,C.J., Schweickart,V.L., Chantry,D., Eddy,R.L. Jr.,
            Shows,T.B., Godiska,R. and Gray,P.W.
  TITLE     New members of the chemokine receptor gene family
  JOURNAL   J Leukoc Biol 59 (1), 18-23 (1996)
   PUBMED   8558062
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D89079.1, AL096870.5 and BQ182452.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143919.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D89079.1, U41070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345363.8/ ENSP00000307445.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1244              D89079.1           4-1247
            1245-2105           AL096870.5         72517-73377         c
            2106-2703           BQ182452.1         18-615              c
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..2703
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /note="leukotriene B4 receptor"
                     /db_xref="GeneID:1241"
                     /db_xref="HGNC:HGNC:6713"
                     /db_xref="MIM:601531"
     exon            1..303
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /inference="alignment:Splign:2.1.0"
     exon            304..2703
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1377
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /note="chemokine receptor-like 1; G protein-coupled
                     receptor 16; purinergic receptor P2Y, G-protein coupled,
                     7; LTB4-R1; LTB4-R 1; P2Y purinoceptor 7; chemoattractant
                     receptor-like 1"
                     /codon_start=1
                     /product="leukotriene B4 receptor 1"
                     /protein_id="NP_001137391.1"
                     /db_xref="CCDS:CCDS9626.1"
                     /db_xref="GeneID:1241"
                     /db_xref="HGNC:HGNC:6713"
                     /db_xref="MIM:601531"
                     /translation="MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSIL
                     KRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMY
                     ASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVP
                     WKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRR
                     TGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFL
                     SSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEP
                     GPSESLTASSPLKLNELN"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /note="hexamer: ATTAAA"
     polyA_site      1613
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /note="major polyA site"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
                     /note="hexamer: AATAAA"
     polyA_site      2703
                     /gene="LTB4R"
                     /gene_synonym="BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1;
                     P2RY7; P2Y7"
ORIGIN      
        1 agttctagcg tcaacccggt gctctacgtc ttcaccgctg gagatctgct gccccgggca
       61 ggtccccgtt tcctcacgcg gctcttcgaa ggctctgggg aggcccgagg gggcggccgc
      121 tctagggaag ggaccatgga gctccgaact acccctcagc tgaaagtggt ggggcagggc
      181 cgcggcaatg gagacccggg gggtgggatg gagaaggacg gtccggaatg ggacctttga
      241 cagcagaccc tacaacctgc tgcccttccc tgtccctttc caccccccac ccaccctcca
      301 gaggtcctcc cgacggccat gaacactaca tcttctgcag cacccccctc actaggtgta
      361 gagttcatct ctctgctggc tatcatcctg ctgtcagtgg cgctggctgt ggggcttccc
      421 ggcaacagct ttgtggtgtg gagtatcctg aaaaggatgc agaagcgctc tgtcactgcc
      481 ctgatggtgc tgaacctggc cctggccgac ctggccgtat tgctcactgc tccctttttc
      541 cttcacttcc tggcccaagg cacctggagt tttggactgg ctggttgccg cctgtgtcac
      601 tatgtctgcg gagtcagcat gtacgccagc gtcctgctta tcacggccat gagtctagac
      661 cgctcactgg cggtggcccg cccctttgtg tcccagaagc tacgcaccaa ggcgatggcc
      721 cggcgggtgc tggcaggcat ctgggtgttg tcctttctgc tggccacacc cgtcctcgcg
      781 taccgcacag tagtgccctg gaaaacgaac atgagcctgt gcttcccgcg gtaccccagc
      841 gaagggcacc gggccttcca tctaatcttc gaggctgtca cgggcttcct gctgcccttc
      901 ctggctgtgg tggccagcta ctcggacata gggcgtcggc tacaggcccg gcgcttccgc
      961 cgcagccgcc gcaccggccg cctggtggtg ctcatcatcc tgaccttcgc cgccttctgg
     1021 ctgccctacc acgtggtgaa cctggctgag gcgggccgcg cgctggccgg ccaggccgcc
     1081 gggttagggc tcgtggggaa gcggctgagc ctggcccgca acgtgctcat cgcactcgcc
     1141 ttcctgagca gcagcgtgaa ccccgtgctg tacgcgtgcg ccggcggcgg cctgctgcgc
     1201 tcggcgggcg tgggcttcgt cgccaagctg ctggagggca cgggctccga ggcgtccagc
     1261 acgcgccgcg ggggcagcct gggccagacc gctaggagcg gccccgccgc tctggagccc
     1321 ggcccttccg agagcctcac tgcctccagc cctctcaagt taaacgaact gaactaggcc
     1381 tggtggaagg aggcgcactt tcctcctggc agaatgctag ctctgagcca gttcagtacc
     1441 tggaggagga gcaggggcgt ggagggcgtg gagggcgtgg gagcgtggga ggcgggagtg
     1501 gagtggaaga agagggagag gtggagcaaa gtgagggccg agtgagagcg tgctccagcc
     1561 tggctcccac aggcagcttt aaccattaaa actgaagtct gaaatttggt caaccttgtg
     1621 agtggggtac atgtgctgtg ggtatcgggg tgctcgtggg cgccctggtg gggcccctct
     1681 cggtagttga gagtcacgtc ctttagttcc ccatgattta caattttgga agggacacaa
     1741 agaaacatag acttccccca tcccagatga ttccgagtac atagtctgca gataatactt
     1801 agcaaaacgc agtctacaga ctcctaaagc agcttgtcta ggaagaccac ccatgtgggc
     1861 ttatcactcc aggttctgtg acccgggacc ttctgagaaa acagcactgc tgtgaaatat
     1921 cttccttgaa gcctgtgata agtctccttg ttagaatgac tccaacttcc tgccaataat
     1981 ctttgtcctc tccataggag atgttctagg ggatgccttc cttccctcca tttcacaaag
     2041 aggccagact tgaggactaa gtcattagat cttatccctt agaattttgc atatcagcat
     2101 ctgctaacct ccacaacaca ccctggcaca gggtggggct gagggcccca ggaaacaaag
     2161 attcccaaaa gtgagaggga tgagtcatta tttcctagag atgactgttg ttttagagaa
     2221 ccttggtcca actctgttct gacaaggttt taggaagatg gcaacaacag tggcagcagt
     2281 gtactttttg gatctttctc ataaaaaaac aaaagagcaa gtaagagagg gaaaccaaat
     2341 atccacatgc aacatccgca acaaatctag tatgtcaagg tttgacatac tcccatggac
     2401 cccaaagtat gagccagtga gaatgagtca tcaatatctc aagacccata taccagcatc
     2461 tgtgcagaag gatgcagaag gaagcaaagg gatgttggat ggacctaaga agaggagatc
     2521 cccaagctgt ctacagatcc ttactggaag gtatggtgca ccaatttgag aacagcagct
     2581 gaaactggga gggacctaac ggagtatttc ccagtcctct cgcccattct gtatggtgag
     2641 cacataatag gtacttattt agtgtttgtc gaattaataa agttcaaatg acatttccct
     2701 gga
//
