LOCUS       NM_002340               4886 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lanosterol synthase (LSS), transcript variant 1, mRNA.
ACCESSION   NM_002340
VERSION     NM_002340.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4886)
  AUTHORS   Umano,G.R., Cirillo,G., Rondinelli,G., Sanchez,G., Marzuillo,P.,
            Guarino,S., Di Sessa,A., Papparella,A. and Miraglia Del Giudice,E.
  TITLE     LSS rs2254524 Increases the Risk of Hypertension in Children and
            Adolescents with Obesity
  JOURNAL   Genes (Basel) 14 (8), 1618 (2023)
   PUBMED   37628669
  REMARK    GeneRIF: LSS rs2254524 Increases the Risk of Hypertension in
            Children and Adolescents with Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4886)
  AUTHORS   Cesarato,N., Wehner,M., Ghughunishvili,M., Schmidt,A., Axt,D.,
            Thiele,H., Lentze,M.J., Has,C., Geyer,M., Basmanav,F.B. and
            Betz,R.C.
  TITLE     Four hypotrichosis families with mutations in the gene LSS
            presenting with and without neurodevelopmental phenotypes
  JOURNAL   Am J Med Genet A 185 (12), 3900-3904 (2021)
   PUBMED   34318586
  REMARK    GeneRIF: Four hypotrichosis families with mutations in the gene LSS
            presenting with and without neurodevelopmental phenotypes.
REFERENCE   3  (bases 1 to 4886)
  AUTHORS   Hua,S., Ding,Y., Zhang,J., Qian,Q. and Li,M.
  TITLE     Novel mutations in Chinese hypotrichosis simplex patients
            associated with LSS gene
  JOURNAL   J Dermatol 48 (3), 408-412 (2021)
   PUBMED   33222230
  REMARK    GeneRIF: Novel mutations in Chinese hypotrichosis simplex patients
            associated with LSS gene.
REFERENCE   4  (bases 1 to 4886)
  AUTHORS   Zou,X., Wang,H., Zhou,D., Liu,Z., Wang,Y., Deng,G. and Guan,H.
  TITLE     The Polymorphism rs2968 of LSS Gene Confers Susceptibility to
            Age-Related Cataract
  JOURNAL   DNA Cell Biol 39 (11), 1970-1975 (2020)
   PUBMED   32877255
  REMARK    GeneRIF: The Polymorphism rs2968 of LSS Gene Confers Susceptibility
            to Age-Related Cataract.
REFERENCE   5  (bases 1 to 4886)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4886)
  AUTHORS   Young,M., Chen,H., Lalioti,M.D. and Antonarakis,S.E.
  TITLE     The human lanosterol synthase gene maps to chromosome 21q22.3
  JOURNAL   Hum Genet 97 (5), 620-624 (1996)
   PUBMED   8655142
REFERENCE   7  (bases 1 to 4886)
  AUTHORS   Mark,M., Muller,P., Maier,R. and Eisele,B.
  TITLE     Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the
            regulation of cholesterol biosynthesis in HepG2 cells
  JOURNAL   J Lipid Res 37 (1), 148-158 (1996)
   PUBMED   8820110
REFERENCE   8  (bases 1 to 4886)
  AUTHORS   Sung,C.K., Shibuya,M., Sankawa,U. and Ebizuka,Y.
  TITLE     Molecular cloning of cDNA encoding human lanosterol synthase
  JOURNAL   Biol Pharm Bull 18 (10), 1459-1461 (1995)
   PUBMED   8593458
REFERENCE   9  (bases 1 to 4886)
  AUTHORS   Baker,C.H., Matsuda,S.P., Liu,D.R. and Corey,E.J.
  TITLE     Molecular cloning of the human gene encoding lanosterol synthase
            from a liver cDNA library
  JOURNAL   Biochem Biophys Res Commun 213 (1), 154-160 (1995)
   PUBMED   7639730
REFERENCE   10 (bases 1 to 4886)
  AUTHORS   Cattel,L., Ceruti,M., Viola,F., Delprino,L., Balliano,G.,
            Duriatti,A. and Bouvier-Nave,P.
  TITLE     The squalene-2,3-epoxide cyclase as a model for the development of
            new drugs
  JOURNAL   Lipids 21 (1), 31-38 (1986)
   PUBMED   3515096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312489.1, D63807.1 and
            AP001468.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002340.5.
            
            Summary: The protein encoded by this gene catalyzes the conversion
            of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a
            member of the terpene cyclase/mutase family and catalyzes the first
            step in the biosynthesis of cholesterol, steroid hormones, and
            vitamin D. Alternative splicing results in multiple transcript
            variants encoding different isoforms.[provided by RefSeq, Feb
            2009].
            
            Transcript Variant: This variant (1) differs in the 3' UTR,
            compared to variant 2. Variants 1 and 2 encode the same protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic and transcript sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312489.1, SRR1660809.18854.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397728.8/ ENSP00000380837.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1082              AK312489.1         1-1082
            1083-2266           D63807.1           1072-2255
            2267-4886           AP001468.1         33977-36596         c
FEATURES             Location/Qualifiers
     source          1..4886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..4886
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /note="lanosterol synthase"
                     /db_xref="GeneID:4047"
                     /db_xref="HGNC:HGNC:6708"
                     /db_xref="MIM:600909"
     exon            1..43
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2228
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /EC_number="5.4.99.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2,3-epoxysqualene-lanosterol cyclase; hOSC;
                     oxidosqualene--lanosterol cyclase; lanosterol synthase
                     (2,3-oxidosqualene-lanosterol cyclase); epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="lanosterol synthase isoform 1"
                     /protein_id="NP_002331.3"
                     /db_xref="CCDS:CCDS13733.1"
                     /db_xref="GeneID:4047"
                     /db_xref="HGNC:HGNC:6708"
                     /db_xref="MIM:600909"
                     /translation="MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERA
                     GREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPL
                     FLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS
                     LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLF
                     PDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQ
                     RNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSIS
                     IGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFA
                     IQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCG
                     WIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRG
                     GHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEF
                     CRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQM
                     ADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL
                     PNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP"
     exon            44..209
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            210..348
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            349..457
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            458..579
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            580..676
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            677..812
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            813..921
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1040
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1138
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1166
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1223
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1295
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1346
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1496
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1593
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1699
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1765
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1846
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2017
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2096
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..4886
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /note="hexamer: AATAAA"
     polyA_site      4201
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /note="major polyA site"
     regulatory      4865..4870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
                     /note="hexamer: ATTAAA"
     polyA_site      4886
                     /gene="LSS"
                     /gene_synonym="APMR4; CTRCT44; HYPT14; OSC"
ORIGIN      
        1 agtgggcggc gtagagcact gcagcagcaa tgacggaggg cacgtgtctg cggcgccgag
       61 ggggccccta caagaccgag cccgccaccg acctcggccg ctggcgactc aactgcgaga
      121 ggggccggca gacgtggacc tacctgcagg acgagcgcgc cggccgcgag cagaccggcc
      181 tggaagccta cgccctgggg ctggacacca agaattactt taaggacttg cccaaagccc
      241 acaccgcctt tgagggggct ctgaacggga tgacatttta cgtggggctg caggctgagg
      301 atgggcactg gacgggtgat tatggtggcc cacttttcct cctgccaggc ctcctgatca
      361 cttgccacgt ggcacgcatc cctctgccag ccggatacag agaagagatt gtgcggtacc
      421 tgcggtcagt gcagctccct gacggtggct ggggcctgca cattgaggat aagtccaccg
      481 tgtttgggac tgcgctcaac tatgtgtctc tcagaattct gggtgttggg cctgacgatc
      541 ctgacctggt acgagcccgg aacattcttc acaagaaagg tggtgctgtg gccatcccct
      601 cctgggggaa gttctggctg gctgtcctga atgtttacag ctgggaaggc ctcaataccc
      661 tgttcccaga gatgtggctg tttcctgact gggcaccggc acacccctcc acactctggt
      721 gccactgccg gcaggtgtac ctgcccatga gctactgcta cgccgttcgg ctgagtgccg
      781 cggaagaccc gctggtccag agcctccgcc aggagctcta tgtggaggac ttcgccagca
      841 ttgactggct ggcgcagagg aacaacgtgg cccccgacga gctgtacacg ccgcacagct
      901 ggctgctccg cgtggtatat gcgctcctca acctgtatga gcaccaccac agtgcccacc
      961 tgcggcagcg ggccgtgcag aagctgtatg aacacattgt ggccgacgac cgattcacca
     1021 agagcatcag catcggcccg atctcgaaaa ccatcaacat gcttgtgcgc tggtatgtgg
     1081 acgggcccgc ctccactgcc ttccaggagc atgtctccag aatcccggac tatctctgga
     1141 tgggccttga cggcatgaaa atgcagggca ccaacggctc acagatctgg gacaccgcat
     1201 tcgccatcca ggctctgctt gaggcgggcg ggcaccacag gcccgagttt tcgtcctgcc
     1261 tgcagaaggc tcatgagttc ctgaggctct cacaggtccc agataaccct cccgactacc
     1321 agaagtacta ccgccagatg cgcaagggtg gcttctcctt cagtacgctg gactgcggct
     1381 ggatcgtttc tgactgcacg gctgaggcct tgaaggctgt gctgctcctg caggagaagt
     1441 gtccccatgt caccgagcac atccccagag aacggctctg cgatgctgtg gctgtgctgc
     1501 tgaacatgag aaatccagat ggagggttcg ccacctatga gaccaagcgt ggggggcact
     1561 tgctggagct gctgaacccc tcggaggtct tcggggacat catgattgac tacacctatg
     1621 tggagtgcac ctcagccgtg atgcaggcgc ttaagtattt ccacaagcgt ttcccggagc
     1681 acagggcagc ggagatccgg gagaccctca cgcagggctt agagttctgt cggcggcagc
     1741 agagggccga tggctcctgg gaaggctcct ggggagtttg cttcacctac ggcacctggt
     1801 ttggcctgga ggccttcgcc tgtatggggc agacctaccg agatgggact gcctgtgcag
     1861 aggtctcccg ggcctgtgac ttcctgctgt cccggcagat ggcagacgga ggctgggggg
     1921 aggactttga gtcctgcgag gagcggcgtt atttgcagag tgcccagtcc cagatccata
     1981 acacatgctg ggccatgatg gggctgatgg ccgttcggca tcctgacatc gaggcccagg
     2041 agagaggagt ccggtgtcta cttgagaaac agctccccaa tggcgactgg ccgcaggaaa
     2101 acattgctgg ggtcttcaac aagtcctgtg ccatctccta cacgagctac aggaacatct
     2161 tccccatctg ggccctcggc cgcttctccc agctgtaccc tgagagagcc cttgctggcc
     2221 acccctgaga acatgcctac ctgctgggtg ccgtctgtgc gttccagtga ggccaagggg
     2281 tcctggccgg gttggggagc cctcccataa ccctgtcttg ggctccaacc cctcaacctc
     2341 tatctcatag atgtgaatct gggggccagg ctggaggcag ggatggggac agggtgggtg
     2401 gcttagactc ttgattttta ctgtaggttc atttctgaaa gtagcttgtc gggcttgggt
     2461 gaggaagggg gcacaggagc cgtgacccct gaggaggcac agcgccttct gccacctctg
     2521 ggcacggcct caaggtagtg aggctaggag gttttttctg accaatagct gagttcttgg
     2581 gagaggagca gctgtgcctg tgtgattcct tagtgtcgag tgggctctgg gctggggtcg
     2641 gccctgggca ggcttctcct gcaccttttg tctgctgggc tgagggacac gagggcaacc
     2701 ctgtgacaat ggcaggtagt gtgcatccgt gaatagccca gtgcgggggt tgctcatgga
     2761 gcatcctgag gccgtgcagc agggagcccc atgcccctgg gtcgtgagct tgcctgcgta
     2821 tggggtggtg tcatggagcc tcatgcccct gggtcgtgag ctcgcctgag tatggggtgg
     2881 tgtcatggag ccgcataccc ctgggttgtg agctcgcctg catatgcagg gtctgtcatg
     2941 gaacatccca agtctgtgca gcagggagcc ccatgcccct gggacatgaa cccacctgcg
     3001 tggaatgctg tttgtgaggt gtctacaggg tttatagtag tcttgtggac acagaaatgc
     3061 acaggggaca cttacggaca cagaaatgca caggggaggc cgagcataac caggggtgag
     3121 gggcaggcag cagttgtagt tactgccgcg gggcactgct atgtgcaggg acagccagca
     3181 cccagcccat caccactccc tgggctggct ggcaggtatg gcaccctggg agcccggcat
     3241 atacccaggg cacccctacg gctgccgcca gtctcatgcc caggtgggtg ctctgggctg
     3301 gagcgagggc caggttttgg gccgaggctt ccccaggcaa tcctgtgagc tcccttctag
     3361 cctctgaccc agtctggtct ggcttgcatg gatgtagggc ttggggtggg aagttcaggt
     3421 cctggctttg cctttgcctg atgtggatga gcagctcaca tgctcagggc cacctgagac
     3481 tgtcactgct ctcccctggc tactgggagg agtcactgag agcttcgtta cccctgctgc
     3541 cttgcccagg gcacacccta tacctcctta tctgctcttc ccctccctgc cgccttctgg
     3601 gcaggtagca gtccctggcc tctccccctg gctgatcact ctccctcagg cagtggagat
     3661 ctgcgtctgg acaccctcag atcctgtcat tgcctgccca gagtccttca ggggcacccc
     3721 tctgccttgg tgtgcagtcc agggctctca cccaggtgcc gcaccctctg gggtcttctg
     3781 tccagctccc ttgccccatg tgctgtcact gactctcctt gggactcgcc tgcctgctca
     3841 gagccctgca gggcttggtc agctgcctgt tcagtgtcaa cacttccctg cacatcttaa
     3901 aactgggctt tattttcgct gaaggaactg tgttgggacc cttgacatct gtcaggtttg
     3961 cacatgctgt ttttttttct cagcccacgt gttctccccc acgtggggta gcagcaggac
     4021 agacagtgaa tcacagagtc tgccctgagc agaggctgct gtccctggga ctcctagcca
     4081 tggtcagact gtacaaaacg gttttccaga aatgaaatgt aaatccattt ttatactgaa
     4141 aatgttactg aaagtcactt ttatgagcat ctgccttaat aaacagacat tgattccctt
     4201 atcagaagcc tgtcacactg tgtttcgttt catcctgggg agaactgcag atttggggtt
     4261 tctggctgtc atacgtcacc tgcctgtggg gcgagtggga ggcccagcct ggtttaggga
     4321 acaagagtga cgtgaggagt agcagggtgc gtctccagtt acctgaggga aaacagatat
     4381 tttaagagat aatagcatag cctattttaa tatgttttaa aggccataag catatccagg
     4441 aagataaata aacgtgatac aatgtccaca taggaggaac tttctttcac tgcattgttt
     4501 tccttcacag tggccttcaa gtcacaggac gcagcgattc cctgccctct tcggtgttat
     4561 tacacaggca ggacttcagt gtcagtatcc ctgccttcag tcttctttag aaatcacatc
     4621 tgtgttcaat ccattgttta gagggagtgt atttttcctg ttccacgaag aggacttttt
     4681 gttcacaatt ggatcacaat gcagaggagt ctgttcctcc cccgtcggct tctcggtgct
     4741 gggagggtga cctgtcccag atgactcatc accctgacat gctcttgaca aaggacacca
     4801 ccaagaggag atggcagctg taccggtgca gcctctgtct gagggggata tttgcctcag
     4861 tgtgattaaa aatcagtcat gaaaga
//
