LOCUS       NP_653304                385 aa            linear   PRI 28-APR-2025
DEFINITION  protein LSM14 homolog B [Homo sapiens].
ACCESSION   NP_653304
VERSION     NP_653304.2
DBSOURCE    REFSEQ: accession NM_144703.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 385)
  AUTHORS   Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
            Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
            Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
            Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
            Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
            Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
            Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
            Huentelman,M., Weil,D. and Piton,A.
  TITLE     Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
            Intellectual Disability and Dysmorphic Features and Lead to P-Body
            Defects and RNA Dysregulation
  JOURNAL   Am J Hum Genet 105 (3), 509-525 (2019)
   PUBMED   31422817
REFERENCE   4  (residues 1 to 385)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (residues 1 to 385)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
REFERENCE   6  (residues 1 to 385)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM547301.1, BX375905.2, BC035702.1, BX370449.2, DB336439.1,
            AL137077.31 and CX166280.1.
            
            On Jun 15, 2007 this sequence version replaced NP_653304.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.338451.1,
                                           DRR138522.99055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279068.11/ ENSP00000279068.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     Protein         1..385
                     /product="protein LSM14 homolog B"
                     /note="family with sequence similarity 61, member B;
                     hRAP55B; RNA-associated protein 55B; LSM14 homolog B;
                     LSM14B, SCD6 homolog B"
                     /calculated_mol_wt=41940
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Region          6..79
                     /region_name="LSm14_N"
                     /note="Like-Sm protein 14, N-terminal domain; cd01736"
                     /db_xref="CDD:212483"
     Site            order(14..20,22..34,37..41)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212483"
     Site            order(32,34,70)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212483"
     Site            66..77
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212483"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Region          164..246
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Region          247..349
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          310..326
                     /region_name="FFD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            329
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Region          330..350
                     /region_name="TFG box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            349
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Site            351
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8CGC4; propagated from
                     UniProtKB/Swiss-Prot (Q9BX40.1)"
     Region          357..385
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BX40.1)"
     CDS             1..385
                     /gene="LSM14B"
                     /gene_synonym="bA11M20.3; C20orf40; FAM61B; FT005; LSM13;
                     RAP55B"
                     /coded_by="NM_144703.3:193..1350"
                     /db_xref="CCDS:CCDS46626.1"
                     /db_xref="GeneID:149986"
                     /db_xref="HGNC:HGNC:15887"
                     /db_xref="MIM:620689"
ORIGIN      
        1 msgssgtpyl gskisliska qiryegilyt idtdnstval akvrsfgted rptdrpappr
       61 eeiyeyiifr gsdikditvc eppkaqhtlp qdpaivqssl gsasaspfqp hvpyspfrgm
      121 apygplaass llsqqyaasl glgagfpsip vgkspmveqa vqtgsadnln akkllpgkgt
      181 tgtqlngrqa qpssktasdv vqpaavqaqg qvndenrrpq rrrsgnrrtr nrsrgqnrpt
      241 nvkentikfe gdfdfesana qfnreeldke fkkklnfkdd kaekgeekdl avvtqsaeap
      301 aeedllgpnc yydksksffd nisselktss rrttwaeerk lntetfgvsg rflrgrssrg
      361 gfrggrgngt trrnptshra gtgrv
//
