LOCUS       NM_205835               1728 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens lipolysis stimulated lipoprotein receptor (LSR),
            transcript variant 3, mRNA.
ACCESSION   NM_205835
VERSION     NM_205835.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Arai,W., Konno,T., Kohno,T., Kodera,Y., Tsujiwaki,M., Shindo,Y.,
            Chiba,H., Miyajima,M., Sakuma,Y., Watanabe,A. and Kojima,T.
  TITLE     Downregulation of angulin-1/LSR induces malignancy via upregulation
            of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism
            in human lung adenocarcinoma A549 cells
  JOURNAL   Oncotarget 14, 261-275 (2023)
   PUBMED   36961882
  REMARK    GeneRIF: Downregulation of angulin-1/LSR induces malignancy via
            upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell
            metabolism in human lung adenocarcinoma A549 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Kohno,T., Konno,T., Kikuchi,S., Kondoh,M. and Kojima,T.
  TITLE     Translocation of LSR from tricellular corners causes
            macropinocytosis at cell-cell interface as a trigger for breaking
            out of contact inhibition
  JOURNAL   FASEB J 35 (9), e21742 (2021)
   PUBMED   34403506
  REMARK    GeneRIF: Translocation of LSR from tricellular corners causes
            macropinocytosis at cell-cell interface as a trigger for breaking
            out of contact inhibition.
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Zhang,M. and Ma,C.
  TITLE     LSR Promotes Cell Proliferation and Invasion in Lung Cancer
  JOURNAL   Comput Math Methods Med 2021, 6651907 (2021)
   PUBMED   33763152
  REMARK    GeneRIF: LSR Promotes Cell Proliferation and Invasion in Lung
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Takahashi,Y., Serada,S., Ohkawara,T., Fujimoto,M., Hiramatsu,K.,
            Ueda,Y., Kimura,T., Takemori,H. and Naka,T.
  TITLE     LSR promotes epithelial ovarian cancer cell survival under energy
            stress through the LKB1-AMPK pathway
  JOURNAL   Biochem Biophys Res Commun 537, 93-99 (2021)
   PUBMED   33388415
  REMARK    GeneRIF: LSR promotes epithelial ovarian cancer cell survival under
            energy stress through the LKB1-AMPK pathway.
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Hu,J.E., Bojarski,C., Branchi,F., Fromm,M. and Krug,S.M.
  TITLE     Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3
  JOURNAL   Int J Mol Sci 21 (21), 7824 (2020)
   PUBMED   33105684
  REMARK    GeneRIF: Leptin Downregulates Angulin-1 in Active Crohn's Disease
            via STAT3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Amendola,M. and Squires,J.E.
  TITLE     Pediatric Genetic Cholestatic Liver Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36108118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002128.1 and AD000684.1.
            
            On Jul 10, 2020 this sequence version replaced NM_205835.3.
            
            Transcript Variant: This variant (3) lacks an exon in the coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130367.1, SRR14038197.1160624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC002128.1         30457-30586
            131-475             AC002128.1         31770-32114
            476-595             AC002128.1         40400-40519
            596-769             AD000684.1         15324-15497
            770-829             AD000684.1         15644-15703
            830-961             AD000684.1         15801-15932
            962-1587            AD000684.1         16074-16699
            1588-1728           AD000684.1         16789-16929
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1728
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:51599"
                     /db_xref="HGNC:HGNC:29572"
                     /db_xref="MIM:616582"
     exon            1..130
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1623
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; liver-specific bHLH-Zip transcription factor;
                     immunoglobulin-like domain containing receptor 3;
                     lipolysis-stimulated remnant; LISCH protein; angulin-1"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 3 precursor"
                     /protein_id="NP_991404.2"
                     /db_xref="CCDS:CCDS12451.2"
                     /db_xref="GeneID:51599"
                     /db_xref="HGNC:HGNC:29572"
                     /db_xref="MIM:616582"
                     /translation="MALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQV
                     TVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLN
                     AQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQT
                     AWGDSGVYYCSVVSAQDLQGNNEAYAELIVLVYAAGKAATSGVPSIYAPSTYAHLSPA
                     KTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYR
                     IQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGP
                     ALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAES
                     GSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRS
                     HHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYS
                     ETDSQASRERRLKKNLALSRESLVV"
     exon            131..475
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..769
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            770..829
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            830..961
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1587
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1728
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1709..1714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="hexamer: AATAAA"
     polyA_site      1728
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgccc agacggccgc gatggcgctg ttggccggcg ggctctccag agggctgggc
       61 tcccacccgg ccgccgcagg ccgggacgcg gtcgtcttcg tgtggcttct gcttagcacc
      121 tggtgcacag ctcctgccag ggccatccag gtgaccgtgt ccaaccccta ccacgtggtg
      181 atcctcttcc agcctgtgac cctgccctgt acctaccaga tgacctcgac ccccacgcaa
      241 cccatcgtca tctggaagta caagtctttc tgccgggacc gcatcgccga tgccttctcc
      301 ccggccagcg tcgacaacca gctcaatgcc cagctggcag ccgggaaccc aggctacaac
      361 ccctacgttg agtgccagga cagcgtgcgc accgtcaggg tcgtggccac caagcagggc
      421 aacgctgtga ccctgggaga ttactaccag ggccggagga ttaccatcac cggaaatgct
      481 gacctgacct ttgaccagac ggcgtggggg gacagtggtg tgtattactg ctccgtggtc
      541 tcagcccagg acctccaggg gaacaatgag gcctacgcag agctcatcgt ccttgtgtat
      601 gccgccggca aagcagccac ctcaggtgtt cccagcattt atgcccccag cacctatgcc
      661 cacctgtctc ccgccaagac cccaccccca ccagctatga ttcccatggg ccctgcctac
      721 aacgggtacc ctggaggata ccctggagac gttgacagga gtagctcagc tggtggccaa
      781 ggctcctatg tacccctgct tcgggacacg gacagcagtg tggcctctga agtccgcagt
      841 ggctacagga ttcaggccag ccagcaggac gactccatgc gggtcctgta ctacatggag
      901 aaggagctgg ccaacttcga cccttctcga cctggccccc ccagtggccg tgtggagcgg
      961 gccatgagtg aagtcacctc cctccacgag gacgactggc gatctcggcc ttcccggggc
     1021 cctgccctca ccccgatccg ggatgaggag tggggtggcc actccccccg gagtcccagg
     1081 ggatgggacc aggagcccgc cagggagcag gcaggcgggg gctggcgggc caggcggccc
     1141 cgggcccgct ccgtggacgc cctggacgac ctcaccccgc cgagcaccgc cgagtcaggg
     1201 agcaggtctc ccacgagtaa tggtgggaga agccgggcct acatgccccc gcggagccgc
     1261 agccgggacg acctctatga ccaagacgac tcgagggact tcccacgctc ccgggacccc
     1321 cactacgacg acttcaggtc tcgggagcgc cctcctgccg accccaggtc ccaccaccac
     1381 cgtacccggg accctcggga caacggctcc aggtccgggg acctccccta tgatgggcgg
     1441 ctactggagg aggctgtgag gaagaagggg tcggaggaga ggaggagacc ccacaaggag
     1501 gaggaggaag aggcctacta cccgcccgcg ccgcccccgt actcggagac cgactcgcag
     1561 gcgtcccgag agcgcaggct caagaagaac ttggccctga gtcgggaaag tttagtcgtc
     1621 tgatctgacg ttttctacgt agcttttgta tttttttttt taatttgaag gaacactgat
     1681 gaagccctgc catacccctc ccgagtctaa taaaacgtat aatcacaa
//
