LOCUS       NM_016199                491 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LSM7 homolog, U6 small nuclear RNA and mRNA
            degradation associated (LSM7), mRNA.
ACCESSION   NM_016199
VERSION     NM_016199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Li,C., Zhang,Y., Wang,Y., Ouyang,J., Yang,Y., Zhu,Q., Lu,Y.,
            Kang,T., Li,Y., Xia,M., Chen,J., Li,Q., Zhu,C. and Ye,L.
  TITLE     RNA-binding protein LSM7 facilitates breast cancer metastasis
            through mediating alternative splicing of CD44
  JOURNAL   Life Sci 356, 123013 (2024)
   PUBMED   39182568
  REMARK    GeneRIF: RNA-binding protein LSM7 facilitates breast cancer
            metastasis through mediating alternative splicing of CD44.
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 491)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 491)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 491)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 491)
  AUTHORS   Eystathioy,T., Peebles,C.L., Hamel,J.C., Vaughn,J.H. and Chan,E.K.
  TITLE     Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm
            sera
  JOURNAL   Arthritis Rheum 46 (3), 726-734 (2002)
   PUBMED   11920408
REFERENCE   7  (bases 1 to 491)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 491)
  AUTHORS   Friesen,W.J. and Dreyfuss,G.
  TITLE     Specific sequences of the Sm and Sm-like (Lsm) proteins mediate
            their interaction with the spinal muscular atrophy disease gene
            product (SMN)
  JOURNAL   J Biol Chem 275 (34), 26370-26375 (2000)
   PUBMED   10851237
REFERENCE   9  (bases 1 to 491)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
REFERENCE   10 (bases 1 to 491)
  AUTHORS   Salgado-Garrido,J., Bragado-Nilsson,E., Kandels-Lewis,S. and
            Seraphin,B.
  TITLE     Sm and Sm-like proteins assemble in two related complexes of deep
            evolutionary origin
  JOURNAL   EMBO J 18 (12), 3451-3462 (1999)
   PUBMED   10369684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI553911.1, AF182293.1 and BC018621.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016199.2.
            
            Summary: Sm-like proteins were identified in a variety of organisms
            based on sequence homology with the Sm protein family (see SNRPD2;
            MIM 601061). Sm-like proteins contain the Sm sequence motif, which
            consists of 2 regions separated by a linker of variable length that
            folds as a loop. The Sm-like proteins are thought to form a stable
            heteromer present in tri-snRNP particles, which are important for
            pre-mRNA splicing.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.371098.1, BU535736.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252622.15/ ENSP00000252622.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BI553911.1         35-45
            12-438              AF182293.1         1-427
            439-491             BC018621.1         421-473
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..491
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /note="LSM7 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:51690"
                     /db_xref="HGNC:HGNC:20470"
                     /db_xref="MIM:607287"
     exon            1..26
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..332
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /note="LSM7 homolog, U6 small nuclear RNA associated; LSM7
                     U6 small nuclear RNA and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm7"
                     /protein_id="NP_057283.1"
                     /db_xref="CCDS:CCDS45907.1"
                     /db_xref="GeneID:51690"
                     /db_xref="HGNC:HGNC:20470"
                     /db_xref="MIM:607287"
                     /translation="MADKEKKKKESILDLSKYIDKTIRVKFQGGREASGILKGFDPLL
                     NLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNPFIQQQD
                     A"
     exon            27..117
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /inference="alignment:Splign:2.1.0"
     exon            118..189
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /inference="alignment:Splign:2.1.0"
     exon            190..491
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      472..477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /note="hexamer: AATAAA"
     polyA_site      491
                     /gene="LSM7"
                     /gene_synonym="YNL147W"
                     /note="major polyA site"
ORIGIN      
        1 gagccacacg gcgcgacaag atggcggata aggagaagaa gaaaaaggag agcatcttgg
       61 acttgtccaa gtacatcgac aagacgatcc gggtaaagtt ccagggaggc cgcgaagcca
      121 gtggaatcct gaagggcttc gacccactcc tcaaccttgt gctggacggc accattgagt
      181 acatgcgaga ccctgacgac cagtacaagc tcacggagga cacccggcag ctgggcctcg
      241 tggtgtgccg gggcacgtcc gtggtgctaa tctgcccgca ggacggcatg gaggccatcc
      301 ccaacccctt catccagcag caggacgcct agcctggccg ggggcgcggg gggtgcaggg
      361 caggcccgag cagctcggtt tcccgcggac ttggctgctg ctcccaccgc agtaccgcct
      421 cctggaacgg aagcattttc ctttttgtat aggttgaatt tttgttttct taataaaatt
      481 gcaaacctca a
//
