LOCUS       NM_001371445            2552 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LSM12 homolog (LSM12), transcript variant 5, mRNA.
ACCESSION   NM_001371445
VERSION     NM_001371445.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Gunaratne,G.S., Brailoiu,E., Kumar,S., Yuan,Y., Slama,J.T.,
            Walseth,T.F., Patel,S. and Marchant,J.S.
  TITLE     Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12
  JOURNAL   Sci Signal 16 (799), eadg0485 (2023)
   PUBMED   37607218
  REMARK    GeneRIF: Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12.
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Zhuang,Y., Ning,C., Liu,P., Zhao,Y., Li,Y., Ma,Z., Shan,L.,
            Piao,Y., Zhao,P. and Jin,X.
  TITLE     LSM12 facilitates the progression of colorectal cancer by
            activating the WNT/CTNNB1 signaling pathway
  JOURNAL   Oncol Res 30 (6), 289-300 (2023)
   PUBMED   37303493
  REMARK    GeneRIF: LSM12 facilitates the progression of colorectal cancer by
            activating the WNT/CTNNB1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Dong,Y., Xue,L., Zhang,Y., Liu,C., Zhang,Y., Jiang,N., Ma,X.,
            Chen,F., Li,L., Yu,L., Liu,X., Shao,S., Guan,S., Zhang,J., Xiao,Q.,
            Li,H., Dong,A., Huang,L., Shi,C., Wang,Y., Fu,M., Lv,N. and Zhan,Q.
  TITLE     Identification of RNA-splicing factor Lsm12 as a novel
            tumor-associated gene and a potent biomarker in Oral Squamous Cell
            Carcinoma (OSCC)
  JOURNAL   J Exp Clin Cancer Res 41 (1), 150 (2022)
   PUBMED   35449073
  REMARK    GeneRIF: Identification of RNA-splicing factor Lsm12 as a novel
            tumor-associated gene and a potent biomarker in Oral Squamous Cell
            Carcinoma (OSCC).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Zhang,J., Guan,X., Shah,K. and Yan,J.
  TITLE     Lsm12 is an NAADP receptor and a two-pore channel regulatory
            protein required for calcium mobilization from acidic organelles
  JOURNAL   Nat Commun 12 (1), 4739 (2021)
   PUBMED   34362892
  REMARK    GeneRIF: Lsm12 is an NAADP receptor and a two-pore channel
            regulatory protein required for calcium mobilization from acidic
            organelles.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Lee,J., Park,J., Kim,J.H., Lee,G., Park,T.E., Yoon,K.J., Kim,Y.K.
            and Lim,C.
  TITLE     LSM12-EPAC1 defines a neuroprotective pathway that sustains the
            nucleocytoplasmic RAN gradient
  JOURNAL   PLoS Biol 18 (12), e3001002 (2020)
   PUBMED   33362237
  REMARK    GeneRIF: LSM12-EPAC1 defines a neuroprotective pathway that
            sustains the nucleocytoplasmic RAN gradient.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY010534.1, DR762377.1, AL832076.1 and AC023855.15.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044587.1, AL832076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293406.8/ ENSP00000293406.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                HY010534.1         27-73
            48-802              DR762377.1         6-760
            803-2245            AL832076.1         730-2172
            2246-2552           AC023855.15        100872-101178
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2552
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="LSM12 homolog"
                     /db_xref="GeneID:124801"
                     /db_xref="HGNC:HGNC:26407"
                     /db_xref="MIM:611793"
     exon            1..208
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..672
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="isoform 3 is encoded by transcript variant 5;
                     protein LSM12 homolog"
                     /codon_start=1
                     /product="protein LSM12 isoform 3"
                     /protein_id="NP_001358374.1"
                     /db_xref="CCDS:CCDS11475.1"
                     /db_xref="GeneID:124801"
                     /db_xref="HGNC:HGNC:26407"
                     /db_xref="MIM:611793"
                     /translation="MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCP
                     SSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQA
                     YAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALS
                     HVRKIVEKHFRDVESQKILQRSQAQQPQKEAALSS"
     exon            209..342
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            343..452
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            453..579
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            580..2552
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="hexamer: AACAAG"
     polyA_site      1122
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="major polyA site"
     polyA_site      1151
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="hexamer: AGTAAA"
     polyA_site      2552
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
ORIGIN      
        1 gccgtcgcgt cgcggcgctc actgggggcc cggctttcgc ccgctgctgc cgccgccgcc
       61 gccggccgcg gctgcactcc caagatggcg gctcctccgg gcgagtactt cagcgttggg
      121 agccaggtgt cgtgccggac gtgccaggag cagcggctgc agggcgaggt ggtagccttt
      181 gactaccaat ccaaaatgct ggctttaaaa tgtccctctt ccagtggaaa gcccaaccat
      241 gcagacatct tgctcataaa cttacagtat gtttcagaag tggaaataat taatgaccga
      301 acagaaaccc ctcctcccct agcttcactc aatgttagta agcttgccag caaagcacgg
      361 acagagaagg aggagaagct gagccaggcc tatgcaatca gtgctggtgt ctctctagag
      421 ggccagcagc tcttccagac cattcacaag accattaaag actgtaaatg gcaagaaaaa
      481 aacatcgtag tcatggaaga agttgttatt acacccccat atcaagtgga aaactgtaaa
      541 ggcaaagagg ggagtgcact gagccatgta cgcaaaatag ttgaaaaaca ttttagagac
      601 gtggaaagcc aaaagatact gcaacgttca caagcccagc aaccacagaa ggaggctgcc
      661 ctgtcatcct gagtccgtac acatggagga ctcttccagc atccagccaa ggaggcgctg
      721 gtggtggctt cagcggaggc aggccggggg agggaaggga tcctatatgt cctgttggct
      781 cttaacaaag ggtcagcatt tccaaatctt agacttgaac aaacaaaaca cccaacaaaa
      841 aagaacaaga gaataattta aaagttgaat cattacttga ctaacagact tcggtccacc
      901 atgtcctttt cacagccctc ttctggaaca gtcaccttgt taattttatt tttgaaaatt
      961 attttcccac tctgcccttt acttctgact ttcctttcct agtttgttcc tgccattctg
     1021 tttttataag tggctacact tgccttctga atgattgaaa gaaactttta catcttttct
     1081 tccaaaataa aagtaacaag ctgactgtga ttcttaaatt gagaccagag cagcaaacgt
     1141 ctcactttaa atttttgttt tcttttcctt tttttttctt ttttcttttt tttttttttt
     1201 ttgcacaggg catggcttga attagtttta tttttcttaa ctttaaatat atatatgaaa
     1261 atatatatta aaatgttctc taaatatttt ctgcttcttg caggtctctt tttactagat
     1321 catggctgtt cttcccacct catccctctg aaaataaaaa tgtattgccc tccccaccat
     1381 ccatcatagc caggccacta acttgacttg gtgcaagaga ttcttgctgc gaactttgta
     1441 gagccagtgt gcagatagaa tttggctttg agggttcctg atggcttttt agtctttaac
     1501 tgtgtgtgta ccagtctcac atttggccca aacctcagga ttctccctct gcctgtctta
     1561 cttcatggta ctagaagacc ttcctcgcca ctctctccac atgagagagt cagctgccct
     1621 ttctcctgtg cctctgcagg aagaactctc ttgcatggca catctcagct cctcattgag
     1681 ggatagtttt ctttgataag aaacctggag tccatttact ctgacctctc tttaaatcta
     1741 tatccagagc cactagccca ggaaaaactt gggtgacccg taatttctct tctcctgctg
     1801 tccttttgct cttacgcccc accccaactc cccttaaatt ttacaggctt atgacagttt
     1861 gtatgtgctc agccaatgag cagaaaacct ggaaagaatt tctggacttt agcccaccag
     1921 tttgtctggt tgactaacct gctgagagct aaaattggca cccattgccc cgtgccttca
     1981 ggcagtctcc tggggcagag tatgccacca tccgaatatc aggcactgag tgggatgtgg
     2041 gtgatgctca catgactggc tagagctttg ggggtggggt gggggttaac tactattttt
     2101 ttggccatga tctctttccc cttccttttt tttttaatta aataaatgga tcaaattaaa
     2161 taattcaagc cctgccttca aaatgaaatt ttttttttag tattatttag caaaaacaat
     2221 aaaacccaaa tttttttaac catcactcat gtctcaggtt tgtgcgtcct tcagaggccc
     2281 caggggagag gatccaaggt atgtctgtct gatttgacct ttctctttag agtctcttct
     2341 tcctactatt taccctctct tttcaccccc gaggactcat ccagaaatat aatgcagggt
     2401 ataatttaag atgggggtcc agggtttgga gtggtgtgta ggtggagtgt ggggaaaagg
     2461 ctgtagtcac atacatagaa ccatttgtta caggactgtt tggaggcaca aatggtcggc
     2521 gagctgagaa gtaaactttc agatccacct gc
//
