LOCUS       NM_015564               6064 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat transmembrane neuronal 2 (LRRTM2),
            mRNA.
ACCESSION   NM_015564
VERSION     NM_015564.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6064)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6064)
  AUTHORS   Yamagata,A., Goto-Ito,S., Sato,Y., Shiroshima,T., Maeda,A.,
            Watanabe,M., Saitoh,T., Maenaka,K., Terada,T., Yoshida,T.,
            Uemura,T. and Fukai,S.
  TITLE     Structural insights into modulation and selectivity of
            transsynaptic neurexin-LRRTM interaction
  JOURNAL   Nat Commun 9 (1), 3964 (2018)
   PUBMED   30262834
  REMARK    GeneRIF: The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated
            interactions and overlaps with the Nrxn-neuroligin interface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6064)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   4  (bases 1 to 6064)
  AUTHORS   Kask,M., Pruunsild,P. and Timmusk,T.
  TITLE     Bidirectional transcription from human LRRTM2/CTNNA1 and
            LRRTM1/CTNNA2 gene loci leads to expression of N-terminally
            truncated CTNNA1 and CTNNA2 isoforms
  JOURNAL   Biochem Biophys Res Commun 411 (1), 56-61 (2011)
   PUBMED   21708131
  REMARK    GeneRIF: CTNNA1 and CTNNA2 contain alternative 5' exons linked to
            bidirectional promoters that are shared with the antisense oriented
            LRRTM2 and LRRTM1 genes, respectively.
REFERENCE   5  (bases 1 to 6064)
  AUTHORS   Graubert,T.A., Payton,M.A., Shao,J., Walgren,R.A., Monahan,R.S.,
            Frater,J.L., Walshauser,M.A., Martin,M.G., Kasai,Y. and Walter,M.J.
  TITLE     Integrated genomic analysis implicates haploinsufficiency of
            multiple chromosome 5q31.2 genes in de novo myelodysplastic
            syndromes pathogenesis
  JOURNAL   PLoS One 4 (2), e4583 (2009)
   PUBMED   19240791
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6064)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     A novel gene family encoding leucine-rich repeat transmembrane
            proteins differentially expressed in the nervous system
  JOURNAL   Genomics 81 (4), 411-421 (2003)
   PUBMED   12676565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA400927.1, AC011405.6 and AB007876.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015564.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.68259.1,
                                           SRR1803615.211180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274711.7/ ENSP00000274711.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               DA400927.1         34-151
            119-428             AC011405.6         8084-8393           c
            429-4542            AC011405.6         3619-7732           c
            4543-5595           AB007876.1         4520-5572
            5596-6064           AC011405.6         2097-2565           c
FEATURES             Location/Qualifiers
     source          1..6064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..6064
                     /gene="LRRTM2"
                     /note="leucine rich repeat transmembrane neuronal 2"
                     /db_xref="GeneID:26045"
                     /db_xref="HGNC:HGNC:19409"
                     /db_xref="MIM:610868"
     exon            1..428
                     /gene="LRRTM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1975
                     /gene="LRRTM2"
                     /note="leucine-rich repeat transmembrane neuronal 2
                     protein; leucine-rich repeat transmembrane neuronal
                     protein 2; leucine-rich repeat neuronal 2 protein"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 2 precursor"
                     /protein_id="NP_056379.1"
                     /db_xref="CCDS:CCDS47272.1"
                     /db_xref="GeneID:26045"
                     /db_xref="HGNC:HGNC:19409"
                     /db_xref="MIM:610868"
                     /translation="MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLL
                     FYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKE
                     DAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQ
                     TLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT
                     KINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETM
                     PNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWE
                     HSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTEYTKRISSSSYHV
                     GDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPP
                     TLRRIRQCSMVQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIIINGYGQCKCQQ
                     LPYKECEV"
     exon            429..6064
                     /gene="LRRTM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5211..5216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRTM2"
                     /note="hexamer: AATAAA"
     polyA_site      5230
                     /gene="LRRTM2"
                     /note="major polyA site"
     regulatory      5883..5888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRTM2"
                     /note="hexamer: AATACA"
     polyA_site      5902
                     /gene="LRRTM2"
     regulatory      6035..6040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRTM2"
                     /note="hexamer: ATTAAA"
     polyA_site      6064
                     /gene="LRRTM2"
ORIGIN      
        1 attcttgtgc cgtttctcgg aaaagctttt cagtaaatgc actcatgctg ctccaggagc
       61 tcttctctgc aacaagccac ccatctgcca tcaacaagtt aagaccaaga gaactaacgg
      121 ctgcggaaag gagactgaag ctttgattaa ccagctgagc agttagaggt ggagaaattt
      181 aataacttat attcaaaact gatttaggga tcagagcaat cacagaaaat gaaaccaatg
      241 ctttccagag ggatatccta aggaaaaaac aactcgtcct ggtggattca attttacttg
      301 gaaagcctgg gacacagaaa acaggaaact ggtcaaaggc tcctacatgt tagagccttt
      361 tacagactca ctgcgttgag tctaacaacc gcgactgaat gcagcctcca atgtgctcag
      421 aagaatgggc ttacatttca agtggccatt aggggcccct atgctggcag caatatatgc
      481 aatgagtatg gttttaaaaa tgctgcctgc cctgggtatg gcgtgtccac ccaaatgccg
      541 ctgcgagaag ctgctcttct actgcgactc tcagggcttc cactcagtgc caaacgccac
      601 agacaagggc tctctgggcc tgtccctgag gcacaatcac atcacagagc tcgaaagaga
      661 tcaatttgcc agcttcagtc aacttacttg gctccactta gatcacaatc aaatttcaac
      721 agtaaaagaa gatgcttttc aaggactata taaacttaag gaattaatct taagttccaa
      781 caaaatattt tacttgccaa acacaacttt tacccaactg attaacctgc aaaatttgga
      841 cctgtctttt aatcagctgt catctctgca cccagagctc ttctatggcc ttcggaagct
      901 gcagaccttg catttacgtt ccaactccct gcggactatc ccagtacgcc tgttctggga
      961 ctgtcgtagt ctggagtttc tggatttgag cacaaatcgt ttgcgaagtt tggctcgcaa
     1021 tggatttgca ggattaatta aactgagaga gcttcaccta gagcacaacc agctgacgaa
     1081 gattaatttt gctcatttcc tacggctaag cagtctgcac acgctcttct tacaatggaa
     1141 caaaatcagc aacttgacat gtgggatgga gtggacctgg ggcactttag aaaagctaga
     1201 cctgactgga aatgaaatca aagccatcga cttgacagtg tttgaaacga tgcccaatct
     1261 taaaatactc ctcatggata acaacaagtt aaacagcctt gattccaaga tcttaaactc
     1321 cctgagatcc ctcacaaccg ttggtctctc tggcaatctg tgggaatgca gcgcccgaat
     1381 atgtgctctg gcctcctggc tgggcagttt ccaaggtcgg tgggaacact ccatcctatg
     1441 ccacagtcct gaccacaccc aaggagagga tattctagat gcagtccatg gatttcagct
     1501 ctgctggaat ttgtcaacca ctgtcactgt catggctaca acttatagag atccaaccac
     1561 tgaatataca aaaagaataa gctcatcaag ttaccatgtg ggagacaaag aaatcccaac
     1621 tactgcaggc atagcagtta ctaccgagga acactttcct gaaccagaca atgccatctt
     1681 cactcagcgg gtaattacgg gaacaatggc tttattgttt tctttctttt ttattatttt
     1741 tatagtgttc atctccagga agtgctgccc tcccacttta agaagaatta ggcagtgctc
     1801 aatggttcag aaccacaggc agctccgatc ccaaacacga ctccatatgt caaacatgtc
     1861 agaccaagga ccgtataatg aatatgaacc cacccatgaa ggacccttca tcatcattaa
     1921 tggttatgga cagtgcaagt gtcagcagct gccatacaaa gaatgtgaag tataatatct
     1981 acccatcatc aaaaatcaca tcagataagt aacctatttt acatagtaga ggctaaatac
     2041 atatctaatt tttaccaatg gtgacattaa gcctaatttt ccaaactaag tggagactta
     2101 gtttttgaag tgttgaagta tttttaattt tttaaatgaa accatatttt aagtgttaaa
     2161 tgaatcaatg ctcacattaa tttgcactcc tgttggaaag tctaaaatgc ttacttcaaa
     2221 ataagaaatg tatgtaatta tatacaatcg tgtgtaaacc tttacactaa ggtctccata
     2281 tactattttt ttctactgaa aacaatttag aaagaagcta ttgggcagaa acagatatag
     2341 atcaatacct gtttgatcac tgctctccat cccatgtacc acaactatct tgctgcttaa
     2401 aaggagactt agtaaagttc tcttgtatga taatttggta tttactcaaa tcttcaattt
     2461 cttgccaggg tgggaagtag aatttcatgt atgctgaaga ctggtaaata ttaaacattc
     2521 tccttccaga gtttctgcct gggttagtag atattatcaa agtccatatc atgaattcag
     2581 aaccctttaa tgtaattcta ataagctgag tgactcttta atatatttac acaatgaatc
     2641 caagtgactg tgaaaaggtc tcattacaat gaaaccaatc ctaaataatt acaccaactt
     2701 cttatacatt tctcgtttga cttataatgg acatgatttt tgtggcattt agacaactgt
     2761 tttaaactag cattaaactg tcattgtact aattaatgta ctaaatccta tgtttacatt
     2821 aatatgtgaa aaaagattta gaagatattt tggagataaa caagacaaac tgagtcaatt
     2881 taacaatcct gacatgctcc ctccaattta aaagcgcaca cacacacaca cacacacaca
     2941 cacacacaca cacacactct cgcgctctct ctctcaacta tcatgatcaa agatgccttg
     3001 acaaaggggt ttaaacctct ttcttctgct ttttcctgat cttcaaacct caaagagcca
     3061 agttaaaaat aattggctag caacaggctt aacactgatt cttattgtat tacaaaggaa
     3121 ccatgaaaaa aaacactttc caactattat ataatacatt tcgatctttc aataaagata
     3181 cgcattcacg ctgtaagtgt agttcagtgt aggtgaagaa aacagcacca ctgagatgaa
     3241 tctcatggca gaacaactcg acatgcctat gcagccacac agtggtaact tgaaggcagc
     3301 acagaggtga gggattaaaa ggaaaggcag attttgaaat ctgactctca ggttagctgg
     3361 agttacaagg cagccaacaa tgattataca caatctgcac caaacaggga aaggacctgc
     3421 tgctgaaaag ggaagagggg tagatcctcc aatgtaaata taaacatgcc atagttaaca
     3481 aatgataagg atgccacatt tttcatgcag aaaagaacca caggtattca gtttcttgta
     3541 ttatgatttc taaagaaaac ctattaaata tttggaattt agatgcaagc tactcattca
     3601 cacagaactt ttccataaac attgttccac atattgaaaa aactgtaaaa ttatagcact
     3661 aacttgattt tagaaaatga gcatttttta caactgccat ttactgtatg tagaaaaaag
     3721 acataaaacc ttagagaaag ccactaccat ttttcaagtt atcttttccc caacatcaac
     3781 atcaacatga tatccttcat tcagggcata ttttttcttc ccaggatcaa actgaaaaca
     3841 tgttaaggct atagtttagc cagtaagatt taatcacaat ttttcttctt taatactaag
     3901 agatgggtac cttagtaccc ttcacctaac atctctcggt aaaaagcaga caagatcaca
     3961 aattacagta aaaatgtgct cttttttaag gtgggcagat tagtttgtca aagtctcagc
     4021 ccagttcaat tcagttgatc tcgagtggtg agtattttgt ctcttgttaa accagaccct
     4081 gggcttgtct gggcagagac agaagctgat ttaacagcat agagcacagc gccctacttc
     4141 cccacagaca ggctgaatta gaagccccta ttacaaataa gagcaccacg agctaaaatt
     4201 taccaaccca tttatcagga tgaccattgc catttgtcag gtgacagaca gcttggtcac
     4261 aacacaactg tgtcctgagc acacaagatt ccatcagccc tgaaggacag cagaggagta
     4321 ttttccatca tttcaaacca caaacaaaat taagatttaa actgtgggat gggtaagaaa
     4381 tccccttctt tggctgggaa tctccacctt aatccttaaa ggaccataac tggcaaaatc
     4441 cttagtgtac ggacaaaagc aaattggaaa agccagccat ttactaattc agaggaacag
     4501 catagccaag gctagcgagg catactttcc agttgaaaaa aatcaaaatt ttttgccttc
     4561 catttttctg ggtaatgtcc tttaagaaaa gtgaatgaca gtagtaccaa aaaggtattt
     4621 tcctttctca tttaaaagca aaaacctccc tttttaattg cctgtagaag gcaagatttt
     4681 ctttcatttt tgtccatttg tgtttcagaa tcagcacagg tttgaagatt agactgttag
     4741 tcatctgtgc tttctttacc aactggctag aacggaacag catcacagca acgctgcgga
     4801 tcttggttac acagtgtcag agcttttgtt ttttgatggg gttttatcct cttcaccacc
     4861 actacccact ccattttttt tctattttta agattagagg aaaatgacca ttaagaacca
     4921 gaaaaataat taatctctct ggaaaaagga aagctaaaga agactatgat accataccca
     4981 tctagaaacc aagaactagt ttgaaatcgt ttatattcat ttctgtagca tgacagggat
     5041 ttcaatcacc tttctgaaaa gagtgggctg ataaacttgt aaatccacac acaactctga
     5101 gaatacccac tgccagcatc aaaaagcaaa gatactaatt ttttaagcca aaaatctgta
     5161 ctaacacatg taatttctta atgtgcctaa gttaatttct gtatcaattc aataaatgga
     5221 attgactgaa cttcccaacg ccactaatta ttaaaatcca tctgcttatt ctaatgctag
     5281 tcaccaagag ctagactcca tctttccaat aaaaatgagc cctatgtagc actaggtttg
     5341 aattctaaaa ttcaaaacag gcatttcatt ttcttaaggc acacttccta cacacagcta
     5401 tcaggggaaa aagctataaa tgtcctgttc tttttctgaa gtgtggatat caatataaaa
     5461 tttgttaaag aatattttta acagctgact tacatgatcg ttttcctaat acaggaatac
     5521 agcgacagac ctatctgaaa agtctgtttg ggggcatact tttcatatct tattgactaa
     5581 agcccttgag ccaggaaaaa aaaaaaaaaa gagagagaga cagtaaggcc atctatagat
     5641 aattaaatat ttctctatct aacctggggc aaactcatag tacttgaata aggccaaaaa
     5701 caaatagaaa attactgttt aagctttcat tctgctattg caaacatttg gaaacctctg
     5761 caactctttc aactaacatt tttgtcctta gcggtttttt tttttttttt taagtctgat
     5821 atatggaatg tttggtgaac cttcctatca acactgagac tggaaactca aagtacagtc
     5881 caaatacatt gtgttcaatc accttcaaga gccatttttc tttttgggtg ggaggtgggc
     5941 agatgggttg agggtgggaa gaaaatacta ttatgcaggg tgttttggga ggggggaggg
     6001 taacataaag agcagtgtac aggcaagttt tgttattaaa attgtgtata ctgtaaaaag
     6061 tgaa
//
