LOCUS       NM_012321               1704 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA
            degradation associated (LSM4), transcript variant 1, mRNA.
ACCESSION   NM_012321
VERSION     NM_012321.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1704)
  AUTHORS   He,G., Gu,K., Wei,J. and Zhang,J.
  TITLE     METTL3-mediated the m6A modification of SF3B4 facilitates the
            development of non-small cell lung cancer by enhancing LSM4
            expression
  JOURNAL   Thorac Cancer 15 (11), 919-928 (2024)
   PUBMED   38462740
  REMARK    GeneRIF: METTL3-mediated the m6A modification of SF3B4 facilitates
            the development of non-small cell lung cancer by enhancing LSM4
            expression.
REFERENCE   2  (bases 1 to 1704)
  AUTHORS   Li,H., Ju,Y., Liu,W.W., Ma,Y.Y., Ye,H. and Li,N.
  TITLE     [Phase Separation of Purified Human LSM4 Protein]
  JOURNAL   Mol Biol (Mosk) 57 (1), 124-126 (2023)
   PUBMED   36976747
  REMARK    GeneRIF: [Phase Separation of Purified Human LSM4 Protein].
REFERENCE   3  (bases 1 to 1704)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1704)
  AUTHORS   Hou,W. and Zhang,Y.
  TITLE     Circ_0025033 promotes the progression of ovarian cancer by
            activating the expression of LSM4 via targeting miR-184
  JOURNAL   Pathol Res Pract 217, 153275 (2021)
   PUBMED   33285422
  REMARK    GeneRIF: Circ_0025033 promotes the progression of ovarian cancer by
            activating the expression of LSM4 via targeting miR-184.
REFERENCE   5  (bases 1 to 1704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1704)
  AUTHORS   Ingelfinger,D., Arndt-Jovin,D.J., Luhrmann,R. and Achsel,T.
  TITLE     The human LSm1-7 proteins colocalize with the mRNA-degrading
            enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
  JOURNAL   RNA 8 (12), 1489-1501 (2002)
   PUBMED   12515382
  REMARK    GeneRIF: LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in
            cytoplasmic foci
REFERENCE   7  (bases 1 to 1704)
  AUTHORS   Eystathioy,T., Peebles,C.L., Hamel,J.C., Vaughn,J.H. and Chan,E.K.
  TITLE     Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm
            sera
  JOURNAL   Arthritis Rheum 46 (3), 726-734 (2002)
   PUBMED   11920408
REFERENCE   8  (bases 1 to 1704)
  AUTHORS   Friesen,W.J. and Dreyfuss,G.
  TITLE     Specific sequences of the Sm and Sm-like (Lsm) proteins mediate
            their interaction with the spinal muscular atrophy disease gene
            product (SMN)
  JOURNAL   J Biol Chem 275 (34), 26370-26375 (2000)
   PUBMED   10851237
REFERENCE   9  (bases 1 to 1704)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
REFERENCE   10 (bases 1 to 1704)
  AUTHORS   Salgado-Garrido,J., Bragado-Nilsson,E., Kandels-Lewis,S. and
            Seraphin,B.
  TITLE     Sm and Sm-like proteins assemble in two related complexes of deep
            evolutionary origin
  JOURNAL   EMBO J 18 (12), 3451-3462 (1999)
   PUBMED   10369684
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB493307.1, BC000387.2,
            BU539495.1, CF147062.1, BX096089.1 and AA722246.1.
            
            On Jun 2, 2019 this sequence version replaced NM_012321.4.
            
            Summary: This gene encodes a member of the LSm family of
            RNA-binding proteins. LSm proteins form stable heteromers that bind
            specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may
            play a role in pre-mRNA splicing by mediating U4/U6 snRNP
            formation. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.692678.1,
                                           DRR138519.308927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593829.6/ ENSP00000469468.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB493307.1         199-203
            6-705               BC000387.2         1-700
            706-1024            BU539495.1         241-559
            1025-1235           CF147062.1         320-530
            1236-1689           BX096089.1         30-483              c
            1690-1704           AA722246.1         10-24               c
FEATURES             Location/Qualifiers
     source          1..1704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1704
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /note="LSM4 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:25804"
                     /db_xref="HGNC:HGNC:17259"
                     /db_xref="MIM:607284"
     exon            1..59
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..476
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /note="isoform 1 is encoded by transcript variant 1; U6
                     snRNA-associated Sm-like protein LSm4; glycine-rich
                     protein; LSM4 homolog, U6 small nuclear RNA associated;
                     LSM4 U6 small nuclear RNA and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm4 isoform
                     1"
                     /protein_id="NP_036453.1"
                     /db_xref="CCDS:CCDS12374.1"
                     /db_xref="GeneID:25804"
                     /db_xref="HGNC:HGNC:17259"
                     /db_xref="MIM:607284"
                     /translation="MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVI
                     CTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGR
                     GMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ"
     exon            60..101
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /inference="alignment:Splign:2.1.0"
     exon            102..200
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /inference="alignment:Splign:2.1.0"
     exon            201..384
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1704
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1003..1008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /note="major polyA site"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
                     /note="hexamer: AATAAA"
     polyA_site      1704
                     /gene="LSM4"
                     /gene_synonym="GRP; YER112W"
ORIGIN      
        1 agcgtgtgca gcggcggcgg cggaagtggc cggcgagccc ggtccccgcc ggcaccatgc
       61 ttcccttgtc actgctgaag acggctcaga atcaccccat gttggtggag ctgaaaaatg
      121 gggagacgta caatggacac ctggtgagct gcgacaactg gatgaacatt aacctgcgag
      181 aagtcatctg cacgtccagg gacggggaca agttctggcg gatgcccgag tgctacatcc
      241 gcggcagcac catcaagtac ctgcgcatcc ccgacgagat catcgacatg gtcaaggagg
      301 aggtggtggc caagggccgc ggccgcggag gcctgcagca gcagaagcag cagaaaggcc
      361 gcggcatggg cggcgctggc cgaggtgtgt ttggtggccg gggccgaggt gggatcccgg
      421 gcacaggcag aggccagcca gagaagaagc ctggcagaca ggcgggcaaa cagtgagcgc
      481 ccacccagac cggctgctgc gccccctcct gccagggtgg cgattccgct ccacagtctc
      541 ggacggatct gctcagaaag gaagaggcag gcgccagggg gaaccccctt cgtgttttgt
      601 gaccctccct tttaggtgaa gccccttttt cttgctaaaa ccggcaattc tccggttaga
      661 aatgttactt ggtgtttttt ggttttgtga aacggccgtc ccaaaactgg ctggattcct
      721 agaagagtct gtgttgaagg catctttcaa gccctcgctc tggttctcag ggcagcattt
      781 tccaggcggg tttgttttgc atttcttgga gcctctccga gcagcaacca gacgggagat
      841 ttttatttta agctgttcat gctgggactg acagcctgca gggtttcctt gggcgcggcc
      901 ccaaaattgc cttcaaaaca aacccgggac ggttgaaagc cttcgaaccg tgcaggggat
      961 gcctcgggcc ctggcccttc gcttcctctc ttgtgttatg gaaataaaaa caaataaaac
     1021 tacacactgc acatccactg ttccttttga gcttctgggt gcacctagcg ggtctcctgc
     1081 cctctgtcca tcgctggact ctcaggaaat ccccgttccc gtaagggaag cttccttttg
     1141 agagttctca ccaggtgtca gcggcacagt gaggcactga tgtcctttta caaaaggcaa
     1201 gaccagcatc tggacagtgg gggctcttga gagtccccgg cgccccccac accaggttgt
     1261 cctataaccc tctcccctct gtggagacgt taatgccaag gggtgtgtgg ggagggaagt
     1321 cccaggcagg ggccacgcat ggtccccatc accccctcct gggtggcctg gactccatca
     1381 tctatcctca tctgtccaca ctggcgttca cacagagaag acaggacagg aatcccctcg
     1441 gaagatgctc atggaagatt ctcacgaggc tcctgccccc tttctgagcc aggccgggtt
     1501 tgccactcct cgggcgcgca cctgagacac tgagtcagcg ctttcgagaa aggctccggg
     1561 tagcatctgt ggaccgtgaa gaaaccagag ggaagccctg agccaggcag cggcccgtcc
     1621 ccctgcatag ccttctcttc agggtcctcg ttcggagacc tattttgaga ggtgattgga
     1681 ataaaaggtc ccgtccgtga ggaa
//
