LOCUS       NM_015578               3431 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens LSM14A mRNA processing body assembly factor (LSM14A),
            transcript variant 2, mRNA.
ACCESSION   NM_015578
VERSION     NM_015578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Zhang,L., Fu,Y., Zhang,R., Guan,Y., Jiang,N., Zheng,N. and Wu,Z.
  TITLE     Nonstructural Protein NSs Hampers Cellular Antiviral Response
            through LSm14A during Severe Fever with Thrombocytopenia Syndrome
            Virus Infection
  JOURNAL   J Immunol 207 (2), 590-601 (2021)
   PUBMED   34244294
  REMARK    GeneRIF: Nonstructural Protein NSs Hampers Cellular Antiviral
            Response through LSm14A during Severe Fever with Thrombocytopenia
            Syndrome Virus Infection.
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Peter,D., Ruscica,V., Bawankar,P., Weber,R., Helms,S., Valkov,E.,
            Igreja,C. and Izaurralde,E.
  TITLE     Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated
            translational repression
  JOURNAL   Genes Dev 33 (19-20), 1355-1360 (2019)
   PUBMED   31439631
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
            Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
            Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
            Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
            Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
            Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
            Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
            Huentelman,M., Weil,D. and Piton,A.
  TITLE     Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
            Intellectual Disability and Dysmorphic Features and Lead to P-Body
            Defects and RNA Dysregulation
  JOURNAL   Am J Hum Genet 105 (3), 509-525 (2019)
   PUBMED   31422817
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Brandmann,T., Fakim,H., Padamsi,Z., Youn,J.Y., Gingras,A.C.,
            Fabian,M.R. and Jinek,M.
  TITLE     Molecular architecture of LSM14 interactions involved in the
            assembly of mRNA silencing complexes
  JOURNAL   EMBO J 37 (7) (2018)
   PUBMED   29510985
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Yoshino,H., Hirano,M., Stoessl,A.J., Imamichi,Y., Ikeda,A., Li,Y.,
            Funayama,M., Yamada,I., Nakamura,Y., Sossi,V., Farrer,M.J.,
            Nishioka,K. and Hattori,N.
  TITLE     Homozygous alpha-synuclein p.A53V in familial Parkinson's disease
  JOURNAL   Neurobiol Aging 57, 248 (2017)
   PUBMED   28666710
  REMARK    GeneRIF: alpha-synuclein p.A53V homozygous mutation leads to a
            distinct phenotype of progressive parkinsonism and cognitive
            decline, commonly observed in patients with SNCA missense mutation
            or multiplications
            Erratum:[Neurobiol Aging. 2025 Feb;146:74-76. doi:
            10.1016/j.neurobiolaging.2024.09.001.. PMID: 39294004]
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Matsumoto,K., Nakayama,H., Yoshimura,M., Masuda,A., Dohmae,N.,
            Matsumoto,S. and Tsujimoto,M.
  TITLE     PRMT1 is required for RAP55 to localize to processing bodies
  JOURNAL   RNA Biol 9 (5), 610-623 (2012)
   PUBMED   22614839
  REMARK    GeneRIF: RAP55 is important for the assembly of cytoplasmic mRNP
            granules and that PRMT1 is required for RAP55A to localize to
            P-bodies.
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Marnef,A., Sommerville,J. and Ladomery,M.R.
  TITLE     RAP55: insights into an evolutionarily conserved protein family
  JOURNAL   Int J Biochem Cell Biol 41 (5), 977-981 (2009)
   PUBMED   18723115
  REMARK    GeneRIF: this protein family has evolved a common and fundamental
            role in the control of mRNA translation. Human RAP55A is an
            autoantigen detected in the serum of patients with primary biliary
            cirrhosis (PBC).
            Review article
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
REFERENCE   10 (bases 1 to 3431)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010614.8.
            
            On Jun 18, 2020 this sequence version replaced NM_015578.3.
            
            Summary: Sm-like proteins were identified in a variety of organisms
            based on sequence homology with the Sm protein family (see SNRPD2;
            601061). Sm-like proteins contain the Sm sequence motif, which
            consists of 2 regions separated by a linker of variable length that
            folds as a loop. The Sm-like proteins are thought to form a stable
            heteromer present in tri-snRNP particles, which are important for
            pre-mRNA splicing.[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon
            compared to variant 1 and encodes isoform b. While isoforms a and b
            are of the same length, their C-termini are different.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027643.1, SRR11853558.12591.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544216.8/ ENSP00000446271.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC010614.8         30149-30408
            261-424             AC010614.8         52123-52286
            425-554             AC010614.8         54279-54408
            555-677             AC010614.8         66574-66696
            678-854             AC010614.8         72769-72945
            855-920             AC010614.8         73241-73306
            921-1103            AC010614.8         77036-77218
            1104-1275           AC010614.8         77351-77522
            1276-1507           AC010614.8         79152-79383
            1508-3431           AC010614.8         85010-86933
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..3431
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:26065"
                     /db_xref="HGNC:HGNC:24489"
                     /db_xref="MIM:610677"
     exon            1..260
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1531
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="isoform b is encoded by transcript variant 2;
                     family with sequence similarity 61, member A; protein
                     LSM14 homolog A; RNA-associated protein 55; hRAP55;
                     hRAP55A; alphaSNBP; protein SCD6 homolog; RNA-associated
                     protein 55A; putative alpha-synuclein-binding protein;
                     LSM14A, SCD6 homolog A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform b"
                     /protein_id="NP_056393.2"
                     /db_xref="CCDS:CCDS12435.1"
                     /db_xref="GeneID:26065"
                     /db_xref="HGNC:HGNC:24489"
                     /db_xref="MIM:610677"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSST
                     SSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSS
                     AVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPV
                     STRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNG
                     EDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLN
                     AETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREF
                     ADFEYRKDNKVAA"
     exon            261..424
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            425..554
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            555..677
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            678..854
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            855..920
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1103
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1275
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1507
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..3431
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="hexamer: AATAAA"
     polyA_site      2239
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="major polyA site"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="LSM14A"
                     /gene_synonym="C19orf13; FAM61A; RAP55; RAP55A"
                     /note="major polyA site"
ORIGIN      
        1 agcggagccg gcgccgccgc catgttgggt ctgaagcggc tgctgtaggc gccgacggag
       61 cgagcgggcg tgcggagcgg gcgacagtgg cgtgggatct gcctctctgc gagcagctgg
      121 gagcggcggc ggcggcgcca tgagcggggg caccccttac atcggcagca agatcagcct
      181 catctccaag gcggagatcc gctacgaggg catcctctac accatcgaca ccgaaaactc
      241 caccgtagcc cttgccaaag ttcgatcctt tggtacagaa gacagaccga cagatcgtcc
      301 aataccacct cgagatgaag tctttgaata cattatattc cgtgggagtg acattaaaga
      361 ccttactgtt tgtgagccac caaaaccaca gtgttctttg cctcaagacc cagctattgt
      421 tcagtcctca ctaggctcat cgacttcttc attccagtcc atgggttctt atggaccttt
      481 cggcaggatg cccacataca gtcagttcag tccgagttcc ttagttgggc agcagtttgg
      541 tgctgttggt gttgctggaa gctctttgac atcctttgga acagaaacat caaacagtgg
      601 taccttaccc caaagtagtg cggttggttc tgcctttaca caggatacaa gatctctaaa
      661 aacacagtta tctcaaggtc gctcaagccc tcagttagac cctttgagaa aaagcccaac
      721 catggaacaa gcagtgcaga ccgcctcagc ccacttacct gctccagcag ctgttgggag
      781 aaggagtcct gtatcaacca ggcctttgcc atctgccagc caaaaggcag gagagaatca
      841 ggagcacagg cgagctgaag tacacaaagt ttcaaggcca gaaaatgagc aactcagaaa
      901 tgataacaag agacaagtag ctccaggtgc tccttcagct ccaaggagag ggcgtggggg
      961 tcatcggggt ggcaggggaa gatttggtat tcggcgagat gggccaatga aatttgagaa
     1021 agactttgac tttgaaagtg caaatgcaca attcaacaag gaagagattg acagagagtt
     1081 tcataataaa cttaaattaa aagaagataa acttgagaaa caggagaagc ctgtaaatgg
     1141 tgaagataaa ggagactcag gagttgatac ccaaaacagt gaaggaaatg ccgatgaaga
     1201 agatccactt ggacctaatt gctattatga caaaactaaa tccttctttg ataatatttc
     1261 ttgtgatgac aatagagaac ggagaccaac ctgggctgaa gaaagaagat taaatgctga
     1321 aacatttgga atcccacttc gtccaaaccg tggccgtggg ggatacagag gcagaggagg
     1381 tcttggtttc cgtggtggca gagggcgtgg tggtggcaga ggtggtacct tcactgcccc
     1441 tcgaggattt cgcggtggat tcagaggagg tcgtgggggc cgggagtttg cggattttga
     1501 atataggaaa gacaacaaag ttgctgcata gtctacaaac aagtctctga aaataggtga
     1561 atttctagct cttcatggtc ctgaacattg atttcagtct ttgcaaagaa tgaagaagtg
     1621 aattcgctgt acatttgtca ccagcactgg gtttttgttt tttgtttgtt tttccgctta
     1681 atttcaaaga taaaatgcag ttacttttgg gggtggaagg ctcatcttaa aacatgagca
     1741 ttaaatatat ttggaatagc agaaggttaa gtaatttctt atgtatagtt aaactaaagc
     1801 agtacttcag tgggacttaa caagtatttt ttcatcactg aaaggttttt tttttttatc
     1861 actaaattgt atttggcaat tgcaagttgc ctgcagatag ggccgtgata ctgtgttttg
     1921 agccacagaa ggttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgtgtgt
     1981 gtctttttcc tcctttcttt tggggaatcc tgtaatatga ggtagcttat ttcgtcaatt
     2041 aattagggtg ctggatggta gagaattttg tcagtcaact atgtacacac agtaaatact
     2101 gtttcttagg caaaggtaac ttttttatat agttgtaaaa ttccattata ttccattgcc
     2161 aaagaaacat taagaacttt gtatagctgt ataaaaagca actaattttt taaagaataa
     2221 acattttaaa gtcagcaaac atactgtgtc cttgcagaag ttgatgtgct gagcagcagc
     2281 cttatgggtg ggtctttttt tcttagtttt ccaggcttaa catttttgat tttgtttttt
     2341 aatgtttgga acataaatga agatttgata cattatttca ttatctaaaa aggattaatt
     2401 attcatgctc attgtaagaa cttcattttg tagcaaatgg catatcacag gatctgtcca
     2461 gataatcgat attttcagta tacaaatgta aataatcaca gatgagaatg tacttagctg
     2521 tattttcaaa taagtaatct tccccccttt tgtaggactt taaaactagg catcaatgaa
     2581 cctgtttttc ctattatgcc tggaatttag tcatgatacc ttgactcatt ccatcatatt
     2641 tcaagaggat tcagagtgct agaaattatt ttggtagcct gtaacacacg gcaacactgg
     2701 tccttgggcc tatgatgacc cacagatgac tcagtataga gttcattgct aattataaat
     2761 tactagtgaa tctttttgat attttaagct ctagtgggaa aaatctggcc acttttgtgt
     2821 ttttatgaag gccatggaat aaaaggatcc aaagatttaa atatttttat ctaatatttt
     2881 gattgttttc ttaactttct ccttaaaaca ttcagtagtg ataaagatat agaaactgca
     2941 ctgtaggaga attggaatat ttaaggctgg ttgacatttt ttattttcat tttatatctt
     3001 ttgtatagct ctacaaggca gtgttttgta atttggtttc attatgaaga tccagtactt
     3061 ggcagccata gtttagacaa tattgttcag tgctgtttgc ttgcatgtta acaacaaaac
     3121 cttttagagg acccacaaat catgatattg aacacagttc cgaggcattc agagcatcag
     3181 agcaagtacc atggcaatac atgtgtagac tgttggagat gtcccgggcc aatttcaaga
     3241 aagaaaactg taaatactag ttctacttgc tctgaaatta tgagtttatg cgttttccca
     3301 gccctccgaa tcactgactg gggcgttttg tgccccagca ataactggca gcatggcata
     3361 cctgcagtac cccttacaat attaaagcaa agtttttatt ctaaaacaga ataaaactgt
     3421 tcaataaaaa a
//
