LOCUS       NM_205839                666 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leukocyte specific transcript 1 (LST1), transcript
            variant 4, mRNA.
ACCESSION   NM_205839
VERSION     NM_205839.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 666)
  AUTHORS   Zhang,J., Cheng,S., Xie,S., Xie,Z., Zhang,H., Wang,F., Gao,K. and
            Jiang,W.
  TITLE     Significance of leukocyte-specific transcript 1 levels in nasal
            mucosal tissue to predict recurrence of nasal polyps
  JOURNAL   Braz J Otorhinolaryngol 89 (2), 321-328 (2023)
   PUBMED   36754676
  REMARK    GeneRIF: Significance of leukocyte-specific transcript 1 levels in
            nasal mucosal tissue to predict recurrence of nasal polyps.
REFERENCE   2  (bases 1 to 666)
  AUTHORS   Weidle,U.H., Rohwedder,I., Birzele,F., Weiss,E.H. and Schiller,C.
  TITLE     LST1: A multifunctional gene encoded in the MHC class III region
  JOURNAL   Immunobiology 223 (11), 699-708 (2018)
   PUBMED   30055863
  REMARK    GeneRIF: the present review describes LST1 promotor, gene
            organization, splice variants and expression in human tissues, cell
            lines and cancer with the focus on LST1 expression in inflammation,
            autoimmune diseases and cancer
            Review article
REFERENCE   3  (bases 1 to 666)
  AUTHORS   Fritsch-Stork,R.D., Silva-Cardoso,S.C., Groot Koerkamp,M.J.,
            Broen,J.C., Lafeber,F.F. and Bijlsma,J.W.
  TITLE     Expression of ERAP2 and LST1 is increased before start of therapy
            in rheumatoid arthritis patients with good clinical response to
            glucocorticoids
  JOURNAL   Clin Exp Rheumatol 34 (4), 685-689 (2016)
   PUBMED   27384923
  REMARK    GeneRIF: Increased expression of LST1 in GC-responders before
            therapy warrants further investigation into their role as potential
            predictors for the response to GC, and in the inflammatory process
            of rheumatoid arthritis.
REFERENCE   4  (bases 1 to 666)
  AUTHORS   Woo,J. and Lee,C.
  TITLE     Identification of functional haplotypes in the promoter region of
            the LST1 gene
  JOURNAL   Biochem Genet 52 (7-8), 365-371 (2014)
   PUBMED   24803336
  REMARK    GeneRIF: Psoriasis was associated with promoter variant, rs9267502
            of LST1.Promoter activity was examined and it was larger than that
            of the other genetic variants, most probably due to changes in
            binding affinity to transcription factors.
REFERENCE   5  (bases 1 to 666)
  AUTHORS   Schiller,C., Nowak,C., Diakopoulos,K.N., Weidle,U.H. and Weiss,E.H.
  TITLE     An upstream open reading frame regulates LST1 expression during
            monocyte differentiation
  JOURNAL   PLoS One 9 (5), e96245 (2014)
   PUBMED   24816991
  REMARK    GeneRIF: Data indicate that the MHC class III gene LST1 5'
            untranslated regions (5'-UTR) contains several upstream open
            reading frames (uORFs).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 666)
  AUTHORS   Pende,D., Parolini,S., Pessino,A., Sivori,S., Augugliaro,R.,
            Morelli,L., Marcenaro,E., Accame,L., Malaspina,A., Biassoni,R.,
            Bottino,C., Moretta,L. and Moretta,A.
  TITLE     Identification and molecular characterization of NKp30, a novel
            triggering receptor involved in natural cytotoxicity mediated by
            human natural killer cells
  JOURNAL   J Exp Med 190 (10), 1505-1516 (1999)
   PUBMED   10562324
REFERENCE   7  (bases 1 to 666)
  AUTHORS   de Baey,A., Fellerhoff,B., Maier,S., Martinozzi,S., Weidle,U. and
            Weiss,E.H.
  TITLE     Complex expression pattern of the TNF region gene LST1 through
            differential regulation, initiation, and alternative splicing
  JOURNAL   Genomics 45 (3), 591-600 (1997)
   PUBMED   9367684
REFERENCE   8  (bases 1 to 666)
  AUTHORS   Nalabolu,S.R., Shukla,H., Nallur,G., Parimoo,S. and Weissman,S.M.
  TITLE     Genes in a 220-kb region spanning the TNF cluster in human MHC
  JOURNAL   Genomics 31 (2), 215-222 (1996)
   PUBMED   8824804
REFERENCE   9  (bases 1 to 666)
  AUTHORS   Holzinger,I., de Baey,A., Messer,G., Kick,G., Zwierzina,H. and
            Weiss,E.H.
  TITLE     Cloning and genomic characterization of LST1: a new gene in the
            human TNF region
  JOURNAL   Immunogenetics 42 (5), 315-322 (1995)
   PUBMED   7590964
REFERENCE   10 (bases 1 to 666)
  AUTHORS   Abraham,L.J., Grimsley,G., Zhang,W.J., Degli-Esposti,M.A. and
            Dawkins,R.L.
  TITLE     Polymorphism in the human B144 gene in different MHC haplotypes
  JOURNAL   Eur J Immunogenet 19 (3), 165-168 (1992)
   PUBMED   1352700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF000425.1, AL662801.7 and
            AI091696.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_205839.2.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can inhibit the proliferation of lymphocytes. Expression of
            this gene is enhanced by lipopolysaccharide, interferon-gamma, and
            bacteria. Several transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (4) includes an additional exon in
            the 5' UTR and uses an alternate in-frame splice site in the 3'
            coding region, compared to variant 1. The encoded isoform (4) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF000425.1, DRR138524.36057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438075.7/ ENSP00000391929.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AF000425.1         77-350
            275-275             AL662801.7         61189-61189
            276-567             AF000425.1         352-643
            568-666             AI091696.1         6-104               c
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..666
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /note="leukocyte specific transcript 1"
                     /db_xref="GeneID:7940"
                     /db_xref="HGNC:HGNC:14189"
                     /db_xref="MIM:109170"
     exon            1..39
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            40..158
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..433
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     lymphocyte antigen 117; leukocyte-specific transcript 1
                     protein"
                     /codon_start=1
                     /product="leukocyte-specific transcript 1 protein isoform
                     4"
                     /protein_id="NP_995311.2"
                     /db_xref="CCDS:CCDS43450.2"
                     /db_xref="GeneID:7940"
                     /db_xref="HGNC:HGNC:14189"
                     /db_xref="MIM:109170"
                     /translation="MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERS
                     WAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT"
     exon            159..251
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..274
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..666
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      493..498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /note="hexamer: AGTAAA"
     polyA_site      514
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
     regulatory      633..638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /note="hexamer: AATAAA"
     polyA_site      666
                     /gene="LST1"
                     /gene_synonym="B144; D6S49E; LST-1"
                     /note="major polyA site"
ORIGIN      
        1 agtttggagt ctgtccatcc tgcaggccac aagctctgga tgaggaactt gaggcaagtc
       61 accagcccct gatcatttcg cctaaaagag caaggactag agttcctgac ctccaggcca
      121 gtccctgatc cctgacctaa tgttatcgcg gaatgatgat atatgtatct acgggggcct
      181 ggggctgggc gggctcctgc ttctggcagt ggtccttctg tccgcctgcc tgtgttggct
      241 gcatcgaaga gtaaagaggc tggagaggag ctgggcccag ggctcctcag agcaggaact
      301 ccactatgca tctctgcaga ggctgccagt gcccagcagt gagggacctg acctcagggg
      361 cagagacaag agaggcacca aggaggatcc aagagctgac tatgcctgca ttgctgagaa
      421 caaacccacc tgagcacccc agacaccttc ctcaacccag gcgggtggac agggtccccc
      481 tgtggtccag ccagtaaaaa ccatggtccc cccacttctg tgtctcagtc ctctcagtcc
      541 atctcgagcc tccgttcaaa ttgatcatca tcaaaactta tgtggctttt tgacctttga
      601 atagggaatt ttttaaattt tttaaaaatt aaaataaaaa aaacacatgg ctcacccttc
      661 caccca
//
