LOCUS       NM_021177                858 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LSM2 homolog, U6 small nuclear RNA and mRNA
            degradation associated (LSM2), mRNA.
ACCESSION   NM_021177
VERSION     NM_021177.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Qin,P., Huang,H., Wang,J., Jiang,T., Zeng,N., Wang,Q., He,Y. and
            Zhou,Y.
  TITLE     The mechanism of LSM2 in the progression of live hepatocellular
            carcinoma was analyzed based on bioinformatics
  JOURNAL   Med Oncol 40 (9), 276 (2023)
   PUBMED   37612479
  REMARK    GeneRIF: The mechanism of LSM2 in the progression of live
            hepatocellular carcinoma was analyzed based on bioinformatics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Sun,X., Zhang,J., Hu,J., Han,Q. and Ge,Z.
  TITLE     LSM2 is associated with a poor prognosis and promotes cell
            proliferation, migration, and invasion in skin cutaneous melanoma
  JOURNAL   BMC Med Genomics 16 (1), 129 (2023)
   PUBMED   37312186
  REMARK    GeneRIF: LSM2 is associated with a poor prognosis and promotes cell
            proliferation, migration, and invasion in skin cutaneous melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Eystathioy,T., Peebles,C.L., Hamel,J.C., Vaughn,J.H. and Chan,E.K.
  TITLE     Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm
            sera
  JOURNAL   Arthritis Rheum 46 (3), 726-734 (2002)
   PUBMED   11920408
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Schmarda,A., Fresser,F., Gschwentner,M., Furst,J., Ritter,M.,
            Lang,F., Baier,G. and Paulmichl,M.
  TITLE     Determination of protein-protein interactions of ICIn by the yeast
            two-hybrid system
  JOURNAL   Cell Physiol Biochem 11 (1), 55-60 (2001)
   PUBMED   11275683
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Friesen,W.J. and Dreyfuss,G.
  TITLE     Specific sequences of the Sm and Sm-like (Lsm) proteins mediate
            their interaction with the spinal muscular atrophy disease gene
            product (SMN)
  JOURNAL   J Biol Chem 275 (34), 26370-26375 (2000)
   PUBMED   10851237
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU189898.1 and AF136977.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021177.4.
            
            Summary: This gene encodes a member of the LSm family of
            RNA-binding proteins. LSm proteins form stable heteromers that bind
            specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may
            play a role in pre-mRNA splicing by mediating U4/U6 snRNP
            formation. Pseudogenes of this gene are located on the short arm of
            chromosomes 6 and 19. [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009192.2, CD049667.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375661.6/ ENSP00000364813.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               BU189898.1         10-544
            536-858             AF136977.1         539-861
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..858
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /note="LSM2 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:57819"
                     /db_xref="HGNC:HGNC:13940"
                     /db_xref="MIM:607282"
     exon            1..212
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..497
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /note="protein G7b; snRNP core Sm-like protein Sm-x5;
                     small nuclear ribonuclear protein D homolog; LSM2 homolog,
                     U6 small nuclear RNA associated; LSM2 U6 small nuclear RNA
                     and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm2"
                     /protein_id="NP_067000.1"
                     /db_xref="CCDS:CCDS4722.1"
                     /db_xref="GeneID:57819"
                     /db_xref="HGNC:HGNC:13940"
                     /db_xref="MIM:607282"
                     /translation="MLFYSFFKSLVGKDVVVELKNDLSICGTLHSVDQYLNIKLTDIS
                     VTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ"
     exon            213..280
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /inference="alignment:Splign:2.1.0"
     exon            281..311
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /inference="alignment:Splign:2.1.0"
     exon            312..371
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /inference="alignment:Splign:2.1.0"
     exon            372..858
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /note="hexamer: AATAAA"
     polyA_site      858
                     /gene="LSM2"
                     /gene_synonym="C6orf28; G7B; snRNP; YBL026W"
                     /note="major polyA site"
ORIGIN      
        1 ctcccctcta ctctacccag cttgcgctcc ccagccgcaa gtcggccgcg ctttgcccgt
       61 cagcgcttgg agctttctgc gtcgcttccc gctgcgcctg cgcggtcccg cctcgcccca
      121 cgcgcgggct cgcgcttcgg tttccccaga cctgctcgca gcaccctgct gtcttcccgg
      181 tccggcccgc tgcccgcggc gccagcacca tgctcttcta ttcttttttc aagtcccttg
      241 tgggcaagga tgtggtcgtg gaactaaaga atgacctgag catctgtgga accctccatt
      301 ctgtggatca gtatctcaac atcaaactaa ctgacatcag tgtcacagac cctgagaaat
      361 accctcacat gttatcagtg aagaactgct tcattcgggg ctcagtggtc cgatacgtgc
      421 agctgccagc agatgaggtc gacacacagt tgctacagga tgcggcaagg aaggaagccc
      481 tgcagcagaa acagtgatgg ctcctcctcc tcttcccctc cctctttcat tggtgaccca
      541 taaccccaag tcccagccca gaacccctaa cccccaatac ttgaaggggt tttgtttttt
      601 tactaatgat ggttttgtgg gtttttttta agggatgagt ggatgagagg agtaataggg
      661 aacagctatc ctctcttgag aaggggagga taagtaggct gggaaacttc aaagccttcc
      721 cagtccccag cacctgcctt tctcactact tctctggaga tggtaggaga gtttcctagg
      781 tctttccagg gcagcatgtg attcatttgg ggatggaagg aatctgtccc gcatcgggaa
      841 taaaatttat gatgcaaa
//
