LOCUS       NM_000895               2140 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant
            1, mRNA.
ACCESSION   NM_000895
VERSION     NM_000895.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Guo,Z., Huang,J., Huo,X., Huang,C., Yu,X., Sun,Y., Li,Y., He,T.,
            Guo,H., Yang,J. and Xue,L.
  TITLE     Targeting LTA4H facilitates the reshaping of the immune
            microenvironment mediated by CCL5 and sensitizes ovarian cancer to
            Cisplatin
  JOURNAL   Sci China Life Sci 67 (6), 1226-1241 (2024)
   PUBMED   38300441
  REMARK    GeneRIF: Targeting LTA4H facilitates the reshaping of the immune
            microenvironment mediated by CCL5 and sensitizes ovarian cancer to
            Cisplatin.
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Wu,X., Sun,A.R., Crawford,R., Xiao,Y., Wang,Y., Prasadam,I. and
            Mao,X.
  TITLE     Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage
            Degradation and Synovial Inflammation in a Mouse Model of
            Experimental Osteoarthritis
  JOURNAL   Cartilage 15 (2), 184-194 (2024)
   PUBMED   37086004
  REMARK    GeneRIF: Inhibition of Leukotriene A4 Hydrolase Suppressed
            Cartilage Degradation and Synovial Inflammation in a Mouse Model of
            Experimental Osteoarthritis.
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Ren,T., Wang,S., Zhang,B., Zhou,W., Wang,C., Zhao,X. and Feng,J.
  TITLE     LTA4H extensively associates with mRNAs and lncRNAs indicative of
            its novel regulatory targets
  JOURNAL   PeerJ 11, e14875 (2023)
   PUBMED   36923505
  REMARK    GeneRIF: LTA4H extensively associates with mRNAs and lncRNAs
            indicative of its novel regulatory targets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Kumar,S.S., Solomon,R., Gautam,P., Inbaraj,L.R., Sivadasan,A.,
            Michael,J.S., Karthik,R., Varghese,G.M., Christudass,C.S.,
            Samuel,P. and Manesh,A.
  TITLE     Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and
            paradoxical reactions in extrapulmonary tuberculosis
  JOURNAL   Sci Rep 13 (1), 3746 (2023)
   PUBMED   36879040
  REMARK    GeneRIF: Leukotriene A4 hydrolase (LTA4H rs17525495) gene
            polymorphisms and paradoxical reactions in extrapulmonary
            tuberculosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Zhao,Y., Xu,M., Liu,M., Zhang,Q. and Xiong,W.
  TITLE     Clinical Implications of LTA4H Genetic Polymorphism in Patients
            with Chronic Obstructive Pulmonary Disease
  JOURNAL   COPD 18 (6), 664-671 (2021)
   PUBMED   34694182
  REMARK    GeneRIF: Clinical Implications of LTA4H Genetic Polymorphism in
            Patients with Chronic Obstructive Pulmonary Disease.
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Wetterholm,A., Medina,J.F., Radmark,O., Shapiro,R.,
            Haeggstrom,J.Z., Vallee,B.L. and Samuelsson,B.
  TITLE     Leukotriene A4 hydrolase: abrogation of the peptidase activity by
            mutation of glutamic acid-296
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9141-9145 (1992)
   PUBMED   1357660
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Minami,M., Bito,H., Ohishi,N., Tsuge,H., Miyano,M., Mori,M.,
            Wada,H., Mutoh,H., Shimada,S., Izumi,T. et al.
  TITLE     Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of
            leukotriene A4 hydrolase and aminopeptidase activities by
            site-directed mutagenesis at Glu-297
  JOURNAL   FEBS Lett 309 (3), 353-357 (1992)
   PUBMED   1516710
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Medina,J.F., Wetterholm,A., Radmark,O., Shapiro,R.,
            Haeggstrom,J.Z., Vallee,B.L. and Samuelsson,B.
  TITLE     Leukotriene A4 hydrolase: determination of the three zinc-binding
            ligands by site-directed mutagenesis and zinc analysis
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7620-7624 (1991)
   PUBMED   1881903
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Odlander,B., Claesson,H.E., Bergman,T., Radmark,O., Jornvall,H. and
            Haeggstrom,J.Z.
  TITLE     Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji:
            indications of catalytically divergent forms of the enzyme
  JOURNAL   Arch Biochem Biophys 287 (1), 167-174 (1991)
   PUBMED   1897988
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Toh,H., Minami,M. and Shimizu,T.
  TITLE     Molecular evolution and zinc ion binding motif of leukotriene A4
            hydrolase
  JOURNAL   Biochem Biophys Res Commun 171 (1), 216-221 (1990)
   PUBMED   1975494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from J03459.1 and R41544.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000895.2.
            
            Summary: The protein encoded by this gene is an enzyme that
            contains both hydrolase and aminopeptidase activities. The
            hydrolase activity is used in the final step of the biosynthesis of
            leukotriene B4, a proinflammatory mediator. The aminopeptidase
            activity has been shown to degrade proline-glycine-proline (PGP), a
            neutrophil chemoattractant and biomarker for chronic obstructive
            pulmonary disease (COPD). Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005567.1, SRR1803616.79480.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228740.7/ ENSP00000228740.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2045              J03459.1           1-2045
            2046-2140           R41544.1           9-103               c
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..2140
                     /gene="LTA4H"
                     /note="leukotriene A4 hydrolase"
                     /db_xref="GeneID:4048"
                     /db_xref="HGNC:HGNC:6710"
                     /db_xref="MIM:151570"
     exon            1..227
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1904
                     /gene="LTA4H"
                     /EC_number="3.3.2.6"
                     /EC_number="3.4.11.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leukotriene A-4 hydrolase; LTA-4 hydrolase; testicular
                     secretory protein Li 27; tripeptide aminopeptidase LTA4H"
                     /codon_start=1
                     /product="leukotriene A-4 hydrolase isoform 1"
                     /protein_id="NP_000886.1"
                     /db_xref="CCDS:CCDS9059.1"
                     /db_xref="GeneID:4048"
                     /db_xref="HGNC:HGNC:6710"
                     /db_xref="MIM:151570"
                     /translation="MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQ
                     SQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIV
                     IEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAE
                     VSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPR
                     TLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCL
                     TFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLF
                     GEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLF
                     YLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
                     SPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTL
                     QRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMK
                     FTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD"
     exon            228..358
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            359..479
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            480..548
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            549..653
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            654..706
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            707..779
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            780..920
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            921..944
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1015
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1127
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1272
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1376
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1447
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1502
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1598
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1681
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1786
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2140
                     /gene="LTA4H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTA4H"
                     /note="hexamer: AATAAA"
     polyA_site      2063
                     /gene="LTA4H"
                     /note="major polyA site"
     polyA_site      2090
                     /gene="LTA4H"
     regulatory      2116..2121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LTA4H"
                     /note="hexamer: ATTAAA"
     polyA_site      2140
                     /gene="LTA4H"
ORIGIN      
        1 ctctatcgac gagtctggta gctgagcgtt gggctgtagg tcgctgtgct gtgtgatccc
       61 ccagagccat gcccgagata gtggatacct gttcgttggc ctctccggct tccgtctgcc
      121 ggaccaagca cctgcacctg cgctgcagcg tcgactttac tcgccggacg ctgaccggga
      181 ctgctgctct cacggtccag tctcaggagg acaatctgcg cagcctggtt ttggatacaa
      241 aggaccttac aatagaaaaa gtagtgatca atggacaaga agtcaaatat gctcttggag
      301 aaagacaaag ttacaaggga tcgccaatgg aaatctctct tcctatcgct ttgagcaaaa
      361 atcaagaaat tgttatagaa atttcttttg agacctctcc aaaatcttct gctctccagt
      421 ggctcactcc tgaacagact tctgggaagg aacacccata tctctttagt cagtgccagg
      481 ccatccactg cagagcaatc cttccttgtc aggacactcc ttctgtgaaa ttaacctata
      541 ctgcagaggt gtctgtccct aaagaactgg tggcacttat gagtgctatt cgtgatggag
      601 aaacacctga cccagaagac ccaagcagga aaatatacaa attcatccaa aaagttccaa
      661 taccctgcta cctgattgct ttagttgttg gagctttaga aagcaggcaa attggcccaa
      721 gaactttggt gtggtctgag aaagagcagg tggaaaagtc tgcttatgag ttttctgaga
      781 ctgaatctat gcttaaaata gcagaagatc tgggaggacc gtatgtatgg ggacagtatg
      841 acctattggt cctgccacca tccttccctt atggtggcat ggagaatcct tgccttactt
      901 ttgtaactcc tactctactg gcaggcgaca agtcactctc caatgtcatt gcacatgaaa
      961 tatctcatag ctggacaggg aatctagtga ccaacaaaac ttgggatcac ttttggttaa
     1021 atgagggaca tactgtgtac ttggaacgcc acatttgcgg acgattgttt ggtgaaaagt
     1081 tcagacattt taatgctctg ggaggatggg gagaactaca gaattcggta aagacatttg
     1141 gggagacaca tcctttcacc aaacttgtgg ttgatctgac agatatagac cctgatgtag
     1201 cttattcttc agttccctat gagaagggct ttgctttact tttttacctt gaacaactgc
     1261 ttggaggacc agagattttc ctaggattct taaaagctta tgttgagaag ttttcctata
     1321 agagcataac tactgatgac tggaaggatt tcctgtattc ctattttaaa gataaggttg
     1381 atgttctcaa tcaagttgat tggaatgcct ggctctactc tcctggactg cctcccataa
     1441 agcccaatta tgatatgact ctgacaaatg cttgtattgc cttaagtcaa agatggatta
     1501 ctgccaaaga agatgattta aattcattca atgccacaga cctgaaggat ctctcttctc
     1561 atcaattgaa tgagttttta gcacagacgc tccagagggc acctcttcca ttggggcaca
     1621 taaagcgaat gcaagaggtg tacaacttca atgccattaa caattctgaa atacgattca
     1681 gatggctgcg gctctgcatt caatccaagt gggaggacgc aattcctttg gcgctaaaga
     1741 tggcaactga acaaggaaga atgaagttta cccggccctt attcaaggat cttgctgcct
     1801 ttgacaaatc ccatgatcaa gctgtccgaa cctaccaaga gcacaaagca agcatgcatc
     1861 ccgtgactgc aatgctggtg gggaaagact taaaagtgga ttaaagacct gcgtattgat
     1921 gattttagag atttctcttt tttaaatgga attcgtaaag aaatataaaa cttcagctca
     1981 caattaaaac tgtcttttta gttttggctt tttattgttt tgttggtgat tttactgaaa
     2041 taaagttgag ctacttcttc ttatagtggc atattctttg taaattttaa caaggtttaa
     2101 tcttttgatt tacaaattaa aaaattttga attagcttta
//
