LOCUS       NM_020678               1414 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeats and transmembrane domains 1
            (LRTM1), transcript variant 1, mRNA.
ACCESSION   NM_020678
VERSION     NM_020678.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Samata,B., Doi,D., Nishimura,K., Kikuchi,T., Watanabe,A.,
            Sakamoto,Y., Kakuta,J., Ono,Y. and Takahashi,J.
  TITLE     Purification of functional human ES and iPSC-derived midbrain
            dopaminergic progenitors using LRTM1
  JOURNAL   Nat Commun 7, 13097 (2016)
   PUBMED   27739432
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   van der Valk,R.J., Duijts,L., Timpson,N.J., Salam,M.T., Standl,M.,
            Curtin,J.A., Genuneit,J., Kerhof,M., Kreiner-Moller,E., Caceres,A.,
            Gref,A., Liang,L.L., Taal,H.R., Bouzigon,E., Demenais,F., Nadif,R.,
            Ober,C., Thompson,E.E., Estrada,K., Hofman,A., Uitterlinden,A.G.,
            van Duijn,C., Rivadeneira,F., Li,X., Eckel,S.P., Berhane,K.,
            Gauderman,W.J., Granell,R., Evans,D.M., St Pourcain,B., McArdle,W.,
            Kemp,J.P., Smith,G.D., Tiesler,C.M., Flexeder,C., Simpson,A.,
            Murray,C.S., Fuchs,O., Postma,D.S., Bonnelykke,K., Torrent,M.,
            Andersson,M., Sleiman,P., Hakonarson,H., Cookson,W.O.,
            Moffatt,M.F., Paternoster,L., Melen,E., Sunyer,J., Bisgaard,H.,
            Koppelman,G.H., Ege,M., Custovic,A., Heinrich,J., Gilliland,F.D.,
            Henderson,A.J., Jaddoe,V.W. and de Jongste,J.C.
  CONSRTM   EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium
  TITLE     Fraction of exhaled nitric oxide values in childhood are associated
            with 17q11.2-q12 and 17q12-q21 variants
  JOURNAL   J Allergy Clin Immunol 134 (1), 46-55 (2014)
   PUBMED   24315451
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM716618.1, AF225421.1, AC092797.2 and AC109584.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020678.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF225421.1, BC074741.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273286.6/ ENSP00000273286.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BM716618.1         16-29
            15-73               AF225421.1         1-59
            74-138              AC092797.2         134099-134163       c
            139-1312            AF225421.1         125-1298
            1313-1414           AC109584.2         172528-172629       c
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..1414
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /note="leucine rich repeats and transmembrane domains 1"
                     /db_xref="GeneID:57408"
                     /db_xref="HGNC:HGNC:25023"
     exon            1..155
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1186
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich repeat and transmembrane
                     domain-containing protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and transmembrane
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_065729.1"
                     /db_xref="CCDS:CCDS2876.1"
                     /db_xref="GeneID:57408"
                     /db_xref="HGNC:HGNC:25023"
                     /translation="MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEI
                     PSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQV
                     LNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQ
                     LDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKG
                     KDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPK
                     PRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKV
                     EEKERFDSSPA"
     exon            156..752
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1414
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="LRTM1"
                     /gene_synonym="HT017"
                     /note="major polyA site"
ORIGIN      
        1 gttttctgca ttgaagaaaa gcaagggcag ggttcagaaa gactgaatgt aaagctgggc
       61 tctgagtctg ccatgccctt cgtgtgttgc tctgcacatt aattaaaggg tctacgaggt
      121 cagcaaggac gcccaaggag actcagtcat gaaaggtgaa ctgctcctgt tttccagtgt
      181 gattgtcctg ctccaggtgg tatgcagctg cccggacaag tgttactgtc agtcatctac
      241 aaattttgta gactgcagcc agcagggtct ggccgaaatc ccttcccatt tacctcctca
      301 gactcgaacg ctgcatttac aagataatca gatacaccat cttcctgctt ttgcatttag
      361 gtcagtgcca tggctcatga ccttaaactt gtccaacaat tccctttcaa atctggcccc
      421 tggagctttc catgggcttc agcacttgca ggttttaaat ctaacccaga attcactcct
      481 ttccctggaa agcagacttt tccattccct ccctcagctg agggagcttg atttgtcatc
      541 aaacaacata agccaccttc ccacatcctt gggagagact tgggagaacc taactatact
      601 tgcggttcaa caaaaccagc ttcagcagct tgatcgagcg ctcctggaat ccatgcccag
      661 tgtgaggctt ttacttctca aggacaacct ctggaaatgc aattgccact tgctcggtct
      721 taaactctgg ctggagaaat ttgtctataa agggggacta acagacggca tcatctgtga
      781 atcaccagac acctggaagg gaaaggacct ccttaggatc cctcatgagc tgtaccagcc
      841 ctgccctctt cctgctcctg atccagtgtc ctcgcaggct cagtggcccg gctctgccca
      901 cggtgtggtc ctgaggcctc ctgagaacca caacgcgggg gagcgagaac tcttggagtg
      961 cgagctcaaa cccaagccaa ggccggccaa cctgcgtcat gccattgcca ctgtcatcat
     1021 cactggcgtt gtgtgtggga ttgtgtgtct catgatgttg gcagctgcca tctatggctg
     1081 cacctatgcg gcaatcacag cccagtacca tgggggaccc ttggctcaaa ccaatgatcc
     1141 tgggaaggtg gaagaaaaag agcgatttga cagctcacca gcctgagagc ttttgtctca
     1201 aataggattg gtcattgcag gccagaagat agtgtctgag tagggctgat gtgtttcctg
     1261 ttagtctgat tttgcttttg ccaaaagaca aaaaaaaaaa aaaaaaaaaa aagaaaaaaa
     1321 aaagatgtgt ctgtaaaaaa tatttctggg gaggaattta tgttgcgatt tttaaaatac
     1381 tataggtaaa ataaagatga tacttgtgct ctgg
//
