LOCUS       NM_001134745            3198 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens leucine rich repeat transmembrane neuronal 4 (LRRTM4),
            transcript variant 1, mRNA.
ACCESSION   NM_001134745
VERSION     NM_001134745.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Clarke,R.A. and Eapen,V.
  TITLE     LRRTM4 Terminal Exon Duplicated in Family with Tourette Syndrome,
            Autism and ADHD
  JOURNAL   Genes (Basel) 13 (1), 66 (2021)
   PUBMED   35052406
  REMARK    GeneRIF: LRRTM4 Terminal Exon Duplicated in Family with Tourette
            Syndrome, Autism and ADHD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Reichman,R.D., Gaynor,S.C., Monson,E.T., Gaine,M.E., Parsons,M.G.,
            Zandi,P.P., Potash,J.B. and Willour,V.L.
  TITLE     Targeted sequencing of the LRRTM gene family in suicide attempters
            with bipolar disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 183 (2), 128-139 (2020)
   PUBMED   31854516
  REMARK    GeneRIF: Targeted sequencing of the LRRTM gene family in suicide
            attempters with bipolar disorder.
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   de Wit,J., O'Sullivan,M.L., Savas,J.N., Condomitti,G.,
            Caccese,M.C., Vennekens,K.M., Yates,J.R. 3rd and Ghosh,A.
  TITLE     Unbiased discovery of glypican as a receptor for LRRTM4 in
            regulating excitatory synapse development
  JOURNAL   Neuron 79 (4), 696-711 (2013)
   PUBMED   23911103
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     A novel gene family encoding leucine-rich repeat transmembrane
            proteins differentially expressed in the nervous system
  JOURNAL   Genomics 81 (4), 411-421 (2003)
   PUBMED   12676565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126961.1, AY358324.1, AC068616.5 and AI079273.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001134745.2.
            
            Transcript Variant: This variant (1) and variant 3 encode the same
            isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358324.1, SRR1803613.48027.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409884.6/ ENSP00000387297.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AK126961.1         1-103
            104-2318            AY358324.1         13-2227
            2319-2810           AC068616.5         146500-146991       c
            2811-3160           AI079273.1         8-357               c
            3161-3198           AC068616.5         146112-146149       c
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..3198
                     /gene="LRRTM4"
                     /note="leucine rich repeat transmembrane neuronal 4"
                     /db_xref="GeneID:80059"
                     /db_xref="HGNC:HGNC:19411"
                     /db_xref="MIM:610870"
     exon            1..268
                     /gene="LRRTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            269..419
                     /gene="LRRTM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..2188
                     /gene="LRRTM4"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; leucine-rich repeat transmembrane neuronal
                     protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 4 isoform a precursor"
                     /protein_id="NP_001128217.1"
                     /db_xref="CCDS:CCDS46346.1"
                     /db_xref="GeneID:80059"
                     /db_xref="HGNC:HGNC:19411"
                     /db_xref="MIM:610870"
                     /translation="MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKI
                     VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE
                     DAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLI
                     ILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFS
                     KINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL
                     PNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKE
                     STMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKP
                     DVTQSTFETPSPSPGFQIPGAEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRY
                     PASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTY
                     TISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELG
                     RDHSFIATIARSAAPAIYLERIAN"
     exon            420..1966
                     /gene="LRRTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3198
                     /gene="LRRTM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3138..3143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRTM4"
                     /note="hexamer: AAGAAA"
     regulatory      3159..3164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRTM4"
                     /note="hexamer: AATATA"
     polyA_site      3160
                     /gene="LRRTM4"
     polyA_site      3198
                     /gene="LRRTM4"
                     /note="major polyA site"
ORIGIN      
        1 agtgtatcac aaactcaagc attagcacca acaagctctg agcatcatca gtctctggaa
       61 agccttctga attagacaag ggctgcctcc cagcacagct acaaaacact ttaaacctga
      121 ccagctaaat ggataaacct agcctgcata gcttttaaac tggggtctca tacagcacag
      181 gaggcctact tgcttcaaga actgaaaatc cagaggatga attgctttat ctgggaatgg
      241 caaaagccag cacaataagg aatgccagtt tgtatggggc tactagctca catgcgggat
      301 cagaatggtg tgaatgacag ccgcactgtg tcatgaaggt ggtggtggtt tccgcacaag
      361 agaccaaata agaagaaagc tgagagaggg gggaaacgtt tttggatgac aaaggatggg
      421 tttccattta attacgcagc tgaaaggcat gagtgtggtg ctggtgctac ttcctacact
      481 gctgcttgtt atgctcacgg gtgctcagag agcttgccca aagaactgca gatgtgatgg
      541 caaaattgtg tactgtgagt ctcatgcttt cgcagatatc cctgagaaca tttctggagg
      601 gtcacaaggc ttatcattaa ggttcaacag cattcagaag ctcaaatcca atcagtttgc
      661 cggccttaac cagcttatat ggctttatct tgaccataat tacattagct cagtggatga
      721 agatgcattt caagggatcc gtagactgaa agaattaatt ctaagctcca acaaaattac
      781 ttatctgcac aataaaacat ttcacccagt tcccaatctc cgcaatctgg acctctccta
      841 caataagctt cagacattgc aatctgaaca atttaaaggc cttcggaaac tcatcatttt
      901 gcacttgaga tctaactcac taaagactgt gcccataaga gtttttcaag actgtcggaa
      961 tcttgatttt ttggatttgg gttacaatcg tcttcgaagc ttgtcccgaa atgcatttgc
     1021 tggcctcttg aagttaaagg agctccacct ggagcacaac cagttttcca agatcaactt
     1081 tgctcatttt ccacgtctct tcaacctccg ctcaatttac ttacaatgga acaggattcg
     1141 ctccattagc caaggtttga catggacttg gagttcctta cacaacttgg atttatcagg
     1201 gaatgacatc caaggaattg agccgggcac atttaaatgc ctccccaatt tacaaaaatt
     1261 gaatttggat tccaacaagc tcaccaatat ctcacaggaa actgtcaatg cgtggatatc
     1321 attaatatcc atcacattgt ctggaaatat gtgggaatgc agtcggagca tttgtccttt
     1381 attttattgg cttaagaatt tcaaaggaaa taaggaaagc accatgatat gtgcgggacc
     1441 taagcacatc cagggtgaaa aggttagtga tgcagtggaa acatataata tctgttctga
     1501 agtccaggtg gtcaacacag aaagatcaca cctggtgccc caaactcccc agaaacctct
     1561 gattatccct agacctacca tcttcaaacc tgacgtcacc caatccacct ttgaaacacc
     1621 aagcccttcc ccagggtttc agattcctgg cgcagagcaa gagtatgagc atgtttcatt
     1681 tcacaaaatt attgccggga gtgtggctct ctttctctca gtggccatga tcctcttggt
     1741 gatctatgtg tcttggaaac gctacccagc cagcatgaaa caactccagc aacactctct
     1801 tatgaagagg cggcggaaaa aggccagaga gtctgaaaga caaatgaatt cccctttaca
     1861 ggagtattat gtggactaca agcctacaaa ctctgagacc atggatatat cggttaatgg
     1921 atctgggccc tgcacatata ccatctctgg ctccagggaa tgtgagatgc cacaccacat
     1981 gaagcccttg ccatattaca gctatgacca gcctgtgatc gggtactgcc aggcccacca
     2041 gccactccat gtcaccaagg gctatgagac agtgtctcca gagcaggacg aaagccccgg
     2101 cctggagctg ggccgagacc acagcttcat cgccaccatc gccaggtcgg cagcaccggc
     2161 catctaccta gagagaattg caaactaacg ctgaagccaa ctcctcactg gggagctcca
     2221 tgggggggag ggagggcctt catcttaaag gagaatgggt gtccacaatc gcgcaatcga
     2281 gcaagctcat cgttcctgtt aaaacattta tggcatagag aaaagaaaaa gagaaaaaaa
     2341 aactgcttga agagggcagc gaatgcacct gcagcattac cgggaggact gcagaacttt
     2401 ctttgcttta aaacataaaa caaacaaaaa tgctcccgga tgtaaatagt aagagtgtca
     2461 agttcttata aaaatagatt tcaccctagc tacatatagg tttgtttgta tatttgattt
     2521 ttctacactg catggttcct gggctggaga accacagggg agcaaataaa caggggtggg
     2581 tgggaagcta gggaaacaac cgttttcctc tttaggtgtg tgtaattctc acagatttta
     2641 tttaaattgc tttcatttat tttttcttta aaaatgctgt ttgttcttgt tttgtttgtt
     2701 ttaatttttt tctttcctgg tcaagtttct aatacaaaac atgagcatta aagcttatgt
     2761 tgtaccaaaa gaaaatgtgc tttaccacgg accacggaga aagttgacca caaagtttga
     2821 caaaactact ggaaaaccca ataagtctgg gtgaatgacc cttcatgaca aatgccatat
     2881 atggtacatg atagaaggaa ttttgttttg tcccattggc agccctcact gtgtaggatg
     2941 cctgagagag ccatgaagat ctccgaatga gaagaccagc agaatcattc tcatgtggac
     3001 taaggctata agagagatat gaccatgggc tcaatgaatg aaactgccaa gctgacaaat
     3061 ttctaaacac aagataatgt gtaacattgc tttttaaatt aattatcaat tagcttttgt
     3121 gtagttttta tcaataaaag aaaaaatatt gaaaaataaa tatattattt tgtggttggt
     3181 ataccacagc ccacctaa
//
