LOCUS       NM_016200              12384 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8),
            mRNA.
ACCESSION   NM_016200
VERSION     NM_016200.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12384)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 12384)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 12384)
  AUTHORS   Charenton,C., Wilkinson,M.E. and Nagai,K.
  TITLE     Mechanism of 5' splice site transfer for human spliceosome
            activation
  JOURNAL   Science 364 (6438), 362-367 (2019)
   PUBMED   30975767
REFERENCE   4  (bases 1 to 12384)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   5  (bases 1 to 12384)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 12384)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   7  (bases 1 to 12384)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   8  (bases 1 to 12384)
  AUTHORS   Eystathioy,T., Peebles,C.L., Hamel,J.C., Vaughn,J.H. and Chan,E.K.
  TITLE     Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm
            sera
  JOURNAL   Arthritis Rheum 46 (3), 726-734 (2002)
   PUBMED   11920408
REFERENCE   9  (bases 1 to 12384)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
REFERENCE   10 (bases 1 to 12384)
  AUTHORS   Salgado-Garrido,J., Bragado-Nilsson,E., Kandels-Lewis,S. and
            Seraphin,B.
  TITLE     Sm and Sm-like proteins assemble in two related complexes of deep
            evolutionary origin
  JOURNAL   EMBO J 18 (12), 3451-3462 (1999)
   PUBMED   10369684
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA478457.1 and AC006389.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016200.4.
            
            Summary: This gene encodes a member of the like-Sm family of
            proteins. The encoded protein consists of a closed barrel shape,
            made up of five anti-parallel beta strands and an alpha helix. This
            protein partners with six paralogs to form a heteroheptameric ring
            which transiently binds U6 small nuclear RNAs and is involved in
            the general maturation of RNA in the nucleus. [provided by RefSeq,
            Jan 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA247272.1, SRR1803617.184135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249299.7/ ENSP00000249299.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               DA478457.1         1-577
            578-12384           AC006389.2         67068-78874
FEATURES             Location/Qualifiers
     source          1..12384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..12384
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="LSM8 homolog, U6 small nuclear RNA associated"
                     /db_xref="GeneID:51691"
                     /db_xref="HGNC:HGNC:20471"
                     /db_xref="MIM:607288"
     exon            1..91
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..351
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="MAK31-like protein; U6 snRNA-associated Sm-like
                     protein LSm8; N-alpha-acetyltransferase 38, NatC auxiliary
                     subunit; LSM8 U6 small nuclear RNA associated"
                     /codon_start=1
                     /product="LSM8 homolog, U6 small nuclear RNA associated"
                     /protein_id="NP_057284.1"
                     /db_xref="CCDS:CCDS5775.1"
                     /db_xref="GeneID:51691"
                     /db_xref="HGNC:HGNC:20471"
                     /db_xref="MIM:607288"
                     /translation="MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHER
                     VFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH"
     exon            92..132
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /inference="alignment:Splign:2.1.0"
     exon            133..260
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /inference="alignment:Splign:2.1.0"
     exon            261..12384
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      531
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="major polyA site"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: AATAAA"
     polyA_site      1175
                     /gene="LSM8"
                     /gene_synonym="NAA38"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: ATTAAA"
     polyA_site      2695
                     /gene="LSM8"
                     /gene_synonym="NAA38"
     regulatory      4069..4074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: ATTAAA"
     polyA_site      4100
                     /gene="LSM8"
                     /gene_synonym="NAA38"
     regulatory      4725..4730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: AATATA"
     polyA_site      4741
                     /gene="LSM8"
                     /gene_synonym="NAA38"
     regulatory      10090..10095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: AATAAA"
     polyA_site      10115
                     /gene="LSM8"
                     /gene_synonym="NAA38"
     regulatory      12362..12367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM8"
                     /gene_synonym="NAA38"
                     /note="hexamer: AATAAA"
     polyA_site      12384
                     /gene="LSM8"
                     /gene_synonym="NAA38"
ORIGIN      
        1 ctttcagttc tgcttgctgt cggcaccgct gcgttacccg gaaccgccgg gccgaacagc
       61 atgacgtccg ctttggagaa ctacatcaac cgaactgttg ccgttattac atcagatggg
      121 agaatgattg tgggaacact gaaaggtttt gaccagacca ttaatttgat tttggatgaa
      181 agccatgaac gagtattcag ctcttcacag ggggtagaac aagtggtact aggattatac
      241 attgtaagag gtgacaacgt tgcagtcatt ggagaaatcg atgaagaaac agattctgcg
      301 cttgatttgg ggaatattcg agcagaacct ttaaattctg tagcacactg aggaaaaact
      361 acatacttgg acatctgtaa atctttgtac agaaactgat tattctgagg atgatatatg
      421 gagtttttat gagtgtgtca ctggattttg actccttatt gattcattgt aatatgtaaa
      481 ttaaaatatt tctacatttt attgaaaaaa aaaccttttt ttttgcctaa atataagttt
      541 ggtagcttgg tttctttttt ttattaaata gtgtgaaaat ataatgggca ttttgaaaac
      601 ttttagaaaa aagtagtact ttttgatact ttagtattta tggaaactag tggaaaagag
      661 aaattagtgt gctatataaa tcaggcattc aagtaacagt aatacaggat atatgtgttt
      721 tctttccctg atgtttagga aaatcacagg agggtaaatc tttgctggag ttatctgaat
      781 cattggcatt tatccgattc cactggtggt agtttgctag tgcttctaaa agttgctccc
      841 tagcactgag aggtgtgggt aggtaaaaat gtgtttgctt gagaaaagca aaaatgctaa
      901 caaggttttg atagattggc ccaaaattct aacttgaata ttaagaatga ctaggaatgg
      961 tagaattgac agagatgatt agtaaagtct cttgatgccc aattggttag gtatgaaagt
     1021 aatatgaaca cattaatgtt gaattttaca gacagtatat ttgaaaaaaa ttgattccat
     1081 gtagtcttca atttttaatt tttaagaatt ggagaatttc taatgttaaa gttagtttat
     1141 aaatgtgagt aaataaactc taagtttgta ttgaagtagt gctagctatt attgtcagca
     1201 attttccatg attcattatc cataaacctg atttcagaag acgtcaactc agttttttaa
     1261 ataattgaaa gaaacaatgt aagtagtgtt tagatattca ggctagtcca taaaatttct
     1321 gatcaactca tgtataggcc caagtgtgtg tctttgtgat gagaagaaca tagaaaaata
     1381 tttacatcct tgtaattgaa acaaatttaa atagtttatt tgttttgttt ttatgaaagt
     1441 gcttaaaaat agtagttggc aagctttttc tatgaagatc cagatagtct tttaggcttt
     1501 gaaggccatg tggtctgtca cagctactca cctctgctat tgtggcctac aaataaccat
     1561 agataataca taaatgaata gtggctgtct tccagtaaaa cttcatttat aaaaatggag
     1621 gtgggggttg gattgggctt gaaggcatag ttgctgaccc ttggcttaat acaagttcaa
     1681 taagaaaaaa tgaacaattt gtataaattc tggaatagat ccttatagag agtttagagg
     1741 tgggtttcat tcatatttta aaatatttta aacttcatac ttattaaaca taatagcttt
     1801 ttgggggagg aaaatatctt cactcaaatc agccttataa ggggagaagc actattctct
     1861 agaattattt ggttgatgtt aagggctgtc tctgggagaa ttagagaagt tagctagtat
     1921 tggctattca taagtacttg acttgtagta taatgtttta taatcaattt attaataaaa
     1981 tgatggaaag tgggtaaggc aaacaggcaa atttagggac tgtgaatgaa atattgtagt
     2041 atatggcatt ttgaattggt aaagtaattc caaaaattaa ataagaatac acattgttca
     2101 gttgctaaga aaaatgcatt ctaacagtac aaatgaagtc cagagtcaga tcttttctca
     2161 aaatacttgg catatcaaca cattacacat aaacaaataa aaaccagtcc tgtccctcat
     2221 gataatgggt ttctaatgtg atgtattctt gcaatctgaa acaccttata aagctgtatt
     2281 ttcctgattg atgttggaaa aagcattccc aaaatgtgaa ttattgtttt tatgaatagt
     2341 tacagaggat gtgatgacaa tatgccagat aatctatgta attctttatt cctggataca
     2401 agcacatggt ggactgtttt ctcacaaccg attaaaattg gatttatttt tgcatgagaa
     2461 ttgtaaggga gccacaacca tgagtagtaa cataattaat atacagtgtc aatattttat
     2521 atttaatgag acatttattc tataatcagt tcttatttat aaagaggcgc aaatcaattt
     2581 caacctgtaa ttacctctgt gctttgtgac tcaggcacaa tctaaaccca gcttaatgaa
     2641 tcaaagagat gtttcttggc aagatatttt cattaaagtt atttggaaag ggcaattaac
     2701 tgcaaaaggg actttttttt ttttaactga caagatacta tctaaactaa tagtttaaaa
     2761 taacattgct tttatgtcaa agcactttgg taacttggcc tcacatgctg acagttttgg
     2821 ctaaatatta caaatcttga tcccagaaga gcaagagaga aagttttact aatatttgct
     2881 taaacatcct gtttaacaac tttataacat ccttcggaat ttttaaggta ataatgtgag
     2941 atataagtat gataaaaaca acttttaaat ggtatttaat gcaaatacag aataacgatg
     3001 tcaacatttt cctcagccgt gtaacctgag attcatcatg ggaatgagaa agtaaaggcc
     3061 ctttgtaatg gcatgtgaac cagacaattt agtagccagg gttgtaaggc aactcttaac
     3121 tgacaatata gttagtatat tctgggcctt catcttcaaa attagtaggt agtatttatt
     3181 gagtgcatat catgtgccag gcctggtgct gagtgcttac aatgatcatt ttatatatgg
     3241 gaaaattgag gctcagcagg gtcaagtgac ttgtaagagg tagcactagt aagtaacagt
     3301 gctcaaattc aactaggtct ttcagctttt tatacaatac tgcctgttat cagaaagtat
     3361 agtcttaaaa tctgctatca agcatctatc agaagcctga tgagaaatat tcagatgatc
     3421 taacgcagtt cccaaacctg cattgtgggc cgttttcatt acaattacct aaggtgcttt
     3481 aaaaattttc ttgggcccta ctcgttgtgg ttcagcagct gtgtaatgga gcaaaaagga
     3541 atagtcacta aacagcgaag gaaagtggtg gaattattaa aagacctagc acttacctgc
     3601 tgggatgagt ctctaacccc acagaattga tttcaaacac aggatcttat tcaagataag
     3661 gataataaca gctatcttct tgggttgtaa aaagtagcat tagactgcat tttaaacatt
     3721 tggtatgatt ttgaggacat aaccgtaaac agctatttaa tactattcca ggtagtcaaa
     3781 ggccaatgta taaaagttaa aaatataggt cttgtcagct ttttaagcgt ctgtcccact
     3841 gactaccata tctctacaag agaatagatg aggaattgag gttatgtggg aagtacgtgt
     3901 aagtttacag tattaagaaa tgtacaataa aatttgtttc tatgtcagcg aatattcttg
     3961 actcaaggag tttgaaagtg taaactcaaa ggtctttcac atgtaaagag gaacctctcc
     4021 attctgtact tgtatagtca ttacctcata tagatttaat tttattaaat taaattttac
     4081 ttattttggg tttaaaaaaa cttgggctgt gaatctcagt tttaagtcat gggcaaattt
     4141 gataaaaatt cctttctgtc tacatgtaat actgaaaaaa atgttgataa ggtaaagcta
     4201 tctccattta gattgatacc cattaaatag catagtgctc ccattaaact agcgacaaat
     4261 tcatttaatt gtgagatatc tagtacttat gctccatcct gtttataggg attattgatg
     4321 tgagatttgg tcagatgctt tgatgtgatc ttcattcctc tgtatagtgg gaaaccatga
     4381 gacgtgctta gtcttcataa atcgatgctg cctcctagtg gccattgctt tcttttctac
     4441 ctgtccacaa acttcaaaaa aatagatttt ggaattttgt cagggacact tatcaagcca
     4501 ttaatacatg ccaggcagta tgctcaaagc tgtggatagg ccagggaaca gtattcttgt
     4561 gcttgtgaag cttctatctg tctgtatcta cctcaaccaa atcatcttga ctcagattta
     4621 ctgtcgaagg tcgtgttatt tcatcagatt ctttcagtat tctgggatat aatttatggg
     4681 ttctggattc attcaaaaca actagaaaca gtctttttaa aataaatata attcaagtca
     4741 attattttcc ccatctattt tttttctttt aagattgcta agtctgtagg ttgcataatt
     4801 ctaaggataa aggcgaaata ggacttcacc aggagaattt ctttcattag ttaacagtat
     4861 gccatctcct acttactggc atcatctggg gaatgaagga gctgagaatt gttcttccag
     4921 atacctttcc gacctcttct tggttttggc attaagtttt tttttaactc aatttttgtg
     4981 ttagtttttt gttatgcctt ttcatttcct tcttttttta atgtttcttt ttttttaagt
     5041 cctttaattt ttatttattt atttatttat ttatttattt atttatttat ttatttttga
     5101 gacacttctt gctctttcgc caggctggag tgcagtggtg caatcttggc tcactacaac
     5161 ctccgcatcc tgggttcaag cgattcccct gccttagcct cccgagtagc tgggactaca
     5221 ggcacgcgcc accacacctg gctaattttt ttgttttagt agagacgggg tttcaccatg
     5281 ttggccagga tggtcttgat ctcctgacct cgtgatctgc ccacttcggc gtcccaaagt
     5341 gctggaatta caggcatgaa ccaccacgcc cagcctaagt ccttttattt tacagagtat
     5401 tacttgttag aaatggcaca gatcaagcat tgctacaact ggtatcaaat tcccatcaat
     5461 gtccctacaa ggatatgata cgctttctct cttctcttta gggtaatgtt caattacact
     5521 gcatatattt tgctattatg taggtttttt ttttttttcc acatatactg gctttacaaa
     5581 tgccatataa ttagtatggt accaaattgt tattacattt gaaatacgtt aaaaagaatc
     5641 caggagtcag ggtgggtggg gagacaactc cagggacaca atacattgtg tcttgtatta
     5701 aaaactagtg tgtgttgggg tggggaacag gcaggaaact aatatgtttc tgtttgatat
     5761 atgaaaatat gcacaagcta tcatgtttca tctcatatca acaaaatgat tataataaat
     5821 catactctag aaaactcatt aactgataca agttgccaga aaatgctgca ctatggctta
     5881 tttcacattt taaaataaat gccctgaaag tgatcacaat gatagttaaa agttaaattt
     5941 tttattttaa aatttaaatt tttattttaa aaaatagctc tctgaatctg acttggataa
     6001 gctttatttt aattgtgatt ctgctaatta cagagacact tcaattcaca ctcataggag
     6061 gtatgatttt taaaaggaaa ttgttgatta gggtcttggg ctagtccagt gtagcatggc
     6121 agtgaaaggc acagactctg gagtcatact tagtttgcag agcttagcat attaatctta
     6181 ccatgtctta gttgctatga aaatgagtac ctgcttcctt gtactgtcaa gattaagata
     6241 agcagttagc actccctaga acatactaat ttgtcaatat taatgatagc taacaattat
     6301 cctgatattg aatgatggac tccaaattat ttattgtggc ctaggaaaag tactaagaag
     6361 taattgatag cattccctga taattttggt gaaaagaaaa actatgaaaa ttctggacag
     6421 gactggaaat ttattgtaaa tgaaagtatg cttccctggt gcaaaggtaa tgtgatgttt
     6481 ttaatcacat attttaaaat taaaaatttg atcaaatttt taaaagtaac acgaggcaga
     6541 gaaagtacag aaaggagcaa ccagagtcaa agtgattaag ttataaaaag gttagatttc
     6601 tttggtgtga aaagataaat gagaaatgag aatatgccag agatctgaaa tgaagaatgg
     6661 ataagagctt gcatatttaa ttttgtatat taaaaccaaa tattctatga agattggaag
     6721 gataatttta ggtcaaatga aattctacat taaagaaaga agaataaacc ttaacaactc
     6781 attagtaatc cttcatttcc tgagtattta ctgcatgaca gtaacagaga tgacatgccc
     6841 ggtaaactgg tgtttgaagg caatatataa aagcttccca tgcatggcaa agatgcattt
     6901 tcctctatgc atagcaatat gggagagatt ggaggagaat cttcatggaa atggatgact
     6961 tgtgcttgac cctaaggata gtaaggattt ccatagatgg ttaggaaaac ttcaaattgg
     7021 cagacaggaa ggcaagaagg agtaagatgt ggttgagtaa taaggagtag actgacctct
     7081 ctgtacagta aaggctcaaa tcctttttat tgcaaagaaa ggacctgtcc ttcaccagtt
     7141 cctggaagaa aatctcttga gtccttggga tgtcttacct gttaagagtg cttttgtatg
     7201 cctgagacca taggccttgc tgttacagtt taagctctgg gaaacgagat tcaggagcta
     7261 aggtcagtta tgagggaact gaatatttat gtgactgaac cctcataaaa accctgaaca
     7321 ccaaggctca agagagctta ttagcaatac tttgcatgtg ttggtaaaca ccgttgctga
     7381 actaggtgct gtctgtgcag ctccactggg agaggacatc ttgaagtttg tgcctggttt
     7441 ctcctgattt tcaccctgca caccttttcc atttactgat tttaatctat atcctctcac
     7501 tataatctgc aactgggagc atagcagctt ttctgagtcc tatgattcca agtgtatcaa
     7561 tgaacctcag tatgatcttg gggaccccca actcactatc taaataaaat tttcattgaa
     7621 aattagtgag aagggaagag atggccttca atactagtgc aaagttaata ctttattctt
     7681 agagcagcaa gttgatttta ggggattaaa aatctaagac gtttaaggga acatgaattt
     7741 ggatgcattg aacagaattg gtaacctgaa ggagaaactg gaggcaaatt gtttcaagtt
     7801 aggaagctat tgcagtaatt aaactgagct gacacatttt catgtcagat tttcagatat
     7861 gataaaggct ggaagtacag agtttcaaaa gatgtacata aatttatgga aaggaaattt
     7921 tggaatggtg attctaacct ttaaggttgg tgccatggaa ggaaaacaag taactttgca
     7981 acaatctgtt caacaatgag agttaccaaa tgccagacac tgctaagtgc tgggaactta
     8041 gatgtaacca aagacttaaa agatactagt ctttaagaca ggctttgaga aattcaagtg
     8101 tagggtaagg ccacctcccc agcaagtaaa tactgacatg gtgaagatat gtattgggtg
     8161 atatgagagc ccataggaga gacatctaaa gtttaatagc aacactaggc tggactgagt
     8221 ggtgaatacg ttgatatagc aatttaataa atgtgttatt gtcaatgtag gcattttgct
     8281 catagcttag ggcaagtgat aaaaaacaga gcttaacaaa ggactggatg ttttagtttg
     8341 acagcagtgt ctaaattaca gattagagaa ctaatgacta gccataccga agacatttat
     8401 ctggaaatgc cttccctaag tgccaacaga gaatgaaaat atagtcaata gctttaagtg
     8461 accccatgca tcttaatgcc tttcaagcaa catgtttttc tgacttccaa atataaacaa
     8521 cctaagcatt gtgcagtagc catgagggac taggtatcca agtgcacatt atattggctt
     8581 tgtagagcca ttggagggag taatagtttc agagtcatga aacaaatcat aagtagctgc
     8641 tctggtgctc tctagaggca gaacttgctg aatttgaaga ctattaatga tgcagctctc
     8701 actggtacaa gtgaaaaacc tctcagccct acacagcatc tttaagaaag ctttaatttt
     8761 ggtttttcag agcaatattc acatgacatc tttcggatct ggaatcttaa ttaccattag
     8821 gttggaactc tacctgaact aaaaataagt ggtctctatc acgttgaaat tactttaata
     8881 ttttcattta tgtttatact atttatttaa atgcggagaa catggctaac cattcaggac
     8941 catttaatta tcaaattatt aatgattctt ccataataaa caagcaaact gtcatacttg
     9001 ttgacttata tttcattcca tggaattcaa atttaattaa ttgataaatc acattgtact
     9061 ttataagagt ttattcctta agtgtttgaa tttacacttt tttctcctgt gacagcatct
     9121 attcccaagg caatcaacat tttaatggaa cgaactgagg tttgcaattg ctaatgttat
     9181 tctcccatcc cagtttctac ttgtttcttg taaaaaagga ggtttctaaa tcttgactgt
     9241 tgattgacaa ttaatgggct aaatttccca ttagcaaaca cttttcacat atacactaat
     9301 attagtatct aaattatatt aaaatctaat ttggtagcaa ttgacttgaa atttgtgata
     9361 cttcaacttg tgctaggttg tagttttgct tgtatcactc atagttacta aaaatgcaaa
     9421 aggcaaattt gaaataacta taaaaataaa cctttaatga actttttaat atgcaatact
     9481 caattgtaaa taaccattat ctttactgaa tcagatgttt cattaactgt tagcagttat
     9541 ttcgagttat ttatatatca cagaattttg aactaaagat catctagctg aatttccttt
     9601 atattaaaga agaggagaaa atcttaatac taagtatgtg tgagcctgga gctgccatgg
     9661 agcatgtaga gagagtctcc tagttgatac caactcagga aagcagaatc aagcaataaa
     9721 gagacatttt gggcctgatg acatcatttc agcacctgga tccagcgatg cctaaagatg
     9781 tgactcctag acttttcact tacatgagcc aaaacggttc ctttgcatca ataaatcgct
     9841 ctgtgatgca ttttataatg tacaaccaag aatctcaata tttattattt tgcattaaat
     9901 atcagtaagt ttgatataaa aagctcagta aaattcatta atttgagaat gtgtctatat
     9961 catagtaaag ttttaaacct acataatttt caatatttat accttttact gcaaaaataa
    10021 aaatgagttt atccttgccc taaagctgta aaattaaact ctgtacaatt ctagttattt
    10081 gaaatataaa ataaaattat tggtcatttc atgtatacat ttgtggtaac actttaactt
    10141 tttccctgta aggccatctt ttgtatgttt ctgtttccat caagcaggct tttaatgcaa
    10201 ctttatcttc tgggtttccc tagtcataat taagggtttg gccctagttc acaagtaatc
    10261 ttccagcaca aattttataa acaaatgccc tgtgaatctg catggcataa atcaagtctc
    10321 tagatcctga tcacttctat gtgaatttgt aatattctgc ttttggactt gtaagaccaa
    10381 gagcagactc cctaaacaca gaggaggcag taatttagga cagcttaaac attctggctg
    10441 actgcctcat caatgctatt taataacaga attctgggga tgtcttgaaa tagatacatt
    10501 ggcagttttt ttgtttttgt ttttgcttgt gtcacacata atgctgatga agaaaccatg
    10561 aagtgtcata tgaaaggaag ttacgattat tattggtgag tacatcagtt agaatggtat
    10621 ttggctataa gcactggaaa ctctgactgc cagtggcttt aacaggcagg aggagttcat
    10681 ttatctcgag agaaaagaac agaaaagtga aaagcaaggc agttcagact ggggcaccta
    10741 ctcaaagaag tgacccagta cccaggccac tattttctct ttgccatcct tttgttctaa
    10801 taatttgcct gtcatctcgt gactcatatt ttccatctaa ttagaataaa gaaagatgaa
    10861 ataggaaagt gagattatca tatgggaaaa ataaatgctt tcccaactat aaccagcaga
    10921 ctatactggc aaaatatact gcttgaatgc cattggccag atctttgtca tatggttacc
    10981 ctaactacaa gggaggctag gaaggtgagg gatttttttc cttttatagt gacattttgc
    11041 cactccaaat aaaaaaaggg ttgctgttag gaaaaagaga agaatgggga tggggtgaac
    11101 aaccaacaat gctgccattg tgctagtata gaagcaagta tctcagaggc aggtgaaaac
    11161 aacttctatg cccaaacaga attctttttt atctctgata taaaatgcag aatatgaatt
    11221 ttaataaatt ccccaggtga gtcatatgca cattaaagtt tgagaagcac tgatctatac
    11281 tgtctttcta cacacttttt taccttactt tatccttcag gattctggcg tcaagtccct
    11341 ccctatcagt ctttaaaaac tgtagcctta aatcagtagg gatatagaag acatgaacaa
    11401 tactttcatc catcttgacc taactgccat ttatagaacg ttctatccca agacatcaga
    11461 atatatattc tttttaaaca tttaatgaaa ggatttaact cccaaactcc aaagcaagat
    11521 gttctaagaa gactcattta aaaaattaat ctcaaaaaac agattttaaa ttgtacagga
    11581 gaaatgctta tatgagaaca gaattatggg gcactctgaa tactaattta agaaagaaat
    11641 ataaacccct tttaaaactc acataatttt cccatttccc ttgaagaaga tactaatatt
    11701 tctgatatca tataggagta aaaattgcgg ggaggtccta atatccaata ttaatagagc
    11761 tgtgattatt caagctgtag acttaaattt tttaaataga gtaatggttg tttagtagag
    11821 attaatatct aaataaggaa aatgaagaaa gggactaaaa atcaagtaaa taggataatt
    11881 gagtttcaat gggcaagaat ttttatatca tgattttacc actctgaata tcaaagtcag
    11941 tgatgtctcc aaaaggcaaa gggaagtgta ccaatttttg gagcactata aaaagtgaaa
    12001 agtcatctgc cagatctaac atggtatact ctaatggaaa aatcatcaag attctcttcc
    12061 tttttatgat tctatagtaa cagtttagtt gagaaaataa atcataattt gtgatttcaa
    12121 acatttaata tgtgcacatg tatattataa tatactcatc ctttatattt atcatgcttt
    12181 tttgaataaa tttgccacct tattgcatat gaagaatatc tccatattct tacagctgtt
    12241 tttcttggtt gctttctaat tcctttcctc ccttattggt tacctatgaa ttgctcagtt
    12301 ctaacaatga tttgtaaatt ttaatactat agatatattg ctgttaatta ttacacctaa
    12361 aaataaatta ttttacagag gcta
//
