LOCUS       NM_144703               2576 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens LSM family member 14B (LSM14B), mRNA.
ACCESSION   NM_144703
VERSION     NM_144703.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
            Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
            Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
            Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
            Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
            Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
            Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
            Huentelman,M., Weil,D. and Piton,A.
  TITLE     Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
            Intellectual Disability and Dysmorphic Features and Lead to P-Body
            Defects and RNA Dysregulation
  JOURNAL   Am J Hum Genet 105 (3), 509-525 (2019)
   PUBMED   31422817
REFERENCE   4  (bases 1 to 2576)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2576)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
REFERENCE   6  (bases 1 to 2576)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM547301.1, BX375905.2, BC035702.1, BX370449.2, DB336439.1,
            AL137077.31 and CX166280.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144703.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.338451.1,
                                           DRR138522.99055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279068.11/ ENSP00000279068.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM547301.1         15-16
            3-602               BX375905.2         1-600
            603-999             BC035702.1         682-1078
            1000-1328           BX370449.2         214-542
            1329-1652           DB336439.1         1-324               c
            1653-1920           AL137077.31        126364-126631
            1921-2576           CX166280.1         1-656
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2576
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /note="LSM family member 14B"
                     /db_xref="GeneID:149986"
                     /db_xref="HGNC:HGNC:15887"
                     /db_xref="MIM:620689"
     exon            1..319
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1350
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /note="family with sequence similarity 61, member B;
                     hRAP55B; RNA-associated protein 55B; LSM14 homolog B;
                     LSM14B, SCD6 homolog B"
                     /codon_start=1
                     /product="protein LSM14 homolog B"
                     /protein_id="NP_653304.2"
                     /db_xref="CCDS:CCDS46626.1"
                     /db_xref="GeneID:149986"
                     /db_xref="HGNC:HGNC:15887"
                     /db_xref="MIM:620689"
                     /translation="MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVR
                     SFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGS
                     ASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQA
                     VQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRR
                     PQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLN
                     FKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTT
                     WAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV"
     exon            320..483
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            484..619
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            620..787
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            788..865
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1027
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1178
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1364
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..2576
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /note="hexamer: AATAAA"
     polyA_site      2576
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc cccttcttgg ttcgctcggt gcccgcgcag gcccctcggg cggtggcgag
       61 gaggcgccca ggcggaggcg gcggcgggcg gaggagcgca ggagcgggcg gccaggccac
      121 cgcgcggcgg cggagcgggc cgcggcccgg cgctccttcc ccaccgcggc ccgacgcacc
      181 ccggccgccg ccatgagcgg ctcctcaggc accccgtatc tgggcagcaa gatcagcctc
      241 atctccaagg cgcagatccg ctacgagggc attctctaca ccatcgacac cgacaactcc
      301 accgtggcgc tcgccaaagt gaggtccttt ggcactgaag accgtcccac agataggcct
      361 gcgcccccca gagaggagat ttatgagtac atcattttcc gaggaagtga catcaaggat
      421 atcactgtgt gtgaacctcc gaaagctcag cacacactcc cgcaggatcc cgccattgtt
      481 cagtcttccc tgggttctgc ctccgcctcg cccttccagc cgcacgtgcc ttacagccct
      541 ttccgaggga tggcgcccta cggcccgctg gcggccagct ccctgctcag ccagcagtat
      601 gccgcctccc tgggtctagg agctggtttt ccatccatcc cagtcggcaa gagccccatg
      661 gtggagcagg ctgtgcagac tggttctgct gacaacctga atgctaaaaa gctgttacct
      721 ggcaagggca ccacagggac gcagctcaac ggtcgtcagg cccagccgag cagcaagacg
      781 gccagcgatg tagtccagcc ggcagctgtg caagctcaag ggcaggtgaa tgacgagaac
      841 agaagacctc agaggaggcg atcaggaaac aggcgaacaa ggaatcgctc cagagggcaa
      901 aaccgtccaa ctaacgttaa ggaaaacaca atcaaatttg agggtgactt tgatttcgag
      961 agtgcaaatg cccagttcaa ccgagaggag cttgacaaag aatttaagaa gaaactgaat
     1021 tttaaagatg acaaggctga gaagggggaa gagaaggacc tggctgtggt gacccagagt
     1081 gccgaagcgc ccgctgagga agaccttctg gggcccaact gctactatga caaatccaag
     1141 tcgttcttcg acaacatctc ttctgaactc aagaccagct ccaggcggac gacgtgggcc
     1201 gaagagagga agctcaacac agagaccttt ggggtgtcag ggaggtttct tcgtggccgc
     1261 agttctcggg gcggattccg aggaggcagg ggcaatggga ccacccgtcg caaccccact
     1321 tcccacaggg ccgggactgg cagggtgtga gggtgcagcc aaaggctcct actgaagtgg
     1381 cgcataactg acgctgtgtg tgtcaggacg cgaggaaaac gctgcactta cagggagagg
     1441 tggtcacttt gtttacggag tttggaagag acccatactg ctacttgtgt tttggactta
     1501 actgaacttg gacatggtct gagttagaac cacttgtttt ggggaagtat tcatgggtaa
     1561 cctctttgag gtctctttat ctgtgtttcc tttttagttg cgcatagcct aattctaagg
     1621 ttttggtatt ttgcaaaaag gtttctatag tgaaagctga atccttactt tgtgactttt
     1681 tttttttttt ttaatgacaa gctttgactt ttaaaagtgg aaccaaatct gttggcagag
     1741 gtggcagcca agtacatctc tgtaacccag ctggcccctg gtgctgttgg cctggcaccc
     1801 cactgccaag ggtggggtct caggagtcag gcagggccag cacagggtgg cgtggggggc
     1861 aggggtgggt gggtggaggg cacggaaggg gttttcccat ggatcatgtt gtataagtga
     1921 accagaccac cctgatggca tccacagtga tgtcaaggtt ggggctggcc aggggtgggt
     1981 ggactagaag catttgggag tagtggccag gggccctgga cgctagccac ggagctgctg
     2041 cacagagcct ggtgtccaca agcttccagg ttggggttgg agcctgggat gagccccggc
     2101 agcgccttgg cccttctgtg gtccctgcca gcctctgacc tgggccggtc agtcattgct
     2161 ggactctggc cacacactgg cgttctcatc cacttggaaa caagccagtc ttttctgcaa
     2221 ggtcagttga ccaagagcat atttcccctc tgttgtacat cgttgttttg tgtttgtgtt
     2281 gtaacagtgg gtggagggag ggtggggtct acatttgttg catgagtcga tgggtcagaa
     2341 ctttagtata cgcatgcgtc ctctgagtga cagggcattt tgtcgaaaat aagcaccttg
     2401 gtaactaaac ccctctaata gctataaagg ctttagttct gtattgatta agttactgta
     2461 aaagcttggg tttatttttg taggacttaa tggctaagaa ttagaacata gcaagggggc
     2521 tcctctgttg gagtaatgta aattgtaatt ataaataaac atgcaaacct ttaaaa
//
