LOCUS       NM_001039029            3653 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens leucine rich repeats and transmembrane domains 2
            (LRTM2), transcript variant 1, mRNA.
ACCESSION   NM_001039029 XM_929892 XM_934058 XM_934059 XM_934061 XM_936982
            XM_943105 XM_943110 XM_943123
VERSION     NM_001039029.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA336140.1, DA418133.1, AK095610.1, BC036868.1, BX115405.1 and
            AC005343.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039029.2.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.21033.1, AK095610.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299194.6/ ENSP00000299194.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               DA336140.1         308-534
            228-241             DA418133.1         220-233
            242-2301            AK095610.1         278-2337
            2302-3232           BC036868.1         1057-1987
            3233-3278           BX115405.1         385-430             c
            3279-3652           AK095610.1         3315-3688
            3653-3653           AC005343.1         39010-39010         c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3653
                     /gene="LRTM2"
                     /note="leucine rich repeats and transmembrane domains 2"
                     /db_xref="GeneID:654429"
                     /db_xref="HGNC:HGNC:32443"
     exon            1..250
                     /gene="LRTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..435
                     /gene="LRTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..575
                     /gene="LRTM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..1621
                     /gene="LRTM2"
                     /note="leucine-rich repeat and transmembrane
                     domain-containing protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and transmembrane
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001034118.1"
                     /db_xref="CCDS:CCDS31726.1"
                     /db_xref="GeneID:654429"
                     /db_xref="HGNC:HGNC:32443"
                     /translation="MLAPGSSPGQRGRLALQWRQVSWITCWIALYAVEALPTCPFSCK
                     CDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNN
                     FLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLF
                     DGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSY
                     RGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEP
                     AKPKPGAEPEPEPSTACPQKQRHRPASVRRAMGTVIIAGVVCGVVCIMMVVAAAYGCI
                     YASLMAKYHRELKKRQPLMGDPEGEHEDQKQISSVA"
     exon            576..1166
                     /gene="LRTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..3653
                     /gene="LRTM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRTM2"
                     /note="hexamer: AATAAA"
     polyA_site      3653
                     /gene="LRTM2"
                     /note="major polyA site"
ORIGIN      
        1 atccctctct ttccttctca gtttgtgact gacccagcag ccccgtcccc cgtctgccac
       61 aagcagtcca cctcctggtg ctgtgtgctg cgtgccagcc gctgctcccg ctgagtggag
      121 actctggcac cagtgcccac tgcgctctgc ctgccggtgg tgtctggatt tctataggaa
      181 tcccaggagg gtcttactgg agggttgaga gccacctgat tgaaggcgtt tgcagtcaga
      241 gtaaagacgg ctgccgcagc atgaacccct gagctgatga gtcttattat agcccggctg
      301 gcggaagaca gagtgctgct attcacctct gcgtgggcgt cggtggtgca gggggaagca
      361 gcaggccatc cagcggctca caccctacgc ggctgcagct gccaagggcc tggcccctgc
      421 ctccctcggg ccatggactg acaggcggcg cacccagggg ctcctctctc cccagagcga
      481 cagggcccgg agagccgtgg gcctcaccat gctggcgccg ggcagcagcc ctgggcagag
      541 gggcaggctc gccctgcagt ggaggcaagt ctcctggatc acctgctgga tcgccctgta
      601 tgctgtggag gccctcccca cctgcccttt ctcctgcaag tgtgacagcc gcagcctgga
      661 ggtggactgc agtggccttg gcctcaccac ggtgccccca gacgtgcccg cagccacccg
      721 aaccctcttg ctcttgaaca ataagctgag tgccctgcca agctgggctt tcgccaacct
      781 ctccagcctg cagcggttgg acctgtccaa caacttcctg gaccggctgc cccgctccat
      841 tttcggggac ctgacgaatc tgactgagct tcagctgcgc aataacagca tcaggaccct
      901 ggacagggac ctgctgcggc actcgccgct gctccgccac ctggacctgt ccatcaacgg
      961 cctggcccag ttgccccctg gtcttttcga cgggctcctg gctctgcgct ccctctcgct
     1021 tcgctccaac cgtctgcaga atctggaccg gctgacattt gaacccctag caaacctgca
     1081 gctgctgcag gtcggggata acccctggga gtgtgactgt aacctgcgtg agttcaaaca
     1141 ctggatggag tggttctcct accgaggggg acgcttggac cagcttgcct gcaccctgcc
     1201 caaggagctg agggggaagg acatgcggat ggtccccatg gagatgttca actactgctc
     1261 ccagctggag gacgagaata gctcagctgg gctggatatt cctgggccac cctgcaccaa
     1321 ggccagtcca gagcctgcta agcccaagcc cggggctgag ccggagccgg agcccagcac
     1381 agcctgccca cagaagcaga ggcaccggcc ggcgagcgtg aggcgagcca tgggcacggt
     1441 gatcattgca ggggtcgtgt gcggcgtcgt ctgcatcatg atggtggtgg ccgctgccta
     1501 tggctgcatc tacgcctccc tcatggccaa gtaccaccgg gagctcaaaa agcgccagcc
     1561 cctgatgggg gaccccgagg gcgagcacga ggaccagaag cagatctctt ctgtggcctg
     1621 agcgcccatc cccacccggc caggtaggaa gggcggggag agcacacggc attgctcagc
     1681 cacagctccc accttgaccc ggcgctggcc actgcctccc cgagtccacc ctcctccccg
     1741 ccctccagca gacaagccac accgggttct ctccctgcac tttcgaggct ccctgaaagc
     1801 caccgtgctg ggggctcctg ctgatgctcc tgtctgggcc agtaaatctt tggaacatgt
     1861 gggggatctc cctaagctct ggccacagca aagcaaggag gtgtgtgcaa gaggaggctt
     1921 ccggactggg cattcccctg tcgcccttcc tgccctgggg tggccatagc tggtgactct
     1981 tcctaccttg ctggtcccac ctcacctgca ttgaggggac ggggagggag ggatctgagg
     2041 gatgaaggta gatttctgag actctctcct aagccagaaa gacgttctta acacccctgc
     2101 agtgtgaaag ctggtccagc tctacaactg ttggtaccaa tgtgcaaaca caccagccct
     2161 gccatctgga cccagcactc agaaacacca tacacccctg gccgacgcca tcatgcccct
     2221 ggatctgcta taggccacac tgaccacatg ctcctggatt cgctaattca ctcacacacc
     2281 cattgcatca ccagtgcggt cacatggatt gaaagaatta atacacacac acacacacac
     2341 acactcacac ggtcacacgg agaccgaggc tatgagcgct cgaacagcag agacatgctc
     2401 ttccccaggg gtctccctga gaccacagag cctctcgcgt gctcactgca atcttctcaa
     2461 gtcaacagca ggaaggaact caaccagtaa caccaggatc ctttgagatc ctctaaagtg
     2521 ggccaaagtg gtgcccctgg aggagccctc ctgtcaccat ggtaaccctc tcacacctct
     2581 cctgctgggc tttcccggga taccacccag gggcctggag cggctgcatg tgtgcatggc
     2641 ggcctcctga ggacccagcc acacaccact ggtgttgcct cggtcctgcc cacgcatctc
     2701 acagcaccag gccctgtggg gcccccactg attcctccac agcctgcagc ctggcaccgt
     2761 gactctgtgc ctctcgccct ccatcttcag tactcctggc ctgtgacttc agggctggga
     2821 cttggtggtg ctttgccatt ggtggcaccc tctggggaaa gcaggtggca ggcagagaac
     2881 acggtggctc ccctgaggct cattgcctgc cagcttattg cagacagagc ccaggagcag
     2941 gagcgggtgg ccacgtgctg cccagaggct cccaggatgg ggcctctgtt cccgggcttt
     3001 gtctgctcag tgtggctccc tagagcaccc agccggggcc aaaccagaga gtgggtgggg
     3061 agcctgtctg ggacagagcc acctgctgcc aaggcagtgc aagttttcca ggttacctgt
     3121 ccccctccct agctctgccc ctcctcagag tgtgaagatg gtgggtacct aggtgtcatg
     3181 ctcacaggct caggaggcat caggctcgtc cctggctctg ggatggaatc tcgatggggg
     3241 ctcaggaaga ggccagcaag aaccctgaag ccaagggtct gagcagaggg agttggcagg
     3301 cctagctcct gtgccccact ccgaccctcc ctgctcatgc ggcagtgggt gggtgaggtg
     3361 ggctgggggc ctggaggagt gcctttgagg aggtcagtcc tggcaggtgg acagaggacg
     3421 cctggcatgg gctgcttact gggaccccag gcggccctgg ccatggccac agtcttcctt
     3481 cttttggcgt gtgggctggt accagatctg gggattttct aaagggactg gggggagggg
     3541 agggcattgt caatggtggt atctttagcc tgagacagaa gatttttaaa ggcaaaatta
     3601 tatttctggt ttgttgtttc agaagaccaa taaagactgt attttcctat gta
//
