LOCUS       NM_032881                860 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LSM10, U7 small nuclear RNA associated (LSM10), mRNA.
ACCESSION   NM_032881
VERSION     NM_032881.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Bucholc,K., Aik,W.S., Yang,X.C., Wang,K., Zhou,Z.H., Dadlez,M.,
            Marzluff,W.F., Tong,L. and Dominski,Z.
  TITLE     Composition and processing activity of a semi-recombinant holo U7
            snRNP
  JOURNAL   Nucleic Acids Res 48 (3), 1508-1530 (2020)
   PUBMED   31819999
  REMARK    GeneRIF: While the molecular basis for this altered cleavage
            activity is unknown, one possibility is that binding of Lsm10 and
            Lsm11 to the spliceosomal Sm site affects the overall geometry of
            the U7-specific Sm ring, resulting in misalignment of the CPSF73
            endonuclease with the substrate.
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Skrajna,A., Yang,X.C., Bucholc,K., Zhang,J., Hall,T.M.T.,
            Dadlez,M., Marzluff,W.F. and Dominski,Z.
  TITLE     U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent
            manner by two separate regions of the stem-loop binding protein
  JOURNAL   RNA 23 (6), 938-951 (2017)
   PUBMED   28289156
  REMARK    GeneRIF: FLASH plays two roles in 3' end processing of histone
            pre-mRNAs: It interacts with Lsm11 to form a docking platform for
            the polyadenylation factors, and it cooperates with SLBP to recruit
            U7 snRNP to histone pre-mRNA.
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Ghule,P.N., Dominski,Z., Lian,J.B., Stein,J.L., van Wijnen,A.J. and
            Stein,G.S.
  TITLE     The subnuclear organization of histone gene regulatory proteins and
            3' end processing factors of normal somatic and embryonic stem
            cells is compromised in selected human cancer cell types
  JOURNAL   J Cell Physiol 220 (1), 129-135 (2009)
   PUBMED   19277982
  REMARK    GeneRIF: The subnuclear organization of histone gene regulatory
            proteins and 3' end processing factors (NPAT/LSM10) of normal
            somatic and embryonic stem cells is compromised in selected human
            cancer cell types.
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
  REMARK    GeneRIF: The overexpression of Lsm10 and Lsm11 increases the
            cellular levels of U7 snRNP but has no effect on histone pre-mRNA
            processing.
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Azzouz,T.N., Pillai,R.S., Dapp,C., Chari,A., Meister,G.,
            Kambach,C., Fischer,U. and Schumperli,D.
  TITLE     Toward an assembly line for U7 snRNPs: interactions of U7-specific
            Lsm proteins with PRMT5 and SMN complexes
  JOURNAL   J Biol Chem 280 (41), 34435-34440 (2005)
   PUBMED   16087681
  REMARK    GeneRIF: Lsm10 and Lsm11, which replace the Sm proteins D1 and D2
            in the histone RNA processing U7 snRNPs, associate with pICln in
            vitro and in vivo without receiving sDMA modifications and with
            PRMT5 and SMN complexes
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Pillai,R.S., Grimmler,M., Meister,G., Will,C.L., Luhrmann,R.,
            Fischer,U. and Schumperli,D.
  TITLE     Unique Sm core structure of U7 snRNPs: assembly by a specialized
            SMN complex and the role of a new component, Lsm11, in histone RNA
            processing
  JOURNAL   Genes Dev 17 (18), 2321-2333 (2003)
   PUBMED   12975319
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
  REMARK    GeneRIF: Purified U7 snRNPs lack the Sm proteins D1 and D2 but
            contain Lsm10, a new 14 kDa Sm D1-like protein.
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Dominski,Z., Zheng,L.X., Sanchez,R. and Marzluff,W.F.
  TITLE     Stem-loop binding protein facilitates 3'-end formation by
            stabilizing U7 snRNP binding to histone pre-mRNA
  JOURNAL   Mol Cell Biol 19 (5), 3561-3570 (1999)
   PUBMED   10207079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119675.2, BC007623.1 and AI150247.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032881.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1007107.1,
                                           SRR1163657.250253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315732.3/ ENSP00000319341.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC119675.2         31822-31837         c
            17-586              BC007623.1         1-570
            587-860             AI150247.1         29-302              c
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..860
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /note="LSM10, U7 small nuclear RNA associated"
                     /db_xref="GeneID:84967"
                     /db_xref="HGNC:HGNC:17562"
                     /db_xref="MIM:617909"
     exon            1..142
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /inference="alignment:Splign:2.1.0"
     exon            143..860
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..538
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /note="U7 snRNP-specific Sm-like protein LSM10"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm10"
                     /protein_id="NP_116270.1"
                     /db_xref="CCDS:CCDS408.1"
                     /db_xref="GeneID:84967"
                     /db_xref="HGNC:HGNC:17562"
                     /db_xref="MIM:617909"
                     /translation="MAVSHSVKERTISENSLIILLQGLQGRVTTVDLRDESVAHGRID
                     NVDAFMNIRLAKVTYTDRWGHQVKLDDLFVTGRNVRYVHIPDDVNITSTIEQQLQIIH
                     RVRNFGGKGQGRWEFPPKNCK"
     regulatory      841..846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /note="hexamer: ATTAAA"
     polyA_site      860
                     /gene="LSM10"
                     /gene_synonym="MST074; MSTP074"
                     /note="major polyA site"
ORIGIN      
        1 gcactctgcg cccggaggac agagcggccc ggtcgccggc atggtttctc cgtcctgctg
       61 cagccggcgg gaggcagcca gtccaggcgc ccgctagctt cggcggcgac ccagacgggg
      121 aaagcggaag gaatgtcgcg tgcaagcagg cagctggtgt ggaagaatgg cggtgagcca
      181 ttcagtgaag gagcggacca tctctgagaa cagcctgatc atcctactgc agggcctcca
      241 gggccgggta accactgtgg acctgcggga tgagagcgtg gcccacggac gcatagacaa
      301 tgtcgatgct ttcatgaaca tccgcctggc caaagtcacc tacacggacc gttgggggca
      361 tcaggtcaag ctggatgacc tctttgtgac aggccgcaat gtccgctacg tccacatccc
      421 agatgacgtg aacatcacct cgaccattga gcagcagctg cagattatcc atcgggtgcg
      481 aaactttggt ggcaagggcc aaggccggtg ggaatttccc ccaaaaaact gtaagtgagg
      541 ccctcagcaa gccctggccc caactcggag tcctccagtg atctccggag ctagttccct
      601 gccctcacac cctgtctggt acccgagaag aaagcagggc caggccagaa gctggtgtcc
      661 aacagacacc acctgtcaaa gctgcctttc acagggttcc acctcccaga ctcactctgg
      721 gacccagaat cctatatgtg gccttggggt aggtgacaat cccccttttt gatgatctga
      781 atctctgact tattgattat ggaacctgtc aagtagtttt caactctccc agtgaggata
      841 attaaacatg ctcagcctga
//
