LOCUS       NM_002338               9416 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens limbic system associated membrane protein (LSAMP),
            transcript variant 1, mRNA.
ACCESSION   NM_002338
VERSION     NM_002338.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9416)
  AUTHORS   Martinez-Monleon,A., Gaarder,J., Djos,A., Kogner,P. and Fransson,S.
  TITLE     Identification of recurrent 3q13.31 chromosomal rearrangement
            indicates LSAMP as a tumor suppressor gene in neuroblastoma
  JOURNAL   Int J Oncol 62 (2) (2023)
   PUBMED   36601748
  REMARK    GeneRIF: Identification of recurrent 3q13.31 chromosomal
            rearrangement indicates LSAMP as a tumor suppressor gene in
            neuroblastoma.
REFERENCE   2  (bases 1 to 9416)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 9416)
  AUTHORS   Mehrjoo,Z., Kahrizi,K., Mohseni,M., Akbari,M., Arzhangi,S.,
            Jalalvand,K., Najmabadi,H., Farhadi,M., Mohseni,M., Asghari,A.,
            Mohebbi,S. and Daneshi,A.
  TITLE     Limbic System Associated Membrane Protein Mutation in an Iranian
            Family Diagnosed with Meniere's Disease
  JOURNAL   Arch Iran Med 23 (5), 319-325 (2020)
   PUBMED   32383616
  REMARK    GeneRIF: Limbic System Associated Membrane Protein Mutation in an
            Iranian Family Diagnosed with Meniere's Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9416)
  AUTHORS   Brant,S.R., Okou,D.T., Simpson,C.L., Cutler,D.J., Haritunians,T.,
            Bradfield,J.P., Chopra,P., Prince,J., Begum,F., Kumar,A., Huang,C.,
            Venkateswaran,S., Datta,L.W., Wei,Z., Thomas,K., Herrinton,L.J.,
            Klapproth,J.A., Quiros,A.J., Seminerio,J., Liu,Z., Alexander,J.S.,
            Baldassano,R.N., Dudley-Brown,S., Cross,R.K., Dassopoulos,T.,
            Denson,L.A., Dhere,T.A., Dryden,G.W., Hanson,J.S., Hou,J.K.,
            Hussain,S.Z., Hyams,J.S., Isaacs,K.L., Kader,H., Kappelman,M.D.,
            Katz,J., Kellermayer,R., Kirschner,B.S., Kuemmerle,J.F., Kwon,J.H.,
            Lazarev,M., Li,E., Mack,D., Mannon,P., Moulton,D.E., Newberry,R.D.,
            Osuntokun,B.O., Patel,A.S., Saeed,S.A., Targan,S.R.,
            Valentine,J.F., Wang,M.H., Zonca,M., Rioux,J.D., Duerr,R.H.,
            Silverberg,M.S., Cho,J.H., Hakonarson,H., Zwick,M.E., McGovern,D.P.
            and Kugathasan,S.
  TITLE     Genome-Wide Association Study Identifies African-Specific
            Susceptibility Loci in African Americans With Inflammatory Bowel
            Disease
  JOURNAL   Gastroenterology 152 (1), 206-217 (2017)
   PUBMED   27693347
  REMARK    GeneRIF: We detected African-specific SNPs at ZNF649 and LSAMP,
            with associations of genome-wide significance for ulcerative
            colitis.
REFERENCE   5  (bases 1 to 9416)
  AUTHORS   Innos,J., Koido,K., Philips,M.A. and Vasar,E.
  TITLE     Limbic system associated membrane protein as a potential target for
            neuropsychiatric disorders
  JOURNAL   Front Pharmacol 4, 32 (2013)
   PUBMED   23532449
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9416)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   7  (bases 1 to 9416)
  AUTHORS   Schmitt-Ulms,G., Hansen,K., Liu,J., Cowdrey,C., Yang,J.,
            DeArmond,S.J., Cohen,F.E., Prusiner,S.B. and Baldwin,M.A.
  TITLE     Time-controlled transcardiac perfusion cross-linking for the study
            of protein interactions in complex tissues
  JOURNAL   Nat Biotechnol 22 (6), 724-731 (2004)
   PUBMED   15146195
REFERENCE   8  (bases 1 to 9416)
  AUTHORS   Chen,J., Lui,W.O., Vos,M.D., Clark,G.J., Takahashi,M.,
            Schoumans,J., Khoo,S.K., Petillo,D., Lavery,T., Sugimura,J.,
            Astuti,D., Zhang,C., Kagawa,S., Maher,E.R., Larsson,C.,
            Alberts,A.S., Kanayama,H.O. and Teh,B.T.
  TITLE     The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved
            in clear cell renal cell carcinomas
  JOURNAL   Cancer Cell 4 (5), 405-413 (2003)
   PUBMED   14667507
REFERENCE   9  (bases 1 to 9416)
  AUTHORS   Pimenta,A.F., Tsui,L.C., Heng,H.H. and Levitt,P.
  TITLE     Assignment of the gene encoding the limbic system-associated
            membrane protein (LAMP) to mouse chromosome 16B5 and human
            chromosome 3q13.2-q21
  JOURNAL   Genomics 49 (3), 472-474 (1998)
   PUBMED   9615236
REFERENCE   10 (bases 1 to 9416)
  AUTHORS   Pimenta,A.F., Fischer,I. and Levitt,P.
  TITLE     cDNA cloning and structural analysis of the human
            limbic-system-associated membrane protein (LAMP)
  JOURNAL   Gene 170 (2), 189-195 (1996)
   PUBMED   8666243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033803.1, AK299851.1,
            AC012598.16, AK091573.1, AK092715.1 and AA702209.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002338.4.
            
            Summary: This gene encodes a member of the immunoglobulin LAMP,
            OBCAM and neurotrimin (IgLON) family of proteins. The encoded
            preproprotein is proteolytically processed to generate a neuronal
            surface glycoprotein. This protein may act as a selective
            homophilic adhesion molecule during axon guidance and neuronal
            growth in the developing limbic system. The encoded protein may
            also function as a tumor suppressor and may play a role in
            neuropsychiatric disorders. Alternative splicing results in
            multiple transcript variants, at least one of which encodes a
            preproprotein that is proteolytically processed. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.87291.1,
                                           SRR1803611.252275.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490035.7/ ENSP00000419000.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1495              BC033803.1         45-1539
            1496-1774           AK299851.1         1431-1709
            1775-4757           AC012598.16        38695-41677
            4758-6192           AK091573.1         1-1435
            6193-7688           AC012598.16        43113-44608
            7689-9229           AK092715.1         1-1541
            9230-9416           AA702209.1         50-236              c
FEATURES             Location/Qualifiers
     source          1..9416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..9416
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /note="limbic system associated membrane protein"
                     /db_xref="GeneID:4045"
                     /db_xref="HGNC:HGNC:6705"
                     /db_xref="MIM:603241"
     exon            1..611
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1473
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; IgLON family member 3"
                     /codon_start=1
                     /product="limbic system-associated membrane protein
                     isoform 1 preproprotein"
                     /protein_id="NP_002329.2"
                     /db_xref="CCDS:CCDS2982.1"
                     /db_xref="GeneID:4045"
                     /db_xref="HGNC:HGNC:6705"
                     /db_xref="MIM:603241"
                     /translation="MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVR
                     QGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVD
                     VYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPE
                     PVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYP
                     PTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLT
                     VTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSISLAVPLWLLAASLLCL
                     LSKC"
     exon            612..844
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            845..970
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1105
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1226
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1375
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..9416
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9388..9393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /note="hexamer: AATAAA"
     polyA_site      9404
                     /gene="LSAMP"
                     /gene_synonym="IGLON3; LAMP"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgtggc tgtttctgta cactcactgg caggcttggt gccggctccc tcgcccgccc
       61 gcccgccagc ctgggaaagt gggttacaga gcgaaggagc tcagctcaga cactggcaga
      121 ggagcatcca gtcacagaga gaccaaacaa gaaccctttc ctttggcttc ctcttcagct
      181 cttccagagg gcttgctatt tgcactctct cttttgaaat tgtgttgctt ttacttttca
      241 cccttctgct tgggttttat gagggctttg ttaagtctta gagggaaaag agactgagcg
      301 agggaaagag agaggcaaag tggaaaggac cataaactgg caaagcccgc tctgcgctcg
      361 ctgtggatga aagccccgtg ttggtgaagc ctctcctcgc gagcagcgcg cacccctcca
      421 gagcaccccg cggacccgca cctcggcgtg gccaccatgg tcaggagagt tcagccggat
      481 cggaaacagt tgccactggt cctactgaga ttgctctgcc ttcttcccac aggactgcct
      541 gttcgcagcg tggattttaa ccgaggcacg gacaacatca ccgtgaggca gggggacaca
      601 gccatcctca ggtgcgttgt agaagacaag aactcaaagg tggcctggtt gaaccgttct
      661 ggcatcattt ttgctggaca tgacaagtgg tctctggacc cacgggttga gctggagaaa
      721 cgccattctc tggaatacag cctccgaatc cagaaggtgg atgtctatga tgagggttcc
      781 tacacttgct cagttcagac acagcatgag cccaagacct cccaagttta cttgatcgta
      841 caagtcccac caaagatctc caatatctcc tcggatgtca ctgtgaatga gggcagcaac
      901 gtgactctgg tctgcatggc caatggccgt cctgaacctg ttatcacctg gagacacctt
      961 acaccaactg gaagggaatt tgaaggagaa gaagaatatc tggagatcct tggcatcacc
     1021 agggagcagt caggcaaata tgagtgcaaa gctgccaacg aggtctcctc ggcggatgtc
     1081 aaacaagtca aggtcactgt gaactatcct cccactatca cagaatccaa gagcaatgaa
     1141 gccaccacag gacgacaagc ttcactcaaa tgtgaggcct cggcagtgcc tgcacctgac
     1201 tttgagtggt accgggatga cactaggata aatagtgcca atggccttga gattaagagc
     1261 acggagggcc agtcttccct gacggtgacc aacgtcactg aggagcacta cggcaactac
     1321 acctgtgtgg ctgccaacaa gctgggggtc accaatgcca gcctagtcct tttcagacct
     1381 gggtcggtga gaggaataaa tggatccatc agtctggccg taccactgtg gctgctggca
     1441 gcatctctgc tctgccttct cagcaaatgt taatagaata aaaatttaaa aataatttaa
     1501 aaaacacaca aaaatgcgtc acacagaata cagagagaga gagacagaga gagagagaga
     1561 gagagagatg ggggagaccg tttatttcac aactttgtgt gtttatacat gaagggggaa
     1621 ataagaaagt gaagaagaaa atacaacatt taaaacaatt ttacagtcca tcattaaaaa
     1681 tttatgtatc attcaggatg gagaaggttc tactgggata tgtttatatc tactaagcaa
     1741 atgtatgctg tgtaaagact acaccacact aaggacatct ggatgctgta aaaataagag
     1801 aagaaccaga tggatattaa gccccccaac acacacttta tccttccttc cttcatcttt
     1861 tttcatctgt ggggaagaaa ataaggtctt gcctttggtg tttatatttc cataaccttt
     1921 taattctatt tttcatttga gctgacttgt agccacttca gactatcaat ggaatcttat
     1981 gttgagcctt tctctggctt tccttcctcc actatctctc caactttaga gatcatcccc
     2041 tctccctcca gtgcgttcta tctcccccac acccacccta gatactccct tttcacccac
     2101 ctttcctccc tcacctctcc tcacctccac cccctcccca gagcactagt catgccgcaa
     2161 atgctaggaa gtgccatttt cattttctcc actgtgcgtg tgtgctcaag tctttcgctc
     2221 tcacgtgggt gtacatgtgt gtgagcgtgt gtgtgtctct ctctaaagca tgccaaggga
     2281 atggtccatg tgtacataga ctcattgtgc tgtagatact gtcctgcatt gtaattgtga
     2341 gatgcggctg taacaagttg ctgggggaga tggcggggaa agaggcaagg agcagagtcc
     2401 tccctacatc catggctgtc acatggcatc agtgtgtatt caaaccaagc tatgctcctt
     2461 ccaagggcag gaccccatat tcctcctagt cccatcatca gaaccgagtg gggagtcact
     2521 cagaatatca ctgtaaatga aagtgcctac tatcgatggg gtaagcaaac agcataagga
     2581 attatgacgt ggacgaggtg acctaggaga gaaaatttca gattttactc tcatttcatg
     2641 agtctgaggg attcttatat ttcctggcat ttaacagggt aggccctgct ccactgtgaa
     2701 aatgagcagc atgtgttgag taaatcccca gaaacaggaa ggtctccaag tgtcaactcc
     2761 cagtgaaaga atgatgaacc acttggagat cctaagcagc cctgttttac ctcctcccta
     2821 atcttaaata acatttgtcc catgaattcc cctgagcaga gattgtttcc tatttcagat
     2881 aaaatacagt gaaagtgagc aaggcagaaa aagtcaacag atgcccaggc tcctactgta
     2941 ttctggagat actgtcagag ctctaataca gagcactggc cataatgaaa agcagttcac
     3001 tccttgtgct cctctgcaga tgtttttccc agtgttctag gttaatgttt tatttggttg
     3061 cctgcataat ccctgttctg tttcactgat ggtgtttgca gcaccactgt tcatggtggt
     3121 ccactgttat cctatgccag ggtgctaaga attgcatgat attcatcttc cctgctctat
     3181 ttaaatttac atctataaga gtcatcttga cattaacact gaaatgtgat ctaggtcctt
     3241 aaccaaaatt gctgggcaac ttgtaataaa tttagacaga aattttatga gtaccacaaa
     3301 gcttggtgtt accacatcac cagaaggatt tcttaggaaa tgtcttgccg agagagctgg
     3361 ctctctgcat atagatgtct ttgtcagaaa accaaccctt gctctcactt acacagtagt
     3421 aagcactgaa agtggttcag ttcatgagag gacagagaat tattttgaga ttatatttga
     3481 atgtaatctt gcagagccaa atatggtatg tcattaagtt ggaaccttgt aaatagctgt
     3541 tccatgttat aaaatgagaa actttgtaac tggaaaaaaa gaaaggaaag aaggaaggaa
     3601 ggaaggaagg aaggcaggga gggggggacg gggaaggggg ggagggaggg agggagggag
     3661 ggagggaggg agggagggag gaaggaagga aggaaggaag gaaggagaaa ggaaaggaag
     3721 gcaggaggga gaaagatcta agtagcattg ttaatttctt caatttcttc taagggattt
     3781 tattgtttgt tttagaagct tatcacagcc ttctttcatg attttgcagt ttagacttga
     3841 tacaaggaaa aattcagctt ggggatggtt aagagtgttt atagcagatt ctgacatagg
     3901 agagaaaaca aattctcatc caagaaggta gctagtaaaa tatagggaag gtgagccata
     3961 ttcctatgca gcatcaattt attgacaatc aggtatttct cttaacagtt tggtcttctt
     4021 agttcaagaa taaagggtat catctttaat aataagcatt ccccaaaaat tgaagaggca
     4081 gtcacacact taagtgtgtg gctttagaaa agcgcatgct aatttaaaga tatacaggaa
     4141 gagaaaagta ggagttaagt tggatgttgt tagaagttgg atgttagtat taccttcagg
     4201 aacagatccc catggcatgt cacaggcctt aattatatac ctggctttct tattgtctcc
     4261 actttatcat gaggacaagg tcttggtttc atgggaggaa cttctccatt gaaataaatg
     4321 tctgccatgt cagcaccgtt tgttccctca gttttaatat aatggaccat atattaaaca
     4381 taattaaaca tatatttaaa tgtggtgttt gcctgtgtct ctagcaggat cttgaaattt
     4441 taaaaatttg cttctggttc ctgtttcaga gaaaacattg tccccagaaa tttcatagga
     4501 ttgaaagtgt tccctaagca gtgtgaacaa tggaggaaaa tatagtttag agaaaagtca
     4561 gggaaaggta gggccagagg actgacacca agaaatcatt gaatctcaac ataagacttc
     4621 ttggaattta gttaatcata ttggaataaa ttccttcaag aatcttgtcc cttggtaatc
     4681 aaagtttgaa accccgcact gaaaagcacc aactggttgg aaataatata ctgagaggag
     4741 tgaaattcat caattaatct gagtggctaa tatatttaat atcctttgta tacaaagtaa
     4801 aactccacca ttcgtaaaag gaaatcctta gacccaactt tcagttaaca aaaacagaaa
     4861 tgactttgac ccagggtgct tcctgaagaa tgagaactat ccagggcttt acaactgcag
     4921 aattgtaatt atgctctgtg caattgttga gcaaaggttt tgccttgctg gataaaaagt
     4981 cttgtttgtt tcgagacatg aaatccccat gtcttaaaag aactaaggct tatagaaaag
     5041 cagatgggtt ttctctcagg aaggactgcc ccattgacct ttgccttctc ttccaagtca
     5101 gacagacttc tcgcttgcca tgggcatttt tttactacat agtcagacta ctggggctac
     5161 ttatagagac cttgtaaaag tactcgtgat tttcacgttc ttggaggacc aaacaaaaat
     5221 ctgtttctcc tccaaaaatg gacttacctc ctttgcacac aaaagctaaa ctcctcagca
     5281 tgaaattgtt tgagttatta ctttaccaag ttgtgagctt cttgaatcct ccagagtcgc
     5341 agattccatc cctgagttgg ttgtggtttc actgtttcta ttggctattc tccctgaatt
     5401 tttcattttg ttctttgcag ggctcgaatt atttgtggaa aacaataata tatatgtgtg
     5461 tgtatttttt atctttatag atgctatatt tacaataatg tatgtattat aagacaaatt
     5521 aagaataatg ttttgatctt aaaaggaaga aaagtactga atttggttgt ttagaaagaa
     5581 aatctatgct cacgtagaaa gacatagagc cccacttttt ccgttttgta attatttggc
     5641 gaaaagaaat ttgcttatag actatgttta atgggattaa ccatgtcctc atttttcttt
     5701 tcatcctcat acacttttag cctgcattta gtcttggtta ccaatatcat tttttaagag
     5761 aaatgtaagt acagtgctat atcttaccta cataaactat taatattttg aagacaaatg
     5821 tgaaacacac cacaaaaatg gtgagataag aaacaaaaat gcagtttagg aagcctcctc
     5881 cttgcttaaa tgtttagaat atttcttctc caaagactgc atttgcctca gtgatgtaaa
     5941 ttttccatca tggttggcat aatatctgta aacatctcac taaatgcaaa atggagttta
     6001 catttatgtg catactagca gaaaagaagt aaactattct catttgcatg tagctatgct
     6061 gttcaaatgt cgccaaccaa aatttaggaa agaatttgtt ttcacccagc atgtacatct
     6121 cacttttctc ttggcaagga agctggtgtt aacgttgggt ttaggtttaa catttacacc
     6181 agcgaaaatg tttatgaata ttatggaaaa cttattttaa accttgattt cttttgagca
     6241 catttacatg ctgcgtgctg attaataaat taggcaccaa tcatgtgtaa atcaatgtaa
     6301 atcactagtt tatgtacata atataaacta tgtaaacttc atttttcatg cagtgcccaa
     6361 ctactgctaa ggtttactat gattcttaag gaaaaaaaaa tcaaataaaa ataaataaaa
     6421 actgaaacgt ttcacagttc agaatcggaa gaattacgac taaagctcca aatatgaggt
     6481 tgccttagcc aaaggaagca gacccacagg aacagttcaa ggtttatatc ctgctcaagt
     6541 cacctctttg gtctttcagg atctaagtgg agattgtccc aactgttgct gtagttgtct
     6601 cacccgaccc caaagcaagg gaaatagagg gaaaggtttt aagggctata tgtctgctgt
     6661 atccactccc agctatcttc tttttactcc tttctcacca tctaagatgt cttatttaaa
     6721 tagctccaag gaagtgacct aaaccttgat gagcaaaata ttactcagtt tttattttcc
     6781 attcaacaaa agcagtggga aagcttgcca tctggattct aagaaattgt gcaatataaa
     6841 aaatgttata tcctcgagaa atatcttgct gagtcaccct aggaaataac taccttttat
     6901 ttatctggta gcctaatgtt tccacacatt tatcctgaat attgcaagtg agggactgaa
     6961 tcatttttaa ttgggagtta tctttctcag gcatgttctc ttggagtctt tttgaagtgc
     7021 ctgacacgtg taacaggatg acatatatat cattcctaca atatgaacaa ctgttacata
     7081 aaaaattatc aaggagatga tttcaggaaa caagtgaact ttctgcaaag acttataaaa
     7141 attttaggtc aaattaactt caggctttaa atgcactaat ctacctaaga gaaaaaaaaa
     7201 gaaaaaaaac aggaaggagt tttaagggct catgtgcctg ttgtatcaac ccccaagtgt
     7261 cttcttggta ctgcttcctc atcatctaag ataaactgac aactttaaag tgaggtagaa
     7321 ggtgtattga attgggagtc aggagaattg ggttctaacc ccaagttcag ccacaaataa
     7381 agctgtgaga cattggcaag tcatttaact ttcctgagtc ttggttttct catcctgaaa
     7441 gtgagggatt cggctgacgt ctctaaaatc tctttcaact ctaaccttta ttctgaataa
     7501 gaatttaata ttcacttagt gctgtgccca gcactgtttg taaacagcag ctgtttgtta
     7561 tctctagttt ggtctctgta ttctcatcac ttctcagaac tatcattcta ccgtcttcat
     7621 ttctaaaccc aaaactgcta gaatacaggg actctggact gggtctgtaa attttttctg
     7681 atcaaaactt tatagcagtg tagagaaggg acacattcaa attacactaa ggacattgac
     7741 atagctgggg ttgtttcctt gtttatatta taaaacctaa atgtggaact atattctaat
     7801 aatctttcat aggaaggaaa atagccagac tgggtattat gcatgtaaca aatgaggaca
     7861 ttgtgcataa gaaaggaaac attagttttc tgtcatcctg ggccaagtac ctcattacag
     7921 taaatgtgtg tctttggaaa ctctttgctt gtgctgatgg cggtaagcat ggggtcccag
     7981 gcaggttcaa aggctgaact gtaagaaatg ggcaagacaa tacattttgt tttggaagga
     8041 atttctcatg ggataagttt cccaaagctt gaattatagg ctatgaaata aagcaaatag
     8101 atggagagaa aacaagtatt gttttcaaaa agtacaagtc aattctattt aaagaagaca
     8161 agctgaaaat aaaacaaaaa taaacacaat ttaggaggtt acagagttga agacagtatg
     8221 aattgttgtg aaggccaaaa tcaaatgtga aagttaggtt ctctgagaaa agggtaagca
     8281 gaaaggatga tttctcaagc aattaataag gaattatttt cttgtgccat gttctagatg
     8341 cattgagcac agatcctctt gtcctaagct gtcctagagg ctcaggttag catctatcca
     8401 aagttgtcct ttgattttat tgtctgaaag aacagaaggc atcagagttt ccagtcactg
     8461 aagagtaggg tttgttcatc acttcccagc aatcacatca ctttgtgtag gtaaggatat
     8521 atgatgtgct tagattactt atgaagctct ctctaagtgg gagaatgacc tgtccatggg
     8581 acaactcccc gttttcatgg tcatttcaga agtacctctt tttgggcagt gctcctggat
     8641 ctacttctac agccacattc tactctgcac aatcctccct atgtaaagcc aggcacagta
     8701 caaatatgct tcttgcaagt gaagaaaacc catggaagtc ctagcttcat ggcacgctgc
     8761 agcaatccca agctaccagg agcctctttt gaacccactt ccctaagtct ttgctcttca
     8821 ccagagaatg gaaattgttc atcctggtga actgtggcca agttctgctc cctaagtatt
     8881 tacttggagt agggaggtta aagggaagaa attcaggggg agagaagcaa aagagaacac
     8941 ttccaactcc ctcccccatc tcccaatgct ccccaccttc cttatcactg ctctactgaa
     9001 gggtgtataa atcctgctct tggttagaat tctccttatt aacagtgtta tatacatata
     9061 aatatatata taaatatatt ccttttttca gccctgtaga catgaactga tcttcccttg
     9121 aagatacaaa cacatggcca ttttttgttt gggatttttt gtttttcaag gtttttcatt
     9181 tttgtttatt aggtggattt ttttccctgg gtactagctc tgtgaaggag ataaaaagcg
     9241 caatgtgtgt taaaaaaaaa aaattaaaat taaaatgaaa aaaagctttt tttcttttct
     9301 ttttaaatgt atttaaattc tgtttctctc ttctgttact ttacacgtat gaatgctctg
     9361 ctcttctgtg atcttaaaac aaaatgaaat aaacgtgaaa aggagatgtg tcttca
//
