LOCUS       NM_173491               6567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LSM11, U7 small nuclear RNA associated (LSM11), mRNA.
ACCESSION   NM_173491
VERSION     NM_173491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6567)
  AUTHORS   Uggenti,C., Lepelley,A., Depp,M., Badrock,A.P., Rodero,M.P.,
            El-Daher,M.T., Rice,G.I., Dhir,S., Wheeler,A.P., Dhir,A.,
            Albawardi,W., Fremond,M.L., Seabra,L., Doig,J., Blair,N.,
            Martin-Niclos,M.J., Della Mina,E., Rubio-Roldan,A.,
            Garcia-Perez,J.L., Sproul,D., Rehwinkel,J., Hertzog,J.,
            Boland-Auge,A., Olaso,R., Deleuze,J.F., Baruteau,J., Brochard,K.,
            Buckley,J., Cavallera,V., Cereda,C., De Waele,L.M.H., Dobbie,A.,
            Doummar,D., Elmslie,F., Koch-Hogrebe,M., Kumar,R., Lamb,K.,
            Livingston,J.H., Majumdar,A., Lorenco,C.M., Orcesi,S.,
            Peudenier,S., Rostasy,K., Salmon,C.A., Scott,C., Tonduti,D.,
            Touati,G., Valente,M., van der Linden,H. Jr., Van Esch,H.,
            Vermelle,M., Webb,K., Jackson,A.P., Reijns,M.A.M., Gilbert,N. and
            Crow,Y.J.
  TITLE     cGAS-mediated induction of type I interferon due to inborn errors
            of histone pre-mRNA processing
  JOURNAL   Nat Genet 52 (12), 1364-1372 (2020)
   PUBMED   33230297
  REMARK    GeneRIF: cGAS-mediated induction of type I interferon due to inborn
            errors of histone pre-mRNA processing.
REFERENCE   2  (bases 1 to 6567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6567)
  AUTHORS   Bucholc,K., Aik,W.S., Yang,X.C., Wang,K., Zhou,Z.H., Dadlez,M.,
            Marzluff,W.F., Tong,L. and Dominski,Z.
  TITLE     Composition and processing activity of a semi-recombinant holo U7
            snRNP
  JOURNAL   Nucleic Acids Res 48 (3), 1508-1530 (2020)
   PUBMED   31819999
  REMARK    GeneRIF: While the molecular basis for this altered cleavage
            activity is unknown, one possibility is that binding of Lsm10 and
            Lsm11 to the spliceosomal Sm site affects the overall geometry of
            the U7-specific Sm ring, resulting in misalignment of the CPSF73
            endonuclease with the substrate.
REFERENCE   4  (bases 1 to 6567)
  AUTHORS   Yang,X.C., Sabath,I., Debski,J., Kaus-Drobek,M., Dadlez,M.,
            Marzluff,W.F. and Dominski,Z.
  TITLE     A complex containing the CPSF73 endonuclease and other
            polyadenylation factors associates with U7 snRNP and is recruited
            to histone pre-mRNA for 3'-end processing
  JOURNAL   Mol Cell Biol 33 (1), 28-37 (2013)
   PUBMED   23071092
  REMARK    GeneRIF: FLASH/Lsm11 complex bind a unique combination of
            polyadenylation factors
REFERENCE   5  (bases 1 to 6567)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   6  (bases 1 to 6567)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
  REMARK    GeneRIF: The overexpression of Lsm10 and Lsm11 increases the
            cellular levels of U7 snRNP but has no effect on histone pre-mRNA
            processing.
REFERENCE   7  (bases 1 to 6567)
  AUTHORS   Wagner,E.J., Ospina,J.K., Hu,Y., Dundr,M., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Conserved zinc fingers mediate multiple functions of ZFP100, a
            U7snRNP associated protein
  JOURNAL   RNA 12 (7), 1206-1218 (2006)
   PUBMED   16714279
REFERENCE   8  (bases 1 to 6567)
  AUTHORS   Azzouz,T.N., Pillai,R.S., Dapp,C., Chari,A., Meister,G.,
            Kambach,C., Fischer,U. and Schumperli,D.
  TITLE     Toward an assembly line for U7 snRNPs: interactions of U7-specific
            Lsm proteins with PRMT5 and SMN complexes
  JOURNAL   J Biol Chem 280 (41), 34435-34440 (2005)
   PUBMED   16087681
  REMARK    GeneRIF: Lsm10 and Lsm11, which replace the Sm proteins D1 and D2
            in the histone RNA processing U7 snRNPs, associate with pICln in
            vitro and in vivo without receiving sDMA modifications and with
            PRMT5 and SMN complexes
REFERENCE   9  (bases 1 to 6567)
  AUTHORS   Pillai,R.S., Grimmler,M., Meister,G., Will,C.L., Luhrmann,R.,
            Fischer,U. and Schumperli,D.
  TITLE     Unique Sm core structure of U7 snRNPs: assembly by a specialized
            SMN complex and the role of a new component, Lsm11, in histone RNA
            processing
  JOURNAL   Genes Dev 17 (18), 2321-2333 (2003)
   PUBMED   12975319
REFERENCE   10 (bases 1 to 6567)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126449.1, BC051353.1, AC026407.4 and AI271367.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173491.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051353.1, AK095592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286307.6/ ENSP00000286307.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1180              BC126449.1         18-1197
            1181-2761           BC051353.1         1121-2701
            2762-6113           AC026407.4         87463-90814         c
            6114-6567           AI271367.1         8-461               c
FEATURES             Location/Qualifiers
     source          1..6567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..6567
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /note="LSM11, U7 small nuclear RNA associated"
                     /db_xref="GeneID:134353"
                     /db_xref="HGNC:HGNC:30860"
                     /db_xref="MIM:617910"
     exon            1..487
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1122
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm11"
                     /protein_id="NP_775762.1"
                     /db_xref="CCDS:CCDS4342.1"
                     /db_xref="GeneID:134353"
                     /db_xref="HGNC:HGNC:30860"
                     /db_xref="MIM:617910"
                     /translation="MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPP
                     IPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDA
                     PAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELH
                     RCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDS
                     SLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHK
                     RSRSVPSSLQASAREESRSELSGRTTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVD
                     YQQVFTRHINQIFIRGENVLLVHLAQ"
     exon            488..627
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            628..711
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            712..6567
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6546..6551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /note="hexamer: AATAAA"
     polyA_site      6567
                     /gene="LSM11"
                     /gene_synonym="AGS8"
                     /note="major polyA site"
ORIGIN      
        1 ccttcttccc atcggcctcg gcttgcgggc ctttcaaaca tggaggagcg ggagcggggg
       61 gcgaggtcgg ctggcgccgg gagccccgcg cgcccgccca gcccgcggct ggatgtcagc
      121 tctgacagct tcgacccgct gctggccctg tacgcgcccc gcctgcctcc cattccctac
      181 cccaatgccc cctgcttcaa caacgtggcg gagtacgaga gcttcctcag gaccggagtc
      241 cggggcggcg ggcgcgggcg cgggcgggct cggggcgcgg ccgcgggctc tggggttccc
      301 gccgcacccg ggccctcggg caggactcgt cgccgcccgg acgcgcccgc cccggacccc
      361 gagcgcatcc agcgcctccg ccgtctcatg gtggccaaag aggaagggga cggggccgca
      421 ggagcgggcc ggaggggtcc gggtcggagc aggaaggcgc cacgcaacgt gctcacgcga
      481 atgcccttgc acgaaggcag ccctctgggt gaactccatc gctgtatccg tgagggggtg
      541 aaggtgaatg ttcacatccg cactttcaag ggacttcggg gcgtctgtac aggcttcctt
      601 gttgcattcg acaagttctg gaatatggca cttactgatg tggatgagac ctaccgaaaa
      661 cctgtcctag gcaaagcata tgaacgggat tcttcactga ctctcactag gctatttgat
      721 cggctgaaac ttcaagattc ctccaagaag gaagcagatt ctaagtctgc agttgaagat
      781 tccactctgt ctagatactc acagacatcc acttggaagt tggcttcagt gtggggaaga
      841 gcagacactg gccggggctc acacaagcgt tcccgctctg tcccttcttc cctgcaggcc
      901 tctgcaaggg aggagtccag gtcagagctg tcagggagga ctacacggac agacggctcc
      961 agtgtgggag gtaccttttc cagggctacc accctttcca gaggccagtc ccgtaagaaa
     1021 aagcgaaagc ccaaagtgga ttaccagcag gtattcactc gacacataaa tcagattttc
     1081 attcgaggcg agaatgtcct gctggttcat cttgcacagt gaccagctca gcctgagctt
     1141 tggtttttag aaataaagtg catgaattgc tgctatgctg tatcctagta tcccagtgaa
     1201 actctgagtt ggaatgattc cctctggtcc tgcatatgca gaggacggag caggctcagc
     1261 cccctggaag atgagctcaa ggggaggaca ggccttggga gggcaggcgt ttgcattaat
     1321 atcaaggcaa aaagcattca tagatacatg catctgattt ggtattgtga tttacttcag
     1381 accctgaaac caaatatctg atcttccatt agacttaggg gtcatgatat gagtggaatt
     1441 tacattttag atactatagg ggaaagaaaa gtctcaaaaa gaagtattgc atgtctaaaa
     1501 gctagtgccc tgagtactca tgaattcgat tccaagagta gtggtgtaaa ttgccttgga
     1561 gccctgcatc cacgtcttgt aactaacttt tgaattttgc ctgacatgat tctctcttga
     1621 tgaagaaatg acatatatta tctttgaata tctacaagga aagttaccaa cttatgtagg
     1681 ggtgaaattt ggataggcgg tatgctcaaa gcagccagca atgagtgctc tgttttgatc
     1741 cttcttctta ttatggaaag gagtacagga cctcttcagt cttcccctta ccagaggtag
     1801 cctctgcaaa tggcatacca gatgggactc taagatgctt gtgtggtggc ttcttgtcct
     1861 tctctttgac ttctgtggca tggtgctagt gcatgtaccc tgtggtattg cccctctgtc
     1921 cgtagtgtga actgtcctgt gagctttatg tcaggagact gtgaccttca tgtccagctt
     1981 caaagagttg tgcatgaact cggtaataca catcacacgg ctgagagtcc cctttccagg
     2041 cagggccagc atgtgtagaa tatctttcag aatatggttt caccatgaaa caggggtggt
     2101 agatttattc ccttgtgtca ggccaaagaa gttcttacaa agtacagtgg gtagtgtcta
     2161 aagcgacact ttactcacag cctggcttga gtcaacagga acaccatagc acccacaaat
     2221 acttctactt gaatcatatt ctgtgctttt tcaatcacta gtgcagaata ggctgcattt
     2281 gacacagact gttaggcaat attgattttt ttgttttgtt tttatttggt tttatctgag
     2341 ataacttatg ttcaaggtga gaataagaaa tagccaacta gttaaaatgt atgaaaagaa
     2401 aactttcccc tgctgtattt gttgtgtaac ataaataagc cttctgagaa gcagggtgaa
     2461 taaagtttag ggagctggga cacctggtcc tgctagctgg accactggct catcatgcaa
     2521 tgaaaaggtg agcagactta acccctccgt gcctcagctt tttccccaca gacacctacc
     2581 tcacaggggc attgagaaaa aaaaaatgaa ggcattttac agtctctaaa catctttaag
     2641 tgccatgagt aatttttcct gactctgttt catagctttg taagaattct gtgtctttat
     2701 aagacacaga agcaaggcag gtgctacata aaaaagtaat ctcagccagg cacggtggct
     2761 cacgcctgta atcccagcac tttgggaggc tgaggcgggt ggatcacaag gtcaggagat
     2821 caagaccatc ctggctaaca cggtgaaacc ctgtctctac taaaaataca aaaattagcc
     2881 gggcgtggtg gcgggcgcct gtagtcccag ctacgtgggt ggctgaggca ggagaatggg
     2941 gtgaacccgg gaggcggagc ttgcagtgag ccaagattgc accactgtac tccagcctgg
     3001 gcgacagagc aagactctgt ctcaaaaaaa ggaaaaaaaa aaaaagtaat cttagggttc
     3061 atagttatga tcctgttgta actatcttcg gaaggcagca gtatcttctg gaacttccat
     3121 attccattcc ttcctcctaa gggacaatgg aagttctcag aagagtatct tcagtaagag
     3181 gagagtaact ttttttttgc tgctcccgct atatcccagg cctcaccctt ttctgatcat
     3241 tatcagaaag aatcccctga acttttcaag gggtttatat ggtagcacca aatggagaat
     3301 gagcatctaa aaatgacaca tcccgaaagg gcaatctgtg gaagtttgtt gtttgtttgt
     3361 ttttattttt aaatgcattg taaagtgtac tctagagcca gatcaggtgc actaaagttt
     3421 atagaggttc cagtttacaa actcaagtga acagtaatct ttggaagctg ccagtctaaa
     3481 ttctaaatag tgtatctgaa atctcagttc ccaaaatagt tgtcaggttt aatcatcagg
     3541 caacactgcg tatacctgtg tggctatcct catctgcctg ccctctcatc cctcggctag
     3601 aatgatgtac tctactttcc caataaggta gaaatttgga atccaacgga atataatcag
     3661 ttttcattca ttccagtgcc tagttaaatc taacctgact taaacatatg cctgttttta
     3721 tgtttaccta taattttcat atagccgtat aaggattgat ttaccatttt ttgcccaaca
     3781 tgacaattct ggctatgaaa attatgttta aactgtgtat gatctatttt atgtgctcta
     3841 tgttcccatt tgtttgtttg gtctggacag tggttctgga atgaattcta tctagtaaat
     3901 tagtaaatgt gctgttttgt ataaagcatg ataattactt tttaacagaa gttcattttt
     3961 aaagattact cccttttctt tctctctttt ttttgagaca atttctctct tgttgcctag
     4021 gcagtgcagt ggcgcgatct cagctccctg caacttctgc ctcccaggtt caagcgattc
     4081 tcctgcctta gcctcctgag tagctgggtc agccaccatg gctgactcat tttttgtatt
     4141 tttagtagag aaggggtttt accgtgttag ccaggctggt cttgaactcc tgaccttggg
     4201 tgatccacct gcctcagcct cccaaagtgc tgggattaca ggcgtgagct atcccgcccg
     4261 gtcccctttt ctttattatc gaagatattg tttaaaagaa agaaaaagta ggtcccaata
     4321 atatatgtgc tattcaaaaa atgtgatcat ttaggacatt atcacaagtt gctatggaaa
     4381 taactgaaga cttcctcagg agaaggaaag aaaatgagga acataatgat agagtcgggg
     4441 aactcccact agctcacctg aggggggctc gatgcagctg aaatactgaa tactgaaata
     4501 ctagaaacca acaaaactgg tttctagaat tctccaggga tttgggcttg ggaaacttgg
     4561 taagaatagt ttttattttt gaacattcaa ctttggttct tcaaagtaat ctttaaacat
     4621 gggaatatgt tttcaagaca atttatagga catacttatg tagttggtga ggtcttctca
     4681 aaagtatcta cctttgttag ataataacaa gtgattaaga aaggggagat atggttttat
     4741 actcataaca atttcctgtg ccattctctg tacacagagg tgattcattt actctcccat
     4801 tagtagaact tgcactttgg gctgtctgtt ctagtatttg ggaagtgttt atgcttcctt
     4861 ccagggacca tcttatgatc agaggcagga tgtctgtgag atggttagct agagttagca
     4921 gtgtccgggg agagtggctt tagaccagtc agtaccttgc tctttgtgca tggtgcatgt
     4981 caagtcagga agccaagaaa ccgttggcat taaaatctag atgcatagag atccttgcta
     5041 tgagttgtgg ataggagtgg ctccatctat ccttgtggtg aaagagtcca ggagctcctt
     5101 tagagattgt caagtcctga gcgatgagct gcccttaatc ctcagaagcc ttacaaaaat
     5161 tgagatgtac catttctacc ctttgagaaa aaagaaatag aaacttactt gatgcagaat
     5221 ggatatttat atttctgctt gcaccatttc catagcagct gacaaaggca aaatcatgaa
     5281 atagaatcat ttctataaat tgcttcttta agttttctct aaattttgcc tctaggaaaa
     5341 aattaaaact attcaatgac agctagctgt cactggtgct accccaaagc tttccaatct
     5401 tttatgtatt ttttgtgaat gaaactgttg ctgtaggaaa gtcaaggttc atgtaagagt
     5461 atcgtggtgt aaatataatg gtttcacagc tgtttgaatt tttcttttcc tgtgccagat
     5521 atagaatgca gtcaaccctt tttcagtaac ttatgttcac cagtctgtgc ttttcttctc
     5581 ccagaaggct tttcttagtg gttgtaaatg caagaatcct gagccctgtg ttgcaaaggt
     5641 gggtggtctg tcagcacttt ctggcaaatt gagttgatgg atttaagata agcctttggg
     5701 gttcctgtca gttttctggg ccctgaggaa gggttgggcc tcctttactc tcagtatttt
     5761 gagtgttttt caaatgtttg tacgttatct tgcactgctc taataaaaat gaaagctctc
     5821 tgacaagaaa tagttctgga tggtttgaag atctgcgggg aaaaataagt gtgcacctga
     5881 gaccttcagt tagtctttta tttatttaga ataaaaaata gtttgataac ctaccagagt
     5941 tagtgcttct ttaaaaacac tccttggaaa gatggggact gtcccttagg aaagccataa
     6001 aagtgattcc caatactttg caattgcttt tgatttttag tcctttggaa caaatgtgtg
     6061 atgttatgtc tgatgttgtg tttttagagc tgtgaaaagt ctgaaaaatt tcaaggggta
     6121 ttatttaaat gatgattatc tggctgaatt atgtgtgagc tagaatctag ggtagctgtc
     6181 cacttctttt tctgttgtcc tgacagtaaa gcaaatagta agccatgtct tgaaagtgat
     6241 ttgcttgttt catactgaca tctaaagaca tcagccttct ctttggcaac cctggggata
     6301 ctcctctgca ccataactta ttaatgtttt tttagacaag gctaaacctg aatgactcta
     6361 cgtatctata gtttcactgc tcatatacca gctgctacaa gaaaaaccat gacttgtaag
     6421 tttgtcttta ctcctaattg ctaaattaac tgaaaccctt cctgtctagg gagaattgct
     6481 gctagtaagg tcagtttgca atgttcagct ttagatatgt gtcgtaatgg gagtctgaaa
     6541 actgtaataa actgtattca tatcctg
//
