LOCUS       NM_205834               1932 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens lipolysis stimulated lipoprotein receptor (LSR),
            transcript variant 2, mRNA.
ACCESSION   NM_205834
VERSION     NM_205834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Arai,W., Konno,T., Kohno,T., Kodera,Y., Tsujiwaki,M., Shindo,Y.,
            Chiba,H., Miyajima,M., Sakuma,Y., Watanabe,A. and Kojima,T.
  TITLE     Downregulation of angulin-1/LSR induces malignancy via upregulation
            of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism
            in human lung adenocarcinoma A549 cells
  JOURNAL   Oncotarget 14, 261-275 (2023)
   PUBMED   36961882
  REMARK    GeneRIF: Downregulation of angulin-1/LSR induces malignancy via
            upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell
            metabolism in human lung adenocarcinoma A549 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Kohno,T., Konno,T., Kikuchi,S., Kondoh,M. and Kojima,T.
  TITLE     Translocation of LSR from tricellular corners causes
            macropinocytosis at cell-cell interface as a trigger for breaking
            out of contact inhibition
  JOURNAL   FASEB J 35 (9), e21742 (2021)
   PUBMED   34403506
  REMARK    GeneRIF: Translocation of LSR from tricellular corners causes
            macropinocytosis at cell-cell interface as a trigger for breaking
            out of contact inhibition.
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Zhang,M. and Ma,C.
  TITLE     LSR Promotes Cell Proliferation and Invasion in Lung Cancer
  JOURNAL   Comput Math Methods Med 2021, 6651907 (2021)
   PUBMED   33763152
  REMARK    GeneRIF: LSR Promotes Cell Proliferation and Invasion in Lung
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Takahashi,Y., Serada,S., Ohkawara,T., Fujimoto,M., Hiramatsu,K.,
            Ueda,Y., Kimura,T., Takemori,H. and Naka,T.
  TITLE     LSR promotes epithelial ovarian cancer cell survival under energy
            stress through the LKB1-AMPK pathway
  JOURNAL   Biochem Biophys Res Commun 537, 93-99 (2021)
   PUBMED   33388415
  REMARK    GeneRIF: LSR promotes epithelial ovarian cancer cell survival under
            energy stress through the LKB1-AMPK pathway.
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Hu,J.E., Bojarski,C., Branchi,F., Fromm,M. and Krug,S.M.
  TITLE     Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3
  JOURNAL   Int J Mol Sci 21 (21), 7824 (2020)
   PUBMED   33105684
  REMARK    GeneRIF: Leptin Downregulates Angulin-1 in Active Crohn's Disease
            via STAT3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1932)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   8  (bases 1 to 1932)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 1932)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
REFERENCE   10 (bases 1 to 1932)
  AUTHORS   Amendola,M. and Squires,J.E.
  TITLE     Pediatric Genetic Cholestatic Liver Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36108118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002128.1 and AD000684.1.
            
            On Jul 10, 2020 this sequence version replaced NM_205834.3.
            
            Transcript Variant: This variant (2) includes an alternate exon in
            the coding region, but maintains the reading frame, compared to
            variant 1. The encoded isoform (2) is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047376.1, SRR11853567.15489.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605618.6/ ENSP00000474797.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC002128.1         30457-30586
            131-475             AC002128.1         31770-32114
            476-595             AC002128.1         40400-40519
            596-652             AC002128.1         43380-43436
            653-799             AC002128.1         44001-44147
            800-973             AD000684.1         15324-15497
            974-1033            AD000684.1         15644-15703
            1034-1165           AD000684.1         15801-15932
            1166-1791           AD000684.1         16074-16699
            1792-1932           AD000684.1         16789-16929
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1932
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:51599"
                     /db_xref="HGNC:HGNC:29572"
                     /db_xref="MIM:616582"
     exon            1..130
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1827
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; liver-specific bHLH-Zip transcription factor;
                     immunoglobulin-like domain containing receptor 3;
                     lipolysis-stimulated remnant; LISCH protein; angulin-1"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 2 precursor"
                     /protein_id="NP_991403.2"
                     /db_xref="CCDS:CCDS12450.2"
                     /db_xref="GeneID:51599"
                     /db_xref="HGNC:HGNC:29572"
                     /db_xref="MIM:616582"
                     /translation="MALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQV
                     TVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLN
                     AQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQT
                     AWGDSGVYYCSVVSAQDLQGNNEAYAELIVLGRTSGVAELLPGFQAGPIEDWLFVVVV
                     CLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYA
                     PSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSS
                     VASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHED
                     DWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALD
                     DLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRS
                     RERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEA
                     YYPPAPPPYSETDSQASRERRLKKNLALSRESLVV"
     exon            131..475
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..652
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            653..799
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            800..973
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1033
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1165
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1791
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1932
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="LSR"
                     /gene_synonym="ILDR3; LISCH7"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgccc agacggccgc gatggcgctg ttggccggcg ggctctccag agggctgggc
       61 tcccacccgg ccgccgcagg ccgggacgcg gtcgtcttcg tgtggcttct gcttagcacc
      121 tggtgcacag ctcctgccag ggccatccag gtgaccgtgt ccaaccccta ccacgtggtg
      181 atcctcttcc agcctgtgac cctgccctgt acctaccaga tgacctcgac ccccacgcaa
      241 cccatcgtca tctggaagta caagtctttc tgccgggacc gcatcgccga tgccttctcc
      301 ccggccagcg tcgacaacca gctcaatgcc cagctggcag ccgggaaccc aggctacaac
      361 ccctacgttg agtgccagga cagcgtgcgc accgtcaggg tcgtggccac caagcagggc
      421 aacgctgtga ccctgggaga ttactaccag ggccggagga ttaccatcac cggaaatgct
      481 gacctgacct ttgaccagac ggcgtggggg gacagtggtg tgtattactg ctccgtggtc
      541 tcagcccagg acctccaggg gaacaatgag gcctacgcag agctcatcgt ccttgggagg
      601 acctcagggg tggctgagct cttacctggt tttcaggcgg ggcccataga agactggctc
      661 ttcgtggttg tggtatgcct ggctgccttc ctcatcttcc tcctcctggg catctgctgg
      721 tgccagtgct gcccgcacac ttgctgctgc tacgtcaggt gcccctgctg cccagacaag
      781 tgctgctgcc ccgaggccct gtatgccgcc ggcaaagcag ccacctcagg tgttcccagc
      841 atttatgccc ccagcaccta tgcccacctg tctcccgcca agaccccacc cccaccagct
      901 atgattccca tgggccctgc ctacaacggg taccctggag gataccctgg agacgttgac
      961 aggagtagct cagctggtgg ccaaggctcc tatgtacccc tgcttcggga cacggacagc
     1021 agtgtggcct ctgaagtccg cagtggctac aggattcagg ccagccagca ggacgactcc
     1081 atgcgggtcc tgtactacat ggagaaggag ctggccaact tcgacccttc tcgacctggc
     1141 ccccccagtg gccgtgtgga gcgggccatg agtgaagtca cctccctcca cgaggacgac
     1201 tggcgatctc ggccttcccg gggccctgcc ctcaccccga tccgggatga ggagtggggt
     1261 ggccactccc cccggagtcc caggggatgg gaccaggagc ccgccaggga gcaggcaggc
     1321 gggggctggc gggccaggcg gccccgggcc cgctccgtgg acgccctgga cgacctcacc
     1381 ccgccgagca ccgccgagtc agggagcagg tctcccacga gtaatggtgg gagaagccgg
     1441 gcctacatgc ccccgcggag ccgcagccgg gacgacctct atgaccaaga cgactcgagg
     1501 gacttcccac gctcccggga cccccactac gacgacttca ggtctcggga gcgccctcct
     1561 gccgacccca ggtcccacca ccaccgtacc cgggaccctc gggacaacgg ctccaggtcc
     1621 ggggacctcc cctatgatgg gcggctactg gaggaggctg tgaggaagaa ggggtcggag
     1681 gagaggagga gaccccacaa ggaggaggag gaagaggcct actacccgcc cgcgccgccc
     1741 ccgtactcgg agaccgactc gcaggcgtcc cgagagcgca ggctcaagaa gaacttggcc
     1801 ctgagtcggg aaagtttagt cgtctgatct gacgttttct acgtagcttt tgtatttttt
     1861 tttttaattt gaaggaacac tgatgaagcc ctgccatacc cctcccgagt ctaataaaac
     1921 gtataatcac aa
//
