LOCUS       NM_014462                906 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1),
            transcript variant 1, mRNA.
ACCESSION   NM_014462
VERSION     NM_014462.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Tzeng,Y.T., Hsiao,J.H., Chu,P.Y., Tseng,L.M., Hou,M.F., Tsang,Y.L.,
            Shao,A.N., Sheu,J.J. and Li,C.J.
  TITLE     The role of LSM1 in breast cancer: Shaping metabolism and
            tumor-associated macrophage infiltration
  JOURNAL   Pharmacol Res 198, 107008 (2023)
   PUBMED   37995895
  REMARK    GeneRIF: The role of LSM1 in breast cancer: Shaping metabolism and
            tumor-associated macrophage infiltration.
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Tzeng,Y.T., Tsui,K.H., Tseng,L.M., Hou,M.F., Chu,P.Y., Sheu,J.J.
            and Li,C.J.
  TITLE     Integrated analysis of pivotal biomarker of LSM1, immune cell
            infiltration and therapeutic drugs in breast cancer
  JOURNAL   J Cell Mol Med 26 (14), 4007-4020 (2022)
   PUBMED   35692083
  REMARK    GeneRIF: Integrated analysis of pivotal biomarker of LSM1, immune
            cell infiltration and therapeutic drugs in breast cancer.
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Streicher,K.L., Yang,Z.Q., Draghici,S. and Ethier,S.P.
  TITLE     Transforming function of the LSM1 oncogene in human breast cancers
            with the 8p11-12 amplicon
  JOURNAL   Oncogene 26 (14), 2104-2114 (2007)
   PUBMED   17001308
  REMARK    GeneRIF: LSM1 is a breast cancer oncogene from the 8p11-12
            amplicon.
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Eystathioy,T., Peebles,C.L., Hamel,J.C., Vaughn,J.H. and Chan,E.K.
  TITLE     Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm
            sera
  JOURNAL   Arthritis Rheum 46 (3), 726-734 (2002)
   PUBMED   11920408
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Friesen,W.J. and Dreyfuss,G.
  TITLE     Specific sequences of the Sm and Sm-like (Lsm) proteins mediate
            their interaction with the spinal muscular atrophy disease gene
            product (SMN)
  JOURNAL   J Biol Chem 275 (34), 26370-26375 (2000)
   PUBMED   10851237
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Salgado-Garrido,J., Bragado-Nilsson,E., Kandels-Lewis,S. and
            Seraphin,B.
  TITLE     Sm and Sm-like proteins assemble in two related complexes of deep
            evolutionary origin
  JOURNAL   EMBO J 18 (12), 3451-3462 (1999)
   PUBMED   10369684
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Schweinfest,C.W., Graber,M.W., Chapman,J.M., Papas,T.S., Baron,P.L.
            and Watson,D.K.
  TITLE     CaSm: an Sm-like protein that contributes to the transformed state
            in cancer cells
  JOURNAL   Cancer Res 57 (14), 2961-2965 (1997)
   PUBMED   9230209
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP376421.1 and AJ238094.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014462.2.
            
            Summary: This gene encodes a member of the LSm family of
            RNA-binding proteins. LSm proteins form stable heteromers that bind
            specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may
            play a role in pre-mRNA splicing by mediating U4/U6 snRNP
            formation. Increased expression of this gene may play a role in
            cellular transformation and the progression of several malignancies
            including lung cancer, mesothelioma and breast cancer.
            Alternatively spliced transcript variants have been observed for
            this gene, and a pseudogene of this gene is located on the short
            arm of chromosome 9. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238094.1, SRR5189655.140371.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311351.9/ ENSP00000310596.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BP376421.1         201-223
            24-906              AJ238094.1         39-921
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..906
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /note="LSM1 homolog, mRNA degradation associated"
                     /db_xref="GeneID:27257"
                     /db_xref="HGNC:HGNC:20472"
                     /db_xref="MIM:607281"
     exon            1..219
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..575
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /note="small nuclear ribonuclear CaSm; cancer-associated
                     Sm-like protein; LSM1 homolog, U6 small nuclear RNA
                     associated; LSM1, U6 small nuclear RNA associated; LSM1
                     mRNA degradation associated; cancer-associated Sm protein;
                     LSM1-like protein U6 small nuclear RNA associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm1"
                     /protein_id="NP_055277.1"
                     /db_xref="CCDS:CCDS6103.1"
                     /db_xref="GeneID:27257"
                     /db_xref="HGNC:HGNC:20472"
                     /db_xref="MIM:607281"
                     /translation="MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLH
                     QTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVE
                     QQTKLEAEKLKVQALKDRGLSIPRADTLDEY"
     exon            220..288
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /inference="alignment:Splign:2.1.0"
     exon            289..404
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /inference="alignment:Splign:2.1.0"
     exon            405..906
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /note="hexamer: AATAAA"
     polyA_site      906
                     /gene="LSM1"
                     /gene_synonym="CASM; YJL124C"
                     /note="major polyA site"
ORIGIN      
        1 aatatggagg agcttccggc agcccccggc ggctgaaagc cggggcagaa gtgctggtct
       61 cggtcgggat tccgggcttg gtcccaccga ggcggcgact gcggtaggag ggaagaggtt
      121 ttggacgcgc tggcctcccg ccgctgtgca ttgcagcatt atttcagttc aaaatgaact
      181 atatgcctgg caccgccagc ctcatcgagg acattgacaa aaagcacttg gttctgcttc
      241 gagatggaag gacacttata ggctttttaa gaagcattga tcaatttgca aacttagtgc
      301 tacatcagac tgtggagcgt attcatgtgg gcaaaaaata cggtgatatt cctcgaggga
      361 tttttgtggt cagaggagaa aatgtggtcc tactaggaga aatagacttg gaaaaggaga
      421 gtgacacacc cctccagcaa gtatccattg aagaaattct agaagaacaa agggtggaac
      481 agcagaccaa gctggaagca gagaagttga aagtgcaggc cctgaaggac cgaggtcttt
      541 ccattcctcg agcagatact cttgatgagt actaatcttt tgcccagagg ctgttggctc
      601 ttgaagagta ggggctgtca ctgagtgaaa gtgacatcct ggccacctca cgcatttgat
      661 cacagactgt agagttttga aaagtcactt ttatttttaa ttattttaca tatgcaacat
      721 gaagaaatcg tgtaggtggg tttttttttt aataacaaaa tcactgttta aagaaacagt
      781 ggcatagact ccttcacaca tcactgtggc accagcaact acttctttat attgttcttc
      841 atatcccaaa ttagagttta cagggacagt cttcatttac ttgtaaataa aatatgaatc
      901 tcaaaa
//
