LOCUS       NM_002339               1585 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens lymphocyte specific protein 1 (LSP1), transcript
            variant 1, mRNA.
ACCESSION   NM_002339
VERSION     NM_002339.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Li,T., Gui,X., Li,B., Hu,X. and Wang,Y.
  TITLE     LSP1 promotes the progression of acute myelogenous leukemia by
            regulating KSR/ERK signaling pathway and cell migration
  JOURNAL   Hematology 29 (1), 2330285 (2024)
   PUBMED   38511641
  REMARK    GeneRIF: LSP1 promotes the progression of acute myelogenous
            leukemia by regulating KSR/ERK signaling pathway and cell
            migration.
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Smeir,M., Chumala,P., Katselis,G.S. and Liu,L.
  TITLE     Lymphocyte-Specific Protein 1 Regulates Expression and Stability of
            Endothelial Nitric Oxide Synthase
  JOURNAL   Biomolecules 14 (1), 111 (2024)
   PUBMED   38254711
  REMARK    GeneRIF: Lymphocyte-Specific Protein 1 Regulates Expression and
            Stability of Endothelial Nitric Oxide Synthase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Ocana-Guzman,R., Ramon-Luing,L.A., Vazquez-Bolanos,L.A.,
            Rodriguez-Alvarado,M., Bulhusen-Rodriguez,F., Torres-Hatem,A.,
            Gonzalez-Torres,K., de Alba-Alvarado,M.C. and Sada-Ovalle,I.
  TITLE     Tim-3 Is Differentially Expressed during Cell Activation and
            Interacts with the LSP-1 Protein in Human Macrophages
  JOURNAL   J Immunol Res 2023, 3577334 (2023)
   PUBMED   37928435
  REMARK    GeneRIF: Tim-3 Is Differentially Expressed during Cell Activation
            and Interacts with the LSP-1 Protein in Human Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Chen,J., Xiao,Q., Li,X., Liu,R., Long,X., Liu,Z., Xiong,H. and
            Li,Y.
  TITLE     The correlation of leukocyte-specific protein 1 (LSP1)
            rs3817198(T>C) polymorphism with breast cancer: A meta-analysis
  JOURNAL   Medicine (Baltimore) 101 (45), e31548 (2022)
   PUBMED   36397430
  REMARK    GeneRIF: The correlation of leukocyte-specific protein 1 (LSP1)
            rs3817198(T>C) polymorphism with breast cancer: A meta-analysis.
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Li,Y., Guerrero,A. and Howard,T.H.
  TITLE     The actin-binding protein, lymphocyte-specific protein 1, is
            expressed in human leukocytes and human myeloid and lymphoid cell
            lines
  JOURNAL   J Immunol 155 (7), 3563-3569 (1995)
   PUBMED   7561054
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Misener,V.L., Hui,C., Malapitan,I.A., Ittel,M.E., Joyner,A.L. and
            Jongstra,J.
  TITLE     Expression of mouse LSP1/S37 isoforms. S37 is expressed in
            embryonic mesenchymal cells
  JOURNAL   J Cell Sci 107 (Pt 12), 3591-3600 (1994)
   PUBMED   7706408
REFERENCE   8  (bases 1 to 1585)
  AUTHORS   Kadiyala,R.K., McIntyre,B.W. and Krensky,A.M.
  TITLE     Molecular cloning and characterization of WP34, a phosphorylated
            human lymphocyte differentiation and activation antigen
  JOURNAL   Eur J Immunol 20 (11), 2417-2423 (1990)
   PUBMED   2174784
REFERENCE   9  (bases 1 to 1585)
  AUTHORS   Jongstra-Bilen,J., Young,A.J., Chong,R. and Jongstra,J.
  TITLE     Human and mouse LSP1 genes code for highly conserved
            phosphoproteins
  JOURNAL   J Immunol 144 (3), 1104-1110 (1990)
   PUBMED   2295815
REFERENCE   10 (bases 1 to 1585)
  AUTHORS   Klein,D.P., Jongstra-Bilen,J., Ogryzlo,K., Chong,R. and Jongstra,J.
  TITLE     Lymphocyte-specific Ca2+-binding protein LSP1 is associated with
            the cytoplasmic face of the plasma membrane
  JOURNAL   Mol Cell Biol 9 (7), 3043-3048 (1989)
   PUBMED   2674678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC051649.21 and BC001785.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002339.2.
            
            Summary: This gene encodes an intracellular F-actin binding
            protein. The protein is expressed in lymphocytes, neutrophils,
            macrophages, and endothelium and may regulate neutrophil motility,
            adhesion to fibrinogen matrix proteins, and transendothelial
            migration. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) contains an alternate exon and
            lacks two exons in the 5' coding region compared to variant 5. The
            resulting protein (isoform 1) has a distinct N-terminus and is
            shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001785.1, SRR1163657.24663.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311604.8/ ENSP00000308383.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC051649.21        144820-144933       c
            115-252             AC051649.21        117793-117930       c
            253-417             AC051649.21        116421-116585       c
            418-559             AC051649.21        114457-114598       c
            560-652             AC051649.21        113993-114085       c
            653-696             AC051649.21        113694-113737       c
            697-778             AC051649.21        113436-113517       c
            779-913             AC051649.21        111151-111285       c
            914-991             AC051649.21        110703-110780       c
            992-1094            AC051649.21        110441-110543       c
            1095-1554           AC051649.21        105785-106244       c
            1555-1585           BC001785.1         1560-1590
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1585
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /note="lymphocyte specific protein 1"
                     /db_xref="GeneID:4046"
                     /db_xref="HGNC:HGNC:6707"
                     /db_xref="MIM:153432"
     exon            1..114
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1081
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /note="isoform 1 is encoded by transcript variant 1; 52
                     kDa phosphoprotein; lymphocyte-specific antigen WP34; 47
                     kDa actin binding protein; leufactin (leukocyte F-actin
                     binding protein); leukocyte-specific protein 1; F-actin
                     binding and cytoskeleton associated protein"
                     /codon_start=1
                     /product="lymphocyte-specific protein 1 isoform 1"
                     /protein_id="NP_002330.1"
                     /db_xref="CCDS:CCDS31334.1"
                     /db_xref="GeneID:4046"
                     /db_xref="HGNC:HGNC:6707"
                     /db_xref="MIM:153432"
                     /translation="MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQL
                     QAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALD
                     SGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGA
                     EEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKS
                     QPDLPISKIDQWLEQYTQAIETAGRTPKLARQASIELPSMAVASTKSRWETGEVQAQS
                     AAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVE
                     GGPAP"
     exon            115..252
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            253..417
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            418..559
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            560..652
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            653..696
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            697..778
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            779..913
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            914..991
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1094
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1585
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /note="hexamer: AATAAA"
     polyA_site      1585
                     /gene="LSP1"
                     /gene_synonym="pp52; WP34"
                     /note="major polyA site"
ORIGIN      
        1 acagcacgta cacccactcc agggatctgc cagcaccctg tggggcccag actacaggct
       61 gatggcggag gcttcgagtg acccgggtgc cgaggagcgg gaagagttgc tggggcccac
      121 tgctcagtgg agcgtggagg acgaggagga ggccgtccac gagcaatgcc agcatgagag
      181 agacaggcag cttcaggccc aggacgagga gggaggcggc catgtccccg agcggccgaa
      241 gcaggagatg ctcctcagcc tgaagccctc ggaggcccct gaactggatg aggacgaggg
      301 ctttggcgac tggtcccaga ggccagagca gcggcagcag cacgaggggg cgcagggcgc
      361 cttggacagc ggagagcccc cccagtgcag gagtcctgag ggggagcaag aggacaggcc
      421 cggcctgcat gcctacgaaa aggaggacag tgatgaagtc cacctggagg agttgagtct
      481 gagcaaggag gggccaggcc cagaggacac tgtccaggac aacctggggg ccgcaggggc
      541 tgaggaggaa caggaggagc accagaaatg tcagcagccc aggacaccca gccccttggt
      601 cttggagggg accatcgaac agagctcgcc tcccctgagc cctaccacca aactcatcga
      661 caggaccgag tccctaaacc gctccataga gaagagtaac agtgtgaaga aatcccagcc
      721 agacttgccc atctccaaga ttgatcagtg gctggaacaa tacacccagg ccatcgagac
      781 cgctggccgg acccccaagc tagcccgcca ggcctccata gagctgccca gcatggctgt
      841 ggccagtacc aagagtcggt gggagacggg tgaggtacag gctcagtctg cggccaagac
      901 tccgtcctgc aaggatattg tggctggaga catgagcaag aaaagcctct gggagcagaa
      961 gggaggctcc aagacctcat caacaattaa gagcacccca tctgggaaga ggtataagtt
     1021 tgtggccacc gggcatggga agtatgagaa ggtgcttgtg gaagggggcc cggctcccta
     1081 ggcgtcccat ctcgcttcct gggtctgcag gtccagccgg ctggcaccct ccatgtaccc
     1141 aggggagatt ccagccagac acccgccccc cggccctggc taagaagttg cttcctgttg
     1201 ccagcatgac ctaccctcgc ctctttgatg ccatccgctg ccacctcctt ttgctcctgg
     1261 accctttagc ctctctgccc ttccactctc tgaccaccgc ccccgccctc cccacccagc
     1321 tccgcttctt gttacttggg ggaggaaaga aactcctgat cattggccaa agggacttac
     1381 ccctggagag gccaagtgcc ttctaggaag ttaggaggtt gaggcacagc ctgtgcagag
     1441 agggtgggtc acccccccag atccaaggag aaactgcagg tcaagggctg ataacggcca
     1501 tgcaggatgc ttgatgctgc gtcccccgct gcttgccgcc ccccaccccg ccattttgta
     1561 taataaagct ccctgtgtat tctca
//
