LOCUS       NM_001369484            2486 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens LSM12 homolog (LSM12), transcript variant 1, mRNA.
ACCESSION   NM_001369484
VERSION     NM_001369484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Gunaratne,G.S., Brailoiu,E., Kumar,S., Yuan,Y., Slama,J.T.,
            Walseth,T.F., Patel,S. and Marchant,J.S.
  TITLE     Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12
  JOURNAL   Sci Signal 16 (799), eadg0485 (2023)
   PUBMED   37607218
  REMARK    GeneRIF: Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12.
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Zhuang,Y., Ning,C., Liu,P., Zhao,Y., Li,Y., Ma,Z., Shan,L.,
            Piao,Y., Zhao,P. and Jin,X.
  TITLE     LSM12 facilitates the progression of colorectal cancer by
            activating the WNT/CTNNB1 signaling pathway
  JOURNAL   Oncol Res 30 (6), 289-300 (2023)
   PUBMED   37303493
  REMARK    GeneRIF: LSM12 facilitates the progression of colorectal cancer by
            activating the WNT/CTNNB1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Dong,Y., Xue,L., Zhang,Y., Liu,C., Zhang,Y., Jiang,N., Ma,X.,
            Chen,F., Li,L., Yu,L., Liu,X., Shao,S., Guan,S., Zhang,J., Xiao,Q.,
            Li,H., Dong,A., Huang,L., Shi,C., Wang,Y., Fu,M., Lv,N. and Zhan,Q.
  TITLE     Identification of RNA-splicing factor Lsm12 as a novel
            tumor-associated gene and a potent biomarker in Oral Squamous Cell
            Carcinoma (OSCC)
  JOURNAL   J Exp Clin Cancer Res 41 (1), 150 (2022)
   PUBMED   35449073
  REMARK    GeneRIF: Identification of RNA-splicing factor Lsm12 as a novel
            tumor-associated gene and a potent biomarker in Oral Squamous Cell
            Carcinoma (OSCC).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Zhang,J., Guan,X., Shah,K. and Yan,J.
  TITLE     Lsm12 is an NAADP receptor and a two-pore channel regulatory
            protein required for calcium mobilization from acidic organelles
  JOURNAL   Nat Commun 12 (1), 4739 (2021)
   PUBMED   34362892
  REMARK    GeneRIF: Lsm12 is an NAADP receptor and a two-pore channel
            regulatory protein required for calcium mobilization from acidic
            organelles.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Lee,J., Park,J., Kim,J.H., Lee,G., Park,T.E., Yoon,K.J., Kim,Y.K.
            and Lim,C.
  TITLE     LSM12-EPAC1 defines a neuroprotective pathway that sustains the
            nucleocytoplasmic RAN gradient
  JOURNAL   PLoS Biol 18 (12), e3001002 (2020)
   PUBMED   33362237
  REMARK    GeneRIF: LSM12-EPAC1 defines a neuroprotective pathway that
            sustains the nucleocytoplasmic RAN gradient.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023855.15.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.288957.1,
                                           SRR1803612.416151.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC023855.15        68835-69042
            209-342             AC023855.15        71572-71705
            343-452             AC023855.15        95250-95359
            453-579             AC023855.15        97968-98094
            580-820             AC023855.15        98404-98644
            821-2486            AC023855.15        99206-100871
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2486
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="LSM12 homolog"
                     /db_xref="GeneID:124801"
                     /db_xref="HGNC:HGNC:26407"
                     /db_xref="MIM:611793"
     exon            1..208
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..777
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LSM12 homolog"
                     /codon_start=1
                     /product="protein LSM12 isoform 1"
                     /protein_id="NP_001356413.1"
                     /db_xref="CCDS:CCDS92334.1"
                     /db_xref="GeneID:124801"
                     /db_xref="HGNC:HGNC:26407"
                     /db_xref="MIM:611793"
                     /translation="MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCP
                     SSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQA
                     YAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALS
                     HVRKIRQSLALSPTLECSGAISAHCNLRLPGSSDSPASASRVPGTTGVCHHTRLEMGF
                     HHVGQAGLELLT"
     exon            209..342
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            343..452
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            453..579
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            580..820
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     exon            821..2486
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="hexamer: AACAAG"
     polyA_site      1363
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="major polyA site"
     polyA_site      1392
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
                     /note="hexamer: AATAAA"
     polyA_site      1620
                     /gene="LSM12"
                     /gene_synonym="PNAS-135"
ORIGIN      
        1 gccgtcgcgt cgcggcgctc actgggggcc cggctttcgc ccgctgctgc cgccgccgcc
       61 gccggccgcg gctgcactcc caagatggcg gctcctccgg gcgagtactt cagcgttggg
      121 agccaggtgt cgtgccggac gtgccaggag cagcggctgc agggcgaggt ggtagccttt
      181 gactaccaat ccaaaatgct ggctttaaaa tgtccctctt ccagtggaaa gcccaaccat
      241 gcagacatct tgctcataaa cttacagtat gtttcagaag tggaaataat taatgaccga
      301 acagaaaccc ctcctcccct agcttcactc aatgttagta agcttgccag caaagcacgg
      361 acagagaagg aggagaagct gagccaggcc tatgcaatca gtgctggtgt ctctctagag
      421 ggccagcagc tcttccagac cattcacaag accattaaag actgtaaatg gcaagaaaaa
      481 aacatcgtag tcatggaaga agttgttatt acacccccat atcaagtgga aaactgtaaa
      541 ggcaaagagg ggagtgcact gagccatgta cgcaaaataa gacagagtct cgctctgtcg
      601 cccacgctgg agtgcagtgg cgcgatctca gctcactgca acctccgcct cccgggttca
      661 agcgattctc ctgcctcagc ctcccgagta cctgggacta caggcgtatg ccaccacacc
      721 cggctagaga tggggtttca ccatgttggc caggctggtc tcgaactcct gacctgaagt
      781 gatctgccca ccttggcctc ccaaagtgct gggattgcag gttgaaaaac attttagaga
      841 cgtggaaagc caaaagatac tgcaacgttc acaagcccag caaccacaga aggaggctgc
      901 cctgtcatcc tgagtccgta cacatggagg actcttccag catccagcca aggaggcgct
      961 ggtggtggct tcagcggagg caggccgggg gagggaaggg atcctatatg tcctgttggc
     1021 tcttaacaaa gggtcagcat ttccaaatct tagacttgaa caaacaaaac acccaacaaa
     1081 aaagaacaag agaataattt aaaagttgaa tcattacttg actaacagac ttcggtccac
     1141 catgtccttt tcacagccct cttctggaac agtcaccttg ttaattttat ttttgaaaat
     1201 tattttccca ctctgccctt tacttctgac tttcctttcc tagtttgttc ctgccattct
     1261 gtttttataa gtggctacac ttgccttctg aatgattgaa agaaactttt acatcttttc
     1321 ttccaaaata aaagtaacaa gctgactgtg attcttaaat tgagaccaga gcagcaaacg
     1381 tctcacttta aatttttgtt ttcttttcct ttttttttct tttttctttt tttttttttt
     1441 tttgcacagg gcatggcttg aattagtttt atttttctta actttaaata tatatatgaa
     1501 aatatatatt aaaatgttct ctaaatattt tctgcttctt gcaggtctct ttttactaga
     1561 tcatggctgt tcttcccacc tcatccctct gaaaataaaa atgtattgcc ctccccacca
     1621 tccatcatag ccaggccact aacttgactt ggtgcaagag attcttgctg cgaactttgt
     1681 agagccagtg tgcagataga atttggcttt gagggttcct gatggctttt tagtctttaa
     1741 ctgtgtgtgt accagtctca catttggccc aaacctcagg attctccctc tgcctgtctt
     1801 acttcatggt actagaagac cttcctcgcc actctctcca catgagagag tcagctgccc
     1861 tttctcctgt gcctctgcag gaagaactct cttgcatggc acatctcagc tcctcattga
     1921 gggatagttt tctttgataa gaaacctgga gtccatttac tctgacctct ctttaaatct
     1981 atatccagag ccactagccc aggaaaaact tgggtgaccc gtaatttctc ttctcctgct
     2041 gtccttttgc tcttacgccc caccccaact ccccttaaat tttacaggct tatgacagtt
     2101 tgtatgtgct cagccaatga gcagaaaacc tggaaagaat ttctggactt tagcccacca
     2161 gtttgtctgg ttgactaacc tgctgagagc taaaattggc acccattgcc ccgtgccttc
     2221 aggcagtctc ctggggcaga gtatgccacc atccgaatat caggcactga gtgggatgtg
     2281 ggtgatgctc acatgactgg ctagagcttt gggggtgggg tgggggttaa ctactatttt
     2341 tttggccatg atctctttcc ccttcctttt ttttttaatt aaataaatgg atcaaattaa
     2401 ataattcaag ccctgccttc aaaatgaaat ttttttttta gtattattta gcaaaaacaa
     2461 taaaacccaa atttttttaa ccatca
//
