LOCUS       NM_182597               1870 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens leucine rich single-pass membrane protein 1 (LSMEM1),
            transcript variant 1, mRNA.
ACCESSION   NM_182597
VERSION     NM_182597.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005192.1, DA898266.1, DA894907.1, BC126149.1 and AA121517.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182597.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096894.1, SRR5189667.150539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312849.4/ ENSP00000323304.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC005192.1         19601-19620
            21-303              DA898266.1         1-283
            304-599             DA894907.1         269-564
            600-1539            BC126149.1         418-1357
            1540-1696           AA121517.1         11-167              c
            1697-1870           AC005192.1         29499-29672
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..1870
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /note="leucine rich single-pass membrane protein 1"
                     /db_xref="GeneID:286006"
                     /db_xref="HGNC:HGNC:22036"
     exon            1..356
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            357..488
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..757
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /codon_start=1
                     /product="leucine-rich single-pass membrane protein 1"
                     /protein_id="NP_872403.1"
                     /db_xref="CCDS:CCDS5756.1"
                     /db_xref="GeneID:286006"
                     /db_xref="HGNC:HGNC:22036"
                     /translation="MTHSSQDTGSCGIQEDGKLYVVDSINDLNKLNLCPAGSQHLFPL
                     EDKIPVLGTNSGNGSRSLFFVGLLIVLIVSLALVFFVIFLIVQTGNKMDDVSRRLTAE
                     GKDIDDLKRINNMIVKRLNQLNQLDSEQN"
     exon            489..617
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            618..1870
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /note="major polyA site"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
                     /note="hexamer: AATAAA"
     polyA_site      1870
                     /gene="LSMEM1"
                     /gene_synonym="C7orf53"
ORIGIN      
        1 agtccaataa aaacctcatc agttaccaac taaatcaggg catggtgttt ttttgttgtt
       61 ttctttttaa agcatagttt tagtaatata tttactaaaa accttagaca ttatgaaaaa
      121 agtcaggatt tggaatctta cactgcttgg ctaaattgac acaatataga ccaacagttt
      181 catcctgggg cttatgggtc tcataggagc acccgtatgc tgaagaaagg caaagagaga
      241 actacagaat ttgtagaaaa gttttgttgt agttgcttct gaacaattag tttttgtttg
      301 tttgttttgt tttgttttgt ttttctggta acctagcagt caaagctcac atttttggac
      361 aatgactcat tcttcccagg acactggttc ttgtggcatt caggaagatg gaaagcttta
      421 tgtggtggat tccataaatg acttaaacaa actaaacctc tgtccagccg gatcgcagca
      481 tctgttccct ctagaggaca aaatcccagt ccttggcaca aactcaggaa atggaagccg
      541 gagtctgttt tttgtggggc tgctaattgt gctgattgtc agcctggcac tggttttttt
      601 cgtgatattt ctaatagttc aaactggaaa caagatggat gatgtgtcaa gaagactaac
      661 agctgaagga aaagacatag atgatcttaa gagaatcaat aacatgatcg taaagcgact
      721 caaccaactc aaccaactgg actctgaaca aaactaaagg aatgattttc tgaaagcacc
      781 tgctaacacc ttgagctttt tactttcctg ggagtgtaca gggttaggaa ctgagaaagt
      841 gcacttcctc aggcaacaga tgatctggtc aggcaaccca cccctggggc ccactttctg
      901 cagcaagatg ggagcaattc caaggcaagt gggtatggga atagcaacta aaaaggggtg
      961 aacttgtctc agcccccttt tatggtaggg cacttcaact ttaatggggt gggcggctag
     1021 cagggaggag aatcaacaaa gcaagagaac ttgactatgt acgtccaact tcttacagaa
     1081 ggagctttgc taccagaaca agttcactgt gtcaatgaag ttcatgacac ctcatgcacc
     1141 tttacagata tctgggaaag cctgagaaat tcattgagtt ttatgtattg aagggaacca
     1201 ggtgattact cttttcaata agagggattc tgctcaggtg attagacttt gactctattt
     1261 ccccagggac agtgatgggt gggccccaga gctagttgct gtctggtgtt tgctggtgaa
     1321 aacatgagca gtagttatgt ggggctgaga gtcaaaaggg aaagcctaat taattcaact
     1381 aatgtttatt aagctcctac tctgtgcaaa tcactctact caagaggagc tcacataaga
     1441 gtgcaggata aagaaaggag atggacagtt atatgtaatt atataaactt tgtgtatttt
     1501 gtttctcatg aaaaaacccc tttggcaccc tgctgattga tttggaagaa atctgataga
     1561 tttgtggcct ttcctaaatt gcactaggaa attatgtagt tagaatattt ggaacctgca
     1621 ttagttccag caatgaaagt aagacacaca gcatatgaca taagacacag tgtgaaataa
     1681 atgagtttaa aaagcatatg agtcttagaa aatcttttat ttaatataaa aatattctac
     1741 cggtcaattg aagaatgtat tatgattcta tcattttgga ttgatcaaaa acatttgggt
     1801 ttactacgat attaagcatt cactttacaa tactaaatag ttaatgaaat aaacacattt
     1861 tgcttaccca
//
