LOCUS       NM_153215               1434 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens leucine rich single-pass membrane protein 2 (LSMEM2),
            transcript variant 1, mRNA.
ACCESSION   NM_153215
VERSION     NM_153215.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028000.1 and U90094.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153215.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028000.1, SRR5189655.45685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316436.4/ ENSP00000315081.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               BC028000.1         1-560
            561-561             U90094.1           22044-22044
            562-1434            BC028000.1         562-1434
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1434
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /note="leucine rich single-pass membrane protein 2"
                     /db_xref="GeneID:132228"
                     /db_xref="HGNC:HGNC:26781"
     exon            1..85
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..522
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="leucine-rich single-pass membrane protein 2
                     isoform 1"
                     /protein_id="NP_694947.1"
                     /db_xref="CCDS:CCDS2814.1"
                     /db_xref="GeneID:132228"
                     /db_xref="HGNC:HGNC:26781"
                     /translation="MPSLAPDCPLLAMPEETQEDSVAPMMPSQRSRGPLAPNHVHEVC
                     LHQVESISDLHSGAGTLRPYLTEEARPWDELLGVLPPSLCAQAGCSPVYRRGGFLLLL
                     ALLVLTCLVLALLAVYLSVLQSESLRILAHTLRTQEETLLKLRLASLSQLRRLNSSEA
                     QAPS"
     exon            86..199
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            200..388
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            389..1434
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="LSMEM2"
                     /gene_synonym="C3orf45"
                     /note="major polyA site"
ORIGIN      
        1 gctgcatttg tccagtcctg ctactggatg ccatcattgg cccccgactg cccactgctt
       61 gccatgcctg aggagaccca agaagactcc gtggcgccaa tgatgcccag ccagaggagc
      121 agggggccat tggcccccaa ccacgtgcat gaggtatgcc tgcaccaggt ggagtccatc
      181 agcgacctac atagtggagc aggcacactg cgcccctatc taactgaaga ggcacgaccg
      241 tgggatgagc tgctgggcgt tttgccgccg tcactgtgtg cccaggctgg ctgcagccct
      301 gtgtacagac gaggagggtt cctgctgctg ctcgcgctgc tggtgctcac ttgcctagtg
      361 ctcgcactcc tggctgtcta cctgagcgtg ctgcagagtg aatccctgcg catcctggca
      421 cacacgctcc gcacgcagga ggagacacta ctcaaactcc gcttggccag cctcagccag
      481 cttcggaggc tcaactccag tgaggcccaa gcacccagct gagatgccat ttggatctgg
      541 ggcctggggg tgtgtgttgg tgggggaata aagtggctat gggcaggtct ctccttccct
      601 actgctggct gccacatcta cactatttcc ttggtgagat ttttgtacaa gaacctgttg
      661 ttaacttaat ggctgcctcc ctctcctgat ctcttcaagc caggcctagc caagcctctg
      721 gtgccaaagc ctcgctttgg gtggcccaag gtcaggggaa ggggcaccag cctcctggct
      781 cctcctgtgg cctgtcaaca ctctctggcc accccagatg gcaggttctg aagtctagaa
      841 atagctgccc ccatagcaat cacccaaact ctgccagggc tcccagtgag ggtccagcct
      901 cagctcttaa agacaggctg ggctctgagt agggggagag gcaccacctg gggaagactg
      961 ccttggaggg caaaggtgac atcgtggaag accagttggg cccaagcctg ggatagtaga
     1021 tggggaggga gaacagaaaa atacccaggg gttaagacca cagaaggctg accgttctgt
     1081 ttaattatct gtaataatcc ttaaaaatca gcacacaaat ccattccagg tagctttgcc
     1141 accccacctg ctgtggtggc atttgtccag atgccaccac ccccctaaga gtgggtcatc
     1201 ctgggggagc aaggcctgag aaaggaaagg aagggaaagg ccccctagtg cctgccccac
     1261 agccctgagg aaggcacata tttagcctgg cctgagacag gacaggaagg ggccacaggg
     1321 ctgagtgcag ggacaaaggg gtcagggtcc caagtgtccg ggcccccagc tacccacccc
     1381 atgtctgttt ttggttttgt cattaaaaaa aataaagtga caaatactgg tgga
//
